Characterization of the CDR3 region of rearranged α heavy chain genes in human fetal liver

Clinical and Experimental Immunology

Volumn 112, Issue 1, 1998, Pages 44-47

  Baskin, B ^a,b   Islam, K B ^a   Smith, C I E ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

CDR3; Fetal liver; Human

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FETUS; FETUS LIVER; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; MULTIGENE FAMILY; PRIORITY JOURNAL;

EID: 0031980970     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00547.x     Document Type: Article

References (19)

1. Cooper MD. Pre-B cells: normal and abnormal development (Review). J Clin Immunol 1981; 1:81.
2. Solvason N, Kearney JF. The human fetal omentum: a site of B cell generation. J Exp Med 1992; 175:397.
3. Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J. VDJ recombination. Immunol Today 1992; 13:306.
4. Kirkham PM, Mortari F, Newton JA, Schroeder H Jr. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J 1992; 11:603.
5. Buluwela L, Albertson DG, Sherrington P, Rabbitts PH, Spurr N, Rabbitts TH. The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. EMBO J 1988; 7:2003.
6. Ichihara Y, Abe M, Yasui H, Matsuoka H, Kurosawa Y. At least five DH genes of human immunoglobulin heavy chains are encoded in 9-kilobase DNA fragments. Eur J Immunol 1988; 18:649.
7. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell 1981; 27:583.
8. Esser C, Radbruch A. Immunoglobulin class switching: molecular and cellular analysis. Annu Rev Immunol 1990; 8:717.
9. Cuisinier AM, Guigou V, Boubli L, Fougereau M, Tonnelle C. Preferential expression of VH5 and VH6 immunoglobulin genes in early human B-cell ontogeny. Scand J Immunol 1989; 30:493.
10. Cuisinier AM, Fumoux F, Moinier D, Boubli V, Milili M, Schiff C, Fougereau F, Tonnelle C. Rapid expansion of human immunoglobulin repertoire (VH, Vk, Vl) expressed in early fetal bone marrow. New Biol 1990; 2:689.
11. Schroeder H Jr, Wang JY. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA 1990; 87:6146.
12. Pascual V, Verkruyse L, Casey ML, Capra JD. Analysis of IgH chain segment utilization in human fetal liver. J Immunol 1993; 151:4165.
13. Tonnelle C, Cuisinier AM, Gauthier L, Guelpa-Fonlupt V, Milili M, Schiff C, Fougereau M. Fetal vs. adult pre B or B cells: the human VH repertoire. Ann NY Acad Sci 1995; 764:231.
14. Sanz I. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 1991; 147:1720.
15. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 1991; 173:395.
16. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156.
17. Milili M, Fougereau M, Guglielmi P, Schiff C. Early occurrence of immunoglobulin isotype switching in human fetal liver. Mol Immunol 1991; 28:753.
18. Cuisinier AM, Gauthier L, Boubli L, Fougereau M, Tonnelle C. Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver. Eur J Immunol 1993; 23:110.
19. Schroeder H Jr, Hillson JL, Perlmutter RM. Early restriction of the human antibody repertoire. Sci 1987; 238:791.