Regulation of ocular inflammation - What experimental and human studies have taught us

Progress in Retinal and Eye Research

Volumn 20, Issue 6, 2001, Pages 761-797

  De Smet, Marc D ^a,b   Chan, Chi Chao ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; LENS PROTEIN; MELANIN; MYELIN BASIC PROTEIN; PEPTIDE FRAGMENT; RETINA S ANTIGEN;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CELL ACTIVATION; DENDRITIC CELL; ENCEPHALITIS; EYE INFLAMMATION; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SYSTEMIC CIRCULATION; TH1 CELL; TH2 CELL; UVEITIS; UVEORETINITIS;

EID: 0034809510     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1350-9462(01)00011-8     Document Type: Review

References (376)

1. Functional diversity of hepler T lymphocytes
2. S-Antigen from the rat retina and pineal gland have identical sequences
3. Characterization of a potent uveitopathogenic site derived from rat phosducin
4. Induction of experimental autoimmune uveitis with rhodopsin synthetic peptides in Lewis rats
5. Myelin basic protein specific T-helper cells induce experimental anterior uveitis
6. Similar pattern of MCP-1 expression in spinal cords and eye of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis
7. Pregnancy ameliorates induction and expression of experimental autoimmune uveitis
8. Immunological memory and protective immunity: Understanding their relation
9. Isolation and characterization of BCP 54, the major soluble protein of bovine cornea
10. Injection repétée de sérum de cheval chez le lapin
11. β-arrestin2, a novel member of the arrestin/β-arrestin gene family
12. A toxic ocular reaction. I. New property of Schwartzman toxins
13. Immunobiology of dendritic cells
14. Characterisation of specific T helper cell activity in mice bearing alloantigen tumors in the anterior chamber of the eye
15. T cell interactions with extracellular matrix proteins in patients with thyroid-associated ophthalmopathy
16. Autoantibodies reactive with extracellular matrix proteins in patients with thyroid-associated ophthalmopathy
17. Human retinal S-antigen. Isolation, purification and characterization
18. Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: Genotype of antigen-presenting cells influences immunodominant epitope of basic protein
19. The reduction of inflammatory responses in polysaccharide-tolerant eyes
20. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells i human autoimmune disease
21. Expression of immunosuppressive somatostatin in normal aqueous humor
22. Pattern of uveitis in a referral uveitis clinic in India
23. An update for health care professionals
24. Evolution and function of the HLA system
25. Definition of the HLA-A29 peptide ligand motif allows prediction of potential T-cell epitopes from the retinal soluble antigen. A candidate autoantigen in birdshot retinopathy
26. Interphotoreceptor retinoid-binding protein: Gene characterization, protein repeat structure, and its evolution
27. Coupling and uncoupling of tumor immunity and autoimmunity
28. Neurogenic amplification of immune complex inflammation
29. Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog
30. Experimental autoimmune anterior uveitis. The preparation of uveitogenic coular melanin
31. Experimental autoimmune posterior uveitis accompanied by epithelioid cell accumulations (EAPU). A new type of experimental ocular disease induced by immunization with PEP-65, a pigment epithelial polypeptide preparation
32. Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunization with purified uveal and skin melanins
33. Experimental autoimmune anterior uveitis (EAAU): Induction by melanin antigen and suppression by various treatments
34. Differential effect of macrophage depletion on two forms of experimental uveitis evoked by pigment epithelial membrane protein (EAPU) and by melanin-protein (EMIU)
35. EAE TCR motifs and antigen recognitioin in myelin basic protein-induced anterior uveitis in lewis rats
36. Uveitis in rabbits with experimental allergic encephalomyelitis
37. Resident and infiltrationg immune cells in the uveal tract in the early and late stages of experimental autoimmune uveoretinitis
38. Increased CD4+ expression and decreased IL-10 in the anterior chamber in idiopathic uveitis
39. IL-12 in autoimmunity
40. Natural and therapeutic control of ocular autoimmunity: Rodent and man
41. Glial cells as suppressor cells: Characterization of the inhibitory function
42. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat
43. A new model of autoimmune disease: Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
