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Volumn 50, Issue 5, 1997, Pages 234-241

Progeroid syndromes: Probing the molecular basis of aging?

Author keywords

Aging; Progeroid syndromes; Werner's syndrome

Indexed keywords

DNA; DNA DIRECTED DNA POLYMERASE;

EID: 0030707880     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.50.5.234     Document Type: Review
Times cited : (33)

References (101)
  • 1
    • 9844229164 scopus 로고
    • Technology Foresight London: HMSO
    • Technology foresight panel on health and life sciences. Progress through partnership Technology Foresight 4. London: HMSO, 1995:20-2.
    • (1995) Progress Through Partnership , vol.4 , pp. 20-22
  • 3
    • 0030038104 scopus 로고    scopus 로고
    • Replicative senescence: Implications for in vitro aging and tumor supression
    • Smith JR, Periera-Smith OM. Replicative senescence: implications for in vitro aging and tumor supression. Science 1996;273:63-7.
    • (1996) Science , vol.273 , pp. 63-67
    • Smith, J.R.1    Periera-Smith, O.M.2
  • 4
    • 0022330944 scopus 로고
    • Genetics and ageing: The Werner syndrome as a segmental progeroid syndrome
    • Martin GM. Genetics and ageing: the Werner syndrome as a segmental progeroid syndrome. Adv Exp Biol Med 1985; 190:161-71.
    • (1985) Adv Exp Biol Med , vol.190 , pp. 161-171
    • Martin, G.M.1
  • 5
    • 0030447280 scopus 로고    scopus 로고
    • Human senescence
    • Kirkwood TBL. Human senescence. Bioessays 1996;18: 1009-16.
    • (1996) Bioessays , vol.18 , pp. 1009-1016
    • Kirkwood, T.B.L.1
  • 6
    • 0026484585 scopus 로고
    • High blood pressure: Hunting the genes
    • Leckie BJ. High blood pressure: hunting the genes. Bioessays 1993;14:37-41.
    • (1993) Bioessays , vol.14 , pp. 37-41
    • Leckie, B.J.1
  • 7
    • 85012145261 scopus 로고
    • Artificial activation of the growth in vitro of connective tissue
    • Carrel A. Artificial activation of the growth in vitro of connective tissue. J Exp Med 1913;16:14-19.
    • (1913) J Exp Med , vol.16 , pp. 14-19
    • Carrel, A.1
  • 8
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid fibroblast cell strains
    • Hayflick L, Moorehead PS. The serial cultivation of human diploid fibroblast cell strains. Exp Cell Res 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorehead, P.S.2
  • 9
    • 50549218525 scopus 로고
    • The limited in vitro life-span of human diploid cell strains
    • Hayflick L. The limited in vitro life-span of human diploid cell strains. Exp Cell Res 1965;37:614-36.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 10
    • 0018634891 scopus 로고
    • The cell biology of aging
    • Hayflick L. The cell biology of aging. J Invest Dermatol 1979;73:8-14.
    • (1979) J Invest Dermatol , vol.73 , pp. 8-14
    • Hayflick, L.1
  • 11
    • 0014816132 scopus 로고
    • Replicative lifespan of cultivated human cells. Effects of donor's age, tissue and genotype
    • Martin GM, Sprague CA, Epstein CJ. Replicative lifespan of cultivated human cells. Effects of donor's age, tissue and genotype. Lab Invest 1970;23:86-92.
    • (1970) Lab Invest , vol.23 , pp. 86-92
    • Martin, G.M.1    Sprague, C.A.2    Epstein, C.J.3
  • 12
    • 0001068487 scopus 로고
    • The relationship between in vitro cellular aging and in vivo human age
    • Schneider HL, Mitsui Y. The relationship between in vitro cellular aging and in vivo human age. Proc Natl Acad Sci 1976;73:3584-8.
