Gene expression in atherogenesis

Thrombosis and Haemostasis

Volumn 86, Issue 1, 2001, Pages 404-412

  Monajemi, H ^a   Arkenbout, E K ^a   Pannekoek, H ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Atherogenesis; LKLF; NF B; NGFI B; PPARs; Vascular cells

Indexed keywords

ERYTHROID KRUPPEL LIKE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE GROWTH FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRANSCRIPTION FACTOR;

ATHEROGENESIS; BIOMEDICAL TECHNOLOGY ASSESSMENT; CARDIOVASCULAR DISEASE; CELL COMMUNICATION; CELL FUNCTION; CONFERENCE PAPER; DISEASE COURSE; ENDOTHELIUM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE THERAPY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; MACROPHAGE; MEDICAL RESEARCH; MOLECULAR DYNAMICS; MONOCYTE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; SMOOTH MUSCLE FIBER;

EID: 0034917653     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616238     Document Type: Conference Paper

References (74)

1. The pathogenesis of therosclerosis: A perspective for the 1990's
2. Atherosclerosis an inflammatory disease
3. Atherosclerosis
4. Mechanical stress mechanisms and the cell: An endothelial paradigm
5. Biomechanical activation: An emerging paradigma in endothelial adhesion biology
6. Vascular endothelial cells to spatial gradients in fluid shear stress by enhanced activation of transcription factors
7. Natural history and histological classification of atherosclerotic lesions
8. Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions
9. The Framingham study. An epidemiological approach to coronary heart disease
10. Novel risk factors for atherosclerosis
11. The combined role of P- and E-selectin in atherosclerosis
12. Molecular structure and functional role of vascular tight junctions
13. Regulation of differentiation of vascular smooth muscle cells
14. Smooth muscle cell heterogeneity: Patterns of gene expression in vascular smooth muscle cells in vitro and in vivo
15. Positive- and negative-acting Krüppel-like transcription factors bind a transforming growth factor control element required for expression of the smooth muscle cell differentiation marker SM22 in vivo
16. Reconstruction of the vessel wall in vitro: A novel model to study the interactions between endothelial cells and smooth muscle cells
17. Monocytes enhance the bidirectional release of type 1 plasminogen activator inhibitor by endothelial cells
18. Differential display of eurkaryotic messenger RNA by means of the polymerase chain reaction
19. Identification of differentially expressed mRNA by an improved display technique (DDRT-PCR)
20. Serial analysis of gene expression
21. Quantitative monitoring of gene expression patterns with complementary DNA microarray
22. Genes expressed in human tumor endothelium
23. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes
24. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells: Local expression in atherosclerotic lesions of smags, smooth muscle cell activation-specific genes
25. Current technoloqies in gene expression profiling: Applications to cardiovascular research
26. Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells
27. Human von Willebrand factor sequences target expression of a subpopulation of endothelial cells in transgenic mice
28. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment
29. PDGF mediates cardiac microvascular communication
30. A vascular-bed specific pathway
31. Endothelial cells in physiology and in the pathophysiology of vascular disorders
32. Cholesterol lowering and endothelial function
33. Blood flow and vascular gene expression: Fluid shear stress as a modulator of endothelial phenotype
34. Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice
35. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
36. IB: A specific inhibitor of the NF-κB transcription factor
37. Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia
38. Serial analysis of gene expression to study the endothelial cell response to an atherogenic stimulus
39. A spatial approach to transcriptional profiling: Mechanotranduction and the focal origin of atherosclerosis
40. Endothelial dysfunction, hemodynamic forces, and atherosclerosis
41. Hemodynamic shear stress and its role in atherosclerosis
42. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectivity up-regulated by steady laminar shear stress
43. Atherosclerosis-prone branch regions in human aorta: Microarchitecture and cell composition of intima
44. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesions formation
45. A tale of three fingers: The family of mammalian Sp/XKLF transcription factors
46. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival
47. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embyrogenesis
48. Endothelial nuclear factor-B and the initiation of the atherosclerotic lesion
49. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
50. Inhibition of fas death signals by FLIPs
51. The beginning of the end: IB Kinase (IKK) and NF-κB Activation
52. Activation of NF-κB by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cell involves TAK1
53. The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signalling pathways
54. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
55. Induction of κBα expression as a mechanism contributing to the anti-inflammatory activities of PPAR activators
56. Activation of human smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
57. Peroxisome proliferator-activated receptor negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
58. Peroxisome proliferator-activated receptor ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
59. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
60. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial interaction
61. Thiazolidinedione inhibits the production of monocyte chemo-attractant protein-1 in cytokine-treated human vascular endothelial cell
62. The NGFI-B subfamily of nuclear receptor superfamily
63. The transforming growth factor beta (TGF) control element drives TGF-induced stimulation of smooth muscle α-actin gene expression in concert with two CarG elements
64. Serial analysis of gene expression in human monocytes and macrophages
65. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma
66. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
67. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage ativation
68. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
69. Targeted disruption of the class B scavenger receptor CD36 protects aginst atherosclerotic lesion development in mice
70. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
71. The role of PPAR-γ in macrophage differentiation and cholesterol uptake
72. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
73. PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway