Genetic Susceptibility to Experimental Autoimmune Uveitis Involves More than a Predisposition to Generate a T Helper-1-Like or a T Helper-2-Like Response

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 1004-1011

  Sun, Bing ^a   Rizzo, Luiz V ^a   Sun, Shu Hui ^a   Chan, Chi Chao ^a   Wiggert, Barbara ^a   Wilder, Ronald L ^b   Caspi, Rachel R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EYE PROTEIN; MESSENGER RNA; RETINOL BINDING PROTEIN; RETINOL-BINDING GLYCOPROTEIN;

ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; DISEASE PREDISPOSITION; FEMALE; GENETICS; IMMUNOLOGY; MOUSE; MOUSE STRAIN; TH1 CELL; TH2 CELL; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; DISEASE SUSCEPTIBILITY; EYE PROTEINS; FEMALE; MICE; MICE, INBRED STRAINS; RETINOL-BINDING PROTEINS; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; UVEITIS;

EID: 0031570957     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Gery, I., M. Mochizuki, and R. B. Nussenblatt. 1986. Retinal specific antigens and immunopathogenic processes they provoke. Prog. Retinal Res. 5:75.
2. Caspi, R. R., F. G. Roberge, C. C. Chan, B. Wiggert, G. J. Chader, L. A. Rozenszajn, Z. Lando, and R. B. Nussenblatt. 1988. A new model of autoimmune disease: experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140:1490.
3. Faure, J. P. 1980. Autoimmunity and the retina. Curr. Top. Eye Res. 2:215.
4. Nussenblatt, R. B., S. M. Whitcup, and A. G. Palestine. 1996. Uveitis: Fundamentals and Clinical Practice, 2nd Ed. Mosby-Year Book, Inc., St. Louis, MO, pp. 22-26.
5. Caspi, R. R., B. G. Grubbs, C. C. Chan, G. J. Chader, and B. Wiggert. 1992. Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model: concomitant regulation by MHC and non-MHC genes. J. Immunol. 148:2384.
6. Caspi, R. R. 1992. Immunogenetic aspects of clinical and experimental uveitis. Reg. Immunol. 4:321.
7. Caspi, R. R., F. G. Roberge, C. G. McAllister, M. el-Saied, T. Kuwabara, I. Gery, E. Hanna, and R. B. Nussenblatt. 1986. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J. Immunol. 136:928.
8. Chan, C. C., M. Mochizuki, R. B. Nussenblatt, A. G. Palestine, C. McAllister, I. Gery, and D. BenEzra. 1985. T-lymphocyte subsets in experimental autoimmune uveitis. Clin. Immunol. Immunopathol. 35:103.
9. + T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice. J. Immunol. 156:1654.
10. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
11. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
12. Paul, W. E., and R. A. Seder. 1994. Lymphocyte response and cytokines. Cell. 76:241.
13. Caspi, R. R. 1994. Th1 and Th2 lymphocytes in experimental autoimmune uveoretinitis. In Advances in Ocular Immunology. S. M. Whitcup, R. B. Nussenblatt, R. R. Caspi, and I. Gery, eds. International Congress Series, Elsevier Science Publishers, Amsterdam, p. 55.
14. Caspi, R. R., P. B. Silver, C. C. Chan, B. Sun, R. K. Agarwal, J. Wells, S. Oddo, Y. Fujiro, F. Najafian, and R. L. Wilder. 1996. Genetic susceptibility to experimental autoimmune uveoretinitis (EAU) in the rat is associated with an elevated Th1 response. J. Immunol. 157:2668.
15. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
16. Racke, M. K., A. Bonomo, D. E. Scott, B. Cannella, A. Levine, C. S. Raine, E. M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961.
17. Saoudi, A., J. Kuhn, K. Huygen, Y. de Kozak, T. Velu, M. Goldman, P. Druet, and B. Bellon. 1993. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur. J. Immunol. 23:3096.
18. Takahashi, S., L. Fossati, M. Iwamoto, R. Merino, R. Motta, T. Kohayakawa, and S. Izui. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97:1597.