    • (1976) Proc Natl Acad Sci , vol.73 , pp. 3584-3588
    • Schneider, H.L.1    Mitsui, Y.2
  • 14
    • 0023599999 scopus 로고
    • The in vitro replicative potential and cellular morphology of human lens epithelial cells derived from different aged donors
    • Lipman RD, Taylor A. The in vitro replicative potential and cellular morphology of human lens epithelial cells derived from different aged donors. Curr Eye Res 1987;6:1453-7.
    • (1987) Curr Eye Res , vol.6 , pp. 1453-1457
    • Lipman, R.D.1    Taylor, A.2
  • 15
    • 0030988166 scopus 로고    scopus 로고
    • Matrix stimulates the proliferation of human corneal endothelial cells in culture
    • Blake DA, Yu H, Young DL, Caldwell DR. Matrix stimulates the proliferation of human corneal endothelial cells in culture. Invest Ophthmol Vis Sci 1997;38:1119-29.
    • (1997) Invest Ophthmol Vis Sci , vol.38 , pp. 1119-1129
    • Blake, D.A.1    Yu, H.2    Young, D.L.3    Caldwell, D.R.4
  • 17
    • 0020573584 scopus 로고
    • Relationship between actinic damage and chronologic aging in keratinocyte cultures in human skin
    • Gilchrest BA. Relationship between actinic damage and chronologic aging in keratinocyte cultures in human skin. J Invest Dermatol 1983;81:184S-9S.
    • (1983) J Invest Dermatol , vol.81
    • Gilchrest, B.A.1
  • 18
    • 0000299214 scopus 로고
    • Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
    • Rohme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci 1981;78: 5009-13.
    • (1981) Proc Natl Acad Sci , vol.78 , pp. 5009-5013
    • Rohme, D.1
  • 19
    • 0031037294 scopus 로고    scopus 로고
    • Long-term calorie restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo
    • Li Y, Yan Q, Wolf NS. Long-term calorie restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo. Invest Ophthmol Vis Sci 1997;38:100-8.
    • (1997) Invest Ophthmol Vis Sci , vol.38 , pp. 100-108
    • Li, Y.1    Yan, Q.2    Wolf, N.S.3
  • 20
    • 0027057374 scopus 로고
    • Arteriosclerosis: Impairment of cellular interactions in the arterial wall
    • Van Hinsburgh VWM. Arteriosclerosis: impairment of cellular interactions in the arterial wall. Ann NY Acad Sci 1992;673:321-30.
    • (1992) Ann NY Acad Sci , vol.673 , pp. 321-330
    • Van Hinsburgh, V.W.M.1
  • 22
    • 0029164707 scopus 로고
    • Cataloging altered gene expression in young and senescent cells using enhanced differential display
    • Linskens MHK, Feng J, Andrews WH, Enlow BE, Shahin MS, Tonkin LA, et al. Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acid Res 1995;23:3244-51.
    • (1995) Nucleic Acid Res , vol.23 , pp. 3244-3251
    • Linskens, M.H.K.1    Feng, J.2    Andrews, W.H.3    Enlow, B.E.4    Shahin, M.S.5    Tonkin, L.A.6
  • 24
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri G, Lee X, Basile G, Acosta M, Scott G, Roskelly C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci 1995; 92:9362-7.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 9362-9367
    • Dimri, G.1    Lee, X.2    Basile, G.3    Acosta, M.4    Scott, G.5    Roskelly, C.6
  • 25
    • 0013918813 scopus 로고
    • The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro
    • Maciera-Coelho A, Ponten J, Philipson L. The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro. Exp Cell Res 1966;42:673-684.
    • (1966) Exp Cell Res , vol.42 , pp. 673-684
    • Maciera-Coelho, A.1    Ponten, J.2    Philipson, L.3
  • 26
    • 0015580671 scopus 로고
    • Cellular senescence and DNA synthesis
    • Cristofalo VJ, Scharf BB. Cellular senescence and DNA synthesis. Exp Cell Res 1973;76:419-27.
