Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL-5

The Journal of Allergy and Clinical Immunology

Volumn 98, Issue 6 PART 2, 1996, Pages

  Adachi, Tetsuya ^a   Motojima, Shinji ^b   Hirata, Akira ^b   Fukuda, Takeshi ^b   Kihara, Norio ^a   Kosaku, Akinori ^b   Ohtake, Hideki ^b   Makino, Sohei ^b  

^a Kihara Hospital   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; bronchial asthma; eosinophil; glucocorticoid; guinea pig; interleukin 5; macrolide; theophylline

Indexed keywords

AMINOPHYLLINE; CLARITHROMYCIN; ERYTHROMYCIN; GLUCOCORTICOID; INTERLEUKIN 5; MACROLIDE; METHYLPREDNISOLONE; THEOPHYLLINE;

ANIMAL CELL; APOPTOSIS; ASTHMA; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; EOSINOPHIL; GUINEA PIG; LEUKOCYTE CULTURE; NONHUMAN; PRIORITY JOURNAL;

AMINOPHYLLINE; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CLARITHROMYCIN; DRUG ANTAGONISM; EOSINOPHILS; ERYTHROMYCIN; GLUCOCORTICOIDS; GUINEA PIGS; HUMANS; INTERLEUKIN-5; MACROLIDES; METHYLPREDNISOLONE; PERITONEAL LAVAGE; THEOPHYLLINE;

EID: 0030444654     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70068-4     Document Type: Article

References (42)

1. The eosinophil and bronchial asthma: current understanding
2. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival
3. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival
4. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3
5. Eosinophil viability enhancing activity in sputum from patients with bronchial asthma: contributions of interleukin-5 and granulocyte-macrophage colony-stimulating factor
6. Rh IL-5 and rh GM-CSF enhance damage to respiratory epithelium induced by IgG-stimulated guinea pig eosinophils [abstract]
7. The effects of glucocorticoids on human eosinophils
8. Human endothelial cells prolong eosinophil survival: regulation by cytokines and glucocorticoids
9. Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor
10. Glucocorticoids inhibit cytokine-mediated eosinophil survival
11. Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids
12. Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor and interleukin-5 enhanced in vitro survival of human eosinophils
13. Theophylline: an immunomodulatory role in asthma?
14. A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis
15. Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases
16. Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma
17. Guinea pig eosinophils possess receptors capable of binding to human interleukin-5 and human granulocyte/macrophage colony-stimulating factor
18. Cell death: the significance of apoptosis
19. Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils
20. Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro
21. Eosinophil hematopoietins antagonize the programmed cell death of eosinophils: cytokine and glucocorticoid effects on eosinophils maintained by entothelial cell-conditioned medium
22. The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of Lyn tyrosine kinase and the Ras-Raf 1-MEK-microtubule-associated protein kinase pathway
23. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for the different signaling
24. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear factors AP-1 and NF-AT
25. Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter involvement of nuclear factor of activated T cell–related factors in interleukin-5 expression
26. Immunomodulation by theophylline in asthma: demonstration by withdrawal of therapy
27. Regulation of interleukin 2 synthesis by cAMP in human T cells
28. Cyclic nucleotides differencially regulate the synthesis of tumor necrosis factor-α and interleukin-1β by human mononuclear cells
29. Methylxantines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells
30. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
31. Effects of isozyme-selective phophodiesterase inhibitors on eosinophils infiltration in the guinea-pig lung
32. Regulation of Ig-induced eosinophil degranulation by adenosine 3’,5’-cyclic monophosphate
33. Theophylline induce apoptosis in eosinophils surviving with interleukin-5 in vitro [Abstract]
34. Antilymphocytic activity of erythromycin distinct from that of FK506 or cyclosporin A
35. Anti-allergic activity of roxithromycin inhibition of interleukin-5 production from mouse T lymphocytes
36. Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: a potential mechanism of its anti-inflammatory action
37. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
38. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
39. The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells
40. An improved protocol for the use of troleandomycin (TAO) in the treatment of steroid-requiring asthma
41. Dose- and time-related effect of troleandomycin on methylprednisolone elimination
42. Inhibition of theophylline clearance by troleandomycin