19. Lo, D. 1996. Animal models of human disease: transgenic and knockout models of autoimmunity: building a better disease? Clin. Immunol. Immunopathol. 79:96.
20. Pepperberg, D. R., T. L. Okajima, H. Ripps, G. J. Chader, and B. Wiggert. 1991. Functional properties of interphotoreceptor retinoid-binding protein. Photochem. Photobiol. 54:1057.
21. Pepperberg, D. R., T. L. Okajima, B. Wiggert, H. Ripps, R. K. Crouch, and G. J. Chader. 1993. Interphotoreceptor retinoid-binding protein (IRBP): molecular biology and physiological role in the visual cycle of rhodopsin. Mol. Neurobiol. 7:61.
22. Rizzo, L. V., R. H. DeKruyff, D. T. Umetsu, and R. R. Caspi. 1995. Regulation of the interaction between Th1 and Th2 cell clones to provide help for antibody production in vivo. Eur. J. Immunol. 25:708.
23. Rizzo, L. V., N. E. Miller-Rivero, C. C. Chan, B. Wiggert, R. B. Nussenblatt, and R. R. Caspi. 1994. Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J. Clin. Invest. 94:1668.
24. Chan, C. C., R. R. Caspi, M. Ni, W. C. Leake, B. Wiggert, G. J. Chader, and R. B. Nussenblatt. 1990. Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun. 1:247.
25. Kotewicz, M. L., C. M. Sampson, J. M. D'Alessio, and G. F. Gerard. 1988. Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity. Nucleic Acids Res. 16:265.
26. Sun, B., J. Wells, E. Goldmuntz, P. Silver, E. F. Remmers, R. L. Wilder, and R. R. Caspi. 1996. A simplified, competitive RT-PCR method for measuring rat IFN-γ mRNA expression. J. Immunol. Methods 195:139.
27. Svetic, A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Cause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391.
28. Gazzinelli, R. T., I. Eltoum, T. A. Wynn, and A. Sher. 1993. acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151:3672.
29. Peterson, V. M., J. J. Adamovicz, T. B. Elliott, M. M. Moore, G. S. Madonna, W. E. R. Jackson, G. D. Ledney, and W. C. Gause. 1994. Gene expression of hematoregulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers. J. Immunol. 153:2321.
30. Xu, H., L. V. Rizzo, P. B. Silver, and R. R. Caspi. 1997. Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis. Cell. Immunol. In press.
31. Jones, L. S., L. V. Rizzo, R. K. Agarwal, T. K. Tarrant, C.-C. Chan, B. Wiggert, and R. R. Caspi. 1997. Interferon gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J. Immunol. In press.
32. Fox, G. M., T. M. Redmond, B. Wiggert, T. Kuwabara, G. J. Chader, and I. Gery. 1987. Dissociation between lymphocyte activation for proliferation and for the capacity to adoptively transfer uveoretinitis. J. Immunol. 138:3242.
33. Gregerson, D. S., S. P. Fling, W. F. Obritsch, C. F. Merryman, and L. A. Donoso. 1989. Identification of T cell recognition sites in S-antigen: dissociation of proliferative and pathogenic sites. Cell. Immunol. 123:427.
34. Greer, J. M., R. A. Sobel, A. Sette, S. Southwood, M. B. Lees, and V. K. Kuchroo. 1996. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J. Immunol. 156:371.
35. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011.
36. + cells correlate with resolution of lesions in murine cutaneous leishmaniasis. J. Immunol. 149:2715.
37. Else, K. J., L. Hultner, and R. K. Grencis. 1992. Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice. Immunology 75:232.
38. Meyaard, L., E. Hovenkamp, S. A. Otto, and F. Miedema. 1996. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:2776.
39. Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J. Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol. 156:3159.
40. Trinchieri, G., and F. Gerosa. 1996. Immuonregulation by interleukin-12. J. Leukocyte Biol. 59:505.
41. Kennedy, M. K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.