For debate: Defective mitochondria, free radicals, cell death, aging-reality or myth-ochondria?

Mechanisms of Ageing and Development

Volumn 114, Issue 3, 2000, Pages 201-206

  Rustin, Pierre ^a   Von Kleist Retzow, Jurgen Christoph ^a   Vajo, Zoltan ^a   Rotig, Agnes ^a   Munnich, Amold ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Aging; Free radicals; Mitochondrium; Oxidation

Indexed keywords

FREE RADICAL; MITOCHONDRIAL DNA;

AGING; ARTICLE; CELL DEATH; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; MITOCHONDRION; MUTANT; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

AGING; ANIMALS; CELL DEATH; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 0034646750     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00102-0     Document Type: Article

References (37)

1. Bourgeron T., Chretien D., Rotig A., Munnich A., Rustin P. Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 268:1993;19369-19376.
2. Chretien D., Gallego J., Barrientos A., Casademont J., Cardellach F., Munnich A., Rotig A., Rustin P. Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem. J. 329:1998;249-254. , part II.
3. Cortopassi G.A., Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic. Acid Res. 18:1990;6927-6933.
4. Cortopassi G.A., Shibata D., Soong N.W., Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. USA. 89:1992;7370-7374.
5. de Grey A.D. A proposed refinement of the mitochondrial free radical theory of aging. Bioessays. 19:1997;161-166.
6. Emster L., Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta. 1271:1995;195-204.
7. Gardner P.R., Nguyen D.D., White C.W. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc. Natl. Acad. Sci. USA. 91:1994;12248-12252.
8. Guarente L. Aging: what makes us tick? Science. 275:1997;943-944.
9. Jonassen T., Marbois B.N., Kim L., Chin A., Xia Y.R., Lusis A.L., Clarke C.F. Isolation and sequencing of the Rat Coq7 gene and the mapping of Mouse Coq7 to chromosome 7. Arch. Biochem. Biophys. 330:1996;285-289.
10. Keightley J.A., Hoffbuhr K.C., Burton M.D., Salas V.M., Johnston W.S., Penn A.M., Buist N.R., Kennaway N.G. A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria. Nat. Genet. 12:1996;410-416.
11. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 21(5303):1997;1132-1136.
12. Kowald A., Kirkwood T.B. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat. Res. 316:1996;209-236.
13. Kroemer G., Petit P., Zamzami N., Vayssiere J.L., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
14. Lakowski B., Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272:1996;1010-1013.
15. Li Y., Huang T.T., Carlson W., Melov S., Ursell P.C., Olson J.L., Noble W., Yoshirnura M.P., Berger C., Chan P.H. et al. Dilated cardiornyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11:1995;376-381.
16. Linnane A.W., Marzuki S., Ozawa T., Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1:1989;642-645.
17. Liu X., Kim C.N., Yang J., Jernmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86(1):1996;147-157.
18. Marbois B.F., Clarke C.F. The COQ7 gene encodes a protein in Sacchaornces cerevisiae necessary for ubiquinone biosyfithesis. J. Biol. Chem. 271:1996;2995-3004.
19. Morais R., Gregoire M., Jeannotte L., Gravel D. Chick embryo cells rendered respirationdeficient by chloramphenicol and ethidium. bromide are auxotrophic for pyrimidines. Biochem. Biophys. Res. Commun. 94:1980;71-77.
20. Munscher Q., Muller-Hocker J., Kadenbach B. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biol. Chem. Hoppe Seyler. 374:1993;1099-10104.
21. Ohkoshi N., Mizusawa H., Shiraiwa N., Shoji S., Harada K., Yoshizawa K. Superoxide dismutases of muscle in mitochondrial encephalomyopathies. Muscle Nerve. 18:1995;1265-1271.
22. Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
23. Pallotti F., Chen X., Bonilla E., Schon E.A. Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am. J. Hum. Genet. 59:1996;591-602.
24. Richter C., Schweizer M., Cossarizza A., Franceschi C. Control of apoptosis by the cellular ATP level. FEBS Lett. 378:1996;107-110.
25. Rotig A., de Lonlay P., Chretien D., Foury F., Koenig M., Sidi D., Munnich A., Rustin P. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat. Genet. 17:1997;215-217.
26. Rotig A., Munnich A., Rustin P. Friedreich's ataxia and mitochondria: the puzzle reconstructed. Arch. Pediatr. 46:1999;498s-499s.
27. Rustin P., von Kleist-Retzow J.C., Rotig A., Munnich A. Iron overload and mitochondrial diseases. Lancet. 351:1998;1286-1287.
28. Saunier P., Chretien D., Wood Q., Rotig A., Bonnefont J.P., Saudubray J.M., Rabier D., Munnich A., Rustin P. Cytochrome c oxidase deficiency presenting as recurrent neonatal, myoglobinuria. Neuromuscul. Disord. 5:1995;285-289.
29. Savoiardo M., Ciceri E., D'Incerti L., Uziel G., Scotti G. Symmetric lesions of the subthalamic nuclei in mitochondrial encephalopathies: an almost distinctive Mark of Leigh disease with COX deficiency. AJNR. Am. J. Neuroradiol. 16:1995;1746-1747.
30. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA. 91:1994;10771-10778.
31. Skulachev V.P. Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett. 397:1996;7-10.
32. Sohal R.S., Dubey A. Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic. Biol. Med. 16:1994;621-626.
33. Vayssiere J.L., Petit P.X., Risler Y., Mignotte B. Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc. Natl. Acad. Sci. USA. 91:1994;11752-11756.
34. Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science. 256:1992;628-632.
35. Wong A., Boutis P., Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics. 139:1995;1247-1259.
36. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 275:1997;1129-1132.
37. Zhang C., Linnane A.W., Nagley P. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem. Biophys. Res. Commun. 195:1993;1104-1110.