Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C

Journal of Autoimmunity

Volumn 13, Issue 2, 1999, Pages 197-204

  Matteson, Dawn M ^a   Shen, De Fen ^a   Chan, Chi Chao ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Apoptosis; Experimental melanin protein induced uveitis (EMIU; Nitric oxide synthase (NOS); Phosphatidylcholine specific phospholipase C (PC PLC); Tricyclodecan 9 yl xanthogenate (D609)

Indexed keywords

DNA FRAGMENT; EYE PROTEIN; FAS ANTIGEN; FAS LIGAND; MELANIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PEROXIDE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; SUPEROXIDE DISMUTASE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ADOLESCENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME INHIBITION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM; UVEITIS;

EID: 0344069486     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1999.0319     Document Type: Article

References (43)

1. Nathan C. Natural resistance and nitric oxide. Cell. 82:1995;873-876.
2. Griffith O.W., Stuehr D.J. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57:1995;707-736.
3. Christopherson K.S., Bredt D.S. Nitric oxide in excitable tissues: Physiological roles and disease. J. Clin. Invest. 100:1997;2424-2429.
4. Southan G.J., Szabo C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem. Pharmacol. 51:1996;383-394.
5. Gold D.P., Schroder K., Powell H.C., Kelly C.J. Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis. Eur. J. Immunol. 27:1997;2863-2869.
6. Hooper D.C., Bagasra O., Marini J.C., Zborek A., Ohnishi S.T., Kean R., Champion J.M., Sarker A.B., Bobroski L., Farber J.L., Akaike T., Maeda H., Koprowski H. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc. Natl. Acad. Sci. U S A. 94:1997;2528-2533.
7. Connor J.R., Manning P.T., Settle S.L., Moore W.M., Jerome G.M., Webber R.K., Tjoeng F.S., Currie M.G. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur. J. Pharmacol. 273:1995;15-24.
8. Parks D.J., Cheung M.K., Chan C.C., Roberge F.G. The role of nitric oxide in uveitis. Arch. Ophthalmol. 112:1994;544-546.
9. Tilton R.G., Chang K., Corbett J.A., Misko T.P., Currie M.G., Bora N.S., Kaplan H.J., Williamson J.R. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production [see comments]. Invest. Ophthalmol. Vis. Sci. 35:1994;3278-3288.
10. Mandai M., Yoshimura N., Yoshida M., Iwaki M., Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest. Ophthalmol. Vis. Sci. 35:1994;3673-3680.
11. Goureau O., Bellot J., Thillaye B., Courtois Y., de Kozak Y. Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase. J. Immunol. 154:1995;6518-6523.
12. Tschaikowsky K., Meisner M., Schonhuber F., Rugheimer E. Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan- 9-yl-xanthogenate (D609). Br. J. Pharmacol. 113:1994;664-668.
13. Pastorino J.G., Simbula G., Yamamoto K., Glascott P.A. Jr., Rothman R.J., Farber J.L. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J. Biol. Chem. 271:1996;29792-29728.
14. Chen C.C., Wang J.K., Lin S.B. Antisense oligonucleotides targeting protein kinase C-alpha, -beta 1, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism. J. Immunol. 161:1998;6206-6214.
15. Nagata S., Golstein P. The Fas death factor. Science. 267:1995;1449-1456.
16. Cohen J. Apoptosis. Immunol. Today. 14:1993;126-130.
17. Nagata S. Fas and Fas ligand: a death factor and its receptor. Adv. Immunol. 57:1994;129-144.
18. Griffith T., Brunner T., Fletcher S., Green D., Ferguson T. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 270:1995;1189-1192.
19. Chan C.C., Matteson D.M., Li Q, Whitcup S.M., Nussenblatt R.B. Apoptosis in patients with posterior uveitis. Arch. Ophthalmol. 115:1997;1559-1567.
