Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis

Ophthalmology

Volumn 105, Issue 1, 1998, Pages 46-56

  Jaffe, Glenn J ^a   Yang, Chang Sue ^a   Wang, Xiao Chun ^a   Cousins, Scott W ^b   Gallemore, Ron P ^a   Ashton, Paul ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYCLOSPORIN A; MYCOBACTERIUM ANTIGEN; POLYVINYL ALCOHOL; TUBERCULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG IMPLANTATION; ELECTRORETINOGRAPHY; INTRAVITREAL DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION; SUSTAINED RELEASE PREPARATION; T LYMPHOCYTE SUBPOPULATION; UVEITIS;

EID: 0031893747     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-6420(98)91176-9     Document Type: Article

References (21)

1. Nussenblatt RB. Uveitis: fundamentals and clinical practice. Chicago: Year Book Medical Publishers, Inc., 1989;59-79.
2. BenEzra D, Maftzir G, deCourten C, Timonen P. Ocular penetration of cyclosporin A. Ill: the human eye. Br J Ophthalmol 1990;74:350-2.
3. Deray G, Benhmida M, Le Hoang P, et al. Renal function and blood pressure in patients receiving long-term, low-dose cyclosporine therapy for idiopathic autoimmune uveitis. Ann Intern Med 1992;117:578-83.
4. Nussenblatt RB, Dinning WJ, Fujikawa LS, et al. Local cyclosporine therapy for experimental autoimmune uveitis in rats. Arch Ophthalmol 1985; 103:1559-62.
5. Pearson PA, Jaffe GJ, Martin DF, et al. Evaluation of a delivery system providing long-term release of cyclosporine. Arch Ophthalmol 1996;114:311-7.
6. Enyedi LB, Pearson PA, Ashton P, Jaffe GJ. An intravitreal device providing sustained release of cyclosporine and dexamethasone. Curr Eye Res 1996; 15:549-57.
7. Cheng CK, Berger AS, Pearson PA, et al. Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis. Invest Ophthalmol Vis Sci 1995; 36:442-53.
8. Atherton SS, Newell CK, Kanter MY, Cousins SW. T cell depletion increases susceptibility to murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci 1992; 33:3353-60.
9. BenEzra D, Maftzir G. Ocular penetration of cyclosporin A: the rabbit eye. Invest Ophthalmol Vis Sci 1990;31:1362-6.
10. Atmaca LS, Batioglu F. The efficacy of cyclosporin-a in the treatment of Behcet's disease. Ophthalmic Surg 1994; 25:321-7.
11. de Smet MD, Nussenblatt RB. Clinical use of cyclosporine in ocular disease. Int Ophthalmol Clin 1993;33:31-45.
12. Jabs DA, Lee B, Burek CL, et al. Cyclosporine therapy suppresses ocular and lacrimal gland disease in MRL/ Mp-lpr/lpr mice. Invest Ophthalmol Vis Sci 1996; 37:377-83.
13. Klein S, Friedrich R, Fricke B, et al. Cyclosporin A in der Therapie der Chronischen Uveitis. Ophthalmologe 1992; 89:411-5.
14. Martin DF, DeBarge LR, Nussenblatt RB, et al. Synergistic effect of rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis. J Immunol 1995; 154:922-7.
15. Mochizuki M, Kawashima H. Effects of FK506, 15-deoxyspergualin, and cyclosporine on experimental au toimmune uveoretinitis in the rat. Autoimmunity 1990; 8:37-41.
16. Nussenblatt RB, de Smet MD, Rubin B, et al. A masked, randomized, dose-response study between cyclosporine A and G in the treatment of sight-threatening uveitis of noninfectious origin. Am J Ophthalmol 1993; 115:583-91.
17. Pacor ML, Biasi D, Lunardi C, et al. Cyclosporin in Behcet's disease: results in 16 patients after 24 months of therapy. Clin Rheumatol 1994; 13:224-7.
18. Vitale AT, Rodriquez A, Foster CS. Low-dose cyclosporin A therapy in treating chronic, noninfectious uveitis. Ophthalmology 1996; 103:365-73.
19. Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 1994; 180:1159-64.
20. Augustin AA, Julius MH, Cosenza H. Antigen-specific stimulation and trans-stimulation of T cells in long-term culture. Eur J Immunol 1979;9:665-70.
21. Hainsworth DP, Pearson PA, Conklin JD, Ashton P. Sustained release intravitreal dexamethasone. J Ocul Pharmacol Ther 1996; 12:57-63.