Insulin receptor gene in hypertension

Clinical and Experimental Hypertension

Volumn 19, Issue 5-6, 1997, Pages 551-565

  Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Essential hypertension; Insulin receptor gene; Molecular genetics; Restriction fragment length polymorphism

Indexed keywords

INSULIN RECEPTOR;

CONFERENCE PAPER; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE;

EID: 0030760392     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969709083169     Document Type: Conference Paper

References (78)

1. Ying, L.-H., Zee, R.Y.L., Griffiths, L.R., Morris, B.J. Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension. Biochem Biophys Res Commun 1991; 181: 486-492.
2. Seino, S., Seino, M., Bell, G.I. Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction. Diabetes 1990; 39: 123-128.
3. Morris, B.J., Zee, R.Y.L., Ying, L.-H., Griffiths, L.R. Independent, marked associations of alleles of the insulin receptor and dipeptidyl carboxypeptidase-1 genes with essential hypertension. Clin Sci 1993; 85: 189-195.
4. Zee, R.Y.L., Lou, Y.-k., Morris, B.J. Insertion variant in intron 9, but not microsatellite in intron 2, of the insulin receptor gene is associated with essential hypertension. J Hypertens 1993; 11: 1283-1288.
5. Zee, R.Y.L., Lou, Y.-k., Morris, B.J. Insertion variant in intron 9, but not microsatellite in intron 2, of the insulin receptor gene is associated with essential hypertension. J Hypertens 1994; 12 (suppl 7): S13-S22.
6. Seino, S., Seino, M., Nishi, S., Bell, G.I. Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 1989; 86: 114-118.
7. Zee, R.Y.L., Griffiths, L.R., Morris, B.J. Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives. Biochem Biophys Res Commun 1992; 189: 965-971.
8. Zee, R.Y.L., Schrader, A.P., Robinson, B.G., Griffiths, L.R., Morris, B.J. Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives. Clin Genet 1995; 47: 118-121.
9. Schrader, A.P., Zee, R.Y.L., Morris, B.J. Association analyses of NsiI RFLP of human insulin receptor gene in hypertensives. Clin Genet 1996; 49: 74-78.
10. Qiu, C., Ji, T. Detection of mutation in insulin receptor gene in patients with essential hypertension. Acta Acad Med Sincae 1995; 17: 81-85.
11. Fujioka, Y., Takekawa, K., Nakagawa, Y., Hamada, Y., Ikegami, H., Yamato, E., Fujisawa, T., Ueda, H., Miki, T., Ogihara, T. Insulin receptor gene polymorphism and hyperinsulinemia in hypertensive patients. Hypertens Res 1995; 18: 215-218.
12. Ikegami, H., Yamato, E., Fujisawa, T., Hamada, Y., Fujioka, Y., Rakugi, H., Higaki, J., Murakami, H., Shimamoto, K., Ogihara, T. Analysis of candidate genes for insulin resistance in essential hypertension. Hypertens Res 1996; 19 (Suppl. I): S31-S34.
13. Hein, H.O., Sørensen, H., Saudicani, P., Gyntelberg, F. The Lewis blood group - a new genetic marker of ischaemic heart disease. J Internal Med 1992; 232: 481-487.
14. McClain, D.A., Henry, R.R., Ullrich, A., Olefsky, J.M. Restriction-fragment-length polymorphism in insulin resistance in NIDDM. Diabetes 1988; 37: 1071-1075.
15. Munroe, P.B., Emilion, G., Daniel, H., Christie, K., Lawson, M., Boulox, P., Caulfield, M. Haplotype analysis of the insulin receptor (INSR) gene in human essential hypertension (EH). (Abstract). J Hypertens 1994; 12 (suppl. 3): S168.
16. Ying, L.-H., Zee, R.Y.L., Griffiths, L.R., Morris, B.J. Non-linkage of insulin receptor locus with essential hypertension in an affected pedigree. Hypertens Res 1993; 16: 25-28.
17. Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y.V., Lifton, R.P., Williams, C.S., Charru, A., Hunt, S.C., Hopkins, P.N., Williams, R.R., Lalouel, J.-M., Corvol, P. Molecular basis of human hypertension: Role of angiotensinogen. Cell 1992; 71: 169-180.
