A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells

Journal of Biological Chemistry

Volumn 273, Issue 32, 1998, Pages 20243-20251

  Sepp Lorenzino, Laura ^a   Rosen, Neal ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; CYCLIN DEPENDENT KINASE; DOXORUBICIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; METHIONINE; MITOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED; UP-REGULATION;

HUMAN PAPILLOMAVIRUS;

EID: 0032493641     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.32.20243     Document Type: Article

References (9)

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