Familial clustering of insulin and abdominal visceral fat: The HERITAGE family study

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 12, 1998, Pages 4239-4245

  Hong, Yuling ^a   Rice, Treva ^a   Gagnon, Jacques ^b   Després, Jean Pierre ^b   Nadeau, André ^b   Pérusse, Louis ^b   Bouchard, Claude ^b   Leon, Arthur S ^c   Skinner, James S ^d   Wilmore, Jack H ^e   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF MINNESOTA   (United States)

^d INDIANA UNIVERSITY   (United States)

^e TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LIPOPROTEIN LIPASE;

ADOLESCENT; AGE; AGED; ARTICLE; ATHEROSCLEROSIS; BODY COMPOSITION; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; FAMILIAL INCIDENCE; GENETIC MARKER; GENETIC POLYMORPHISM; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; LIPID STORAGE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PLEIOTROPY; PRIORITY JOURNAL; RISK FACTOR;

EID: 0032468646     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.12.4239     Document Type: Article

References (55)

1. 1. Vague J. 1956 The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr. 4:22-34.
2. 2. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P,Tibbin G. 1984 Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13-year follow up of participants in the study of men born in 1913. Br Med J. 288:1401-1404.
3. 3. Bouchard C, Bray GA, Hubbard VS. 1990 Basic and clinical aspects of regional fat distribution. Am J Clin Nutr. 52:946-950.
4. 4. Manson JE, Colditz GA, Stampfer MJ, et al. 1990 A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 322:882-889.
5. 5. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. 1992 Prospective analysis of the insulin-resistance (syndrome X). Diabetes. 41:715-722.
6. 6. Mykkänen L, Kuusisto J, Pyörälä K, Laasko M. 1993 Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects. Diabetologia. 36:553-559.
7. 7. Despres J-P, Lamarche B, Mauriege P, et al. 1996 Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 334:952-957.
8. 8. Howard G, O'Leary DH, Zaccaro D, et al. 1996 Insulin sensitivity and atherosclerosis. Circulation. 93:1809-1817.
9. 9. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. 1991 Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 34:416-422.
10. 10. Björntorp P. 1993 Visceral obesity: a "civilization syndrome". Obes Res. 1:206-222.
11. 11. Després J-P. 1993 Abdominal obesity as important component of insulin-resistance syndrome. Nutrition. 9:452-459.
12. 12. Schmidt MI, Watson RL, Duncan BB, et al. 1996 Clustering of dyslipaemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Metabolism. 45:699-706.
13. 13. Laakso M. 1993 How good a marker is insulin level for insulin resistance? Am J Epidemiol. 137:959-965.
14. 14. Kissebah AH, Vydelingun N, Murray R, et al. 1982 Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab. 54:254-260.
15. 15. Rice T, Nadeau A, Pérusse L, Bouchard C, Rao DC. 1996 Familial correlations in the Québec family study: cross-trait familial resemblance for body fat with plasma glucose and insulin. Diabetologia. 39:1357-1364.
16. 16. Liese AD, Mayer-Davis EJ, Tyroler HA, et al. 1997 Development of the multiple metabolic syndrome in the ARIC cohort: joint contribution of insulin, BMI, and WHR. Ann Epidemiol. 7:407-416.
17. 17. Carmelli D, Cardon LR, Fabsitz R. 1994 Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet. 55:566-573.
18. 18. Mitchell BD, Kammerer CM, Mahaney MC, et al. 1996 Genetic analysis of the IRS: pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vase Biol. 16:281-288.
19. 19. Hong Y, Pedersen NL, Brismar K, de Faire U. 1997 Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Genet. 60:143-152.
20. 20. Duggirala R, Stern MP, Mitchell BD, et al. 1996 Quantitative variation in obesity-related trait and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Genet. 59:694-703.
21. 21 . Fleury C, Neverova M, Collins S, et al. 1997 Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 15:269-272.
22. 22. Kissebah AH, Peiris AN. 1989 Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev. 5:83-109.
23. 23. Peiris AN, Sothmann MS, Hoffmann RG, et al. 1989 Adiposity, fat distribution, and cardiovascular risk. Ann Intern Med. 110:867-872.
24. 24. Kissebah AH. 1991 Insulin resistance in visceral obesity. Int J Obes. [Suppl 2] 15:109-115.
25. 25. Park KS, Kim SY, Lee HK, Koh CS, Min HK. 1991 Intraabdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism. 40:600-603.
26. 26. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM. 1996 Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes. 45:1684-1693.
27. 27. Bouchard C, Tremblay A, Després JP, et al. 1990 The response to long-term overfeeding in identical twins. N Engl J Med. 322:1477-1482.