44. T cell mechanisms in experimental autoimmune uveoretinitis: Susceptibility is a function of the cytokine response profile
45. Interphotoreceptor retinoid-binding protein (IRBP): A model for molecular biology and clinical relevant studies
46. Interphotoreceptor retinal-binding protein
47. HLA-B51 may serve as an immunogenic marker for a subgroup of patients with Behçet's syndrome
48. Relationship between sympathetic ophthalmia, phacoanaphylactic endophthalmitis, and Vogt-Koyanagi-Harada disease
49. Sympathetic ophthalmia
50. Kinetics of T lymphocyte subsets in the eye of Lewis rats with experimental autoimmune uveitis
51. Anti-retinal auto-antibodies in Vogt-Koyanagi-Harada syndrome, Behcet's disease, and sympathetic ophthalmia
52. Immunohistopathology of ocular sarcoidosis. Report of a case and discussion of immunopathogenesis
53. Pathology of experimental autoimmune uveoretinitis in mice
54. Experimental melanin-protein-induced uveitis in the Lewis rat. Immunopathologic processes
55. Recombinant adenovirus excoding gp100 modulates experimental melanin-protein induced uveitis (EMIU)
56. CD4+ lymphocyte involvement in ocular Behcet's disease
57. Severe uveitis followed by reactive arthritis after bacillus Calmette-Guerin therapy
58. Characterisation and functional activity of dendritic cells from rat choroid
59. Polyarthritis following intravesical BCG immunotherapy. Report of a case and review of 26 cases in the literature
60. Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins
61. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor
62. Natural autoantibodies
63. Cone arrestin identified by targeting expression of a functional family
64. The human leukocyte antigen complex and chronic ocular inflammatory disorders
65. Analysis of IL-6 levels in human vitreous flid obtained from uveitis patients, patients with proliferative intraocular disorders and eye bank eyes
66. Structural polymophism and function of HLA-B27
67. Antibody response in uveitis
68. Auto-immunité contre le nerf optique
69. Auto-immunité contre la rétine
70. Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis
71. Inhibition of experimental autoimmune uveoretinitis in rats with S-antigen-specific monoclonal antibodies
72. Prevention of experimental autoimmune uveoretinitis by active immunization with autoantigen-specific monoclonal antibodies
73. Humoral immune response against S-antigen/TNF alpha common epitope in rat EAU suppressed by the monoclonal antibody S2D2
74. Prospective determination of T cell responses to S-antigen in Behcet's disease patients and controls
75. Circulating antibodies to inducible heat shock protein 70 in patients with uveitis
76. Cellular immune responses to fragments of S-antigen in patients with uveitis
77. Cellular immune responses of patients with uveitis to retinal antigens and their fragments
78. Human S-antigen: Presence of multiple immunogenic and immunopathogenic sites in the Lewis rat
79. Immunogenicity and immunopathogenicity of peptide determinants of human S-Ag in various rat strains
80. A novel method for the determination of T-cell proliferative responses in patients with uveitis
81. Human S-antigen determinant recognition in patients with uveitis
82. Cytokines and uveitis, a review
83. Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat
84. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat
85. Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penecillin in Behcet's disease: A randomized trial
86. Immune regulation of uveoretinal inflammation
87. Fas-Fas ligand meidated apoptosis within aqueous during idiopathic acute anterior uveitis
88. Humoral and cellular immune responsiveness to human S-antigen in uveitis
89. Anti-retinal S-antigen antibodies in human sera: A comparison of reactivity in Elisa with human or bovine S-antigen
90. S-antigen: Identification of the MAbA9-C6 monoclonal antibody binding site and the uveitopathogenic sites
91. Human IRBP: Characterization of uveitopathogenic sites
92. Human interstitial retinoid binding protein: A potent uveitopathogenic agent for the induction of experimental autoimmune uveitis
93. Neural immunoregulation: Emergin roles for nerves in immune homeostasis and disease
94. The effect of retinal S-antigen-specific monoclonal antibody therapy on experimental autoimmune uveoretinitis (EAU) and experimental autoimmune pinealitis (EAP)
95. Induction of experimental autoimmune uveoretinitis by the retinal photoreceptor protein, phosducin
96. Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice: Evidence of mast cell histamine release in vivo by diamine oxidase-gold ensyme affinity ultrastructural cytochemistry
