Genetic and environmental architecture of the features of the insulin- resistance syndrome

American Journal of Human Genetics

Volumn 60, Issue 1, 1997, Pages 143-152

  Hong, Yuling ^a,b   Pedersen, Nancy L ^a,c   Brismar, Kerstin ^b   De Faire, Ulf ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; GENETICS; HUMAN; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; SYNDROME; SYSTOLIC BLOOD PRESSURE; TWINS;

AGED; AGED, 80 AND OVER; DISEASES IN TWINS; ENVIRONMENT; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MODELS, GENETIC; MULTIVARIATE ANALYSIS; SWEDEN;

EID: 0031019562     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Allison DB, Heshka S, Heymsfield SB (1993) Evidence of a major gene with pleiotropic action for a cardiovascular disease risk syndrome in children younger than 14 years. Am J Dis Child 147:1298-1302
2. Bergman RN, Prager R, Volund A, Olefsky JM (1987) Equivalence of the insulin sensitivity index in man derived by the minimal model and the euglycemic glucose clamp. J Clin Invest 79:790-800
3. Bogardus C, Lillioja S, Mott DM, Hollenbeck C, Reaven GM (1985) Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol 248:E286-E291
4. Carmelli, Cardon LR, Fabsitz R (1994) Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet 55:566-573
5. DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multi-faceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
6. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
7. Despres J-P, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien P-J (1996) Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334:952-957
8. Falconer DS (ed) (1989) Introduction to quantitative genetics, 3d ed. Longman Scientific and Technical, Essex
9. Ferrannini E (1993) Syndrome X. Horm Res Suppl 39 (3): 107-111
10. Ferrannini E, Haffner SM, Mitchell BD, Stern MP (1991) Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 34:416-422
11. Fontbonne A, Charles MA, Thibult N, Richard JL, Claude JR, Warnet JM, Rosselin GE, et al (1991) Hyperinsulinaemia as a predictor of coronary disease mortality in a healthy population: the Paris Prospective Study, 15-year follow up. Diabetologia 34:356-361
12. Haffner SM, Ferrannini E, Hazuda P, Stern MP (1992b) Clustering of cardiovascular risk factors in confirmed pre-hypertensive individuals. Hypertension 20:38-45
13. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK (1988) Increased insulin concentrations in nondiabetic offspring of diabetic parents. N Engl J Med 319:1297-1301
14. _ (1990) Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263:2893-2898
15. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK (1986) Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med 315:220-224
16. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern M (1992b) Prospective analysis of the insulin resistance syndrome (syndrome X). Diabetes 41:715-722
17. Heller DA, de Faire U, Pedersen NL, Dahlen G, McClearn GE (1993) Genetic and environmental influences on serum lipid levels in twins. N Engl J Med 328:1150-1156
18. Heller DA, Pedersen NL, de Faire U, McClearn GE (1994) Genetic and environmental correlations among serum lipids and apolipoproteins in elderly twins reared together and apart. Am J Hum Genet 55:1255-1267
19. Hjermann I (1992) The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol Suppl 20 (8): S5-S10
20. Hong Y, de Faire U, Heller DA, McClearn GE, Pedersen N (1994) Genetic and environmental influences on blood pressure in elderly twins. Hypertension 24:663-670
21. Hong Y, Pedersen N, Brismar K, Hall K, de Faire U (1996) Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and insulin levels in middle-aged and elderly twins. J Clin Endocrinol Metab 81:1791-1797
22. Jöreskog KG, Sörbom D (eds) (1989) LISREL 7: a guide to the program and application, 2d ed. SPSS, Chicago
23. Kissebah AH (1991) Insulin resistance in visceral obesity. Int J Obesity Suppl 15 (2): 109-115
24. Laakso M (1993) How good a marker is insulin level for insulin resistance? Am J Epidemiol 137:959-965
25. Laws A, Reaven GM (1991) Physical activity, glucose tolerance, and diabetes in older adults. Ann Behav Med 13:125-132
26. Mahaney MC, Blangero J, Comuzzie AG, van de Berg JL, Stern MP, MacCluer JW (1995) Plasma HDL cholesterol, triglycerides, and adiposity: a quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study. Circulation 92:3240-3248
27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and J-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
28. Mayer EJ, Newman B, Austin MA, Zhang D, Quesenberry CP Jr, Edwards K, Selby JV (1996) Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins. Am J Epidemiol 143: 323-332
29. Mayer EJ, Newman B, Quesenberry CP Jr, Selby JV (1993) Usual dietary fat intake and insulin concentrations in healthy women twins. Diabetes Care 16:1459-1469
30. McGue M, Bouchard TJ Jr (1984) Adjustment of twin data for the effects of age and sex. Behav Genet 14:325-343
31. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A, et al (1985) Hyperinsulinaemia: a link between hypertension, obesity and glucose intolerance. J Clin Invest 75:809-817
32. Moller DE, Flier JS (1991) Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med 325:938-948
33. Neale MC, Cardon LR (eds) (1992) Methodology for genetic studies of twins and families. Kluwer Academic, Dordrecht
34. 2 cholesterol levels in older adults. N Engl J Med 322:229-234
35. Pedersen NL, Friberg L, Floderus-Myrhed B, McClearn GE, Plomin R (1984) Swedish early separated twins: identification and characterization. Acta Genet Med Gemellol (Roma) 33:243-250
36. Pedersen NL, McClearn GE, Plomin R, Nesselroade JR, Berg S, de Faire U (1991) The Swedish Adoption Twin Study of Aging: an update. Acta Gent Med Gemellol (Roma) 40:7-20
37. Pyörälä K, Savolainen E, Kaukola S, Haapakoski J (1985) Plasma insulin and coronary heart disease risk factor relationship to other risk factors and predictive value during 9 1/2-year follow-up of the Helsinki Policemen Study population. Acta Med Scand Suppl 701:8-52
38. Randle PJ, Garland PB, Hales CN, Newsholme EA (1963) The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789
39. Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595-1607
40. Reaven GM, Lithell H, Landsberg L (1996) Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334: 374-381
41. Seigler L, Wu WT (1981) Separation of serum high-density lipoprotein for cholesterol determination: ultracentrafugation vs. precipitation with sodium phosphotungstate and magnesium chloride. Clin Chem 27:838-841
42. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322:1483-1487
43. Swislocki ALM, Hoffman BB, Reaven GM (1989) Insulin resistance, glucose tolerance and hyperinsulinaemia in patients with hypertension. Am J Hypertens 2:419-423
44. Taylor SI (1992) Lilly lecture: molecular mechanisms of insulin resistance: lessons from patients with mutations in the insulin-receptor gene. Diabetes 41:1473-1490
45. Yarnell JWG, Sweetnam PM, Marks V, Teale JD, Bolton CH (1994) Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study. Br Heart J 71:293-296