IFN-γ increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 510-517

  Egwuagu, Charles E ^a   Sztein, Jorge ^a   Mahdi, Rashid M ^a   Li, Wenmei ^a   Chao Chan, Chi ^a   Smith, Janine A ^a   Charukamnoetkanok, Puwat ^a   Chepelinsky, Ana B ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; DISEASE SEVERITY; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL; UVEITIS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOIMMUNE DISEASES; CRYSTALLINS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; FEMALE; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; MALE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RETINA; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATION (GENETICS); UVEITIS;

EID: 0032933561     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Nussenblatt R. B., S. M. Whitcup, and A. G. Palestine. 1996. Uveitis: Fundamental and Clinical Practice, 2nd ed. Mosby-Year Book, St. Louis, pp. 32-38.
2. Nussenblatt, R. B. 1991. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest. Ophthalmol. Visual Sci. 32:3131.
3. Wacker, W. B. 1991. Experimental allergic uveitis. Invest. Ophthalmol. Visual Sci. 32:3119.
4. + T lymphocytes in experimental autoimmune uveoretinitis induced by two different retinal antigens. J. Immunol. 151:1627.
5. Egwuagu, C. E., S. Bahmanyar, R. Mahdi, R. B. Nussenblatt, I. Gery, and R. Caspi. 1992. Predominant usage of Vβ8.3 T cell receptor in a T cell line that induces experimental autoimmune uveoretinitis. J. Clin. Immunol. Immunopathol. 65:152.
6. Gregerson, D. S., W. F. Obritsch, S. P. Fling, and J. D. Cameron. 1986. S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J. Immunol. 136:2875.
7. Gery, I., and J. W. Streilein. 1994. Autoimmunity in the eye and its regulation. Curr. Opin. Immunol. 6:938.
8. Wacker, W. B., L. A. Donoso, C. M. Kalsow, Jr., T. A. Yankeelov, and D. T. Organisiak. 1977. Experimental allergic uveitis; isolation, characterization and localization of a soluble uveitopathogenic antigen from bovine retina. J. Immunol. 119:1949.
9. Gery, I., B. Wiggert, T. M. Redmond, T. Kuwabara, M. A. Crawford, B. P. Vistica, and G. J. Chader. 1986. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest. Ophthalmol. Visual Sci. 27:1296.
10. Broekhuyse, R. M., H. J. Winkens, and E. D. Kuhlman. 1986. Induction of experimental autoimmune uveoretinitis and pinealitis by IRBP: comparison to uveoretinitis induced by S-antigen and opsin. Curr. Eye Res. 5:231.
11. Sanui, H., T. M. Redmond, S. Kotake, B. Wiggert, L. Hu, H. Margalit, J. A. Berzofsky, G. J. Chader, and I. Gery. 1989. Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). J. Exp. Med. 169:1947.
12. Caspi, R. R., F. G. Roberge, C.-C. Chan, B. Wiggert, G. J. Chader, L. A. Rozenszajn, Z. Lando, and R. B. Nussenblatt. 1988. A new model of autoimmune disease: experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140:1490.
13. Nussenblatt, R. B., T. Kuwabara, F. de Monasterio, W. B. Wacker. 1981. S-antigen uveitis in primates: a new model for human disease. Arch. Ophthalmol. 99:100.
14. Hirose, S., T. Kuwabara, R. B. Nussenblatt, B. Wiggert, T. M. Redmond, and I. Gery. 1986. Uveitis induced in primates by interphotoreceptor retinoid-binding protein. Arch. Ophthalmol. 104:1698.
15. Sanui, H., T. M. Redmond, S. Kotake, B. Wiggert, T. Tanaka, G. J. Chader, and I. Gery. 1990. Uveitis and immune responses in primates immunized with IRBP-derived synthetic peptides. Curr. Eye Res. 9:193.
16. Boehm, U., T. Klamp, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
17. Hanafusa, T., L. Chiovato, D. Doniach, R. Pujol-Borrell, R. C. G. Russell, and G. F. Bottazzo. 1983. Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 2:1111.
18. Bottazzo, G. F., R. Pujol-Borrell, T. Hanafusa, and Feldmann. 1983. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet ii:1115.
19. Detrick, B., D. A. Newsome, C. M. Percopo, and J. J. Hooks. 1985. Class II antigen expression and γ interferon modulation of monocytes and retinal pigment epithelial cells from patients with retinitis pigmentosa. Clin. Immunol. Immunopathol. 36:201.
20. Hooks, J. J., C. C. Chan, and B. Detrick. 1988. Identification of the lymphokines, interferon-γ and interleukin-2, in inflammatory eye diseases. Invest. Ophthalmol. Visual Sci. 29:1444.
21. Mano, T., N. Tokuda, and D. G. Puro. 1991. Interferon-γ induces the expression of major histocompatibility antigens by human retinal glial cells. Exp. Eye Res. 53:603.
