-
3
-
-
0028326047
-
The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
-
(1994)
Development
, vol.120
, Issue.4
, pp. 885-899
-
-
Eldon, E.1
Kooyer, S.2
D'Evelyn, D.3
Duman, M.4
Lawinger, P.5
Botas, J.6
Bellen, H.7
-
4
-
-
0029863950
-
T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.10
, pp. 5777-5783
-
-
Mitcham, J.L.1
Parnet, P.2
Bonnert, T.P.3
Garka, K.E.4
Gerhart, M.J.5
Slack, J.L.6
Gayle, M.A.7
Dower, S.K.8
Sims, J.E.9
-
8
-
-
0028167111
-
The spatzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
-
(1994)
Cell
, vol.76
, Issue.4
, pp. 677-688
-
-
Morisato, D.1
Anderson, K.V.2
-
12
-
-
0033567388
-
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
-
(1999)
Genes and Development
, vol.13
, Issue.16
, pp. 2059-2071
-
-
Kopp, E.1
Medzhitov, R.2
Carothers, J.3
Xiao, C.4
Douglas, I.5
Janeway, C.A.6
Ghosh, S.7
-
13
-
-
0026491071
-
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
-
(1992)
Cell
, vol.71
, Issue.4
, pp. 623-635
-
-
Kidd, S.1
-
15
-
-
0034695443
-
Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.3
, pp. 2071-2079
-
-
Kim, Y.S.1
Han, S.J.2
Ryu, J.H.3
Choi, K.H.4
Hong, Y.S.5
Chung, Y.H.6
Perrot, S.7
Raibaud, A.8
Brey, P.T.9
Lee, W.J.10
-
16
-
-
0032485392
-
Regulated nuclear import of Rel proteins in the Drosophila immune response
-
(1998)
Nature
, vol.392
, Issue.6671
, pp. 93-97
-
-
Wu, L.P.1
Anderson, K.V.2
-
22
-
-
0032100444
-
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
-
(1998)
Blood
, vol.91
, Issue.11
, pp. 4020-4027
-
-
Chaudhary, P.M.1
Ferguson, C.2
Nguyen, V.3
Nguyen, O.4
Massa, H.F.5
Eby, M.6
Jasmin, A.7
Trask, B.J.8
Hood, L.9
Nelson, P.S.10
-
23
-
-
0033614428
-
TLR6: A novel member of an expanding Toll-like receptor family
-
(1999)
Gene
, vol.231
, Issue.1-2
, pp. 59-65
-
-
Takeuchi, O.1
Kawai, T.2
Sanjo, H.3
Copeland, N.G.4
Gilbert, D.J.5
Jenkins, N.A.6
Takeda, K.7
Akira, S.8
-
28
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
(1998)
Molecular Cell
, vol.2
, Issue.2
, pp. 253-258
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Kopp, E.3
Stadlen, A.4
Chen, C.5
Ghosh, S.6
Janeway C.A., Jr.7
-
33
-
-
0032541661
-
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
-
(1998)
Nature
, vol.395
, Issue.6699
, pp. 284-288
-
-
Yang, R.B.1
Mark, M.R.2
Gray, A.3
Huang, A.4
Xie, M.H.5
Zhang, M.6
Goddard, A.7
Wood, W.I.8
Gurney, A.L.9
Godowski, P.J.10
-
37
-
-
0033952268
-
TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages
-
(2000)
FEBS Letters
, vol.467
, Issue.2-3
, pp. 160-164
-
-
Irie, T.1
Muta, T.2
Takeshige, K.3
-
38
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
(1999)
Journal of Experimental Medicine
, vol.189
, Issue.11
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
41
-
-
0033583034
-
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.12
, pp. 7611-7614
-
-
Zhang, F.X.1
Kirschning, C.J.2
Mancinelli, R.3
Xu, X.P.4
Jin, Y.5
Faure, E.6
Mantovani, A.7
Rothe, M.8
Muzio, M.9
Arditi, M.10
-
42
-
-
0032701642
-
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.3
