Activated nuclear factor-κB is present in the coronary vasculature in experimental hypercholesterolemia

Atherosclerosis

Volumn 148, Issue 1, 2000, Pages 23-30

  Wilson, Stephanie H ^a   Caplice, Noel M ^a   Simari, Robert D ^a   Holmes Jr , David R ^a   Carlson, Paula J ^a   Lerman, Amir ^a  

^a MAYO CLINIC   (United States)

Author keywords

Endothelial dysfunction; Hypercholesterolemia; Nuclear factor B

Indexed keywords

BRADYKININ; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORONARY ARTERY; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SWINE; VASODILATATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CORONARY VESSELS; FEMALE; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; LIPIDS; NF-KAPPA B; PROTEIN ISOFORMS; SWINE;

EID: 0033991177     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00211-7     Document Type: Article

References (29)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
2. Celermajer D.S. Endothelial dysfunction: Does it matter? Is it reversible? J. Am. Coll. Cardiol. 30:1997;325-333.
3. Cooke J.P., Tsao P.S. Is NO an endogenous antiatherogenic molecule? Arterioscler. Thromb. 14:1994;653-655.
4. Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:1994;141-179.
5. Brand K., Eisele T., Kruesel U., Page M., Page S., Haas M. et al. Dysregulation of monocytic nuclear factor-κB by oxidized low-density lipoprotein. Arterioscler. Thromb. Vasc. Biol. 17:1997;1901-1909.
6. Barnes P.J., Karin M. Nuclear factor-κB - a pivotal transcriptional factor in chronic inflammatory diseases. NEJM. 336:1997;1066-1071.
7. Kopp E.B., Ghosh S. NF-κB and relative proteins in innate immunity. Adv. Immunol. 58:1995;1-27.
8. Brand K., Page S., Rogler G., Bartsch A., Brand R., Knuechel R. et al. Activated transcriptional factor nuclear factor-κB is present in the atherosclerotic lesion. J. Clin. Invest. 97:1996;1715-1722.
9. Peng H.-B., Libby P., Liao J.K. Induction and stabilisation of IκBα by nitric oxide mediates inhibition of NF-κB. J. Biol. Chem. 270:1995;14214-14219.
10. Mathew V., Cannan C.R., Hasdai D., Schwartz R.S., Holmes D.R., Lerman A. Enhanced endothelin mediated coronary vasoconstriction and attenuated basal nitric oxide activity in experimental hypercholesterolemia. Circulation. 96:1997;1930-1936.
11. Allain C.C., Poon L.S., Chan C.S.L., Richmond W., Fu P.C. Enzymatic determination of total serum cholesterol. Clin. Chem. 20:1974;470-475.
12. Hasdai D., Holmes D.R., Garrat K.G., Edwards W.D., Lerman A. Mechanical pressure and stretch release endothelin-1 from human atherosclerotic coronary arteries in vivo. Circulation. 95:1997;357-362.
13. Hasdai D., Mathew V., Schwartz R.S., Holmes D.R., Lerman A. The effect of basic fibroblast growth factor on coronary vascular tone in experimental hypercholesterolemia in vivo and in vitro. Coron. Artery Dis. 8:1997;299-304.
14. Hernandez-Presa M., Bustos C., Ortego M., Tunon J., Renedo G., Ruiz-Ortega M. et al. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation. 95:1997;1532-1541.
15. Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide production. J. Clin. Invest. 91(6):1993;2546-2551.
16. Drexler H., Zeiher A.M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet. 338:1991;1546-1550.
17. Adams M.A., Jessup W., Hailstones D., Celermajer D.S. L-arginine reduces human monocyte adhesion to vascular endothelium and endothelial expression of cell adhesion molecules. Circulation. 95:1997;662-668.
18. De Caterina R., Libby P., Peng H.-B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A. et al. Nitric oxide decreases cytokine induced-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96:1995;60-68.
19. Libermann T.A., Baltimore D. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10:1990;2327-2334.
20. Kunsch C., Lang R.K., Rosen C.A., Shannon M.F. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-1L-6. J. Immunol. 153:1994;153-164.
21. Parhami F, Fang ZT, Fogelman AM, Andilibi A, Territo MC, Berliner JA. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest; 92:471-478.
22. Schreck R., Rieber P., Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:1991;2247-2258.
23. Weber C., Erl W., Pietsch A., Strobel M., Ziegler-Heitbrock H.W.L., Weber P.C. Anti-oxidants monocyte adhesion by suppressing nuclear factor-κB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler. Thromb. 14:1994;1665-1673.
24. Liao F., Andabi A., Qiao J.-H., Allayee H., Fogelman A.M., Lusis A.J. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J. Clin. Invest. 94:1994;877-884.
25. Graber N., Gopal T.V., Wilson D., Beall L.D., Polte T., Newman W. T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1. J. Immunol. 145:1990;819-830.
26. Dustin M.L., Rothlein R., Bhan A.K., Dinarello C.A., Springer T.A. Induction by IL-1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:1986;245-254.
27. Carlos T.M., Schwartz B.R., Kovach N.L., Yee E., Rosa M., Osborn L. et al. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured endothelial cells. Blood. 76:1990;965-970.
28. Yia-Herttuala S., Lipton B.A., Rosenfeld M.E., Sarkioja T., Yoshimura E.J., Leonard J.L. et al. Expression of monocyte chemoattractant protein-1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Nat. Acad. Sci. USA. 88:1991;5252-5256.
29. Mackman N., Brand K., Edgington T.S. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor-κB binding sites. J. Exp. Med. 174:1991;1517-1526.