The effects of protein farnesyltransferase inhibitors on trypanosomatids: Inhibition of protein farnesylation and cell growth

Molecular and Biochemical Parasitology

Volumn 94, Issue 1, 1998, Pages 87-97

  Yokoyama, Kohei ^a   Trobridge, Patty ^a,c   Buckner, Frederick S ^a   Scholten, Jeffrey ^b   Stuart, Kenneth D ^a,c   Van Voorhis, Wesley C ^a   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PFIZER INC   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Anti parasite therapeutics; Farnesylation; Geranylgeranylation; Isoprenylation; Leishmania mexicana; Mevalonic acid; Parasites; Prenylation; Protein farnesyltransferase; Simvastatin; Trypanosoma brucei; Trypanosoma cruzi; Trypanosomatidae

Indexed keywords

MEVALONIC ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SIMVASTATIN;

ARTICLE; CELL GROWTH; ISOPRENYLATION; LEISHMANIA MEXICANA; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; FLUOROMETRY; LEISHMANIA MEXICANA; MICROSCOPY, PHASE-CONTRAST; PROTEIN ISOPRENYLATION; SIMVASTATIN; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0032128169     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(98)00053-X     Document Type: Article

References (40)

1. [1] Glomset JA, Gelb MH, Farnsworth CC. Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochem Sci 1990;15:139-42.
2. [2] Zhang FL, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Ann Rev Biochem 1996;65:241-69.
3. [3] Farnsworth CC, Wolda SL, Gelb MH, Glomset JA. Human lamin B contains a farnesylated cysteine residue. J Biol Chem 1989;264:20422-9.
4. [4] Clarke S. Protein isoprenylation and methylation at carboxy-terminal cysteine residues. Annu Rev Biochem 1992;61:355-86.
5. [5] Yamane HK, Farnsworth CC, Xie H, et al. Brain G protein γ subunits contain an all-trans-geranylgeranyl cysteine methyl ester a their carboxyl termini. Proc Nat Acad Sci USA 1990;87:5868-72.
6. [6] Mumby SM, Casey PJ, Gilman AG, Gutowski S, Sternweis PC. G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci USA 1990;87:5873-7.
7. [7] Otto JC, Casey PJ. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. J Biol Chem 1996;271:4569-72.
8. ras farnesyl: protein transferase by Cys-AAX tetrapeptides. Cell 1990;62:81-8.
9. [9] Moomaw JF, Casey PJ. Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. J Biol Chem 1992;267:17438-43.
10. [10] Yokoyama K, Gelb MH. Purification of a mammalian protein geranylgeranyltransferase: formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex. J Biol Chem 1993;268:4055-60.
11. [11] Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases, Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci USA 1994;91:11963-7.
12. [12] Lujan HD, Mowatt MR, Chen G-Z, Nash TE. Isoprenylation of proteins in the protozoan Giardia lamblia. Mol Biochem Parasitol 1995;72:121-7.
13. [13] Chen G-Z, Bennett JL. Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni. Mol Biochem Parasitol 1993;59:287-92.
14. [14] Field H, Blench I, Croft S, Field MC. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei. Mol Biochem Parasitol 1996;82:67-80.
15. [15] Yokoyama K, Lin Y, Stuart KD, Gelb MH. Prenylation of proteins in Trypanosoma brucei. Mol Biochem Parasitol 1997;87:61-9.
16. [16] Oz HS, Huang H, Wittner M, et al. Evidence for guanosine triphosphate-binding proteins in Trypanosoma cruzi. Am J Trop Med Hyg 1994;50:620-31.
17. [17] Coso OA, D'iaz AA, Martinetto H, et al. Characterization of a Gi-protein from Trypanosoma cruzi epimastigote membranes. Biochem J 1992;287:443-6.
18. [18] Oliveira MM, Rocha ED, Rondinelli E, Arnholdt AV, Scharfstein J. Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control. Mol Cell Biochem 1993;124:91-9.
19. [19] Gonzales PM, Romero P, Goldenberg S. Cyclic AMP and adenylate cyclase activators stimulate Trypanosoma cruzi differentiation. Exp Parasitol 1988;66:205-12.
20. [20] Bubis J, Millan EJ, Martinez R. Identification of guanine nucleotide binding proteins from Trypanosoma cruzi. Biol Res 1993;26:177-88.
21. [21] Eisenschlos CD, Paladini AA, Molina YVL, Torres HN, Flawi'a MM. Evidence for the existence of an Ns-type regulatory protein in Trypanosoma cruzi membranes. Biochem J 1986;237:913-7.
22. [22] Coulter LJ, Hide G. Trypanosoma brucei: characterisation of a life cycle stage-specific G-protein. Exp Parasitol 1995;80:308-18.
23. [23] Cassel D, Shoubi S, Glusman G, Cukierman E, Rotman M, Zilberstein D. Leishmania donovani: characterization of a 38-kDa membrane protein that cross-reacts with the mammalian G-protein transducin. Exp Parasitol 1991;72:411-7.
24. [24] El-Sayed NM, Alarcon CM, Beck JC, Sheffield VC, Donelson JE. cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Mol Biochem Parasitol 1995;73:75-90.
25. [25] Field H, Field MC. Tandem duplication of rab genes followed by sequence divergence and acquisition of distinct functions in Trypanosoma brucei. J Biol Chem 1997;272:10498-505.
26. [26] Field MC, Boothroyd JC. Trypanosoma brucei: molecular cloning of homologues of small GTP-binding proteins involved in vesicle trafficking. Exp Parasitol 1995;81:313-20.
27. [27] Cappai R, Osborn AH, Gleeson PA, Handman E. Cloning and characterization of a Golgi-associated GTP-binding protein homologue from Leishmania major. Mol Biochem Parasitol 1993;62:73-82.
28. [28] Mendonca SM, Campos CB, Gueiros FFJ, Lopes UG. Identification of GTPase genes in the protozoa parasites Trypanosoma cruzi and Leishmania amazonensis. Biol Res 1993;26:3-9.
29. [29] Yokoyama K, Goodwin GW, Ghomashchi F, Glomset JA, Gelb MH. A protein geranylgeranyltransferase from bovine brain: Implications for protein prenylation specificity. Proc Natl Acad Sci USA 1991;88:5302-6.
30. [30] McGeady P, Kuroda S, Shimizu K, Takai Y, Gelb MH. The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase. J Biol Chem 1995;270:26347-51.
31. [31] Stuart KD, Gobright E, Jenni L, Mihausen M, Thomashow L, Agabian N. The IsTar 1 serodeme of T. brucei; development of a new serodeme. J Parasitol 1984;70:747-54.
32. [32] Hirumi H, Hirumi K. Continuous cultivation of T. brucei bloodstream forms containing a low concentration of serum protein without feeder cell layers. J Parasitol 1989;75:985-9.
33. [33] Buckner FS, Verlinde CLM, La Flamme AC, Van Voorhis WC. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing β-galactosidase. Antimicrob Agents Chemother 1996;40:2592-7.
34. [34] Van Voorhis WC, Eisen H. F1-160: A Surface Antigen of Trypanosomal cruzi that mimics mammalian nervous tissue. J Exp Med 1989;169:641-52.
35. [35] Qian Y, Sebti SM, Hamilton AD. Farnesyltransferase as a target for anticancer drug design. Biopolymers 1997;43:25-41.
36. [36] Casey PJ, Seabra MC. Protein prenyltransferases. J Biol Chem 1996;271:5289-92.
37. [37] Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene 1996;13:1991-9.
38. [38] Whyte DB, Kirschmeier P, Hockenberry TN, et al. K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem 1997;272:14459-64.
39. [39] Rowell CA, Kowalczyk JJ, Lewis MD, Garcia AM. Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J Biol Chem 1997;272:14093-7.
40. [40] Gelb MH, Scholten JD, Sebolt-Leopold JS. Protein prenylation: from discovery to prospects for cancer treatment. Curr Opin Chem Biol 1992;2:40-8.