18. Caulfield, M., Lavender, P., Farrall, M., Munroe, P., Lawson, M., Turner, P., Clark, A.J.L. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994; 330: 1629-1633.
19. Hanis, C.L., Boerwinkle, E., Chakraborty, R., Ellsworth, D.L., Concannon, P., Stirling, B., Morrison, V.A., Wapelhorst, B., Spielman, R.S., Gogolin-Ewens, K.J., Shephard, J.M., Williams, S.R., Risch, N., Hinds, D., Iwasaki, N., Ogata, M., Omori, Y., Petzold, C., Rietzsch, H., Schröder, H.-E. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 1996; 13: 161-166.
20. Risch, N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990; 46: 229-241.
21. Morgan, R., Bishop, A., Owens, D.R., Luzio, S.D., Peters, J.R., Rees, A. Allelic variants at insulin-receptor and insulin gene loci and susceptibility to NIDDM in Welsh population. Diabetes 1990; 39: 1479-1484.
22. Krolewski, A.S., Krolewski, B., Gray, M., Stanton, V., Warram, J.H., Housman, D. High-frequency DNA sequence polymorphisms in the insulin receptor gene detected by denaturing gradient gel blots. Genomics 1992; 12: 705-709.
23. Krolewski, A.S., Doria, A., Magre, J., Warram, J.H., Housman, D. Molecular genetic approaches to the identification of genes involved in the development of nephropathy in insulin-dependent diabetes mellitus. J Am Soc Nephrol 1992; 3: S9-S17.
24. Viberti, G.C., Keen, H., Wiseman, M.J. Raised arterial pressure in parents of proteinuric insulin-dependent diabetics. Br Med J 1987; 295: 515-517.
25. Freire, M.B.S., Ferreira, S.R.G., Vivolo, M.A., Oliveira, J.M., Zanella, M.T. Familial hypertension and albuminuria in normotensive type I diabetic patients. Hypertension 1994; 23 (Suppl. I): I-256-I-258.
26. Barzilay, J., Warram, J.H., Bak, M., Laffel, L.M.B., Canessa, M., Krolewski, A.S. Predisposition to hypertension: Risk factor for nephropathy and hypertension in IDDM. Kidney Internat 1992; 41: 723-730.
27. Trevisan, R., Nosadini, R., Fioretto, P., al., e. Clustering of renal, cardiovascular and metabolic risk factors in hypertensive insulin-dependent diabetes withe high sodium-lithium countertransport. Kidney Internat 1992; 41: 855-861.
28. Nelson, R.G., Pettitt, D.J., Baird, H.R., Charles, M.A., Liu, Q.Z., Bennett, P.H., Knowler, W.C. Pre-diabetic blood pressure predicts urinary albumin excretion after the onset of type-2 (non-insulin-dependent) diabetes-mellitus in Pima indians. Diabetologica 1993; 36: 998-1001.
29. Sharma, A.M., Ruland, K., Spies, K.P., Distler, A. Salt sensitivity in yound normotensive subjects is associated with a hyperinsulinemic response to oral glucose. J Hypertens 1991; 9: 329-335.
30. Allemann, Y., Horber, F.F., Colombo, M., Ferrari, P., Shaw, S., Jaeger, P., Weidmann, P. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 1993; 341: 327-331.
31. Beatty, O.L., Harper, R., Sheridan, B., Atkinson, A.B., Bell, P.M. Insulin resistance in offspring of hypertensive parents. Br Med J 1993; 307: 92-96.
32. Ohno, Y., Suzuki, H., Yamakawa, H., Nakamura, M., Otsuka, K., Saruta, T. Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism. J Hypertens 1993; 11: 21-426.
33. Miura, K., Nakagawa, H., Nishijo, M., Tabata, M., Morikawa, Y., Senma, M., Yoshita, K., Ishizaki, M., Kawano, S. Plasma insulin and blood pressure in normotensive Japanese men with normal glucose tolerance. J Hypertens 1995; 13: 427-432.
34. Ohmori, S., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Nomiyama, K., Yoshitake, T., Ueda, K., Fujishima, M. Hyperinsulinaemia and blood pressure in a general Japanese population: the Hisayama Study. J Hypertens 1994; 12: 1191-1197.
