Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study

Obesity Research

Volumn 8, Issue 2, 2000, Pages 140-150

  Pérusse, Louis ^g   Rice, Treva ^a   Province, Michael A ^a   Gagnon, Jacques ^b   Leon, Arthur S ^c   Skinner, James S ^d   Wilmore, Jack H ^e   Rao, D C ^a   Bouchard, Claude ^f  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITY OF MINNESOTA   (United States)

^d INDIANA UNIVERSITY   (United States)

^e TEXAS A AND M UNIVERSITY   (United States)

^f PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^g NONE

Author keywords

Exercise training; Familial resemblance; Fat distribution; Heritability

Indexed keywords

ADIPOSE TISSUE; ADULT; AGING; ARTICLE; BODY COMPOSITION; BODY MASS; ENDURANCE; EXERCISE; FEMALE; GENETICS; HUMAN; MALE; MIDDLE AGED; PHENOTYPE; SEXUAL DEVELOPMENT; SKINFOLD THICKNESS;

ADIPOSE TISSUE; ADULT; AGING; BODY COMPOSITION; BODY MASS INDEX; EXERCISE; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PHYSICAL ENDURANCE; SEX CHARACTERISTICS; SKINFOLD THICKNESS;

EID: 0034149873     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2000.15     Document Type: Article

References (38)

1. Ohlson LO, Larsson B, Svardsudd K, et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 1985;34:1055-8.
2. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care. 1994; 17:961-9.
3. Folsom AR, Prineas RJ, Kaye SA, Munger RG. Incidence of hypertension and stroke in relation to body fat distribution and other risk factors in older women. Stroke. 1990;21:701-6.
4. Gillum RF, Mussolino ME, Madans JH. Body fat distribution and hypertension incidence in women and men. The NHANES I Epidemiologic Follow-up Study. Int J Obes. 1998; 22:127-34.
5. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J. 1984;289:1257-61.
6. Ducimetiere P, Richard J, Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris prospective study. Int J Obes. 1986;10:229-40.
7. Donahue RP, Abbott RD, Bloom E, Reed DM, Yano K. Central obesity and coronary heart disease in men. Lancet. 1987;1:821-4.
8. Freedman DS, Williamson DF, Croft JB, Ballew C, Byers T. Relation of body fat distribution to ischemic heart disease. The National Health and Nutrition Examination Survey I (NHANES I) Epidemiologic Follow-up Study. Am J Epidemiol. 1995;142:53-63.
9. Macs HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27:325-51.
10. Bouchard C, Pérusse L, Rice T, Rao DC. The genetics of obesity. In: Bray G, Bouchard C, James W, eds. Handbook of Obesity. New York: Marcel Dekker; 1998, pp. 157-90.
11. Donahue RP, Prineas RJ, Gomez O, Hong CP. Familial resemblance of body fat distribution: the Minneapolis children's blood pressure study. Int J Obes. 1992;16:161-7.
12. Ramirez ME. Subcutaneous fat distribution in adolescents. Hum Biol. 1993;65:771-82.
13. Cardon LR, Carmelli D, Fabsitz RR, Reed T. Genetic and environmental correlations between obesity and body fat distribution in adult male twins. Hum Biol. 1994;66:465-79.
14. Comuzzie AG, Blangero J, Mahaney MC, Mitchell BD, Stern MP, MacCluer JW. Genetic and environmental correlations among skinfold measures. Int J Obes Relat Metab Disord. 1994;18:413-8.
15. Sellers TA, Drinkard C, Rich SS, et al. Familial aggregation and heritability of waist-to-hip ratio in adult women: the Iowa Women's Health Study. Int J Obes. 1994;18:607-13.
16. Rotimi C, Cooper R. Familial resemblance for anthropometrie measurements and relative fat distribution among African Americans. Int J Obes. 1995;19:875-80.
17. Li Z, Rice T, Pérusse L, Bouchard C, Rao DC. Familial aggregation of subcutaneous fat patterning: principal components of skinfolds in the Quebec Family Study. Am J Hum Biol. 1996;8:535-42.
18. Bouchard C, Després JP, Mauriège P. Genetic and nongenetic determinants of regional fat distribution. Endocr Rev. 1993;14:72-93.
19. Beunen G, Macs H, Vlietinck R, et al. Univariate and multivariate genetic analysis of subcutaneous fatness and fat distribution in early adolescence. Behav Genet. 1998; 28:279-88.
20. Rose KM, Newman B, Mayer-Davis EJ, Selby JV. Genetic and behavioral determinants of waist-hip ratio and waist circumference in women twins. Obes Res. 1998;6:383-92.
21. Hasstedt SJ, Ramirez ME, Kuida H, Williams RR. Recessive inheritance of a relative fat pattern. Am J Hum Genet 1989;45:917-25.
22. Borecki IB, Rice T, Pérusse L, Bouchard C, Rao DC. Major gene influence on the propensity to store fat in trunk versus extremity depots: evidence from the Quebec Family Study. Obes Res. 1995;3:1-8.
23. Poehlman ET, Tremblay A, Després JP, et al. Genotype-controlled changes in body composition and fat morphology following overfeeding in twins. Am J Clin Nutr. 1986;43:723-31.
24. Bouchard C, Tremblay A, Després JP, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477-82.
25. Poehlman E, Tremblay A, Marcotte M, Pérusse L, Thériault G, Bouchard C. Heredity and changes in body composition and adipose tissue metabolism after short-term exercise-training. Eur J Appl Physiol. 1987;56:398-402.
26. Bouchard C, Tremblay A, Després J-P, et al. The response to exercise with constant energy intake in identical twins. Obes Res. 1994;2:400-10.
27. Bouchard C, Tremblay A. Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. J Nutr. 1997;127-943S-7S.
28. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J. The HERITAGE Family Study: aims, design, and measurement protocol. Med Sci Sports Exerc. 1995;27:721-9.
29. 2max in the sedentary state: the HERITAGE Family Study. Med Sci Sports Exerc. 1998;30:252-8.
30. Wilmore JH, Stanforth PR, Rice T, et al. Alterations in body mass and composition consequent to 20 weeks of endurance exercise training: the HERITAGE Family Study. Am J Clin Nutr. 1999;70:346-52.
31. Wilmore JH, Stanforth PR, Domenick MA, et al. Reproducibility of anthropometric and body composition measurements: the HERITAGE Family Study. Int J Obes. 1997;21: 297-303.
32. Lohman TG, Roche AF, Martorell F. Anthropometric Standardization Reference Manuel. Champaign, IL: Human Kinetics; 1988, p. 177.
33. Pérusse L, Rice T, Després JP, Rao DC, Bouchard C. Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study. Arterioscler Thromb Vasc Biol. 1997;17:3270-7.
34. Province MA, Rao DC. General purpose model and a computer program for combined segregation and path analysis (SEGPATH): automatically creating computer programs from symbolic language model specifications. Genet Epidemiol. 1995;12:203-19.
35. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Cont. 1974;19:716-23.
36. Bouchard C, Pérusse L, Leblanc C, Tremblay A, Thériault G. Inheritance of the amount and distribution of human body fat. Int J Obes. 1988;12:205-15.
37. Pérusse L, Leblanc C, Bouchard C. Inter-generation transmission of physical fitness in the Canadian population. Canadian J Sport Sci. 1988;13:8-14.
38. Wilmore JH. Increasing physical activity: alterations in body mass and composition. Am J Clin Nutr. 1997;63:456S-60S.