메뉴 건너뛰기




Volumn 61, Issue 6, 2001, Pages 723-732

Farnesyltransferase inhibitors: Potential role in the treatment of cancer

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; BMS 241662; CISPLATIN; CP 609754; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPOTHILONE DERIVATIVE; FLUOROURACIL; L 778123; LONAFARNIB; PACLITAXEL; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; TAXANE DERIVATIVE; TIPIFARNIB; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

EID: 0034980637     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200161060-00002     Document Type: Review
Times cited : (74)

References (64)
  • 2
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 6
    • 0028935780 scopus 로고
    • Protein lipidation in cell signaling
    • (1995) Science , vol.268 , pp. 221-225
    • Casey, P.J.1
  • 8
    • 0010194781 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase inhibitors: The saga continues
    • Sebti SM, Hamilton AD, editors. Farnesyltransferase inhibitors in cancer therapy. Totowa (NJ): Humana Press
    • (2000) , pp. 255-273
    • Cox, A.D.1    Toussaint III, L.G.2    Fiordalisi, J.J.3
  • 11
    • 77956672906 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors
    • Tamanoi F, Sigman D, editors. Protein lipidation. San Diego (CA): Academic Press
    • (2000) The Enzymes 1 , vol.21 , pp. 81-103
    • Gibbs, J.B.1
  • 13
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 16
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl: Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3
  • 26
    • 0034730625 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
    • (2000) J Biol Chem , vol.275 , pp. 30451-30457
    • Ashar, H.R.1    James, L.2    Gray, K.3
  • 27
    • 0034674417 scopus 로고    scopus 로고
    • Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
    • (2000) J Biol Chem , vol.275 , pp. 17974-17978
    • Chen, Z.1    Sun, J.2    Pradines, A.3
  • 28
    • 0033860183 scopus 로고    scopus 로고
    • RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors
    • (2000) Mol Cell Biol , vol.20 , pp. 6105-6113
    • Liu, A.1    Du, W.2    Liu, J.P.3
  • 29
    • 0031983131 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
    • (1998) Mol Cell Biol , vol.18 , pp. 85-92
    • Barrington, R.E.1    Subler, M.A.2    Rands, E.3
  • 30
    • 0032521211 scopus 로고    scopus 로고
    • Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
    • (1998) Cancer Res , vol.58 , pp. 1253-1259
    • Mangues, R.1    Corral, T.2    Kohl, N.E.3
  • 31
    • 0034658479 scopus 로고    scopus 로고
    • Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl: Protein transferase inhibitor
    • (2000) Cancer Res , vol.60 , pp. 2680-2688
    • Omer, C.A.1    Chen, Z.2    Diehl, R.E.3
  • 35
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3
  • 38
  • 40
    • 0033214457 scopus 로고    scopus 로고
    • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
    • (1999) Cancer Res , vol.59 , pp. 4919-4926
    • Sun, J.1    Blaskovich, M.A.2    Knowles, D.3
  • 52
    • 0029048924 scopus 로고
    • Suppression of mevalonate pathway activities by dietary isoprenoids: Protective roles in cancer and cardiovascular disease
    • 1666S-1672S
    • (1995) J Nutr , vol.125
    • Elson, C.E.1
  • 53
    • 0032980875 scopus 로고    scopus 로고
    • Prevention and therapy of cancer by dietary monoterpenes
    • 775S-778S
    • (1999) J Nutr , vol.129
    • Crowell, P.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.