Involvement of human CRM1 (Exportin 1) in the export and multimerization of the rex protein of human T-cell leukemia virus type

Journal of Virology

Volumn 72, Issue 8, 1998, Pages 6602-6607

  Hakata, Yoshiyuki ^a   Umemoto, Tomoe ^a   Matsushita, Shuzo ^b   Shida, Hisatoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

EID: 0031878580     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.8.6602-6607.1998     Document Type: Article

References (43)

1. Ballaun, C., G. K. Farrington, M. Dobrovnik, J. Rusche, J. Hauber, and E. Böhnlein. 1991. Functional analysis of human T-cell leukemia virus type 1 Rex response element: direct RNA binding of Rex protein correlates with in vivo activity. J. Virol. 65:4408-4413.
2. Bogerd, H., and W. C. Greene. 1993. Dominant negative mutants of human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo. J. Virol. 67:2495-2502.
3. Bogerd, H. P., G. L. Huckaby, Y. F. Ahmed, S. M. Hanly, and W. C. Greene. 1991. The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. Proc. Natl. Acad. Sci. USA 88:5704-5708.
4. Bogerd, H. P., R. A. Fridell, R. E. Benson, H. Jian, and B. R. Cullen. 1996. Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol. Cell. Biol. 16:4207-4214.
5. Böhnlein, S., F. P. Pirker, L. Hofer, K. Zimmermann, H. Bachmayer, E. Böhnlein, and J. Hauber. 1991. Transdominant repressors for human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev function. J. Virol. 65:81-88.
6. Cochrane, A. W., A. Perkins, and C. A. Rosen. 1990. Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. J. Virol. 64:881-885.
7. Cullen, B. R. 1991. Regulation of human immunodeficiency virus replication. Annu. Rev. Microbiol. 45:219-250.
8. Cullen, B. R., and M. H. Malim. 1991. The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators. Trends Biochem. Sci. 16:346-350.
9. Dingwall, C., S. Kandel-Lewis, and B. Seraphin. 1995. A family of Ran binding proteins that includes nucleoporins. Proc. Natl. Acad. Sci. USA 92:7525-7529.
10. Dobbelstein, M., J. Roth, W. T. Kimberly, A. J. Levine, and T. Shenk. 1997. Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a Rev-like signal sequence. EMBO J. 16:4276-4284.
11. Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 19:1051-1060.
12. Fujii, M., H. Tsuchiya, T. Chuhjo, T. Akizawa, and M. Seiki. 1992. Interaction of HTLV-I Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev. 6:2066-2076.
13. Fukuda, M., S. Asano, T. Nakamura, M. Adachi, M. Yoshida, M. Yanagida, and E. Nishida. 1997. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 20:308-311.
14. Grassman, R., S. Berchtold, C. Aepinus, C. Ballaun, E. Boehnlein, and B. Fleckenstein. 1991. In vitro binding of human T-cell leukemia virus Rex proteins to the Rex response element of viral transcripts. J. Virol. 65:3721-3727.
15. Hanly, S. M., L. T. Rimsky, M. H. Malim, J. J. Kim, J. Hauber, M. DucDodon, S.-Y. Le, J. V. Maizel, B. R. Cullen, and W. C. Greene. 1989. Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev. 3:1534-1544.
16. Hidaka, M., J. Inoue, M. Yoshida, and M. Seiki. 1988. Post-transcriptional regulator (Rex) of HTLV-I initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J. 7:519-523.
17. Hope, T. J., N. P. Klein, M. E. Elder, and T. G. Parslow. 1992. trans-Dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes. J. Virol. 66:1849-1855.
18. Inoue, J.-I., M. Yoshida, and M. Seiki. 1987. Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc. Natl. Acad. Sci. USA 84:3653-3657.
19. Katahira, J., T. Ishizaki, H. Sakai, A. Adachi, K. Yamamoto, and H. Shida. 1995. Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type 1 Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding. J. Virol. 69:3125-3133.
20. Kim, F. J., A. A. Beeche, J. J. Hunter, D. J. Chin, and T. J. Hope. 1996. Characterization of the nuclear export signal of human T-cell lymphotropic virus type 1 Rex reveals that nuclear export is mediated by position-variable hydrophobic interactions. Mol. Cell. Biol. 16:5147-5155.
