Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis

Ocular Immunology and Inflammation

Volumn 7, Issue 2, 1999, Pages 75-84

  Petrinović Dorešić, Jelena ^a   Mažuran, Renata ^b   Henč Petrinović, Ljerka ^a   Kuzmanović, Biljana ^a   Jovičić, Aleksandra ^b  

^a Croatian Academy of Medical Sciences   (Croatia)

^b INSTITUTE OF IMMUNOLOGY   (Croatia)

Author keywords

Interleukin 6; Intraocular inflammation; Soluble receptor for interleukin 6

Indexed keywords

HLA B27 ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE INFLAMMATION; FEMALE; HUMAN; IRIDOCYCLITIS; MALE; REGULATORY MECHANISM; UVEITIS;

ADULT; AGED; AGED, 80 AND OVER; AQUEOUS HUMOR; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; RECEPTORS, INTERLEUKIN-6; SOLUBILITY; UVEITIS; VISUAL ACUITY;

EID: 0032881147     PISSN: 09273948     EISSN: None     Source Type: Journal    
DOI: 10.1076/ocii.7.2.75.4017     Document Type: Article

References (26)

1. Van Snick J. Interleukin-6: An overview. Annu Rev Immunol 1990;8:253-278.
2. Borish L, Rosenwasser LJ. Update on cytokines. J Allergy Clin Immunol 1996;97:719-734.
3. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 1990;11:443-449.
4. Yoshizaki K, Kuritani T, Kishimoto T. Interleukin-6 in autoimmune disorders. Semin Immunol 1992; 4:155-166.
5. De Vos AF, Hoekzema R, Kijlstra A. Cytokines and uveitis, a review. Curr Eye Res 1992;11:581-597.
6. Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995;86: 1243-1247.
7. Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med 1989;170:1409-1414.
8. Honda M, Yamamoto S, Cheng M, Yasukawa K, Suzuki H, Saito T, Osugi Y, Tokunaga T, Kishimoto T. Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection. J Immunol 1992; 148:2175-2180.
9. Frieling JTM, Sauerwein RW, Wijdenes J, Hendriks T, Van den Lindenn CJ. Soluble interleukin-6 receptor in biological fluids from human origin. Cytokine 1994;6:376-381.
10. Muller-Newen G, Kohne C, Keul R, Hemmann U, Muller-Esterl W, Wijdenes J, Brakenhoff JPJ, Kart MHL, Heinrich PC. Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. Eur J Biochem 1996;236:837-842.
11. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with possible signal transducer, gp13o. Cell 1989;58:573-581.
12. De Boer JH, Van Haren MAC, De Vries-Knoppert WAEJ, Baarsma GS, De Jong PVTM, Postema FJ, Rademakers AJJM, Kijlstra A. Analysis of IL-6 levels in human vitreous fluid obtained from uveitis patients, patients with proliferative intraocular disorders and eye bank eyes. Curr Eye Res 1992;11(Suppl):181-186.
13. Malecaze F, Chollet P, Cavrois E, Vita N, Arne JL, Ferrara P. Role of interleukin 6 in the inflammatory response after cataract surgery, an experimental and clinical study. Arch Ophthalmol 1991;109:1681-1683.
14. Hoekzema R, Murray PI, Kijlstra A. Cytokines and intraocular inflammation. Curr Eye Res 1990;9(Suppl): 207-211.
15. Murray PI, Hoekzema R, Van Haren MAC, De Hon FD, Kijlstra A. Aqueous humor interleukin-6 levels in uveitis. Invest Ophthalmol Vis Sci 1990;31:917-920.
16. Kauffmann DJH, Van Meurs JC, Mertens DAE, Peperkamp E, Master C, Gerritsen ME. Cytokines in vitreous humor: Interleukin-6 is elevated in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1994;35:900-906.
17. Kijlstra A. Cytokines: their role in uveal disease. Eye 1997;11:200-205.
18. Hoekzema R, Verhagen K, Van Haren MAC, Kijlstra A. Endotoxin-induced uveitis in the rat: The significance of intraocular interleukin 6. Invest Ophthalmol Vis Sci 1992;33:532-539.
19. Novak J, Touskova M, Krejzek J. Cytokines in aqueous humor - Clinical study. In: Abstract Book of the XIthCongress of the European Society of Ophthalmology, Hungary, Budapest, June 1-5, 1997; 198.
20. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994; 83:113-118.
21. Zhou D, Munster A, Wincurch RA. Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-b. FASEB J 1991;5:2582.
22. Forrester JV, Lumsden L, Liversidge J, Kuppner M, Mesri M. Immunoregulation of uveoretinal inflammation. Prog Retinal Eye Res 1995;14:393-412.
23. Rosenbaum JT, Kievit P, Han YB, Park JM, Planck SR. Interleukin-6 does not mediate endotoxin-induced uveitis in mice: Studies in gene deletion animals. Invest Ophthalmol Vis Sci 1998;39:64-69.
24. De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A. Serum soluble interleukin 6 receptor and IL-6/sIL-6R complex in systemic juvenile rheumatoid arthritis. J Clin Invest 1994;93:2114-2119.
25. Honda M, Yamamoto S, Cheng M, Yasukawa K, Suzuki H, Saito T, Osugi Y, Tokunaga T, Kishimoto T. Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection. J Immunol 1992; 148:2175-2180.
26. Gaillard JP, Bataille R, Brailly H, Zuber C, Yasukawa K, Attal M, Maruo N, Taga T, Kishimoto T, Klein B. Increased and highly stable levels of functional interleukin 6 receptor in sera of patients with monoclonal gammopathy. Eur J Immunol 1993;23:820-824.