20. Shen Y.H., Wang X.L., Wilcken D.E.L. Nitric oxide induces and inhibits apoptosis through different pathways. FEBS Lett. 433:1998;125-131.
21. Mannick J.B., Miao X.Q., Stamler J.S. Nitric oxide inhibits Fas-induced apoptosis. J. Biol. Chem. 272:1997;24125-24128.
22. Sciorati C., Rovere P., Ferrarin M., Heltai S., Manfredi A.A., Clementi E. Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes. J. Biol. Chem. 272:1997;23211-23215.
23. Broekhuyse R.M., Kuhlmann E.D., Winkens H.J., Van Vugt A.H.M. Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. Exp. Eye. Res. 52:1991;465-474.
24. Chan C.C., Hikita N., Dastgheib K., Whitcup S.M., Gery I., Nussenblatt R.B. Experimental melanin-protein-induced uveitis in the Lewis rat. Immunopathologic processes. Ophthalmology. 101:1994;1275-1280.
25. Li Q., Matteson D., Nussenblatt R.B., Chan C.C. Programmed cell death in experimental autoimmune uveitis (EAU) and experimental melanin protein induced uveitis (EMIU). Invest. Ophthalmol. Vis. Sci. 38:1997;S436.
26. Broekhuyse R.M., Kuhlmann E.D. Experimental autoimmune anterior uveitis. The preparation of uveitogenic ocular melanin. Invest. Ophthalmol. Vis. Sci. 34:1993;698-700.
27. Li Q., Luyo D., Matteson D.M., Chan C.C. Suppressive effect of antiflammin-2 on compound 48/80-induced conjunctivitis. Ocul. Immunol. Inflamm. 6:1997;65-73.
28. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol. 119:1992;493-501.
29. Ding A.H., Nathan C.F., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:1988;2407-2412.
30. Wasowich W., Neve J., Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage. J. Clin. Chem. 39:1993;2522-2526.
31. McCord J.M., Fridovich I. Superoxide dismutase; an enzymic function for erythrocuperein (Hemocuprein). J. Biol. Chem. 244:1969;6049-6055.
32. Broekhuyse R.M., Kuhlmann E.D., Winkens H.J. Experimental autoimmune anterior uveitis (EAAU). II. dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium. Exp. Eye. Res. 55:1992;401-411.
33. Bora N.S., Kim M.C., Kabeer N.H., Simpson S.C., Tandhasetti M.T., Cirrito T.P., Kaplan A.D., Kaplan H.J. Experimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body. Invest. Ophthalmol. Vis. Sci. 36:1995;1056-1066.
34. Nathan C. Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100:1997;2417-2423.
35. +T cells correlates with Th1/Th2 phenotype. J. Immunol. 160:1998;5347-5354.
36. Li Q., Sung B., Luyo D., Caspi R.R., Chan C.C. Cytokine profile of experimental melanin-protein induced uveitis (EMIU): expression and kinetics. Invest. Ophthalmol. Vis. Sci. 37:1996;S538.
37. Muller-Decker K. Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction. Biochem. Biophys. Res. Commun. 162:1989;198-205.
38. Schutze S., Potthoff K., Machleidt T., Berkovic D., Wiegmann K., Kronke M. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell. 71:1992;765-776.
39. Ratnam S., Mookerjea S. The regulation of superoxide generation and nitric oxide synthesis by C-reactive protein. Immunology. 94:1998;560-568.
40. Tschaikowsky K., Schmidt J., Meisner M. Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C. J. Pharmacol. Exp. Ther. 285:1998;800-804.
41. Rao N.A. Role of oxygen free radicals in retinal damage associated with experimental uveitis. Trends Am. Ophthalmol. Soc. 88:1990;797-850.
42. Chen C.C., Wang J.K., Chen W.C., Lin S.B. Protein kinase C eta mediates lipopolysaccharide- induced nitric-oxide synthase expression in primary astrocytes. J. Biol. Chem. 273:1998;19424-19430.
43. Weber C., Erl W., Pietsch A., Danesch U., Weber P.C. Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha. Arterioscler. Thromb. Vas. Biol. 15:1995;622-628.