    • (1973) Exp Cell Res , vol.76 , pp. 419-427
    • Cristofalo, V.J.1    Scharf, B.B.2
  • 27
    • 0018890645 scopus 로고
    • Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular ageing
    • Smith JR, Whitney RG. Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular ageing. Science 1980;207:82-4.
    • (1980) Science , vol.207 , pp. 82-84
    • Smith, J.R.1    Whitney, R.G.2
  • 28
    • 0021058256 scopus 로고
    • A quantitative analysis of the ageing of human glial cells in culture
    • Ponten J, Stein WD, Shall S. A quantitative analysis of the ageing of human glial cells in culture. J Cell Physiol 1983;117:342-52.
    • (1983) J Cell Physiol , vol.117 , pp. 342-352
    • Ponten, J.1    Stein, W.D.2    Shall, S.3
  • 29
    • 0018377134 scopus 로고
    • A mortalisation theory for the control of cell proliferation and for the origin of immortal cell lines
    • Shall S, Stein WD. A mortalisation theory for the control of cell proliferation and for the origin of immortal cell lines. J Theoret Biol 1979;76:219-31.
    • (1979) J Theoret Biol , vol.76 , pp. 219-231
    • Shall, S.1    Stein, W.D.2
  • 30
    • 0001173605 scopus 로고
    • Mortalisation or reproductive sterility of animal cells in culture
    • Potten CS, ed. Oxford: Oxford University Press
    • Shall S. Mortalisation or reproductive sterility of animal cells in culture. In: Potten CS, ed. Perspectives on mammalian cell death. Oxford: Oxford University Press, 1987:184-201.
    • (1987) Perspectives on Mammalian Cell Death , pp. 184-201
    • Shall, S.1
  • 31
    • 0015811623 scopus 로고
    • Attempted hydridisations with senescent human nbroblasts
    • Littlefield JW. Attempted hydridisations with senescent human nbroblasts. J Cell Physiol 1973;82:129-32.
    • (1973) J Cell Physiol , vol.82 , pp. 129-132
    • Littlefield, J.W.1
  • 32
    • 0000547195 scopus 로고
    • Aging at the cellular level: The human fibroblast-like cell model
    • Schneider EL, Rowe JW, eds. San Diego: Academic Press Inc
    • Norwood TH, Smith JR, Stein GH. Aging at the cellular level: the human fibroblast-like cell model. In: Schneider EL, Rowe JW, eds. Handbook of the biology of aging. San Diego: Academic Press Inc, 1990:131-54.
    • (1990) Handbook of the Biology of Aging , pp. 131-154
    • Norwood, T.H.1    Smith, J.R.2    Stein, G.H.3
  • 33
    • 0025217463 scopus 로고
    • Genetic and molecular studies of cellular immortalisation
    • Smith JR, Periera-Smith OM. Genetic and molecular studies of cellular immortalisation. Adv Cancer Res 1990;54:63-77.
    • (1990) Adv Cancer Res , vol.54 , pp. 63-77
    • Smith, J.R.1    Periera-Smith, O.M.2
  • 34
    • 0028342664 scopus 로고
    • Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Periera-Smith OM, Smith JR. Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994;211:90-8.
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Periera-Smith, O.M.4    Smith, J.R.5
  • 35
    • 0029317383 scopus 로고
    • 1 arrest in senescent human fibroblasts
    • 1 arrest in senescent human fibroblasts. Bioessays 1995;17:537-43.
    • (1995) Bioessays , vol.17 , pp. 537-543
    • Stein, G.H.1    Dulic, V.2
  • 36
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • Campisi J. The biology of replicative senescence. Eur J Cancer 1997;33:703-10.
    • (1997) Eur J Cancer , vol.33 , pp. 703-710
    • Campisi, J.1
  • 37
    • 0031127177 scopus 로고    scopus 로고
    • Cyclins, cyclin dependent kinases and differentiation
    • Gao CY, Zelenka PS. Cyclins, cyclin dependent kinases and differentiation. Bioessays 1997;19:207-315.
