Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: No evidence for a major susceptibility role

Diabetologia

Volumn 41, Issue 11, 1998, Pages 1389-1391

  Kalidas, K ^a   Wasson, J ^a   Glaser, B ^b   Meyer, J M ^c   Duprat, L J ^c   White, M F ^d   Permutt, M Alan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

Affected sib pair analysis; Ashkenazi Jews; IRS 2 gene; Microsatellite marker; Radiation hybrid (RH) mapping; Type II diabetes

Indexed keywords

INSULIN RECEPTOR; MICROSATELLITE DNA;

ARTICLE; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; GENOTYPE; HUMAN; JEW; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 13; DIABETES MELLITUS, TYPE 1; EUROPE, EASTERN; GENETIC MARKERS; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JEWS; LINKAGE (GENETICS); MICE; MICROSATELLITE REPEATS; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; STATISTICS, NONPARAMETRIC;

EID: 0031739242     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051081     Document Type: Article

References (10)

1. Yenush L, White MF (1997) The IRS-signaling system during insulin and cytokine action. BioEssays 19: 491-500
2. Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald SM, Pedersen O (1993) Amino-acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 342: 828-832
3. Araki E, Lipes MA, Patti ME, et al. (1994) Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372: 186-190
4. Sun X J, Wang L M, Zhang Y, et al. (1995) Role of IRS-2 in insulin and cytokine signaling. Nature 377: 173-177
5. Withers DJ, Gutierrez L, Towery H, et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391: 900-903
6. World Health Organization Study Group Diabetes Mellitus (1985) Technical report series No. 727, WHO, Geneva
7. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58: 1347-1363
8. Kruglyak L, Lander ES (1995) Complete multipoint sibpair analysis of qualitative and quantitative traits. Am J Hum Genet 57: 439-454
9. Jorde L (1992) Genetic diseases in the Ashkenazi population: Evolutionary considerations. In: Bonne-Tamir B, Adam A (eds) Genetic Diversity among Jews: Diseases and Markers at the DNA Level. Oxford University Press, New York, pp 305-318
10. Bernai D, Almind K, Yenush L et al. (1998) Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians. Diabetes 47: 976-979