22. Feldman, M., M. Londei, and G. Buchan. 1987. Interferons and autoimmunity. Interferon 9:75.
23. Caspi, R. R., C-C. Chan, B. G. Grubbs, P. B. Silver, B. Wiggert, C. F. Parsa, S. Bahmanyar, A. Billiau, and H. Heremans. 1994. Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J. Immunol. 152:890.
24. Egwuagu, C. E., P. Charukamnoetkanok, and I. Gery. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109.
25. Chatot, C. L., C. A. Ziomek, B. D. Bavister, J. L. Lewis and I. Torres. 1989. An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro. J. Reprod. Fertil. 86:679.
26. Egwuagu, C. E., J. Sztein, C. C. Chan, W. Reid, R. Mahdi, R. B. Nussenblatt, and A. B. Chepelinsky. 1994. Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression. Invest. Ophthalmol. Visual Sci. 35:332.
27. Egwuagu, C. E., J. Sztein, C. C. Chan, R. Mahdi, R. B. Nussenblatt, and A. B. Chepelinsky. 1994. γ-Interferon expression disrupts lens and retinal differentiation in transgenic mice. Dev. Biol. 166:557.
28. Nudel, U., J. M. Calvo, and Z. Levy. 1983. The nucleotide sequence of the rat cytoplasmic β-actin gene. Nucleic Acids Res. 11:1759.
29. Kita, Y., T. Takashi, Y. Iigo, T. Tamatani, M. Miyasaka, and T. Horiuchi. 1992. Sequence and expression of ICAM-1. Biochim. Biophys. Acta 1131:108.
30. Barran, P. A., and W. R. McMaster. 1988. DNA sequence analysis of the rat RT1.B α gene, Immunogenetics 26:56.
31. + T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens. J. Immunol. 151:1627.
32. Geiger, K., E. Howes, M. Gallina, X. J. Huang, G. H. Travis, and N. Sarvetnick. 1994. Transgenic mice expressing IFN-γ in the retina develop inflammation of the eye and photoreceptor loss. Invest. Ophthalmol. Visual Sci. 35:2667.
33. Efiok, B. J., J. A. Chiorini, and B. Safer. 1994. A key transcription factor for eukaryotic initiation factor-2 α is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J. Biol. Chem. 269:18921.
34. Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630.
35. Decker, T., P. Kovarik, and A. Meinke. 1997. GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17:121.
36. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. V. Kaer, H-P., Pircher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
37. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
38. Whitcup, S. M., L. R. DeBarge, H. Rosen, R. B. Nussenblatt, and C-C. Chan. 1993. Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis. Invest. Ophthalmol. Visual Sci. 34:673.
39. Billiau, A. 1996. Interferon-γ in autoimmunity. Cytogenet. Growth Factor Rev. 7:25.
40. Tang, H., K. Mignon-Godefrey, P. L. Meroni, G. Garotta, J. Charriere, F. Nicoletti. 1993. The effects of a monoclonal antibody to interferon-γ on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol. 23:275.
41. Campbell, I. L., T. W. H. Kay, L. Oxbrow, L. C. Harrison. 1991. Essential role of interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:739.
42. Hartung, H-P., B. Shafer, P. H. Van der Meide, W. Fierz, K. Heininger, K. V. Toyka. 1990. The role of interferon-γ in the pathogenesis of experimental autoimmune diseases of the peripheral nervous system. Ann. Neurol. 27:247.
43. Krakowski, M., and T. Owens. 1996. Interferon-γ confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26:1641.
44. Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalto, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:5.
45. Willenborg, D. O., S. Fordham, C. C. A. Bernard, W. B. Cowden, I. A. Ramshaw. 1996. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157:3223.
46. Jones, L. S., L. V. Rizzo, R. K. Agarwal, C-C. Chan, B. Wiggert, and R. R. Caspi. 1997. IFN-γ-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J. Immunol. 158:5997.
47. Bogdan, C. 1998. The multiple function of nitric oxide in (auto)immunity. J. Exp. Med. 187:1361.
48. MacMicking, J., Q.-W. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323.
49. Liew, F. Y. 1995. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7:396.
50. Martin, E., C. Nathan, and Q.-W. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977.
51. Gold, D. P., K. Schroder, H. C. Powell, and C. J. Kelly. 1997. Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis. Eur. J. Immunol. 27:2863.
52. Hoey, S., P. S. Grabowski, S. H. Ralston, J. V. Forrester, and J. Liversidge. 1997. Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-γ-dependent mechanism. J. Immunol. 159:5132.
53. Nussenblatt, R. B., I. Gery, E. J. Ballintine, and W. B. Wacker. 1980. Cellular immune responsiveness of uveitis patients to retinal S-antigen. Am. J. Ophthalmol. 89:173.