97. Jekyll and Hyde: The transformation of HLA-B27
98. Peptide-specific T clonal expansion in vivo following immunization in the eye, an immun priviledged site
99. Ginterferon expression disrupts lens and retinal differentiation in transgenic mice
100. Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression
101. IFN- g increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats
102. Uveoretinitis in rabbits following immunization with IRBP
103. High levels of interleukin-12 in the aqueous humor and vitreous of patients with uveitis
104. Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy
105. Studien zur sympathischen ophthalmis. Die antigene wirkung des augenpigmentes
106. Peripheral blood T cell expansions in patients with Behçet's disease
107. Autoimmunity and the retina
108. Uvéo-rétinite expérimentale induite par lantigène S rétinien chez le singe: Induction, histopathologie
109. Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1
110. Synergistic uveitic effects of tumor necrosis factor-a and interleukin-1β
111. In vitro unresponsiveness to autologous sequences of the immunopathogenic autoantigen, S-antigen
112. Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA
113. Purification and characterization of a retinol-binding glycoprotein snthesized and secreted by bovien neural retina
114. Characterization and comparative structural features of the gene for human interstitial retinol-binding protein
115. Microglia induce CD4 T-lymphocyte final effector function and death
116. Naturally occurring antibodies to bovine and human S-antigen: A comparison between uveitis patients and healthy volunteers
117. Localisation and characterisation of major histocompatibility complex class II - Positive cells in the posterior segment of the eye: Implications for induction of autoimmune uveoretinitis
118. Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats
119. Cytokines in human intraocular inflammation
120. The role of costimulatory molecules B7-1 and B7-2 in mice with experimental autoimmune uveoretinitis
121. The interleuki-12/interleukin-12 receptor system: Role in normal and pathologic immune responses
122. Retinal specific antigen and immunopathogenic processes they provoke
123. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein
124. Recoverin is highly uveitopathogenic in Lewis rats
125. HLA-DRB10405 is the predominant allele in brazilian patients with Vogt-Koyanagi-Harada disease
126. Cancer-associated retinopathy
127. Retinal vasculitis
128. X-ray crystal structure of arrestin from bovine rod outer segments
129. Identification of T cell recognition sites in S-Antigen: Dissociation of proliferative and pathogenic sites
130. A new perspective of S-antigen from immunochemical analysis
131. Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental autoimmune uveoretinitis in LEW rats
132. Unresponsiveness to self-peptides of S-antigen in EAU: An overview of recent results
133. Fas ligand induced apoptosis as a mechanism of immune privilege
134. Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin induced uveitis
135. Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: Autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' x{'}}- hyperthyroidism
136. Cellular immune responses of patients with juvenile chronic arthritis to retinal antigens and their synthetic peptides
137. Treatment of paraneoplastic visual loss with intravenous immunoglobulin
138. Etiology of uveitis: A clinical study of 562 cases
139. Non-specific stimulation of a secondary ocular antibody response
140. Evaluation of Ia expression in rat ocular tissues following inoculation with interferon-gamma
141. Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers
142. Interleukin 10 inhibits inflammatory cells infiltration in endotoxin-induced uveitis
143. Dual effect of ciliary body cells on T lymphocyte proliferation
144. Uveitis induced in primates by interphotoreceptor retinoid-binding protein
145. Uveitis induced in primates by IRBP: Humoral and cellular immune responses
146. The 2.8 Å crystal structure of visual arrestin: A model for arrestin's regulation
147. Serum antibody response to human and bovine IRBP in uveitis
148. Cytokines and intraocular inflammation
149. Endotoxin-induced uveitis in the rat: The significance of intraocular interleukin 6
150. T cell reactivity to an epitope of the mycobacterial 60-kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses
151. Ocular localization of circulating bacterial lipopolysaccharide
152. Lipopolysaccharide tolerance inhibits eye inflammation. II. Preliminary studies on the mechanism
153. Lipopolysaccharide tolerance inhibits eye inflammation. I. Reduced immune complex or lipopolysaccharide effects
154. Experimental mucosal induction of uveitis with the 60-kDa heat shock protein-derived peptide 336-351
155. Origin of myelinated nerves in the rat iris
156. HLA-B27 typing in the categorisation of uveitis in a HLA-B27 rich population
157. Clinical features of sarcoidosis in relation to HLA distribution and HLA-DRB3 genotyping by PCR-RFLP
158. Antigen-presenting cells in experimental autoimmune uveoretinitis
159. Intravitreal sustained release cyclosporin in the treatment of experimental uveitis
160. Idiotypic network and other preconceived ideas
161. Chronic uveitis in Kinshasa (D R Congo)
162. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
163. Role of ICAM-1 and LFA-1 in endotoxin-induced uveitis in mice
164. Retinal autoimmunity and circulating immune complexes in ocular Behçet disease
165. The 22 kDa antigen in optic nerve and retinal diseases
166. Cytokines: Their role in uveal disease
167. Primary association of HLA-B51 with Behçet's disease in Ireland
168. Ophthalmologic evaluation in patients undergoing immunization with melanoma-associated antigens
169. Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans
170. Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis
171. Elevated serum IL-8 levels are associated with disease activity in idiopathic intermediate uveitis
172. Soluble ICAM-1 serum levels in patients with intermediate uveitis
173. Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient
174. The bacteriological and immunological aspects of iritis
175. Endotoxin-induced uveitis in mice. 1. Induction of uveitis and role of T lymphocytes
176. Repeated determinants within the retinal interphotoreceptor retinoid-binding protein (IRBP): Immunological properties of the repeats of an immunodominant determinant
177. Analysis of the pivotal residues of the immunodominant and higly uveitogenic determinant of interphotoreceptor retinoid-binding protein (IRBP)
178. Unusual immunologic properties of the uveitogenic interphotoreceptor retinoid-binding protein-derivated peptide R23
179. Characteristics of endogenous uveitis in Hokkaido, Japan
180. 2a: A pilot study
181. Immunogenicity and immunopathogenicity of an autoimmune epitope are potentiated by increasing MHC binding through residue substitution
182. Autoimmunity against corneal antigens. I. Isolation of a soluble 54 kD corneal epithelium antigen
183. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
184. Studies on intraocular inflammation produced by intravitreal human interleukins in rabbits
185. Anti-MHC autoimmunity in Behçet's disease: T cell responses to an HLA-B-derived peptide cross-reactive with retinal-S antigen in patients with uveitis
186. Immunoglobulins and the regulation of autoimmunity through the immune network
187. Intraocular inflammation in transgenic mice expressing a foreign antigen in their lens
188. Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein
189. Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
190. TNF alpha, IL-1 alpha and bFGF are implicated in the complex disease of GM-CSF transgenic mice
191. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet's syndrome
192. Intravenous immunoglobulin (IVIg) for the treatment of birshot retinochoroidopathy
193. Suppressive effect of transforming growth factor β1 on the recurrence of experimental melanin protein-induced uveitis: Upregulation of cular interleukin-10
194. Cytokines and apoptotic molecules in experimental melanin-protein induced uveitis (EMIU) and experimental autoimmune uveoretinitis (EAU)
195. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
196. Immune mechanisms in choroido-retinal inflammation in man
197. Immunological features of synthetic peptides derived from the retinal protein IRBP: Differences between immunodominant and non-dominant peptides
198. Immunological features of synthetic peptides derived from the retinal protein IRBP: Differences between immunodomiant and nondominant peptides
199. Experimental autoimmune dacryoadenitis. I. Lacrimal gland disease in the rat
200. Experimental autoimmune dacryoadenitis. II. Harderian gland disease in the rat
201. 2 and membrane-bound mechanisms
202. Beta-arrestin: A protein that regulates beta-adrenergic receptor function
203. Heat shock proteins: Immunity and immunopathology
204. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids
205. Mechanisms of intraocular inflammation
206. The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis
207. Clonotypic heterogeneity of lewis rat T cells specific for the encephalitogenic 68-86 region of myelin basic protein