, pp. 271-280
-
-
Frantz, S.1
Kobzik, L.2
Kim, Y.D.3
Fukazawa, R.4
Medzhitov, R.5
Lee, R.T.6
Kelly, R.A.7
-
45
-
-
0034646695
-
Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.15
, pp. 11058-11063
-
-
Faure, E.1
Equils, O.2
Sieling, P.A.3
Thomas, L.4
Zhang, F.X.5
Kirschning, C.J.6
Polentarutti, N.7
Muzio, M.8
Arditi, M.9
-
47
-
-
0034651729
-
Human toll-like receptor 2 mediates monocyte activation by listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
-
(2000)
Journal of Immunology
, vol.164
, Issue.4
, pp. 2064-2069
-
-
Flo, T.H.1
Halaas, O.2
Lien, E.3
Ryan, L.4
Teti, G.5
Golenbock, D.T.6
Sundan, A.7
Espevik, T.8
-
49
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the tlr4 gene
-
(1998)
Science
, vol.282
, Issue.5396
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.-Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
50
-
-
0345561540
-
Endotoxin-tolerant mice have mutations in Toll-like receptor 4
-
(1999)
Journal of Experimental Medicine
, vol.189
, Issue.4
, pp. 615-625
-
-
Qureshi, S.T.1
Lariviere, L.2
Leveque, G.3
Clermont, S.4
Moore, K.J.5
Gros, P.6
Malo, D.7
-
51
-
-
0033120081
-
Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
52
-
-
0026791975
-
The immune system evolved to discriminate infectious nonself from noninfectious self
-
(1992)
Immunology Today
, vol.13
, Issue.1
, pp. 11-16
-
-
Janeway, C.A.1
-
54
-
-
0033585011
-
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.47
, pp. 33419-33425
-
-
Lien, E.1
Sellati, T.J.2
Yoshimura, A.3
Flo, T.H.4
Rawadi, G.5
Finberg, R.W.6
Carroll, J.D.7
Espevik, T.8
Ingalls, R.R.9
Radolf, J.D.10
Golenbock, D.T.11
-
55
-
-
0033198204
-
Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
-
(1999)
Journal of Immunology
, vol.163
, Issue.5
, pp. 2382-2386
-
-
Hirschfeld, M.1
Kirschning, C.J.2
Schwandner, R.3
Wesche, H.4
Weis, J.H.5
Wooten, R.M.6
Weis, J.J.7
-
56
-
-
0033618630
-
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
-
(1999)
Science
, vol.285
, Issue.5428
, pp. 736-739
-
-
Aliprantis, A.O.1
Yang, R.B.2
Mark, M.R.3
Suggett, S.4
Devaux, B.5
Radolf, J.D.6
Klimpel, G.R.7
Godowski, P.8
Zychlinsky, A.9
-
57
-
-
0034650420
-
Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
-
(2000)
Journal of Immunology
, vol.164
, Issue.2
, pp. 554-557
-
-
Takeuchi, O.1
Kaufmann, A.2
Grote, K.3
Kawai, T.4
Hoshino, K.5
Morr, M.6
Muhlradt, P.F.7
Akira, S.8
-
64
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
-
(1999)
Science
, vol.285
, Issue.5428
, pp. 732-736
-
-
Brightbill, H.D.1
Libraty, D.H.2
Krutzik, S.R.3
Yang, R.B.4
Belisle, J.T.5
Bleharski, J.R.6
Maitland, M.7
Norgard, M.V.8
Plevy, S.E.9
Smale, S.T.10
Brennan, P.J.11
Bloom, B.R.12
Godowski, P.J.13
Modlin, R.L.14
-
66
-
-
0033592748
-
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
-
(1999)
Nature
, vol.401
, Issue.6755
, pp. 811-815
-
-
Underhill, D.M.1
Ozinsky, A.2
Hajjar, A.M.3
Stevens, A.4
Wilson, C.B.5
Bassetti, M.6
Aderem, A.7
-
68
-
-
0029919991
-
Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
-
