Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells

Stroke

Volumn 29, Issue 12, 1998, Pages 2631-2640

  Malek, Adel M ^a,c   Goss, Greg G ^b   Jiang, Lianwei ^b   Izumo, Seigo ^b   Alper, Seth L ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium; Hypertonicity; Hypotonicity; Osmotic agents; Protein tyrosine kinases

Indexed keywords

CALCIUM; CYCLOHEXIMIDE; DACTINOMYCIN; FOCAL ADHESION KINASE; HERBIMYCIN; HYPERTONIC SOLUTION; HYPOTONIC SOLUTION; MANNITOL; OSMOTIC AGENT; PAXILLIN; PROTEIN TYROSINE KINASE; QUIN 2 AM; SODIUM CHLORIDE; TYROSINE; UREA;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; CATTLE; CONTROLLED STUDY; ENDOTHELIUM CELL; IN VITRO STUDY; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0031785280     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.29.12.2631     Document Type: Article

References (35)

1. Better OS, Rubinstein I, Winaver JM, Knochel JP. Mannitol therapy revisited 1940-1997. Kidney Int. 1997;52:886-894.
2. Paczynski R. Osmotherapy: basic concepts and controversies. Crit Care Clin. 1997;13:105-129.
3. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med. 1997;336:540-546.
4. Bullock R, Chestnut RM, Clifton G, Ghajar J, Marion DW, Narayan RK, Newell DW, Pitts LH, Rosner MJ, Wilberger JW. Guidelines for the management of severe head injury. Brain Trauma.. 1996;13:639-734.
5. Hartwell RC, Sutton LN. Mannitol, intracranial pressure and vasogenic edema. Neurosurgery. 1993;32:444-449.
6. Paczynski RP, He YY, Diringer MN, Hsu CY. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28:1437-1444.
7. Better OR. I: management of shock and acute renal failure in casualties suffering from the crush syndrome. Ren Fail. 1997;19:647-653.
8. Harada K, Franklin A, Johnson RG, Grossman W, Morgan JP. Acidemia and hypernatremia enhance postischemic recovery of excitation-contraction coupling. Circ Res. 1994;74:1197-1209.
9. Ogilvy CS, Carter BS, Kaplan S, Rich C, Crowell R. Temporary vessel occlusion for aneurysm surgery: risk factors for stroke in patients protected by induced hypothermia and hypertension and intravenous mannitol administration. J Neurosurg. 1996;84:785-791.
10. Suzuki J, Imaizumi S, Kayma T, Yoshimoto T. Chemiluminescence in hypoxic brain: the second report: cerebral protective effect of mannitol, vitamin E, and glucocorticoid. Stroke. 1985;16:695-700.
11. Doran SE, Ren XD, Betz AL, Pagel MA, Neuwelt EA, Roessler BJ, Davidson BL. Gene expression from recombinant viral vectors in the central nervous system after blood-brain barrier disruption. Neurosurgery. 1995;36:965-970.
12. Zunkeler B, Carson RE, Olson J, Blasberg RG, DeVroom H, Lutz RJ, Saris SC, Wright DC, Kammerer W, Patronas NJ, Dedrick RL, Herscovitch P, Oldfield EH. Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg. 1996;85: 1056-1065.
13. Shapiro L, Dinarello CA. Hyperosmotic stress as a stimulant for proinflammatory cytokine production. Exp Cell Res. 1997;231:354-362.
14. Richmon JD, Fukuda K, Sharp FR, Noble LJ. Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neurosci Lett. 1995:202:1-4.
15. Berl T, Siriwardana G, Ao L, Butterfield LM, Heasley LE. Multiple mitogen-activated protein kinases are regulated by hyperosmolarity in mouse IMCD cells. Am J Physiol. 1997;272:F305-F311.
16. Galcheva-Gargova Z, Derijard B, Wu IH, Davis RJ. An osmosensing signal transduction pathway in mammalian cells. Science. 1994;265: 806-808.
17. Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 1996;274:1194-1197.
18. Malek AM, Jackman R, Rosenberg RD, Izumo S. Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res. 1994;74:852-860.
19. 2+ homeostasis in vascular smooth muscle cells. Circ Res. 1997;80:617-626.
20. 2+ ATPase. Am J Physiol. 1997;272:C1947-C1959.
21. Khwaja A, Downward J. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. J Cell Biol. 1997;139:1017-1023.
22. Bortner CD, Cidlowski JA. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am J Physiol. 1996;271:C950-C961.
23. Palfrey HC, O'Donnell ME. Characteristics and regulation of the Na/K/2Cl cotransporter. Cell Physiol Biochem. 1992;2:293-307.
24. + efflux in the activation of apoptosis. J Biol Chem. 1997;272: 32436-32432.
25. Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol. 1996;134: 793-799.
26. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE. Geometric control of cell life and death. Science. 1997;276:1425-1428.
27. Frisch SM, Vuori K, Kelaita D, Sicks S. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J Cell Biol. 1996;135:1377-1382.
28. Chen Y-R, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation: duration of JNK activation may determine cell death and proliferation. J Biol Chem 1996;271:31929-31936.
29. + exchanger activation bduring shrinkage of human neutrophils. J Biol Chem. 1997;272:17303-17311.
30. Escargueil-Blanc I, Meilhac O, Pieraggi M-T, J-F, Salvayre R, Nègre-Salvayre A. Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway: prevention by aurintricarboxylic acid. Arterioscler Thromb Vasc Biol. 1997;17: 331-339.
31. 2+ stores in induction and suppression of apoptosis in S49 cells. Am J Physiol. 1997;272: C1241-C1249.
32. McConkey DJ, Orrenius S. The role of calcium in the regulation of apoptosis. Biochem Biophys Res Comm. 1997;239:357-366.
33. Okazaki T, Ishikawa T, Nishimori S, Igarashi T, Hata K, Fujita T. Hyperosmolarity-induced gene stimulation is mediated by the negative calcium responsive element. J Biol Chem. 1997;272:32274-32279.
34. 2+ stores and arachidonic acid metabolism. J Clin Invest. 1998;101:1623-1632.
35. Gulbins E, Welsch J, Lepple-Wienhuis H, Heinle H, Lang F. Inhibition of Fas-induced apoptotic cell death by osmotic cell shrinkage. Biochem Biophys Res Commun. 1997;236:517-521.