Importin-β-like nuclear transport receptors

Genome Biology

Volumn 2, Issue 6, 2001, Pages

  Strom A C ^a   Weis, K ^a  

^a University of California Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; EXPORTIN; GUANOSINE TRIPHOSPHATASE; KARYOPHERIN; KARYOPHERIN BETA; RAN PROTEIN; UNCLASSIFIED DRUG;

CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOPLASM; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN BINDING; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SOLUBILITY;

ACTIVE TRANSPORT, CELL NUCLEUS; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; HUMANS; KARYOPHERINS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEIN STRUCTURE, SECONDARY; RAN GTP-BINDING PROTEIN; REPETITIVE SEQUENCES, AMINO ACID;

SACCHAROMYCES CEREVISIAE;

EID: 0034913423     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (89)

1. Transport between the cell nucleus and the cytoplasm
2. Identification of two novel RanGTP-binding proteins belonging to the importin {beta} superfamily
3. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2
4. Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex
5. Functional domains in nuclear import factor p97 for binding the nuclear localization sequence receptor and the nuclear pore
6. Structure of importin-beta bound to the IBB domain of importin-alpha
7. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp
8. Structural view of the Ran-importin beta interaction at 2.3 A resolution
9. Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking
10. The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport
11. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
12. Transport of proteins and RNAs in and out of the nucleus
13. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
14. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
15. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup 153 and the adjacent nuclear filament protein Tpr
16. A role for RanBPI in the release of CRMI from the nuclear pore complex in a terminal step of nuclear export
17. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
18. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex
19. Nuclear targeting sequences- A consensus?
20. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
21. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
22. Distinct functions for the two importin subunits in nuclear protein import
23. The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile
24. Identification of hSRPI alpha as a functional receptor for nuclear localization sequences
25. Snurportin I, an m3G-cap-specific nuclear import receptor with a novel domain structure
26. Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRI-Palpha but not importin alpha
27. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone HI
28. Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97
29. The arginine-rich domains present in human immunodeficiency virus type I Tat and Rev function as direct importin beta-dependent nuclear localization signals
30. Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha
31. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
32. Nuclear import of Cdk/cyclin complexes: Identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin Bl
33. Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta
34. Importin beta mediates nuclear translocation of Smad 3
35. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha
36. A distinct nuclear import pathway used by ribosomal proteins
37. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
38. Kap 104p: A karyopherin involved in the nuclear transport of messenger RNA binding proteins
39. A novel receptor-mediated nuclear protein import pathway
40. Nuclear import of hnRNP AI is mediated by a novel cellular cofactor related to karyopherin-beta
41. Karyopherin beta2 mediates nuclear import of a mRNA binding protein
42. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins
43. Transportin-SR, a nuclear import receptor for SR proteins
44. A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins
45. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
46. CRMI is an export receptor for leucine-rich nuclear export signals
47. Evidence for a role of CRM1 in signal-mediated nuclear protein export
48. Exportin I (Crmlp) is an essential nuclear export factor
49. CRMI is responsible for intracellular transport mediated by the nuclear export signal
50. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway
51. CRMI-mediated recycling of snurportin I to the cytoplasm
52. Involvement of human CRM 1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type I
53. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
54. Control of cyclin B 1 localization through regulated binding of the nuclear export factor CRMI
55. NF-AT activation requires suppression of Crm 1 -dependent export by calcineurin
56. Crmlp mediates regulated nuclear export of a yeast AP-I-like transcription factor
57. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: Cell cycle-regulated transcription factor Ace2p shows cell cycle-independent nucleocytoplasmic shuttling
58. Regulated nucleo/cytoplasmic exchange of HOGI MAPK requires the importin beta homologs NMD5 and XPOI
59. A nuclear export signal prevents Saccharomyces cerevisiae Hsp70 SsbIp from stimulating nuclear localization signal-directed nuclear transport
60. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
61. Cselp is required for export of Srplp/importin-alpha from the nucleus in Saccharomyces cerevisiae
62. Cselp functions as the nuclear export receptor for importin alpha in yeast
63. Cselp is involved in export of yeast importin alpha from the nucleus
64. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
65. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
66. Identification of a tRNA-specific nuclear export receptor
67. Identification of a nuclear export receptor for tRNA
68. Yeast Loslp has properties of an exportin-like nucleocytoplasmic transport factor for tRNA
69. Importins and exportins: How to get in and out of the nucleus
70. The direction of transport through the nuclear pore can be inverted
71. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
72. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCCI
73. RanGAPI induces GTPase activity of nuclear Ras-related Ran
74. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBPI
75. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
76. A giant nucleopore protein that binds Ran/TC4
77. Gradient of increasing affinity of importin β for nucleoporins along the pathway of nuclear import
78. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, elF4E
79. A nuclear import pathway for a protein involved in tRNA maturation
80. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p
81. A novel nuclear import pathway for the transcription factor TFIIS
82. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Psel/Kap121
83. Nuclear import of Spo12p, a protein essential for meiosis
84. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus
85. Exportin 4: A mediator of a novel nuclear export pathway in higher eukaryotes
86. The nuclear exportin Msn5p is required for nuclear export of the Miglp glucose repressor of Saccharomyces cerevisiae
87. Nuclear export of Farlp in response to pheromones requires the export receptor Msn5p/Ste21p
88. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
89. A novel class of RanGTP binding proteins