Familial correlations in the Quebec family study: Cross-trait familial resemblance for body fat with plasma glucose and insulin

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1357-1364

  Rice, T ^a   Nadeau, A ^b   Perusse L ^b   Bouchard, C ^b   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Bivariate; Environmental; Genetic; Pleiotropy

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; BODY FAT; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; BLOOD; BODY COMPOSITION; BODY MASS; CANADA; CHILD; COMPARATIVE STUDY; DIET RESTRICTION; ETHNOLOGY; FAMILY; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; OBESITY; PROSPECTIVE STUDY; SKINFOLD THICKNESS;

ADOLESCENT; ADULT; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; CHILD; FAMILY; FASTING; HUMANS; INSULIN; MIDDLE AGED; OBESITY; PROSPECTIVE STUDIES; QUEBEC; SKINFOLD THICKNESS;

EID: 0029658549     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050583     Document Type: Article

References (33)

1. Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607
2. Björntorp P (1992) Abdominal obesity and the metabolic syndrome. Ann Med 24: 465-468
3. Kissebah AH, Freedman DS, Peiris AN (1989) Health risks of obesity. Med Clin North Am 73: 111-138
4. Bouchard C, Després JP, Mauriège P (1993) Genetic and nongenetic determinants of regional fat distribution. Endocr Rev 14: 72-93
5. DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194
6. Oppert JM, Vohl MC, Chagnon M et al. (1995) DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obesity 18: 526-531
7. Krotkiewski M, Mandroukas K, Sjöström L, Sullivan L, Wetterqvist H, Björntorp P (1979) Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity. Metabolism 28: 650-658
8. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP (1992) Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 41: 715-722
9. Bouchard C, Pérusse L (1994) Genetics of causes and manifestations of the metabolic syndrome. In: Padova G, Crepaldi G (eds) 6th European Symposium on metabolism: the plurimetabolic syndrome.Elsevier Science Publishers, Amsterdam, pp 67-74
10. Schumacher MC, Hasstedt SJ, Hunt SC, Williams RR, Elbein SC (1992) Major gene effect for insulin levels in familial NIDDM pedigrees. Diabetes 41: 416-423
11. Schork NJ, Weder AB, Trevisan M, Laurenzi M (1994) The contribution of pleiotropy to blood pressure and body mass index variation: the Gubbio study. Am J Hum Genet 54: 361-373
12. Rice T, Province M, Pérusse L, Bouchard C, Rao DC (1994) Cross-trait familial resemblance for body fat and blood pressure: familial correlations in the Québec Family Study. Am J Hum Genet 55: 1019-1029
13. Blishen BR, McRoberts HA (1976) A revised index for occupations in Canada. Can Rev Soc Anthropol 13: 71-79
14. Blishen BR (1970) Social class and opportunity in Canada. Can Rev Soc Anthropol 7: 110-172
15. Himes JH, Bouchard C (1985) Do the new Metropolitan Life Insurance weight-height tables correctly assess body frame and body fat relationships? Am J Public Health 75: 1076-1079
16. Bouchard C (1985) Reproducibility of body-composition and adipose-tissue measurements in humans. In: AF Roche (ed) Body-composition assessments in youth and adults: report of the Sixth Ross Conference on medical research. Ross Laboratories, Columbus, Ohio, pp 9-14
17. Weiner JS, Lourie JA (1969) Human biology: a guide to field methods. Blackwell, Oxford
18. Richterich R, Dauwalder H (1971) Zur Bestimmug der Plasmaglucosekonzentra-tion mit der Hexokinase-glucose-6-phosphat-dehydrogenase-methode. Schweiz Med Wochenschr 101:615-618
19. Desbuquois B, Aurbach GD (1971) Use of the polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 37: 732-738
20. Borecki IB, Rice T, Bouchard C, Rao DC (1991) Commingling analysis of generalized body mass and composition measures: the Québec Family Study. Int J Obesity 15: 763-773
21. Rice T, Borecki IB, Bouchard C, Rao DC (1992) Commingling analysis of regional fat distribution measures: the Québec Family Study. Int J Obesity 16: 831-844
22. Province MA, Rao DC (1995) A general purpose model and a computer program for combined segregation and path analysis (SEGPATH): automatically creating computer programs from symbolic language model specifications. Genet Epidemiol 12: 203-219
23. Mitchell BD, Kammerer CM, Mahaney MC et al. (1996) Genetic analysis of the IRS: pleiotropic effects of genes influencing insulin levels on lipoproteins and obesity measures. Arterioscler Thromb Vasc Biol 16: 281-288
24. Mayer EJ, Newman B, Austin MA, et al. (1996) Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins. Am J Epidemiol 143: 323-332
25. Fain PR (1978) Characteristics of simple sibship variance tests for the detection of major loci and application to height, weight and spatial performance. Ann Hum Genet London 42: 109-120
26. Rao DC, MacLean CJ, Morton NE, Yee S (1975) Analysis of family resemblance. V. Height and weight in Northeastern Brazil. Am J Hum Genet 24: 509-520
27. Zonta LA, Jayakar SD, Bosisio M, Galante A, Pennetti V (1987) Genetic analysis of human obesity in an Italian sample. Hum Hered 37: 129-139
28. Karlin S, Williams PT, Jensen S, Farquhar JW (1981) Genetic analysis of the Stanford LRC Family Study data: I Structured exploratory data analysis of height and weight measurements. Am J Epidemiol 113: 307-324
29. Moll PP, Burns TL, Lauer RM (1991) The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. Am J Hum Genet 49: 1243-1255
30. Price RA, Ness R, Laskarzewski P (1990) Common major gene inheritance of extreme overweight. Hum Biol 62: 747-765
31. Province MA, Arnqvist P, Keller J, Higgins M, Rao DC (1990) Strong evidence for a major gene for obesity in the large, unselected total Community Health Study of Tecumseh, Am J Hum Genet 47 [Suppl]:A143 (Abstract)
32. Borecki IB, Bonney GE, Rice T, Bouchard C, Rao DC (1993) Influence of genotype-dependent effects of covariates on the outcome of segregation analysis of the body mass index. Am J Hum Genet 53: 676-687
33. Tiret L, André JL, Ducietière P et al. (1992) Segregation analysis of height-adjusted weight with generation- and age-dependent effects: the Nancy Family Study. Genet Epidemiol 9: 389-403