35. Lind, L., Berne, C., Lithell, H. Prevalence of insulin resistance in essential hypertension. J Hypertens 1995; 13: 1457-1462.
36. Yokota, C., Ikebuchi, M., Suzuki, M., Norioka, M., Ikeda, K., Shinozaki, K., Harano, Y. Insulin resistance rather than hyperinsulinaemai is more closely associated with essential hypertension. Clin Exp Hypertens 1995; 17: 523-536.
37. Sinagra, D., Greco, D., Scarpitta, A.M., Bonaventura, V. Blood pressure, insulin secretion and resistance in nonhypertensive and hypertensive obese female subjects. Internat J Obesity 1995; 19: 610-613.
38. Phillips, D.I.W., Barker, D.J.P., Hales, C.N., Osmond, C. Thinness at birth and insulin resistance in adult life. Diabetologia 1994; 37: 150-154.
39. Knutson, V.P., Donnelly, P.V., Balba, Y., Lopezreyes, M. Insulin resistance is mediated by a proteolytic fragment of the insulin receptor. J Biol Chem 1995; 270: 24972-24981.
40. Seino, S., Bell, G.I. Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Commun 1989; 159: 312-316.
41. McClain, D.A. Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action. Mol Endocrinol 1991; 5: 734-739.
42. Mosthaf, L., Vogt, B., Häring, H.U., Ullrich, A. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc Natl Acad Sci USA 1991; 88: 4728-4730.
43. Kellerer, M., Lammers, R., Ermel, B., Tippmer, S., Vogt, B., Obermaier,-Kusser, B., Ullrich, A., Häring, H.-U. Distinct α-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry 1992; 31: 4588-4596.
44. Vogt, B., Carrascosa, J.M., Ullrich, A., Häring, H. The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem Biophys Res Commun 1991; 177: 1013-1018.
45. Sesti, G., Marini, A.A., Tullio, A.N., Montemurro, A., Borboni, P., Fusco, A., Accili, D., Lauro, R. Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem Biophys Res Commun 1991; 181: 1419-1424.
46. Kellerer, M., Sesti, G., Seffer, E., Obermaierkusser, B., Pongratz, D.E., Mosthaf, L., Haring, H.U. Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type-2 (non-insulin-dependent) diabetic subjects. Diabetologia 1993; 3: 628-632.
47. Mosthaf, L., Eriksson, J., Häring, H.U., Groop, L., Widen, E., Ullrich, A. Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes. Proc Natl Acad Sci USA 1993; 90: 2633-2635.
48. Norgren, S., Zierath, J., Galuska, D., Wallberg-Henriksson, H., Luthman, H. Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. Diabetes 1993; 42: 675-681.
49. Kosaki, A., Webster, N.J.G. Effect of dexamethasone on the alternative splicing of the insulin receptor messenger RNA and insulin action in HepG2 hepatoma cells. J Biol Chem 1993; 268: 21990-21996.
50. Norgren, S., Li, L.S., Luthman, H. a:Regulation of human insulin receptor RNA splicing in HepG2 cells - effects of glucocorticoid and low glucose concentration. Biochem Biophys Res Commun 1994; 19: 277-284.
51. Norgren, S., Zierath, J., Wedell, A., Wallberghenriksson, H., Luthman, H. Regulation of human insulin receptor RNA splicing in vivo. Proc Natl Acad Sci USA 1994; 91: 1465-1469.
52. Green, M.R. Biochemical mechanisms of constitutive and regulated pre-mRNA splicing. Ann Rev Cell Biol 1991; 7: 559-599.
53. Lou, Y.-k., Zee, R.Y.L., Morris, B.J. No difference in the proportion of insulin receptor exon 11+/- isoform mRNA in the liver of rats after development of hypertension. Clin Exp Pharmacol Physiol 1996; 23: 564-566.
54. Nolan, J.J., Freidenberg, G., Henry, R., Reichart, D., Olefsky, J.M. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 1994; 78: 471-477.
55. Hanberg, A., Vaag, A., Vinten, J., Becknielsen, H. Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type-2 (non-insulin-dependent) diabetes-mellitus. Diabetologia 1993; 36: 668-674.
