Clustering of metabolic abnormalities in obese individuals: The role of genetic factors

Annals of Medicine

Volumn 33, Issue 2, 2001, Pages 79-90

  Ukkola, O ^a   Bouchard, C ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Genes; Metabolic syndrome; Obesity

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; FATTY ACID; GLUCOCORTICOID; INSULIN; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADRENERGIC SYSTEM; BLOOD PRESSURE REGULATION; BODY FAT; COMORBIDITY; DISEASE ASSOCIATION; ENDURANCE; FATTY ACID METABOLISM; GENETIC POLYMORPHISM; GENETIC RISK; GLUCOSE METABOLISM; HEREDITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN METABOLISM; INSULIN RESISTANCE; LIPOPROTEIN METABOLISM; METABOLIC DISORDER; OBESITY; PRIORITY JOURNAL; REVIEW;

EID: 0035051032     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853890109002062     Document Type: Review

References (99)

1. Syndrome X
2. Role of insulin resistance in human disease
3. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridaemia, and hypertension
4. Abdominal obesity and the metabolic syndrome
5. Genetics and the metabolic syndrome
6. The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances in diabetes mellitus
7. Insulin resistance in obesity: Metabolic mechanisms and measurement methods
8. Central role of the adipocyte in insulin resistance
9. Associations between regional body fat distribution, fasting plasma free fatty acid levels and glucose tolerance in premenopausal women
10. Visceral fat and insulin resistance-causative or correlative?
11. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
12. Relationships of generalized and regional adiposity to insulin sensitivity in men
13. Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: Is there a contribution of subcutaneous fat cell hypertrophy?
14. Insulin resistance and hypersecretion in obesity
15. Genetic aspects of susceptibility to obesity and related dyslipidemias
16. Mechanisms of TNF-alpha-induced insulin resistance
17. Tumor necrosis factor alpha: A key component of the obesity-diabetes link
18. Hypertension, dyslipidemia, and insulin resistance: Links in a chain or spokes on a wheel?
19. Metabolic syndrome and hypertension: Pathophysiology and molecular basis of insulin resistance
20. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus
21. Hypothalamic origin of the metabolic syndrome X
22. The role of leptin in human obesity and disease: A review of current evidence
23. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
24. Clinical endocrinology of human leptin
25. Hyperleptinaemia: The missing link in the metabolic syndrome?
26. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
27. Medical significance of peroxisome proliferator-activated receptors
28. Skeletal muscle peroxisome proliferator-activated receptor-gamma expression in obesity and non-insulin-dependent diabetes mellitus
29. Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
30. PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes
31. Genetics of causes and manifestations of the metabolic syndrome
32. Genetic and environmental influences on body fat distribution, fasting insulin levels and CVD: Are the influences shared?
33. Bivariate genetic analysis of fasting insulin and glucose levels
34. Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins
35. Genetic influences on insulinemia in normotensive twins
36. Familial components of the multiple metabolic syndrome: The ARIC Study
37. Clustering of hypertension, diabetes, and obesity in adult male twins: Same genes or same environments?
38. Concordance for dyslipidemic hypertension in male twins
39. Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures
40. Genetic and environmental architecture of the features of the insulin-resistance syndrome
41. Genetic and environmental influences on insulin levels and the insulin resistance syndrome: An analysis of women twins
42. Cross-trait familial resemblance for body fat and blood pressure: Familial correlations in the Québec Family Study
43. Familial correlations in the Québec Family Study: Cross-trait familial resemblance for body fat with plasma glucose and insulin
44. Cross-trait familial resemblance for body fat and blood lipids: Familial correlations in the Quebec Family Study
45. Familial clustering of insulin and abdominal visceral fat: The HERITAGE Family Study
46. Cross-trait familial resemblance for resting blood pressure and body composition and fat distribution: The HERITAGE Family Study
47. Genetics of insulin resistance
48. A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
49. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes
50. A missense mutation of the muscle glycogen synthase gene (M416 V) is associated with insulin resistance in the Japanese population
51. Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects
52. The I27L amino acid polymorphism of hepatic nuclear factor-1 alpha is associated with insulin resistance
53. Genetic variation at the lipoprotein lipase locus and plasma lipoprotein and insulin levels in the Quebec Family Study
54. The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity
55. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
56. Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′flanking region of the human insulin gene
57. Insulin receptor gene in hypertension
58. A Pro12Ala substitution in PPAR gamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
59. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
60. Trp64Arg mutation in beta 3-adrenoceptor gene of doubtful significance for obesity and insulin resistance
61. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
62. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells
63. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians
64. Evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (FABP2) in Mexican-Americans
65. Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men
66. Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus
67. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin and dysregulation of the hypothalamic-pituitary-adrenal axis
68. An association between a BclI restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women
69. Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec Family Study
70. Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Quebec Family Study
71. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: A four-corners approach to the identification of genetic determinants of blood pressure
72. A polymorphism of the 5′flanking region of the glucocorticoid receptor gene locus is associated with basal cortisol secretion in men
73. Body fat, resting and exercise blood pressure and the angiotensinogen M235T polymorphism: The HERITAGE Family Study
74. Hypertension in obesity and the leptin receptor gene locus
75. Circulating levels of factor VII, fibrinogen, and von Willebrand factor and features of insulin resistance in first-degree relatives of patients with NIDDM
76. Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients - Relationship with plasma insulin
77. Genetic factors determining thrombosis and fibrinolysis
78. Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene
79. Plasminogen activator inhibitor-1 (PAI-1) antigen plasma levels in subjects attending a metabolic ward: Relation to polymorphisms of PAI-1 and angiotensin converting enzyme (ACE) genes
80. The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels
81. Polymorphism of tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients
82. Apolipoprotein E polymorphism alters the association between body fatness and plasma lipoproteins in women
83. Apolipoprotein E polymorphism modifies relation of hyperinsulinemia to hypertriglyceridemia
84. Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyper-insulinemia and an SstI polymorphism
85. The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity
86. The MspI polymorphism of the apolipoprotein A-II gene as a modulator of the dyslipidemic state found in visceral obesity
87. ApoB-100 Gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity
88. The apoB-100 gene EcoRI polymorphism influences the relationship between features of the insulin resistance syndrome and the hyper-apoB and dense LDL phenotype in men
89. Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome
90. Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives
91. The response to long-term overfeeding in identical twins
92. Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins
93. Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding
94. Glucocorticoid receptor Bcl I variant is associated with increased atherogenic profile in response to long-term overfeeding
95. Alterations in body weight and composition consequent to 20 wk of endurance training: The HERITAGE Family Study
96. Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study
97. Association and linkage between an insulin-like growth factor-1 gene polymorphism and fat free mass in the HERITAGE Family Study
98. AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study
99. Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and plasma insulin and lipid levels in the Quebec Family Study