Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

Journal of Molecular Biology

Volumn 263, Issue 4, 1996, Pages 551-567

  Schier, Robert ^a,c   McCall, Adrian ^b   Adams, Gregory P ^b   Marshall, Keith W ^a   Merritt, Hanne ^a   Yim, Michael ^a   Crawford, Robert S ^a   Weiner, Louis M ^b   Marks, Cara ^a   Marks, James D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c Nussdorfer Laende 11   (Austria)

Author keywords

Affinity maturation; Antibody phage display; BIAcore; c erbB 2; Single chain Fv

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; PHAGE DISPLAY; PRIORITY JOURNAL;

EID: 0030575802     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0598     Document Type: Article

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