56. Flack, J.M., Sowers, J.R. Epidemiological and clinical aspects of insulin resistance and hyperinsulinemia. Am J Med 1991; 91 (suppl. 1A): 11S-21S.
57. Standley, P.R., Zhang, F., Ram, J.L., Zemel, M.B., Sowers, J.R. Insulin attenuates vasopressin-induced calcium transients and a voltage-dependent calcium response in rat vascular smooth muscle cells. J Clin Invest 1991; 88: 1230-1236.
58. Morris, B.J. Identification of essential hypertension genes. (Editorial review). J Hypertens 1993; 11: 115-120.
59. Sanchez-Margalet, V., Valle, M., Lobón, J.A., Maldonado, A., Escobar, F., Pérez, R., Goberna, R. Diminished insulin receptors on erythrocyte ghosts in nonobese patients with essential hypertension independent of hyperinsulinemia. J Cardiovasc Pharmacol 1994; 24: 74-77.
60. Sechi, L.A., Griffin, C.A., Schambelan, M. Effect of dietary sodium chloride on insulin receptor number and mRNA levels in rat kidney. Am J Physiol 1994; 266: F31-F38.
61. Mondon, C.E., Reaven, G.M. Evidence for abnormalities of insulin metabolism in rats with spontaneous hypertension. Metabolism 1988; 37: 303-305.
62. Swislocki, A., Tsuzuki, A. Insulin resistance and hypertension: Glucose intolerance, hyperinsulinaemia, and elevated free fatty acids in the lean spontaneously hypertensive rat. Am J Med Sci 1993; 30 : 282-286.
63. Sechi, L.A., Griffin, C.A., G., G., Zingaro, L., Catena, C., Bartoli, E., Schambelan, M. Abnormalities of insulin receptors in spontaneously hypertensive rats. Hypertension 1996; 27: 955-961.
64. Lee, J.-k., Tsai, S.Y. Multiple hormone response elements can confer glucocorticoid regulation on the human insulin receptor gene. Mol Endocrinol 1994; 8: 625-634.
65. Chen, H., Walker, G.E., Taylor, S.I., McKeon, C. Proximal enhancer of the human insulin receptor gene binds the transcription factor Sp1. Diabetes 1994; 43: 884-889.
66. Webster, N.J.G., Resnik, J.L., Reichart, D.B., Strauss, B., Haas, M., Seely, B.L. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: A possible mechanism for receptor overexpression in breast cancer. Cancer Res 1996; 56: 2781-2788.
67. Brunetti, A., Brunetti, L., Foti, D., Accili, D., Goldfine, I.D. Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene. J Clin Invest 1996; 97: 258-262.
68. Swislocki, A. Insulin resistance and hypertension. Am J Med 1990; 299: 104-115.
69. DeFronzo, R.A., Ferrannini, E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia, and atherosclerotic disease. Diabetes Care 1991; 14: 173-194.
70. Reaven, G.M. Insulin resistance and compensatory hyperinsulinemia: Role in hypertension, dyslipidemia, and coronary heart disease. Am Heart J 1991; 121: 1283-1288.
71. Brands, M.W., Half, J.E. Insulin resistance, hyperinsulinaemia, and obesity-associated hypertension. J Am Soc Nephrol 1992; 3: 1064-1077.
72. Morris, A.D., Petrie, J.R., McConnell, M.C. Insulin and hypertension. J Hypertens 1994; 12: 633-642.
73. Young, A.A., Rink, T.J., Vine, W., Gedulin, B. Amylin and Syndrome-X. Drug Devel Res 1994; 32: 90-99.
74. Cooper, M.E., McNally, P.G., Phillips, P.A., Johnston, C.I. Amylin stimulates plasma renin concentration in humans. Hypertension 1995; 26: 460-464.
75. Walker, W.G., Whelton, P.K., Saito, H., Russell, R.P., Hermann, J. Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension 1979; 1: 287-291.
76. 235→Thr variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun 1993; 197: 833-839.
77. Cassis, L.A., Saye, J.A., Peach, M.J. Location and regulation of rat angiotensinogen messenger RNA. Hypertension 1988; 11: 591-596.
78. Murakami, E., Hiwada, K., Kokubu, T. Effects of insulin and glucagon on production of renin substrate by the isolated rat liver. J Endocrinol 1980; 85: 151-153.