    • (1997) Bioessays , vol.19 , pp. 207-315
    • Gao, C.Y.1    Zelenka, P.S.2
  • 38
    • 0001214436 scopus 로고    scopus 로고
    • Distinction between differentiation and senescence and the abscence of increased apoptosis in human keratinocytes undergoing cellular ageing in vitro
    • Norsgaard H, Clark BFC, Rattan SIS. Distinction between differentiation and senescence and the abscence of increased apoptosis in human keratinocytes undergoing cellular ageing in vitro. Exp Gerontol 1996;31:655-68.
    • (1996) Exp Gerontol , vol.31 , pp. 655-668
    • Norsgaard, H.1    Clark, B.F.C.2    Rattan, S.I.S.3
  • 39
    • 0003893135 scopus 로고
    • Oxford: Oxford University Press
    • Kipling D. The telomere. Oxford: Oxford University Press, 1995.
    • (1995) The Telomere
    • Kipling, D.1
  • 40
    • 0002309826 scopus 로고
    • Telomere dynamics and genome instability in human cancer
    • Blackburn EH, Greider CW, eds. New York: Cold Spring Harbor Press
    • de Lange T. Telomere dynamics and genome instability in human cancer. In: Blackburn EH, Greider CW, eds. Telomeres New York: Cold Spring Harbor Press, 1995:265-93.
    • (1995) Telomeres , pp. 265-293
    • De Lange, T.1
  • 41
    • 0028958708 scopus 로고
    • Telomeres and telomerase in aging and cancer
    • Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 1995;5:249-55.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 249-255
    • Harley, C.B.1    Villeponteau, B.2
  • 42
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 43
    • 0030006735 scopus 로고    scopus 로고
    • In situ analysis of changes in telomere size during replicative aging and cell transformation
    • Henderson S, Allsopp R, Spector D, Wang SS, Harley C. In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol 1996;134:1-12.
    • (1996) J Cell Biol , vol.134 , pp. 1-12
    • Henderson, S.1    Allsopp, R.2    Spector, D.3    Wang, S.S.4    Harley, C.5
  • 44
    • 0030447657 scopus 로고    scopus 로고
    • The Saccharomyces CDC13 protein is a single-stranded TG telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
    • Lin JJ, Zakian VA. The Saccharomyces CDC13 protein is a single-stranded TG telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc Natl Acad Sci USA 1996;93:13760-5.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13760-13765
    • Lin, J.J.1    Zakian, V.A.2
  • 46
    • 0026452286 scopus 로고
    • Loss of transcription factor AP1 DNA binding activity during lymphocyte aging in vivo
    • Sikora E, Kaminska B, Radziszewska E, Kaczmarek L. Loss of transcription factor AP1 DNA binding activity during lymphocyte aging in vivo. FEBS Lett 1992;312:179-82.
    • (1992) FEBS Lett , vol.312 , pp. 179-182
    • Sikora, E.1    Kaminska, B.2    Radziszewska, E.3    Kaczmarek, L.4
  • 47
    • 0025052004 scopus 로고
    • Repression of c-fos and an altered genetic programme in senescent human fibroblasts
    • Sheshadri T, Campisi J. Repression of c-fos and an altered genetic programme in senescent human fibroblasts. Science 1990;247:205-9.
    • (1990) Science , vol.247 , pp. 205-209
    • Sheshadri, T.1    Campisi, J.2
  • 49
    • 4243305752 scopus 로고
    • Senescence and immortalisation of human cells
    • Studzinski, GP, ed. Oxford: IRL Press
    • Hubbard K, Ozer HL. Senescence and immortalisation of human cells. In: Studzinski, GP, ed. Cell growth and apoptosis: a practical approach. Oxford: IRL Press, 1995: 229-49.
