메뉴 건너뛰기




Volumn 256, Issue 5, 1996, Pages 813-817

The imprint of somatic hypermutation on the repertoire of human germline V genes

Author keywords

Antibody; Diversity; Evolution; Germline; Hypermutation

Indexed keywords

ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ARTICLE; GENE; GENE MUTATION; GENE SEQUENCE; GENOME; HUMAN; IMMUNE SYSTEM; MULTIGENE FAMILY; PRIORITY JOURNAL;

EID: 0029961133     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0127     Document Type: Editorial
Times cited : (166)

References (30)
  • 2
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C. & Milstein, C. (1987). Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96, 23-41.
    • (1987) Immunol. Rev. , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 4
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechansim: Clustering, polarity and specific hotspots
    • Betz, A. G., Rada, C., Pannell, R., Milstein, C. & Neuberger, M. S. (1993). Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechansim: clustering, polarity and specific hotspots. Proc. Natl Acad. Sci. USA, 90, 2385-2388.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 5
    • 0021129784 scopus 로고
    • The immunoglobulin heavy-chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes
    • Brodeur, P. H. & Riblet, R. (1984). The immunoglobulin heavy-chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14, 922-930.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 922-930
    • Brodeur, P.H.1    Riblet, R.2
  • 12
    • 0015247402 scopus 로고
    • Attempts to locate complementarity-determining residues in the variable positions of light and heavy-chains
    • Kabat, E. A. & Wu, T. T. (1971). Attempts to locate complementarity-determining residues in the variable positions of light and heavy-chains. Ann. NY Acad. Sci. 190, 382-393.
    • (1971) Ann. NY Acad. Sci. , vol.190 , pp. 382-393
    • Kabat, E.A.1    Wu, T.T.2
  • 16
    • 0025760317 scopus 로고
    • Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes
    • Marks, J. D., Tristrem, M., Karpas, A. & Winter, G. (1991). Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur. J. Immunol. 21, 985-991.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 985-991
    • Marks, J.D.1    Tristrem, M.2    Karpas, A.3    Winter, G.4
  • 20
    • 0026319199 scopus 로고
    • Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
    • Nicholls, A., Sharp, K. A. & Honig, B. (1991). Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins: Struct. Funct. Genet. 11, 281-296.
    • (1991) Proteins: Struct. Funct. Genet. , vol.11 , pp. 281-296
    • Nicholls, A.1    Sharp, K.A.2    Honig, B.3
  • 21
    • 0028053754 scopus 로고
    • Analysis of the patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: Evolutionary implications
    • Rothenfluh, H. S., Gibbs, A. J., Blanden, R. V. & Steele, E. J. (1994). Analysis of the patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications. Proc. Natl Acad. Sci. USA, 91, 12163-12167.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12163-12167
    • Rothenfluh, H.S.1    Gibbs, A.J.2    Blanden, R.V.3    Steele, E.J.4
  • 22
    • 0027688019 scopus 로고
    • The variable genes of the human immunoglobulin κ locus
    • Schäble, K. F. & Zachau, H. G. (1993). The variable genes of the human immunoglobulin κ locus. Biol. Chem. Hoppe-Seyler, 374, 1001-1022.
    • (1993) Biol. Chem. Hoppe-Seyler , vol.374 , pp. 1001-1022
    • Schäble, K.F.1    Zachau, H.G.2
  • 23
    • 0026785856 scopus 로고
    • The repertoire of human germline VH segments reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B. & Winter, G. (1992). The repertoire of human germline VH segments reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 227, 776-798.
    • (1992) J. Mol. Biol. , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 26
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. (1983). Somatic generation of antibody diversity Nature, 302, 575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 27
    • 0028304866 scopus 로고
    • Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2
    • Tormo, J., Blaas, D., Parry, N. R., Rowlands, D., Stuart, D. & Fita, I. (1994). Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2. EMBO J. 13, 2247-2256.
    • (1994) EMBO J. , vol.13 , pp. 2247-2256
    • Tormo, J.1    Blaas, D.2    Parry, N.R.3    Rowlands, D.4    Stuart, D.5    Fita, I.6
  • 29
    • 0014828908 scopus 로고
    • An analysis of the sequences of the variable regions of Bence-Jones proteins and myeloma light-chains and their implications for antibody complementarity
    • Wu, T. T. & Kabat, E. A. (1970). An analysis of the sequences of the variable regions of Bence-Jones proteins and myeloma light-chains and their implications for antibody complementarity. J. Expt. Med. 132, 211-250.
    • (1970) J. Expt. Med. , vol.132 , pp. 211-250
    • Wu, T.T.1    Kabat, E.A.2
  • 30
    • 0027753921 scopus 로고
    • The immunoglobulin κ locus - Or -what has been learned from looking closely at one-tenth of a percent of the human genome
    • Zachau, H. G. (1993). The immunoglobulin κ locus - or -what has been learned from looking closely at one-tenth of a percent of the human genome. Gene, 135, 167-173.
    • (1993) Gene , vol.135 , pp. 167-173
    • Zachau, H.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.