(1996)
Immunity
, vol.4
, Issue.4
, pp. 407-414
-
-
Haziot, A.1
Ferrero, E.2
Kontgen, F.3
Hijiya, N.4
Yamamoto, S.5
Silver, J.6
Stewart, C.L.7
Goyert, S.M.8
-
72
-
-
0028981285
-
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition
-
(1995)
Proceedings of the National Academy of Sciences of the United States of America
, vol.92
, Issue.20
, pp. 9288-9292
-
-
Delude, R.L.1
Savedra, R.2
Zhao, H.3
Thieringer, R.4
Yamamoto, S.5
Fenton, M.J.6
Golenbock, D.T.7
-
74
-
-
0028941067
-
E5531, a pure endotoxin antagonist of high potency
-
(1995)
Science
, vol.268
, Issue.5207
, pp. 80-83
-
-
Christ, W.J.1
Asano, O.2
Robidoux, A.L.3
Perez, M.4
Wang, Y.5
Dubuc, G.R.6
Gavin, W.E.7
Hawkins, L.D.8
McGuinness, P.D.9
Mullarkey, M.A.10
-
75
-
-
0034002247
-
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.4
, pp. 497-504
-
-
Lien, E.1
Means, T.K.2
Heine, H.3
Yoshimura, A.4
Kusumoto, S.5
Fukase, K.6
Fenton, M.J.7
Oikawa, M.8
Qureshi, N.9
Monks, B.10
Finberg, R.W.11
Ingalls, R.R.12
Golenbock, D.T.13
-
77
-
-
0033213590
-
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
-
(1999)
Immunity
, vol.11
, Issue.4
, pp. 443-451
-
-
Takeuchi, O.1
Hoshino, K.2
Kawai, T.3
Sanjo, H.4
Takada, H.5
Ogawa, T.6
Takeda, K.7
Akira, S.8
-
78
-
-
0034601022
-
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
-
(2000)
Journal of Experimental Medicine
, vol.192
, Issue.1
, pp. 23-30
-
-
Ogata, H.1
Su, Ih.2
Miyake, K.3
Nagai, Y.4
Akashi, S.5
Mecklenbrauker, I.6
Rajewsky, K.7
Kimoto, M.8
Tarakhovsky, A.9
-
80
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
(1998)
Immunity
, vol.9
, Issue.1
, pp. 143-150
-
-
Adachi, O.1
Kawai, T.2
Takeda, K.3
Matsumoto, M.4
Tsutsui, H.5
Sakagami, M.6
Nakanishi, K.7
Akira, S.8
-
81
-
-
0032526555
-
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
-
(1998)
Journal of Experimenatal Medicine
, vol.187
, Issue.12
, pp. 2073-2079
-
-
Kanakaraj, P.1
Schafer, P.H.2
Cavender, D.E.3
Wu, Y.4
Ngo, K.5
Grealish, P.F.6
Wadsworth, S.A.7
Peterson, P.A.8
Siekierka, J.J.9
Harris, C.A.10
Fung-Leung, W.P.11
-
82
-
-
0033565779
-
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
-
(1999)
Journal of Immunology
, vol.163
, Issue.2
, pp. 978-984
-
-
Thomas, J.A.1
Allen, J.L.2
Tsen, M.3
Dubnicoff, T.4
Danao, J.5
Liao, X.C.6
Cao, Z.7
Wasserman, S.A.8
-
85
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
(1999)
Genes and Development
, vol.13
, Issue.8
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
Duncan, G.S.4
Furlonger, C.5
Ho, A.6
Morony, S.7
Capparelli, C.8
Van, G.9
Kaufman, S.10
Van der Heiden, A.11
Itie, A.12
Wakeham, A.13
Khoo, W.14
Sasaki, T.15
Cao, Z.16
Penninger, J.M.17
Paige, C.J.18
Lacey, D.L.19
Dunstan, C.R.20
Boyle, W.J.21
Goeddel, D.V.22
Mak, T.W.23
more..
-
86
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
(2000)
Nature Genetics
, vol.25
, Issue.2
, pp. 187-191
-
-
Arbour, N.C.1
Lorenz, E.2
Schutte, B.C.3
Zabner, J.4
Kline, J.N.5
Jones, M.6
Frees, K.7
Watt, J.L.8
Schwartz, D.A.9
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