메뉴 건너뛰기




Volumn 15, Issue 7, 1996, Pages 1734-1741

Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids

Author keywords

Aging; Cancer; Cell hybrids; Telomerase; Telomeres

Indexed keywords

DNA; DNA POLYMERASE; OLIGONUCLEOTIDE; TELOMERASE;

EID: 0030004489     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00519.x     Document Type: Article
Times cited : (142)

References (66)
  • 2
    • 0028298519 scopus 로고
    • Assignment of two human epidermal squamous cell carcinoma cell lines to more than one complementation group for the immortal phenotype
    • Berry, I.J., Burns, J.E. and Parkinson, E.K. (1994) Assignment of two human epidermal squamous cell carcinoma cell lines to more than one complementation group for the immortal phenotype. Mol. Carcinogen., 9, 134-142.
    • (1994) Mol. Carcinogen. , vol.9 , pp. 134-142
    • Berry, I.J.1    Burns, J.E.2    Parkinson, E.K.3
  • 4
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M.A., Funk, W.D., Villeponteau, B. and Greider, C.W. (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science, 269, 1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.D.2    Villeponteau, B.3    Greider, C.W.4
  • 5
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli, D., Young, J.W. and de Lange, T (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl Acad. Sci. USA, 92, 9082-9086.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    De Lange, T.3
  • 6
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan, T.M., Engelzou, A., Gupta, J., Bacchetti, S. and Reddel, R.R. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14, 4240-4248.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Engelzou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 7
    • 0019305047 scopus 로고
    • Limited lifespan in somatic cell hybrids and cybrids
    • Bunn, C.L. and Tarrant, G.M. (1980) Limited lifespan in somatic cell hybrids and cybrids. Exp. Cell Res., 127, 385-396.
    • (1980) Exp. Cell Res. , vol.127 , pp. 385-396
    • Bunn, C.L.1    Tarrant, G.M.2
  • 8
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau, C., Hay, K., Hirte, H.W., Galligner, S. and Bacchetti, S. (1995) Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res., 55, 2533-2536.
    • (1995) Cancer Res. , vol.55 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.W.3    Galligner, S.4    Bacchetti, S.5
  • 9
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C.M., Avillon, A.A., LeFeuvre, E., Stewart, N.G., Greider, C W., Harley, C.B. and Bacchetti, S. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11, 1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avillon, A.A.2    LeFeuvre, E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 11
    • 0026541384 scopus 로고
    • Human telomeres are attached to the nuclear matrix
    • de Lange, T. (1992) Human telomeres are attached to the nuclear matrix. EMBO J., 11, 717-724.
    • (1992) EMBO J. , vol.11 , pp. 717-724
    • De Lange, T.1
  • 12
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • El-Deiry, W.S. et al (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1
  • 13
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng, J. et al. (1995) The RNA component of human telomerase. Science, 269, 1236-1241.
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.1
  • 14
    • 0025201982 scopus 로고
    • Position effect at S.cerevesiae telomeres: Reversible repression of PoIII transcription
    • Gottschling, D E., Aparicio, O.M., Billington, B.L. and Zakian, V.A. (1990) Position effect at S.cerevesiae telomeres: reversible repression of PoIII transcription. Cell, 63, 751-762.
    • (1990) Cell , vol.63 , pp. 751-762
    • Gottschling, D.E.1    Aparicio, O.M.2    Billington, B.L.3    Zakian, V.A.4
  • 15
    • 0025472467 scopus 로고
    • Telomeres, telomerase and senescence
    • Greider, C.W. (1990) Telomeres, telomerase and senescence. Bioessays, 12, 363-369.
    • (1990) Bioessays , vol.12 , pp. 363-369
    • Greider, C.W.1
  • 16
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C.W. and Blackburn, E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43, 405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 17
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
    • Hara, E., Tsurai, H., Shinozaki, A., Nakada, S. and Oda, K. (1991) Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun., 179, 528-534.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurai, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 18
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb
    • Harley, C.B. (1991) Telomere loss: mitotic clock or genetic time bomb. Mutat. Res., 256, 271-282.
    • (1991) Mutat. Res. , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 19
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 20
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 21
    • 0025743438 scopus 로고
    • Telomerase primer specificity and chromosome healing
    • Harrington, L. and Greider, C. (1991) Telomerase primer specificity and chromosome healing. Nature, 353, 451-453.
    • (1991) Nature , vol.353 , pp. 451-453
    • Harrington, L.1    Greider, C.2
  • 23
    • 0022458948 scopus 로고
    • Effects of normal human mitochondrial DNA on segregation of HeLaTG mitochondrial DNA and on tumorigenicity of HeLaTG cells
    • Hayashi, J.I., Werbin, H. and Shay, J.W. (1986) Effects of normal human mitochondrial DNA on segregation of HeLaTG mitochondrial DNA and on tumorigenicity of HeLaTG cells. Cancer Res., 46, 4001-4006.
    • (1986) Cancer Res. , vol.46 , pp. 4001-4006
    • Hayashi, J.I.1    Werbin, H.2    Shay, J.W.3
  • 28
    • 0027326367 scopus 로고
    • RAPl and telomere structure regulate telomere position effects in Saccharomyces rerevisiae
    • Kyrion, G., Liu, K., Liu, C. and Lustig, A.J. (1993) RAPl and telomere structure regulate telomere position effects in Saccharomyces rerevisiae. Genes Dev., 7, 1146-1159.
    • (1993) Genes Dev. , vol.7 , pp. 1146-1159
    • Kyrion, G.1    Liu, K.2    Liu, C.3    Lustig, A.J.4
  • 31
    • 0028264813 scopus 로고
    • A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts
    • McEachern, M.J. and Blackburn, E.H. (1995) A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts. Proc. Natl Acad Sci. USA, 91, 3453-3457.
    • (1995) Proc. Natl Acad Sci. USA , vol.91 , pp. 3453-3457
    • McEachern, M.J.1    Blackburn, E.H.2
  • 33
    • 0024325562 scopus 로고
    • The human telomere terminal transferase is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G.B. (1989) The human telomere terminal transferase is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell, 59, 521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 34
    • 0025808098 scopus 로고
    • Recognition of a chromosome truncation sue associated with alpha-thalassemia by human telomerase
    • Morin, G.B. (1991) Recognition of a chromosome truncation sue associated with alpha-thalassemia by human telomerase. Nature, 353, 454-456.
    • (1991) Nature , vol.353 , pp. 454-456
    • Morin, G.B.1
  • 35
    • 0019150024 scopus 로고
    • Replicative potentials of various fusion products between WT-38 and SV40 transformed WI-38 cells and their components
    • Muggleton-Harris, A.L. and DeSimone, D.W (1980) Replicative potentials of various fusion products between WT-38 and SV40 transformed WI-38 cells and their components Somat. Cell Genet., 6, 689-698
    • (1980) Somat. Cell Genet. , vol.6 , pp. 689-698
    • Muggleton-Harris, A.L.1    Desimone, D.W.2
  • 36
    • 0028007237 scopus 로고
    • Telomere dynamics in an immortal human cell line
    • Murnane, J.P., Sabatier, L., Marder, JB.A. and Morgan, W.F. (1994) Telomere dynamics in an immortal human cell line. EMBO J., 13, 4953-4962
    • (1994) EMBO J. , vol.13 , pp. 4953-4962
    • Murnane, J.P.1    Sabatier, L.2    Marder, J.B.A.3    Morgan, W.F.4
  • 37
    • 0027956728 scopus 로고
    • Telomerase activity in vivo in human malignant hematopoietic cells
    • Nilsson, P., Mehle, C., Remes, K. and Roos, G. (1994) Telomerase activity in vivo in human malignant hematopoietic cells. Oncogene, 9, 3043-3048.
    • (1994) Oncogene , vol.9 , pp. 3043-3048
    • Nilsson, P.1    Mehle, C.2    Remes, K.3    Roos, G.4
  • 38
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Ning, Y, Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211, 90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 39
    • 0015844590 scopus 로고
    • A theory of marginotomy
    • Olovnikov, A.M. (1973) A theory of marginotomy. J. Theor. Biol., 41, 181-190.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 41
    • 0019494232 scopus 로고
    • Phenotype of low proliferative potential is dominant in hybrids of normal human fibroblasts
    • Pereira-Smith, O.M. and Smith, J.R. (1981) Phenotype of low proliferative potential is dominant in hybrids of normal human fibroblasts. Somat. Cell Genet., 7, 411-421.
    • (1981) Somat. Cell Genet. , vol.7 , pp. 411-421
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 42
    • 0020610446 scopus 로고
    • Evidence for the recessive nature of cellular immortality
    • Pereira-Smith, O.M. and Smith, J.R. (1983) Evidence for the recessive nature of cellular immortality. Science, 221, 964-966.
    • (1983) Science , vol.221 , pp. 964-966
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 43
    • 0344252789 scopus 로고
    • Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)
    • Psatyszek, M.A., Kim, N.W., Weinnch, S.L., Hiyama, K., Hiyama, E., Wright, W.E. and Shay, J.W (1995) Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods Cell Sci , 17, 1-5.
    • (1995) Methods Cell Sci , vol.17 , pp. 1-5
    • Psatyszek, M.A.1    Kim, N.W.2    Weinnch, S.L.3    Hiyama, K.4    Hiyama, E.5    Wright, W.E.6    Shay, J.W.7
  • 44
    • 0024959479 scopus 로고
    • Recombination occurs during telomere formation in yeast
    • Plauta, A.F. and Zakian, V.A. (1989) Recombination occurs during telomere formation in yeast. Nature, 337, 429-433.
    • (1989) Nature , vol.337 , pp. 429-433
    • Plauta, A.F.1    Zakian, V.A.2
  • 45
    • 0029040101 scopus 로고
    • Developmental and tissue specific regulation of mouse telomerase and telomere length
    • Prowse, K.R. and Greider, C.W. (1995) Developmental and tissue specific regulation of mouse telomerase and telomere length. Proc. Natl Acad Sci USA, 92, 4818-4822.
    • (1995) Proc. Natl Acad Sci USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 46
    • 0025944831 scopus 로고
    • A conserved secondary structure for telomerase RNA
    • Romero, D.P. and Blackburn, E.H. (1991) A conserved secondary structure for telomerase RNA. Cell, 67, 343-353.
    • (1991) Cell , vol.67 , pp. 343-353
    • Romero, D.P.1    Blackburn, E.H.2
  • 47
    • 0028068995 scopus 로고
    • Failure of infinite life span human cells from different immortality complementation groups to yield finite life span hybrids
    • Ryan, P.A , Maher, V.M. and McCormick, J.J. (1994) Failure of infinite life span human cells from different immortality complementation groups to yield finite life span hybrids. J. Cell Physiol., 159, 151-160.
    • (1994) J. Cell Physiol. , vol.159 , pp. 151-160
    • Ryan, P.A.1    Maher, V.M.2    McCormick, J.J.3
  • 48
    • 0029991014 scopus 로고    scopus 로고
    • Telomerase activity in human cancer
    • Shay, J.W. and Wright, W.E. (1996) Telomerase activity in human cancer. Curr. Opin. Oncol., 8, 66-71.
    • (1996) Curr. Opin. Oncol. , vol.8 , pp. 66-71
    • Shay, J.W.1    Wright, W.E.2
  • 49
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay, J.W., Pereira-Smith, O.M. and Wright, W.E. (1991) A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res., 196, 33-39.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 50
    • 0027263711 scopus 로고
    • E6 of human papillomavirus 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
    • Shay, J.W., Wright, W.E., Brasiskyte, D. and Van Der Haegen, B.A. (1993a) E6 of human papillomavirus 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene, 8, 1407-1413
    • (1993) Oncogene , vol.8 , pp. 1407-1413
    • Shay, J.W.1    Wright, W.E.2    Brasiskyte, D.3    Van Der Haegen, B.A.4
  • 51
    • 0027484484 scopus 로고
    • Loss of telomeric DNA during aging may predispose cells to cancer
    • Shay, J W., Wright, W.E. and Werbin, H. (1993b) Loss of telomeric DNA during aging may predispose cells to cancer. Int. J. Oncol., 3, 559-563.
    • (1993) Int. J. Oncol. , vol.3 , pp. 559-563
    • Shay, J.W.1    Wright, W.E.2    Werbin, H.3
  • 53
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerivisiae telomerase
    • Singer, M.S. and Gottschling, D.E. (1994) TLC1: template RNA component of Saccharomyces cerivisiae telomerase. Science, 266, 404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 54
    • 0029019717 scopus 로고
    • Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas
    • Tahara, H., Nakamshi, T., Kitamoto, M., Nakashio, R., Shay, J.W., Tahara, E., Kajiyama, G. and Ide, T. (1995) Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res., 55, 2734-2736.
    • (1995) Cancer Res. , vol.55 , pp. 2734-2736
    • Tahara, H.1    Nakamshi, T.2    Kitamoto, M.3    Nakashio, R.4    Shay, J.W.5    Tahara, E.6    Kajiyama, G.7    Ide, T.8
  • 57
    • 0015515155 scopus 로고
    • Origin of concatameric T4 DNA
    • Watson, J.D. (1972) Origin of concatameric T4 DNA. Nature, 239, 197-201.
    • (1972) Nature , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 58
    • 0025351383 scopus 로고
    • Telomere-telomere recombination provides an express pathway for telomere acquisition
    • Wang, S.S. and Zakian, V.A. (1990) Telomere-telomere recombination provides an express pathway for telomere acquisition. Nature, 345, 456-458.
    • (1990) Nature , vol.345 , pp. 456-458
    • Wang, S.S.1    Zakian, V.A.2
  • 59
    • 0026682717 scopus 로고
    • Telomere positional effects and the regulation of cellular senescence
    • Wright, W E and Shay, J.W. (1992) Telomere positional effects and the regulation of cellular senescence. Trends Genet., 8, 193-197.
    • (1992) Trends Genet. , vol.8 , pp. 193-197
    • Wright, W.E.1    Shay, J.W.2
  • 60
    • 0001397338 scopus 로고    scopus 로고
    • Mechanisms of escaping senescence in human diploid cells
    • Holbrook, J.J., Martin, G.R. and Lockshin, R.A. (eds), Wiley & Sons, Inc.
    • Wright, W.E. and Shay, J.W. (1996) Mechanisms of escaping senescence in human diploid cells. In Holbrook, J.J., Martin, G.R. and Lockshin, R.A. (eds), Modern Cell Biology Series - Cellular Aging and Cell Death. Wiley & Sons, Inc., pp. 153-167.
    • (1996) Modern Cell Biology Series - Cellular Aging and Cell Death , pp. 153-167
    • Wright, W.E.1    Shay, J.W.2
  • 61
    • 0029023065 scopus 로고
    • Modification of a telomeric repeat amplification protocol (TRAP) results in increased reliability, linearity and sensitivity
    • Wright, W.E., Shay, J.W. and Piatyszek, M.A. (1995) Modification of a telomeric repeat amplification protocol (TRAP) results in increased reliability, linearity and sensitivity. Nucleic Acids Res., 23, 3794-3795.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3794-3795
    • Wright, W.E.1    Shay, J.W.2    Piatyszek, M.A.3
  • 62
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • in press
    • Wright, W.E., Piatyszek, M.A., Ramey, W.E., Byrd, W. and Shay, J.W. (1996) Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet, in press.
    • (1996) Dev. Genet
    • Wright, W.E.1    Piatyszek, M.A.2    Ramey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 63
    • 0027717617 scopus 로고
    • p21 is a universal inhibitor of the cyclin kinases and a potential effector of the p53 checkpoint pathway
    • Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R. and Beach, D. (1993) p21 is a universal inhibitor of the cyclin kinases and a potential effector of the p53 checkpoint pathway. Nature, 366, 701-704.
    • (1993) Nature , vol.366 , pp. 701-704
    • Xiong, Y.1    Hannon, G.2    Zhang, H.3    Casso, D.4    Kobayashi, R.5    Beach, D.6
  • 64
    • 0026037255 scopus 로고
    • Developmentally programmed healing of chromosomes by telomerase in Tetrahymena
    • Yu, G.L and Blackbum, E. (1991) Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell, 67, 823-832.
    • (1991) Cell , vol.67 , pp. 823-832
    • Yu, G.L.1    Blackbum, E.2
  • 65
    • 0024297032 scopus 로고
    • Telomere terminal transferase activity in the hypotricous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules
    • Zahler, A.M. and Prescott, D.M. (1988) Telomere terminal transferase activity in the hypotricous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules Nucleic Acids Res., 16, 6953-6972.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 6953-6972
    • Zahler, A.M.1    Prescott, D.M.2
  • 66
    • 0024788528 scopus 로고
    • Structure and function of telomeres
    • Zakian, V.A. (1989) Structure and function of telomeres. Annu. Rev. Genet., 23, 579-604.
    • (1989) Annu. Rev. Genet. , vol.23 , pp. 579-604
    • Zakian, V.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.