    • (1995) Cell Growth and Apoptosis: A Practical Approach , pp. 229-249
    • Hubbard, K.1    Ozer, H.L.2
  • 50
    • 0025130530 scopus 로고
    • Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation
    • Kill IR, Shall S. Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation. J Cell Sci 1990;97:473-8.
    • (1990) J Cell Sci , vol.97 , pp. 473-478
    • Kill, I.R.1    Shall, S.2
  • 51
    • 0027300829 scopus 로고
    • In vitro aging in T lymphocyte cultures: Analysis of DNA content and cell size
    • Perillo NL, Naeim F, Walford RL, Effros RB. In vitro aging in T lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res 1993;207:131-5.
    • (1993) Exp Cell Res , vol.207 , pp. 131-135
    • Perillo, N.L.1    Naeim, F.2    Walford, R.L.3    Effros, R.B.4
  • 52
    • 0024398094 scopus 로고
    • Collagenase production by early and late passage cultures of human fibroblasts
    • Millis AJT, Sottile J, Hoyle M, Mann DM, Diemer V. Collagenase production by early and late passage cultures of human fibroblasts. Exp Gerontol 1989;24:559-75.
    • (1989) Exp Gerontol , vol.24 , pp. 559-575
    • Millis, A.J.T.1    Sottile, J.2    Hoyle, M.3    Mann, D.M.4    Diemer, V.5
  • 53
    • 0028338836 scopus 로고
    • Expression of 72Kd gelatinase and TIMP2 in early and late passage human fibroblasts
    • Zeng G, Millis AJ. Expression of 72Kd gelatinase and TIMP2 in early and late passage human fibroblasts. Exp Cell Res 1994;213:148-55.
    • (1994) Exp Cell Res , vol.213 , pp. 148-155
    • Zeng, G.1    Millis, A.J.2
  • 54
    • 0029962187 scopus 로고    scopus 로고
    • Altered expression of plasminogen activator and plasminogen act ivator inhibitor during cellular senescence
    • West MD, Shay JW, Wright WE, Linskens MHK. Altered expression of plasminogen activator and plasminogen act ivator inhibitor during cellular senescence. Exp Gerontol 1996;31:175-93.
    • (1996) Exp Gerontol , vol.31 , pp. 175-193
    • West, M.D.1    Shay, J.W.2    Wright, W.E.3    Linskens, M.H.K.4
  • 56
    • 0027295499 scopus 로고
    • Failure of senescent human fibroblasts to express the insulin-like growth factor 1 gene
    • Ferber A, Chang CD, Sell C, Ptasznik A, Cristofalo VJ, Hubbard K, et al. Failure of senescent human fibroblasts to express the insulin-like growth factor 1 gene. J Biol Chem 1993;268:17883-8.
    • (1993) J Biol Chem , vol.268 , pp. 17883-17888
    • Ferber, A.1    Chang, C.D.2    Sell, C.3    Ptasznik, A.4    Cristofalo, V.J.5    Hubbard, K.6
  • 57
    • 0028214727 scopus 로고
    • Supression of calcium dependent membrane currents in human fibroblasts by replicative senescence and forced expression of a gene sequence encoding a putative calcium-binding protein
    • Liu S, Thweatt R, Lumpkin CK, Goldstein S. Supression of calcium dependent membrane currents in human fibroblasts by replicative senescence and forced expression of a gene sequence encoding a putative calcium-binding protein. Proc Natl Acad Sci USA 1994;91:2186-90.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2186-2190
    • Liu, S.1    Thweatt, R.2    Lumpkin, C.K.3    Goldstein, S.4
  • 58
    • 0030042853 scopus 로고    scopus 로고
    • Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts
    • Zeng G, Millis AJT. Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts. Exp Cell Res 1996;222:150-6.
    • (1996) Exp Cell Res , vol.222 , pp. 150-156
    • Zeng, G.1    Millis, A.J.T.2
  • 59
    • 0026753051 scopus 로고
    • Cloning and expressionof SAG: A novel marker of cellular senescence
    • Wistrom C, Villeponteau B. Cloning and expressionof SAG: a novel marker of cellular senescence. Exp Cell Res 1992;199:355-62.