21. Kiyokawa, T., T. Umemoto, Y. Watanabe, S. Matsushita, and H. Shida. 1997. Two distinct pathways for intronless mRNA expression: one related, the other unrelated to human immunodeficiency virus Rev and human T cell leukemia virus type I Rex functions. Biol. Signals 6:134-142.
22. Kudo, N., S. Khochbin, K. Nishi, K. Kitano, M. Yanagida, M. Yoshida, and S. Horinouchi. 1997. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. J. Biol. Chem. 21:29742-29751.
23. Madore, S. J., L. S. Tiley, M. H. Malim, and B. R. Cullen. 1994. Sequence requirements for Rev multimerization in vivo. Virology 202:186-194.
24. Malim, M. H., S. Böhnlein, J. Hauber, and B. R. Cullen. 1989. Functional dissection of the HIV-1 Rev trans-activator - deriviation of a trans-dominant repressor of Rev function. Cell 58:205-214.
25. Malim, M. H., L. S. Tiley, D. F. McCarn, J. R. Rusche, J. Hauber, and B. R. Cullen. 1990. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. Cell 60:675-683.
26. Malim, M. H., and B. R. Cullen. 1991. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. Cell 65:241-248.
27. Malim, M. H., D. F. McCarn, L. S. Tiley, and B. R. Cullen. 1991. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. J. Virol. 65:4248-4254.
28. Neville, M., F. Stutz, L. Lee, L. Davis, and M. Rosbash. 1997. The importinbeta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr. Biol. 7:767-775.
29. Ossareh-Nazari, B., F. Bachelerie, and C. Dargemont. 1997. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278:141-144.
30. Roth, J., and M. Dobbelstein. 1997. Export of hepatitis B virus RNA on a Rev-like pathway inhibition by the regenerating liver inhibitory factor IkappaB alpha. J. Virol. 71:8933-8939.
31. Roth, J., M. Dobbelstein, D. A. Freedman, T. Shenk, and A. J. Levine. 1998. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17:554-564.
32. Seiki, M., J.-I. Inoue, M. Hidaka, and M. Yoshida. 1988. Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 85:7124-7128.
33. Siomi, H., H. Shida, S. H. Nam, T. Nosaka, M. Maki, and M. Hatanaka. 1988. Sequence requirements for nucleolar localization of human T-cell leukemia virus type I pX protein, which regulates viral RNA processing. Cell 55:197-209.
34. Solomin, L., B. K. Felber, and G. N. Pavlakis. 1990. Different sites of interaction for Rev, Tev, and Rex proteins within the Rev responsive element of human immunodeficiency virus type 1. J. Virol. 64:6010-6017.
35. Stade, K., C. S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90:1041-1050.
36. Stauber, R., G. A. Gaitanaris, and G. N. Pavlakis. 1995. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology 213:439-449.
37. Szilvay, A. M., K. A. Brokstad, S. O. Boe, G. Haukenes, and K. H. Kalland. 1997. Oligomerization of HIV-1 Rev mutants in the cytoplasm and during nuclear import. Virology 235:73-81.
38. Takebe, Y., M. Seiki, J. Fujisawa, P. Hoy, K. Yokota, K. Arai, M. Yoshida, and N. Arai. 1988. SRα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466-472.
39. Ullman, K. S., M. A. Powers, and D. J. Forbes. 1997. Nuclear export receptors: from importin to exportin. Cell 90:967-970.
40. Venkatesh, L. K., and G. Chinnadurai. 1990. Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype. Virology 178:327-330.
41. Weichselbraun, I., G. K. Farrington, J. R. Rusche, E. Böhnlein, and J. Hauber. 1992. Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type 1 Rex protein activation domain by functional exchange. J. Virol. 66:2583-2587.
42. Weichselbraun, I., J. Borger, M. Dobrovnik, H. Bogerd, R. Grassmann, W. C. Greene, J. Hauber, and E. Böhnlein. 1992 Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type 1 Rex protein: implications for trans dominance. J. Virol. 66:4540-4545.
43. Zapp, M. L., and M. R. Green. 1989. Sequence-specific RNA binding by the HIV-1 Rev protein. Nature (London) 342:714-716.