Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men

Diabetologia

Volumn 40, Issue 6, 1997, Pages 706-710

  Yamada, K ^a   Yuan, X ^a   Ishiyama, S ^a   Koyama, K ^a   Ichikawa, F ^a   Koyanagi, A ^b   Koyama, W ^b   Nonaka, K ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPANESE RED CROSS KUMAMOTO HOSPITAL   (Japan)

Author keywords

Fatty acid binding protein 2; Insulin resistance; Intestinal fatty acid binding protein; Visceral fat

Indexed keywords

FATTY ACID BINDING PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BODY FAT; DIABETES MELLITUS; GENETIC POLYMORPHISM; HUMAN; INSULIN RESISTANCE; JAPAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ABDOMEN; ADIPOSE TISSUE; ALANINE; BODY MASS INDEX; CARRIER PROTEINS; DNA; FATTY ACID-BINDING PROTEINS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INSULIN RESISTANCE; JAPAN; LEUKOCYTES; MALE; MIDDLE AGED; MYELIN P2 PROTEIN; NEOPLASM PROTEINS; POINT MUTATION; POLYMORPHISM, GENETIC; THREONINE; TUMOR SUPPRESSOR PROTEINS;

EID: 0030838107     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050737     Document Type: Article

References (21)

1. Bennett PH, Burch TA, Miller M (1971) Diabetes mellitus in American (Pima) Indians. Lancet 2: 125-128
2. Lillioja S, Mott DM, Zawadzki JK et al. (1987) In vivo insulin action is a familial characteristic in nondiabetic Pima Indians. Diabetes 36: 1329-1335
3. Saad MF, Knowler WC, Pettitt DJ, Nelson RG. Charles MA, Bennett PH (1991) A two-step model for development of non-insulin dependent diabetes. Am J Med 90: 229-235
4. Prochazka M, Lillioja S, Tait JF et al. (1993) Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. Diabetes 42: 514-519
5. Mitchell BD, Kammerer CM, O'Connell P et al. (1995) Evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (FABP2) in Mexican-Americans. Diabetes 44: 1046-1053
6. Baier LJ, Sacchettini JC, Knowler WC et al. (1995) An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 95: 1281-1287
7. Lowe JB, Sacchettini JC, Laposata M, McQuillan JJ, Gordon JI (1987) Expression of rat intestinal fatty acid-binding protein in Escherichia coli. J Biol Chem 266: 17180-17186
8. Sweetser DA, Birkenmeier EH, Klisak IJ et al. (1987) The human and rodent intestinal fatty acid binding protein gene: a comparative analysis of their structure, expression, and linkage relationship. J Bio Chem 262: 16060-16071
9. Kelley D, Mokan M, Simoneau J-A, Mandarino LJ (1993) Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92: 91-98
10. Randle PJ, Garland PB, Hales CN, Newsholme A (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789
11. Felley CP, Felley EM, Van Meile GD, Frascarolo P, Jequier E, Felber J-P (1989) Impairment of glucose disposal by infusion of triglyceride in humans: role of glycemia. Am J Physiol 256: E747-E752
12. Kissebah AH, Vydelingum N, Murray R et al. (1982) Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 54: 254-260
13. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S (1987) Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36: 54-59
14. Kadowaki T, Kadowaki H, Yazaki Y (1993) Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 328: 1568-1569
15. Fujisawa T, Ikegami H, Yamato E et al. (1995) A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. Diabetologia 38: 983-985
16. Yagi T, Nishi S, Hinata S-I, Murakami M, Yoshimi T (1996) A population association study of four candidate genes (hexokinase II, glucagon-like peptide-1 receptor, fatty acid binding protein-2, and apolipoprotein C-II) with type 2 diabetes and impaired glucose tolerance in Japanese subjects. Diabet Med 13: 902-907
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentrations in man. Diabetologia 28: 412-419
18. Armellini F, Zamboni M, Robbi R et al. (1993) Total and intra-abdominal fat measurements by ultrasound and computerized tomography. Int J Obes 17: 209-214
19. Armellini F, Zamboni M, Castelli S et al. (1994) Measured and predicted total and visceral adipose tissue in women. Correlations with metabolic parameters. Int J Obes 18: 641-647
20. Tornaghi G, Raiteri R, Pozzato C et al. (1994) Anthropometric or ultrasonic measurements in assessment of visceral fat? A comparative study. Int J Obes 18: 771-775
21. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Tokunaga K (1995) Pathophysiology and pathogenesis of visceral fat obesity. Ann N Y Acad Sci 748: 399-406