    • (1992) Exp Cell Res , vol.199 , pp. 355-362
    • Wistrom, C.1    Villeponteau, B.2
  • 60
    • 0029116174 scopus 로고
    • Elevated expression of mitochondrial cytochrome b and NADH dehydrogenase subunit 4/4L in senescent human cells
    • Kodama S, Yamada H, Annab L, Barrett JC. Elevated expression of mitochondrial cytochrome b and NADH dehydrogenase subunit 4/4L in senescent human cells. Exp Cell Res 1995;219:82-6.
    • (1995) Exp Cell Res , vol.219 , pp. 82-86
    • Kodama, S.1    Yamada, H.2    Annab, L.3    Barrett, J.C.4
  • 61
    • 0021783284 scopus 로고
    • Progeria: A model disease for the study of accelerated ageing
    • Brown WT, Zebrower M, Kieras F. Progeria: a model disease for the study of accelerated ageing. Basic Life Sci 1984;35:375-96.
    • (1984) Basic Life Sci , vol.35 , pp. 375-396
    • Brown, W.T.1    Zebrower, M.2    Kieras, F.3
  • 62
    • 0028156003 scopus 로고
    • Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes
    • Weirich-Schwaiger H, Weirich HG, Gruber B, Schweiger, M, Hirsch-Kaufmann M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat Res 1994;31:37-48.
    • (1994) Mutat Res , vol.31 , pp. 37-48
    • Weirich-Schwaiger, H.1    Weirich, H.G.2    Gruber, B.3    Schweiger, M.4    Hirsch-Kaufmann, M.5
  • 63
    • 0021171248 scopus 로고
    • Werner's syndrome: An under-diagnosed condition resembling premature aging
    • Tollefsbul TO, Cohen HJ. Werner's syndrome: An under-diagnosed condition resembling premature aging. Age 1984;7:75-88.
    • (1984) Age , vol.7 , pp. 75-88
    • Tollefsbul, T.O.1    Cohen, H.J.2
  • 64
    • 0027377887 scopus 로고
    • Werner's syndrome: A review of the clinical and pathological features and pathogenesis
    • Herd RM, Faragher RGA, Shall S, Hunter JAA. Werner's syndrome: a review of the clinical and pathological features and pathogenesis. Eur J Dermatol 1993;3:425-32.
    • (1993) Eur J Dermatol , vol.3 , pp. 425-432
    • Herd, R.M.1    Faragher, R.G.A.2    Shall, S.3    Hunter, J.A.A.4
  • 65
    • 0019444282 scopus 로고
    • Systematic growth studies, cocultivation and cell hybridisation studies of Werner syndrome cultured skin fibroblasts
    • Salk D, Bryant E, Au K, Hoehn H, Martin GM. Systematic growth studies, cocultivation and cell hybridisation studies of Werner syndrome cultured skin fibroblasts. Hum Genet 1981;58:310-16.
    • (1981) Hum Genet , vol.58 , pp. 310-316
    • Salk, D.1    Bryant, E.2    Au, K.3    Hoehn, H.4    Martin, G.M.5
  • 67
    • 0028295472 scopus 로고
    • The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture
    • Kill IR, Faragher RGA, Lawrence K, Shall S. The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture. J Cell Sci 1994;107:571-9.
    • (1994) J Cell Sci , vol.107 , pp. 571-579
    • Kill, I.R.1    Faragher, R.G.A.2    Lawrence, K.3    Shall, S.4
  • 68
    • 0025169778 scopus 로고
    • Increased frequency of 6-thioguanine resistant peripheral blood lymphocytes in Werner syndrome patients
    • Fukuchi K, Tanaka K, Kumahara Y, Maramo K, Pride M, Martin GM, et al. Increased frequency of 6-thioguanine resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet 1990;84:249-52.
