Mechanism of ligand recognition by BmrR, the multidrug-responding transcriptional regulator: Mutational analysis of the ligand-binding site

Biochemistry

Volumn 38, Issue 51, 1999, Pages 16925-16931

  Vázquez Laslop, Nora ^a   Markham, Penelope N ^a   Neyfakh, Alex A ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Influx Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; TRANSCRIPTION FACTOR;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; ENZYME SPECIFICITY; HYDROGEN BOND; LIGAND BINDING; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

AMINO ACID SUBSTITUTION; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; TRANS-ACTIVATORS; TYROSINE;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 0040436016     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991988g     Document Type: Article

References (23)

1. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398.
2. Paulsen, I. T., Brown, M. H., and Skurray, R. A. (1996) Microbiol Rev. 60, 575-608.
3. Kolaczkowski, M., and Goffeau, A. (1997) Pharmacol. Ther. 76, 219-242.
4. Choi, K. H., Chen, C. J., Kriegler, M., and Roninson, I. B. (1988) Cell 53, 519-529.
5. Gros, P., Dhir, R., Croop, J., and Talbot, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7289-7293.
6. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 19965-19972.
7. Paulsen, I. T., Brown, M. H., Littlejohn, T. G., Mitchell, B. A., and Skurray, R. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 3630-3635.
8. Yerushalmi, H., Lebendiker, M., and Schuldiner, S. (1996) J. Biol. Chem. 271, 31044-31048.
9. Klyachko, K. A., Schuldiner, S., and Neyfakh, A. A. (1997) J. Bacteriol. 179, 2189-2193.
10. Edgar, R., and Bibi, E. (1999) EMBO J. 18, 822-832.
11. Neyfakh, A. A., Bidnenko, V. E., and Chen, L. B. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7289-7293.
12. Ahmed, M., Borsch, C. M., Taylor, S. S., Vazquez-Laslop, N., and Neyfakh, A. A. (1994) J. Biol. Chem. 269, 28506-28513.
13. Markham, P. N., LoGuidice, J., and Neyfakh, A. A. (1997) Biochem. Biophys. Res. Commun. 239, 269-272.
14. Summers, A. O. (1992) J. Bacteriol. 174, 3097-3101.
15. Markham, P. N., Ahmed, M., and Neyfakh, A. A. (1996) J. Bacteriol. 178, 1473-1475.
16. Zheleznova, E. E., Markham, P. N., Neyfakh, A. A., and Brennan, R. G. (1999) Cell 96, 353-362.
17. Baranova, N. N., Danchin, A., and Neyfakh, A. A. (1999) Mol. Microbiol. 31, 1549-1559.
18. Dietze, E. C., Wang, R. W., Lu, A. Y. H., and Atkins, W. M. (1996) Biochemistry 35, 6745-6753.
19. Sundaram, M., Sivaprasadarao, A., van Aalten, D. M. F., and Findlay, J. B. C. (1998) Biochem. J. 334, 155-160.
20. O'Neill, K. T., and DeGrado, W. F. (1990) Science 250, 646-651.
21. Marqusee, S., and Baldwin, R. L. (1989) in Protein Folding (Gierasch, L. M., and King, J., Eds.) pp 85-94, American Association for the Advancement of Science, Washington, DC.
22. Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., and Winter, G. (1985) Nature 314, 235-238.
23. Zheleznova, E. E., Markham, P. N., Neyfakh, A. A., Edgar, R., Bibi, E., and Brennan, R. G. (1999) Trends Biochem. Sci. (submitted for publication).