208. Experimental lens-induced granulomatous endophthalmitis: Preliminary histopathologic observations
209. Epxerimental lens-induced granulamatous endophthalmitis: Passive transfer with serum
210. Effects of complement depletion on experimental allergic uveitis
211. Experimental lens-induced granulomatous endophthalmtis in common laboratory animals
212. Prediction of immunodominant helper T cell antigenic sites from the primary sequence
213. Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C
214. Uveitogenic potential of lymphocytes sensitized to interphotoreceptor retinoid-binding protein
215. Antigen-specific development of primary and memory T cells in vivo
216. The distribution of immune cells in the uveal tract of the normal eye
217. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body
218. Resident and infiltrating cells in the rat iris during the early stages of experimental melanin protein-induced uveitis (EMIU)
219. Immunity to homologous grafted skin: III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to the anterior chamber of the eye
220. Uveitis in the southeastern United States
221. Characterization of a new, potent, immunopathogenic epitope in S-antigen that elicits T cells expressing V beta 8 and V alpha 2-like genes
222. Retinal S-antigen epitopes in vertebrate and invertabrate photoreceptors
223. Arthritis and iritis after bacillus Calmette-Guerin therapy
224. Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis
225. Studies of autoimmune induction in the rat lacrymal gland
226. Association of HLA-B51 and lack of association of class II alleles with Behcet's disease
227. Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behcet's disease
228. Adoptive transfer of experimental autoimmune uveoretinitis in rats
229. The effects of bacterial endotoxins on host mediation systems. A review
230. The expanding universe of T-cell subsets: Th1, Th2 and more
231. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
232. Specificity of T and B cell responses to bovine rhodopsin in Lewis rats
233. Characterization of T cells and cytokines in the aqueous humour (AH) in patients with Fuchs' heterochromic cyclitis (FHC) and idiopathic anterior uveitis (IAU)
234. How the MHC selects Th1/Th2 immunity
235. β-arrestin-related proteins in ocular tissue
236. 2 by lens epithelial cells of human cataracts
237. Cellular immune response of patients with uveitis to peptide M, a retinal S-antigen fragment
238. Dominance of activated T cells and interleukin-6 in aqueous humor in Vogt-Koyanagi-Harada disease
239. S-antigen uveitis in primates: A new model for human disease
240. Effectiveness of cyclosporin therapy for Behcet's disease
241. Human immunoglobulin preparations for intravenous use prevent endotoxin-induced uveitis in rats
242. Molecular genetics of posterior uveitis
243. Effects of experimental ocular inflammation on ocular immune privilege
244. Analysis of immuno-regulatory cytokines in ocular fluid samples from patients with uveitis
245. Enumeration of autoreactive helper T lymphocytes in uveitis
246. Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4(+) T lymphocytes
247. Incidence and prevalence of different uveitis entities in Finland
248. The role of nitric oxide in uveitis
249. Normal immunoglobulin G protects against experimental allergic encephalomyelitis by inducing transferable T cell unresponsiveness to myelin basic protein
250. Effect of transforming growth factor beta-1 in endotoxin-induced uveitis
251. T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behcet's disease
252. Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis
253. Uveitis and arthritis induced by adjuvant: Clinical, immunologic and histologic characteristics
254. Experimental arthritis and uveitis in rats associated with Mycobacterium butyricum
255. Endogenous uveitis: An analysis of 1,417 cases
256. Effect of macrophage depletion by liposomes containing dichloromethylene-diphosphonate on endotoxin-induced uveitis
257. Antigen presentation in uveitis
258. Differential APC requirements of self- and nonself-reactive T cells and T cell hybridomas specific for retina S-antigen
259. Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: A novel mechanism of action of IVIg involving the Fas apoptotic pathway
260. Modulating the immune response with dendritic cells and their growth factors
261. Chronic experimental allergic optic neuritis
262. Experimental allergic optic neuritis in guinea pigs: Preliminary report
263. IL-10 has a protective role in experimental autoimmune uveoretinitis
