Insulin resistance in obesity: Metabolic mechanisms and measurement methods

Molecular Genetics and Metabolism

Volumn 65, Issue 2, 1998, Pages 121-128

  Belfiore, Francesco ^a   Iannello, Silvia ^a  

^a GARIBALDI HOSPITAL   (Italy)

Author keywords

Acetyl CoA; Carnitine palmitoyl transferase; Diabetes; FFA; FFA oxidation; Glucose utilization; Insulin resistance; Insulin sensitivity; Long chain CoA; Malonyl CoA; NEFA; Obesity; Pyruvate dehydrogenase

Indexed keywords

ACETYL COENZYME A; ACYL COENZYME A; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; MALONYL COENZYME A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PYRUVATE DEHYDROGENASE;

FATTY ACID METABOLISM; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MEASUREMENT; OBESITY; PRIORITY JOURNAL; REVIEW;

EID: 0032191009     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.1998.2727     Document Type: Article

References (32)

1. 1. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances in diabetes mellitus. Lancet 1:785-789, 1963.
2. 2. Randle PJ, Priestman DA, Mistry S, Halsall A. Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 37:S155-161, 1994.
3. 3. Felber JP, Golay A. Regulation of nutrient metabolism and energy expenditure. Metabolism 44(2, Suppl 2):4-9, 1995.
4. 4. Belfiore F, Iannello S, Rabuazzo AM, Campione R. Metabolic effects of short-term fasting in obese hyperglycaemic humans and mice. Int J Obesity 11:631-640, 1987.
5. 5. Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 72:96-107, 1991.
6. 6. Perriello G, Misericordia P, Volpi E, Pampanelli S, Santeusanio F, Brunetti P, Bolli GB. Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 80:2464-2469, 1995.
7. 7. Ferrannini E. Physiological and metabolic consequences of obesity. Metabolism 44(9, Suppl 3):15-17, 1995.
8. 8. Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M, DeFronzo RA. Effect of insulin on oxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol 263:E79-84, 1992.
9. 9. Belfiore F. Enzyme Regulation and Metabolic Diseases. Basel: Karger, 1980.
10. 10. Prentki M, Corkey BE. Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996.
11. 11. Castelein H, Gulick T, Declerq PE, Mannaerts GP, Moore DD, Baes MI. The peroxisome proliferator-activated receptor regulates malic enzyme gene expression. J Biol Chem 269:26754-26758, 1994.
12. 12. Gulick T, Cresci S, Caira T, Moore DD, Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidation enzyme gene expression. Proc Natl Acad Sci 91:11012-11016, 1994.
13. 13. Mills SE, Foster DW, McGarry JD. Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues: Relationship between ligand binding and inhibition of carnitine palmitoyl-transferase I. Biochem J 214:83-91, 1983.
14. 14. Keller H, Wahli W. Peroxisome proliferator-activated receptors: A link between endocrinology and nutrition. Trends Endocrinol Metab 4:291-296, 1993.
15. 15. McGarry JD, Mannaerts GP, Foster DW. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 60:265-270, 1977.
16. 16. McGarry JD, Takabayashi Y, Foster DW. The role of malonyl-CoA in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. J Biol Chem 253:8294-8300, 1978.
17. 17. Putman CT, Spriet LL, Hultman E, Lindinger MI, Lands LC, McKelvie RS, Cederblad G, Jones NL, Heigenhauser GJ. Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am J Physiol 265:E752-760, 1993.
18. 18. Saha AK, Kurowski TG, Ruderman NB. Malonyl-CoA fuel-sensing mechanism in muscle: Effects of insulin, glucose, and denervation. Am J Physiol 269:E283-289, 1995.
19. 19. Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: Its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol 272:E641-648, 1997.
20. 20. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88: 960-966, 1991.
21. 21. Kleiber H, Munger R, Jallut D, Tappy L, Felley C, Golay A, Frascarolo P, Jequier E, Felber JP. Interaction of lipid and carbohydrate metabolism after infusion of lipids or of lipid lowering agents: Lack of a direct relationship between free fatty acid concentrations and glucose disposal. Diabetes Metab 18:84-90, 1992.
22. 22. De Fronzo RA, Tobin J, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E273, 1979.
23. 23. Morand C, Besson C, Demigne C, Remesy C. Importance of the modulation of glycolysis in the control of lactate metabolism by fatty acids in isolated hepatocytes from fed rats. Arch Biochem Biophys 309:254-260, 1994.
24. 24. Williamson JR, Browning ET, Scholz R. Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver. J Biol Chem 244: 4607-4616, 1969.
25. 25. Williamson JR, , Scholz R, Browning ET. Control mechanisms of gluconeogenesis and ketogenesis. II. Interactions between fatty acid oxidation and the citric acid cycle in perfused rat liver. J Biol Chem 244:4617-4627, 1969.
26. 26. Antras-Ferry J, Le Bigot G, Robin P, Forest C. Stimulation of phosphoenolpyruvate carboxykinase gene expression by fatty acids. Biochem Biophys Res Commun 203:385-391, 1994.
27. 27. Campbell PJ, Carlson MG, Nurjahan N. Fat metabolism in human obesity. Am J Physiol 266:E600-E605, 1994.
28. 28. Colberg SR, Simoneau J-A, Thaete FL, Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95:1846-1853, 1995.
29. 29. Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 41:1575-1586, 1992.
30. 30. Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89: 782-788, 1992.
31. 31. Reaven GM, Moore J, Greenfield M. Quantification of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with normal glucose tolerance. Diabetes 32:600-604, 1983.
32. 32. Belfiore F, Iannello S, Volpicelli G. Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose and FFA levels. Mol Genet Metab 63:134-141, 1998.