IL-10 has a protective role in experimental autoimmune uveoretinitis

International Immunology

Volumn 10, Issue 6, 1998, Pages 807-814

  Rizzo, Luiz V ^a   Xu, Hui ^a   Chan, Chi Chao ^a   Wiggert, Barbara ^a   Caspi, Rachel R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

Experimental autoimmune uveoretinitis; IL 10

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; EYE; FEMALE; GENE EXPRESSION; HELPER CELL; IMMUNIZATION; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; UVEORETINITIS;

ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; INTERLEUKIN-10; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RETINITIS; RETINOL-BINDING PROTEINS; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; TIME FACTORS;

EID: 0031813361     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.6.807     Document Type: Article

References (32)

1. Gery, I., Mochizuki, M. and Nussenblatt, R. B. 1986. Retinal specific antigens and immunopathogenic processes they provoke. Prog. Retinal Res. 5:75.
2. Caspi, R. R., Roberge, F. G., Chan, C. C., Wiggert, B., Chader, G. J., Rozenszajn, L. A., Lando, Z. and Nussenblatt, R. B. 1988. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140:1490.
3. Faure, J. P. 1980. Autoimmunity and the retina. Curr. Top. Eye Res. 2:215.
4. h1 response. J. Immunol. 157:2668.
5. h2-like response. J. Immunol. 159:1004.
6. h1-like lymphokine profile: cytokine-dependent modulation of primary and committed T cells in EAU. Cell. Immunol. 178:69.
7. Hara, Y, Caspi, R. R., Wiggert, B., Chan, C. C., Wilbanks, G. A. and Streilein, J. W. 1992. Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein. J. Immunol. 148:1685.
8. Saoudi, A., Kuhn, J., Huygen, K., de Kozak, Y., Velu, T., Goldman, M., Druet, P. and Bellon, B. 1993. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur. J. Immunol. 23:3096.
9. Rizzo, L. V. Miller-Rivero, N. E., Chan, C. C., Wiggert, B., Nussenblatt, R. B. and Caspi, R. R. 1994. Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J. Clin. Invest. 94:1668.
10. de Vries, J. E, 1995. Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann. Med. 27:537.
11. Rott, O., Fleischer, B. and Cash, E. 1994. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24:1434.
12. Pennline, K. J., Roque-Gaffney, E. and Monahan, M. 1994. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 71:169.
13. Rabinovitch, A., Suarez-Pinzon, W. L., Sorensen, O., Bleackley, R. C., Power, R. F. and Rajotte, R. V. 1995. Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft. Transplantation 60:368.
14. Mignon-Godefroy, K., Rott, O., Brazillet, M. P. and Charreire, J. 1995. Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT). Evidence for IL-10-enhanced cell death in EAT. J. Immunol. 154:6634.
15. Bai, X. F., Zhu, J., Zhang, G. X., Kaponides, G., Hojeberg, B., van der Meide, P. H. and Link, H. 1997. IL-10 suppresses experimental autoimmune neuritis and down-regulates TH1-type immune responses. Clin. Immunol. Immunopathol. 83:117.
16. Persson, S., Mikulowska, A., Narula, S., O'Garra, A. and Holmdahl, R. 1996. Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats. Scand. J. Immunol. 44:607.
17. Wogensen, L., Lee, M. S. and Sarvetnick, N. 1994. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice. J. Exp. Med. 179:1379.
18. Balasa, B. and Sarvetnick, N. 1996. The paradoxical effects of interleukin 10 in the immunoregulation of autoimmune diabetes. J. Autoimmun. 9:283.
19. Lee, M.S., Mueller, R., Wicker, L. S., Peterson, L. B. and Sarvetnick, N. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J. Exp. Med. 183:2663.
20. Cannella, B., Gao, Y. L., Brosnan, C. and Raine, C. S. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45:735.
21. Pepperberg, D. R., Okajima, T. L., Ripps, H., Chader, G. J. and Wiggert, B. 1991. Functional properties of interphotoreceptor retinoid-binding protein. Photochem. Photobiol. 54:1057.
22. h2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 145:2938.
23. Chan, C. C., Caspi, R. R., Ni, M., Leake, W. C., Wiggert, B., Chader, G. J. and Nussenblatt, R. B. 1990. Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun. 3:247.
24. + T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286.
25. + T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice. J. Immunol. 156:1654.
26. Snedecor, G. W. and Cochran, W. G. 1967. Statistical Methods, 6th edn, p. 246. Iowa State University Press, Ames, IA.
27. van Roon, J. A., van Roy, J. L., Gmelig-Meyling, F. H., Lafeber, F. P. and Bijlsma, J. W. 1996. Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4. Arthritis Rheum. 39:829.
28. Sugiyama, E., Kuroda, A., Taki, H., Ikemoto, M., Hori, T., Yamashita, N., Maruyama, M. and Kobayashi, M. 1995. Interleukin 10 cooperates with interleukin 4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells. J. Rheumatol. 22:2020.
29. Faust, A., Rothe, H., Schade, U., Lampeter, E. and Kolb, H. 1996. Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation 62:648.
30. Kennedy, M. K., Torrance, D. S., Picha, K. S. and Mohler, K. M. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
31. Issazadeh, S., Ljungdahl, A., Hojeberg, B., Mustafa, M. and Olsson, T. 1995. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor alpha and tumor necrosis factor beta. J. Neuroimmunol. 61:205.
32. Zhu, J., Bai, X. F., Mix, E. and Link, H. 1997 Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin. Clin. Immunol. Immunopathol. 84:85.