    • (1990) Hum Genet , vol.84 , pp. 249-252
    • Fukuchi, K.1    Tanaka, K.2    Kumahara, Y.3    Maramo, K.4    Pride, M.5    Martin, G.M.6
  • 69
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterised by extensive deletions
    • Fukuchi K, Martin GM, Monnat RJ. Mutator phenotype of Werner syndrome is characterised by extensive deletions. Proc Natl Acad Sci USA 1989;86:5893-7.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat, R.J.3
  • 70
    • 0026502062 scopus 로고
    • Genetic linkage of Werner's syndrome to five markers on chromosome 8
    • Goto M, Rubenstein M, Weber J, Woods K, Drayna D. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 1992;355:735-7.
    • (1992) Nature , vol.355 , pp. 735-737
    • Goto, M.1    Rubenstein, M.2    Weber, J.3    Woods, K.4    Drayna, D.5
  • 73
    • 0029922445 scopus 로고    scopus 로고
    • Identification of gene sequences overexpressed in senescent and Werner syndrome human fibroblasts
    • Lecka-Czernik B, Moerman EJ, Jones RA, Goldstein S. Identification of gene sequences overexpressed in senescent and Werner syndrome human fibroblasts. Exp Gerontol 1996;31:159-74.
    • (1996) Exp Gerontol , vol.31 , pp. 159-174
    • Lecka-Czernik, B.1    Moerman, E.J.2    Jones, R.A.3    Goldstein, S.4
  • 74
    • 0025866760 scopus 로고
    • Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence
    • Murano S, Thweatt R, Schmookler-Reis RJ, Jones RA, Moerman EJ, Goldstein S. Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence. Mol Cell Biol 1991;11: 3905-14.
    • (1991) Mol Cell Biol , vol.11 , pp. 3905-3914
    • Murano, S.1    Thweatt, R.2    Schmookler-Reis, R.J.3    Jones, R.A.4    Moerman, E.J.5    Goldstein, S.6
  • 75
    • 0027621137 scopus 로고
    • Werner syndrome and biological ageing: A molecular genetic hypothesis
    • Thweatt R, Goldstein S. Werner syndrome and biological ageing: a molecular genetic hypothesis. Bioessays 1993;15: 421-6.
    • (1993) Bioessays , vol.15 , pp. 421-426
    • Thweatt, R.1    Goldstein, S.2
  • 76
    • 0031585872 scopus 로고    scopus 로고
    • Cycling Werner's syndrome fibroblasts display calcium dependent potassium currents
    • Faragher RGA, Hardy S, Dropcova S, Allen MC. Cycling Werner's syndrome fibroblasts display calcium dependent potassium currents. Exp Cell Res 1997;231:119-22.
    • (1997) Exp Cell Res , vol.231 , pp. 119-122
    • Faragher, R.G.A.1    Hardy, S.2    Dropcova, S.3    Allen, M.C.4
  • 78
    • 0028898823 scopus 로고
    • Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that seen in senescing fibroblasts from normal donors
    • Oshima J, Campisi J, Tannock CA, Martin GM. Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that seen in senescing fibroblasts from normal donors. J Cell Physiol 1995;162:277-83.
    • (1995) J Cell Physiol , vol.162 , pp. 277-283
    • Oshima, J.1    Campisi, J.2    Tannock, C.A.3    Martin, G.M.4
  • 79
    • 0011555560 scopus 로고
    • Correlation between deoxyribonucleic acid excision repair and life-span in a number of mammalian species
    • Hart RW, Setow RB. Correlation between deoxyribonucleic acid excision repair and life-span in a number of mammalian species. Proc Natl Acad Sci USA 1974;71:2169-73.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 2169-2173
    • Hart, R.W.1    Setow, R.B.2
  • 80
    • 0018195078 scopus 로고
    • Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture
    • Higashikawa T, Fujiwara Y. Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture. Exp Cell Res 1978;113:438-41.
    • (1978) Exp Cell Res , vol.113 , pp. 438-441
    • Higashikawa, T.1    Fujiwara, Y.2
  • 82
    • 0029944713 scopus 로고    scopus 로고
    • DNA repair fine structure in Werner's syndrome cell lines
    • Webb DK, Evans MK, Bohr VA. DNA repair fine structure in Werner's syndrome cell lines. Exp Cell Res 1996;224: 272-8.
    • (1996) Exp Cell Res , vol.224 , pp. 272-278
    • Webb, D.K.1    Evans, M.K.2    Bohr, V.A.3
  • 83
    • 0025159160 scopus 로고
    • Immune function, mutant frequency and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, cockaynes syndrome and trichthiodystrophy
    • Norris PG, Limb A, Hamblm AS, Lehmann AR, Arlett CF, Cole J, et al. Immune function, mutant frequency and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, cockaynes syndrome and trichthiodystrophy. J Invest Dermatol 1990;94:94-9.
    • (1990) J Invest Dermatol , vol.94 , pp. 94-99
    • Norris, P.G.1    Limb, A.2    Hamblm, A.S.3    Lehmann, A.R.4    Arlett, C.F.5    Cole, J.6
  • 84
    • 0030476278 scopus 로고    scopus 로고
    • Werner's syndrome: Entering the helicase era
    • Epstein CJ, Motulsky AG. Werner's syndrome: entering the helicase era. Biocssays 1996;18:1025-7.
    • (1996) Biocssays , vol.18 , pp. 1025-1027
    • Epstein, C.J.1    Motulsky, A.G.2
  • 85
    • 0020066520 scopus 로고
    • Failure of RNA synthesis to recover after UV irradiation: An early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
    • Mayne LV, Lehmann AR. Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. Cancer Res 1982;42:1473-8.
    • (1982) Cancer Res , vol.42 , pp. 1473-1478
    • Mayne, L.V.1    Lehmann, A.R.2
  • 87
    • 0025852337 scopus 로고
    • Bloom syndrome and Ataxia telangiectasia
    • Llerena JC, Murer-Orlando. Bloom syndrome and Ataxia telangiectasia. Semin Hematol 1991;28:95-103.
    • (1991) Semin Hematol , vol.28 , pp. 95-103
    • Llerena, J.C.1    Murer-Orlando2
  • 89
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp RC, Harley CB. Evidence for a critical telomere length in senescent human fibroblasts. Exp Cell Res 1995;219:130-6.
    • (1995) Exp Cell Res , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2
  • 91
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 92
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, et al. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet 1996;97:750-4.
    • (1996) Hum Genet , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3    McKay, J.4    Jarzebowicz, A.A.5    Edland, S.D.6
  • 94
    • 0029778901 scopus 로고    scopus 로고
    • Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
    • Ogryzku W, Hirai TH, Russanova VR, Barbie DA, Howard BH. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol 1996;16:5210-18.
    • (1996) Mol Cell Biol , vol.16 , pp. 5210-5218
    • Ogryzku, W.1    Hirai, T.H.2    Russanova, V.R.3    Barbie, D.A.4    Howard, B.H.5
  • 96
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik B, Carson M, Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 1995;15:6128-38.
    • (1995) Mol Cell Biol , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 97
    • 0031029001 scopus 로고    scopus 로고
    • Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
    • Grandin N, Reed SI, Charbonneau M. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Der 1997;11: 512-27.
    • (1997) Genes der , vol.11 , pp. 512-527
    • Grandin, N.1    Reed, S.I.2    Charbonneau, M.3
  • 98
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent CI, Hughes TR, Lue NF, Lundblad V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 1996;274:249-52.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.4
  • 99
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
    • Lydall D, Weinert T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 1995;270:1488-91.
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 100
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov VL, Hirose Y, Langmore JP. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 1997;88: 657-66.
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 101
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
    • von Zglinicki T, Saretzki G, Döcke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995;220: 186-93.
    • (1995) Exp Cell Res , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Döcke, W.3    Lotze, C.4


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