Hyperleptinaemia: The missing link in the metabolic syndrome?

Diabetic Medicine

Volumn 14, Issue 3, 1997, Pages 200-208

  De Courten, M ^a   Zimmet, P ^e   Hodge, A ^e   Collins, V ^e   Nicolson, M ^b   Staten, M ^e   Dowse, G ^c   Alberti, K G M M ^d  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b AMGEN INC   (United States)

^c Midwest Public Health Unit   (Australia)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e NONE

Author keywords

insulin sensitivity; leptin; metabolic syndrome; Polynesians

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MULTIPLE REGRESSION; POLYNESIA;

ADULT; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CHOLESTEROL, HDL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INDEPENDENT STATE OF SAMOA; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OBESITY; PROTEINS; REGRESSION ANALYSIS; SEX CHARACTERISTICS; TRIGLYCERIDES;

EID: 0030943158     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199703)14:3<200::AID-DIA336>3.0.CO;2-V     Document Type: Article

References (59)

1. Zimmet P. The pathogenesis and prevention of diabetes in adults: genes, autoimmunity and demography. Diabetes Care 1995; 18: 1050-1064.
2. Vague J. The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout and uric calculus disease. Am J Clin Nutr 1956; 4: 20-34.
3. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
4. De Fronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
5. Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridaemia, and hypertension. Arch Int Med 1989; 149: 1514-1520.
6. Zimmet PZ. Hyperinsulinemia - how innocent a bystander? Diabetes Care 1993; 16 (suppl 1): 56-70.
7. Jarrett RJ. In defence of insulin: a critique of Syndrome X. Lancet 1992; 340: 469-471.
8. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: the key feature of a cardiovascular and Metabolic Syndrome. Diabetologia 1991; 34: 416-422.
9. Björntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14: 1132-1143.
10. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (Syndrome X). Diabetes 1992; 41: 715-722.
11. Collins VC, Dowse GK, Finch CF, Zimmet PZ. An inconsistent relationship between insulin and blood pressure in three Pacific island populations. J Clin Epidemiol 1990; 43: 1369-1378.
12. Saad MF, Lillioja S, Nyomba BL, Castillo C, Ferraro R, De Gregdrio M, et al. Racial differences in the relation between blood pressure and insulin resistance. N Engl J Med 1991; 324: 733-739.
13. Dowse CK, Collins VR, Alberti KGMM, Zimmet P, Tuomilehto J, Chitson P, et al. Insulin and blood pressure levels are not independently related in Mauritians of Asian Indian, Creole or Chinese origin. J Hyper 1993; 11: 297-307.
14. Falkner B, Hulman S, Kushner H. Insulin-stimulated glucose utilization and border-line hypertension in young adult blacks. Hypertension 1993; 22: 18-25.
15. Kolaczynski JW, Caro JF. Molecular mechanism of insulin resistance in human obesity. Current Opinion in Endocrinol & Diabetes 1996; 3: 38-43.
16. Chaiken RL, Banerji MA, Huey H, Lebovitz HE. Do blacks with NIDDM have an insulin-resistance syndrome? Diabetes 1993; 42: 444-449.
17. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
18. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
19. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-549.
20. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser C, et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 1995; 96: 2065-2070.
21. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45: 531-535.
22. Clement K, Garner C, Hager J, Philippi A, LeDue C, Carey A, et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes 1996; 45: 687-690.
23. Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 1996; 45: 691-694.
24. Zimmet PZ, Hodge AM, Nicolson M, Staten M, de Courten M, Moore J, et al. Serum leptin concentration, obesity and insulin resistance in Western Samoans. Br Med J 1996: 313: 965-969.
25. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactiveleptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
26. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 1155-1161.
27. MacDougald OA, Hwang C-S, Fan H, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1995; 92: 9034-9037.
28. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995; 377: 527-529.
29. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, et al. Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 1996; 45: 699-701.
30. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 1996; 45: 695-698.
31. Damani S, Gabriel M, Khan A, Boyadjian R, Kamdar V, Saad M. Adiposity and insulinemia determine plasma leptin concentration. Diabetes 1996; 45: 41A.
32. Gabriel M, Jinagouda S, Boyadjian R, Kades W, Ayad M, Saad M. Is leptin the link between obesity and insulin resistance? Diabetes 1996; 45: 51A.
33. De Courten M, Zimmet P, Hodge A, Collins V, Nicolson M, Staten M, et al. Is hyperleptinemia the missing link in the Metabolic Syndrome? Diabetes 1996; 45: 150A.
34. Zimmet P, Faaiuso S, Ainuu J, Whitehouse S, Milne B, DeBoer W. The prevalence of diabetes in the rural and urban Polynesian population of Western Samoa. Diabetes 1981; 30: 45-51.
35. Collins VR, Dowse GK, Toelupe PM, Imo TT, Aloaina FL, Spark RA, et al. Increasing prevalence of NIDDM in the Pacific island population of Wetern Samoa over a 13-year period. Diabetes Care 1994; 17: 288-296.
36. Serjeantson SW. Migration and admixture in the Pacific. J Pac Hist 1984; 19: 160-165.
37. Soeldner JS, Slone D. Critical variables in radioimmunoassay of serum insulin using the double antibody technique. Diabetes 1965; 14: 771-779.
38. Winocour PH, Ishola M, Durrington PN. Validation of the Friedewald formula for the measurement of low density lipoprotein cholesterol in insulin-dependent diabetes mellitus. Clin Chim Acta 1989; 179: 79-84.
39. Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med 1993; 153: 154-181.
40. World Health Organization. Diabetes Mellitus. WHO Technical Report Series, No. 727. Geneva: WHO, 1985.
41. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
42. Rudenski AS, Matthews DR, Levy JC, Turner RC. Under-standing 'insulin resistance': both glucose resistance and insulin resistance are required to model human diabetes. Metabolism 1991; 40: 908-917.
43. Dowse GK, Qin H, Collins VR, Zimmet PZ, Alberti KGMM, Gareeboo H. Determinants of estimated insulin resistance and β-cell function in Asian Indian, Creole and Chinese Mauritians. Diab Res Clin Practice 1990; 10: 265-279.
44. Norusis MJ. SPSS/PC+ Statistics and Advanced Statistics 4.0 for IBM PC/XT/AT and PS/2. Chicago: SPSS Inc., 1990.
45. Ostlund RE Jr, Klein S, Yang JW. Relation between plasma leptin concentration, body composition, and metabolic covariates. Diabetes 1996; 45: 41A.
46. Tuominen JA, Laquier FW, Heiman ML, Ebeling P, Koistinen HA, Kostamo E, et al. Leptin, exercise and energy metabolism. Diabetes 1996; 45: 256A.
47. Lindpaintner K. Clinical implications of basic research: finding an obesity gene: a tale of mice and man. N Engl J Med 1995; 322: 679-680.
48. Neel JV. Diabetes mellitus: a thrifty genotype rendered detrimental by 'progress'? Am J Hum Genet 1962; 14: 353-362.
49. Zimmet P, O'Dea K. Thrifty genotypes. In: Leslie RDG, ed. Causes of Diabetes. London: John Wiley, 1993: 269-290.
50. Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1995; 1: 950-953.
51. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Sighemoto M, et al. Human obese gene expression adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995; 44: 855-858.
52. Hamilton BS, Paglia D, Kwan AYM, Dietel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med 1995; 1: 953-956.
53. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, et al. Evidence against either a premature stop codon or the absence of gene mRNA in human obesity. J Clin Invest 1995; 95: 2986-2988.
54. Storlein LH, Bauer LA, Kriketos AD, Pan DA, Cooney GJ, lenkins AB, et al. Dietary fats and insulin action. Diabetologia 1996; 39: 621-631.
55. Gallagher D, Vissser M, Sepúlveda D, Pierson RN, Harris T, Heymsfield SB. How useful is body mass index for comparison of body fatness across age, sex, and ethnic groups? Am J Epidemiol 1996; 143: 228-239.
56. Garn SM, Leonard WR, Hawthorne VM. Three limitations of the body mass index. Am J Clin Nutr 1986; 44: 996-997.
57. Weidmann P, Boehlen LM, de Courten M. Pathogenesis and treatment of hypertension associated with diabetes mellitus. Am Heart J 1993; 125: 1498-1513.
58. Groop LC, Pelkonen R. Treatment failures: a common problem in the management of patients with type 2 diabetes. Acta Endocrinol Suppl 1984: 131-135.
59. Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL. Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes 1996; 45: 822-824.