28. 28. Pérusse L, Després J-P, Lemieux S, Rice T, Rao DC, Bouchard C. 1996 Familial aggregation of abdominal viscerl fat level: results from the Quebec Family Study. Metabolism. 45:378-382.
29. 29. Rice T, Després J-P, Daw EW, et al. 1997 Familial resemblance for abdominal visceral fat: the HERITAGE Family Study. Int J Obes. 21:1024-1031.
30. 30. Bouchard C, Rice T, Lemieux S, Després J-P, Perusse L, Rao DC. 1996 Major gene for abdominal visceral fat area in the Québec Family Study. Int J Obes. 20:420-427.
31. 31. Rice T, Després J-P, Pérusse L, et al. 1997 Segregation analysis of abdominal visceral fat: the HERITAGE Family Study. Obes Res. 5:417-424.
32. 32. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J. 1995 The HERITAGE Family Study: aims, design, and measurement protocol. Med Sci Sports Exerc. 27:721-729.
33. 33. Desbuquois B, Aurbuch GD. 1971 Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab. 33:732-738.
34. 34. Røder ME, Porte Jr D, Schwartz RS, Kahn SE. 1998 Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 83:604-608.
35. 35. Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY. 1995 Relationhip of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity - Clinical Research Center Study. J Clin Endocrinol Metab. 80: 1399-1406.
36. 36. Sjöström L, Kvist H, Cederblad A, Tylen U. 1986 Determination of the total adipose tissue and body fat in women by computed tomography: comparison with 40K and tritium techniques. Am J Physiol. 250:E736-E745.
37. 37. Behnke AR, Wilmore JH. 1974 Evaluation and regulation of body build and composition. Englewood Cliffs, NJ: Prentice-Hall; 21-27.
38. 38. Wilmore JH, Vodak PA, Parr RB, Girandola RM, Billing JE. 1980 Further simplification of a method for determining residual lung volume. Med Sci Sports Exerc. 12:216-218.
39. 39. Motley HL. 1957 Comparison of simple helium closed with the oxygen open-circuit method for measuring residual air. Am Rev Tuberc Pulm Dis. 76:601-615.
40. 40. Province MA, Rao DC. 1995 A general purpose model and a computer program for combined segregation and path analysis (SEGPATH): automatically creating computer programs from symbolic language model specification. Genet Epidemiol. 12:203-219.
41. 41. Seidell JC, Bouchard C. 1997 Visceral fat in relation to health: is it a major culprit or simply an innocent bystander? Int J Obes. 21:626-631.
42. 42. Davidson MB. 1979 The effect of aging on carbohydrate metabolism: a review of the English literature and practical approach to the diagnosis of diabetes mellitus in the elderly. Metab Clin Exp. 28:688-705.
43. 43. Cheng LS-C, Carmelli D, Hunt SC, Williams RR. 1995 Evidence for a major gene influencing 7-year increases in diastolic blood pressure with age. Am J Hum Genet. 57:1169-1177.
44. 44. Iselius L, Lindsten J, Morton NE, et al. 1982 Evidence for an autosomal recessive gene regulating the persistence of the insulin response to glucose in man. Clin Genet. 22:180-194.
45. 45. Schumacher MC, Hasstedt SJ, Hunt SC, Williams RR, Elbein SC. 1992 Major gene effects for insulin levels in familial NIDDM pedigree. Diabetes. 41:416-423.
46. 46. Hong Y, Pedersen NL, Brismar K, Hall K, de Faire U. 1996 Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1, and insulin levels in middle-aged and elderly twins. J Clin Endocrinol Metab. 81:1791-1797.
47. 47. Mayer EJ, Newman B, Austin MA, et al. 1996 Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins. Am J Epidemiol. 143:323-332.
48. 48. Snieder H, Boomsma DI, van Doomen LJP, Neale MC. 1996 A bivariate genetic analysis of fasting insulin and glucose. Ph.D. dissertation. Vrije Universiteit, The Netherlands.
49. 49. Björntorp P. 1997 Obesity and the adipocyte: neuroendocrine factors in obesity. J Endocrinol. 155:193-195.
50. 50. Buemann B, Vohl M-C, Chagnon M, et al. 1997 Abdominal visceral fat is associated with a BcII restriction fragment length polymorphism at the glucocordicoid receptor gene locus. Obes Res. 5:186-192.
51. 51. Eckel RH, Yost TJ, Jensen DR. 1995 Alterations in lipoprotein lipase in insulin resistance. Int J Obes. [Suppl 1] 19:S16-S21.
52. 52. Potts JL, Coppack SW, Fisher RM, Humphreys SM, Gibbons GF, Frayn KN. 1995 Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects. Am J Physiol. 268:E588-E594.
53. 53. Wang XL, McCredie RM, Wilcken DEL. 1996 Common DNA polymorphisms at the lipoprotein lipase gene: association with severity of coronary artery disease and diabetes. Circulation. 93:1339-1345.
54. 54. Bouchard C, Després JP, Mauriège P. 1993 Genetic and nongenetic determinants of regional fat distribution. Endocr Rev. 14:72-93.
55. 55. Arner P. 1993 Regulation of adipose tissue lipolysis, importance for the metabolic syndrome. Adv Exp Med Biol. 334:259-267.