264. Glial retinal muller cells produce IL-1 activity and have a dual effect on autoimmune T helper lymphocytes. Antigen presentation manifested after removal of suppressive activity
265. Selective immunosuppresion of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis
266. Immune response to intraocular injection of retinal S-antigen in adjuvant
267. Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction
268. Treatment of uveitis with recombinant human interleukin-13
269. Referral patterns of uveitis in a tertiary eye care center
270. Uveitis and arthritis: Experimental models and clinical correlates
271. Endotoxin-induced uveitis in rats as a model of human diease
272. Ocular inflammatory effects of intravitreal interleukin 1
273. Ocular inflammatory effects of intravitreally injected tumor necrosis factor
274. B lymphocytes as autoantigen-presenting cells in the amplification of autoimmunity
275. Causes and frequency of blindness in patients with intraocular inflammatory disease
276. Origin, structure and motifs of naturally processed MHC class II ligands
277. Cytokine production by T cells infiltrating in the eye of uveitis patients
278. Ocular inflammatory effects of intravitreally injected interleukin-2
279. The Schwartzman phenomenon
280. Synthetic peptides derived from IRBP induce EAU and EAP in Lewis rats
281. Synthetic peptides derived from IRBP induce EAU and EAP in Lewis rats
282. Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP)
283. Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP)
284. Uveitis and immune responses in primates immunized with IRBP-derived synthetic peptides
285. Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis
286. Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat
287. Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients
288. Rhodopsin-induced experimental autoimmune uveoretinitis: Dose-dependent clinico-pathological features
289. Rhodopsin-induced experimental autoimmune uveoretinitis in monkeys
290. The immunostimulatory function of IL-12 in T-helper cell development and its regulation by TGF-beta, IFN-gamma, and IL-4
291. Autoimmunity can benefit self-maintenance
292. Acquisition of lymphokine-producing phenotype by CD4+ T cells
293. Inflammatory cellular kinetics in sympathetic ophthalmia: A study of traumatized (exciting) eyes
294. Biphasic ocular inflammatory response to endotoxin-induced uveitis in the mouse
295. Demonstration of macrophage chemotactic factors in the aqueous humor during experimental immunogenic uveitis in rabbits
296. Regulatory T cells in autoimmunity
297. Local antibody formation within the eye: A study of immunoglobulin class and antibody specificity
298. HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RLFP and the strong association with DRB10405 and DRB10410
299. Primary and secondary structure of bovine retinal S-antigen (48-kDa protein)
300. Review: Age-related cataract: Immunity and lens epithelium-derived growth factor (LEDGF)
301. The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment
302. Ectopic antibody formation in the eye: Pathologic impications
303. Immunogenic uveitis
304. Uveitogenic proteins isolated from bovine iris and ciliary body
305. Molecular mimicry. Yeast histone H3-induced experimental autoimmune uveitis
306. Sequence homology between yeast histone and uveitopathogenic site of S-antigen: Lymphocyte cross reaction and adoptive transfer of disease
307. Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides
308. Antibodies to a microbial peptide sharing sequence homology with betaA3-crystallin damage lens epithelial cells in vitro and in vivo
309. Experimental melanin-induced uveitis in the Fisher 344 rat is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate
310. Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat
311. T lymphocyte heterogeneity in the rat. III. Autoreactive T cells are activated by B cells
312. Pediatric uveitis in southern Turkey
313. Gene expression physiology and pathophysiology of the immune system
314. Vogt-Koyanagi-Harada syndrome and pregnancy
315. Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris
316. Origin and steady-state turnover of major histocompatibility complex class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye
317. Immunologic non-responsiveness and acquisition of tolerance in relation to immune privilege in the eye
318. Regulation of ocular immune response
319. Eye-derived cytokines and the immunosuppressive intraocular microenvironment: A review
320. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response
321. Autoimmunty to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype
322. The possible impact of uveitis in blindness: A literature survey
