Gene expression physiology and pathophysiology of the immune system

Trends in Immunology

Volumn 22, Issue 1, 2001, Pages 35-40

  Staudt, Louis M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 6; REGULATOR PROTEIN;

B CELL LYMPHOMA; CELL FUNCTION; DIAGNOSTIC PROCEDURE; DISEASE ACTIVITY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE TARGETING; GENE TRANSLOCATION; GENETIC ANALYSIS; HUMAN; IMMUNE SYSTEM; LYMPHATIC LEUKEMIA; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; IMMUNE SYSTEM DISEASES;

EID: 0034917132     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(00)01792-0     Document Type: Review

References (41)

1. Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes
2. Expression monitoring by hybridization to high-density oligonucleotide arrays
3. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
4. Genomic views of the immune system
5. Analysis of large-scale gene expression data
6. Cluster analysis and display of genome-wide expression patterns
7. Identification of molecularly and clinically distinct types of diffuse large B-cell lymphoma by gene expression profiling
8. The lymphochip: A specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes
9. Exploring the metabolic and genetic control of gene expression on a genomic scale
10. Systematic variation in gene expression patterns in human cancer cell lines
11. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
12. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
13. Activation changes the spectrum but not the diversity of genes expressed by T cells
14. Transcript imaging of the development of human T helper cells using oligonucleotide arrays
15. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
16. Clonal evolution of a follicular lymphoma: Evidence for antigen selection
17. Immunoglobulin heavy chain somatic mutation is ongoing in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas
18. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
19. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
20. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
21. Gene-target recognition among members of the myc superfamily and implications for oncogenesis
22. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
23. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
24. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
25. BCL-6 represses genes that function in lymphocyte differentiation, inflammation and cell cycle control
26. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6
27. Molecular pathogenesis of B cell malignancy: The role of BCL-6
28. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
29. The BCL-6 proto-oncogene controls germinal-centre formation and Th2- type inflammation
30. Disruption of the Bcl6 gene results in an impaired germinal center formation
31. BCL-6 expression during B-cell activation
32. Bcl-6 protein is expressed in germinal-center B cells
33. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts
34. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
35. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
36. Differential involvement of the transcription factor Blimp-1 in T cell- independent and -dependent B cell differentiation to plasma cells
37. Germinal centers
38. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
39. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
40. Functional discovery via a compendium of expression profiles
41. Target-oriented and diversity-oriented organic synthesis in drug discovery