323. Role of P-selectin in endotoxin-induced uveitis
324. Fc receptors initiate the Arthus reaction: Redefining the inflammatory cascade
325. A new primate model for multiple sclerosis in the commom marmoset
326. Susceptibility to birshot retinochoroidopathy is restricted to the HLA-A29.2 subtype
327. A report of two cases suggesting positive influence of pregnancy on uveitis activity
328. Suppression of spontaneous uveoretinitis development by non-immunopathogenic peptide immunization
329. Experimental autoimmune uveitis (EAU) induced in Lewis rats immunized with amino acod position 518-529 of bovine IRBP (TA12)
330. Rat lens epithelial cell damage and cataract formation induced by immunological response to bovine lens membrane protein
331. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis
332. The cancer-associated retinopathy antigen is a recoverin-like protein
333. Ophthalmological studies of adjuvant disease in rats. II. Statistical data concerning the clinical picture with special reference to recidivations
334. Opthalmological studies of adjuvant disease in rats. I. Clinical and histological observations
335. Ophthalmological studies of the adjuvant disease in rats. 3. Observations following reinjection
336. Retinal periphlebitis in multiple sclerosis: A marker of disease activity?
337. Epidemiological characteristics of uveitis in Switzerland
338. Structural analysis of mouse S-antigen
339. Diversity and plasticity of self recognition during the development of multiple sclerosis
340. Spontaneous regression of primary autoreactivity during chronic regression of experimental autoimmune encephalomyelitis and multiple sclerosis
341. Antibody determination by ELISA in rats with retinal S-antigen induced uveoretinitis
342. HSP-derived peptides inducing uveitis and IgG and IgA antibodies
343. Immunological mechanism if EAU in Lewis rats induced by high level of retinal S-antigen
344. Auto-immunité contre le cristallin
345. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
346. The small heat-shock protein ab-crystallin as candidate autoantigen in multiple sclerosis
347. EBV-induced expression and HLA-DR-restricted presentation by human B cells of ab-crystallin, a candidate autoantigen in multiple sclerosis
348. Prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel disease
349. The effects of complement depletion on corneal inflammation in rats
350. T cell immunity to myelin basic protein induces anterior uveitis in the Lewis rat
351. Experimental autoimmune keratitis induced in rats by anti-cornea T-cell lines
352. IRBP from bovine retina is poorly uveitogenic in guinea pigs and is identical to A-antigen
353. Experimental allergic uveitis. Homologous retina as uveitogenic antigen
354. Experimental allergic uveitis. I. Production in guinea pig and rabbit by immunization with retina in adjuvant
355. The role of cytokines in the pathogenesis of inflammatory eye disease
356. Thyroid-associated ophthalmopathy - A model for the association of organ-specific autoimmune disorders
357. Clinical patterns and associated conditions in chronic uveitis
358. Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood borne signals that induce ACAID
359. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-β
360. Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments
361. Duration and amplitude of the light-induced cGMP hydrolysis in vertebrate photoreceptors are regulated by multiple phosphorylaton of rhodopsin and by arrestin binding
362. Cross-reactivity between an HLA-B27-derived peptide and a retial autoantigen peptide: A clue to major histocompatibility complex association with autoimmune disease
363. Immunoregulatory properties of bone marrow-derived cells in iris and ciliary body
364. Modern concepts of the etiology of uveitis
365. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy
366. Immunogenetics and uveitis
367. The sequence of human retinal S-antigen reveals similarities with a-transducin
368. Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease
369. Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in lewis rats
370. Cellular immune responses to retinal antigens in retinitis pigmentosa
371. Cellular autoimmunity to retinal specific antigens in patients with Behcet's disease
372. Adjvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy definesthe class response
373. Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12
374. Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis
375. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
376. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis