Immune responses in tuberculosis

Current Opinion in Immunology

Volumn 12, Issue 4, 2000, Pages 432-436

  Flynn, Joanne L ^a   Ernst, Joel D ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ANTIGEN DETECTION; CYTOKINE PRODUCTION; IMMUNE RESPONSE; MYCOBACTERIUM TUBERCULOSIS; PHAGOCYTOSIS; REVIEW; T LYMPHOCYTE; TUBERCULOSIS;

EID: 0034047937     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00116-3     Document Type: Review

References (37)

1. Brightbill H.D., Libraty D.H., Krutzik S.R., Yang R.B., Belisle J.T., Bleharski J.R., Maitland M., Norgard M.V., Plevy S.E., Smale S.T.et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 285:1999;732-736. This paper identifies, for the first time, a purified component of M. tuberculosis capable of interacting with TLR2 and stimulating production of IL-12p40 as well as inducing nitric oxide synthase 2.
2. Means T.K., Wang S., Lien E., Yoshimura A., Golenbock D.T., Fenton M.J. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol. 163:1999;3920-3927. This paper demonstrates, for the first time, that live M. tuberculosis interacts with two distinct TLRs.
3. Underhill D.M., Ozinsky A., Smith K.D., Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA. 96:1999;14459-14463.
4. Porcelli A., Morita C.T., Brenner M.B. CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. Nature. 360:1992;593-597.
5. Beckman E.M., Melian A., Behar S.M., Sieling P.A., Chatterjee D., Furlong S.T., Matsumoto R., Rosat J.P., Modlin R.L., Porcelli S.A. CD1c restricts responses of mycobacteria-specific T cells. J Immunol. 157:1996;2795-2803.
6. Beckman E.M., Porcelli S.A., Morita C.T., Bahar S.M., Furlong S.T., Brenner M.B. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature. 372:1994;691-694.
7. - T cells, could recognize lipid antigen presented by CD1 molecules. This expanded the role of CD1 presentation into the standard T cell subsets and suggested that cells restricted by CD1 may participate in adaptive resistance to infection.
8. Stenger S., Mazzaccaro R., Uyemura K., Cho S., Barnes P., Rosat J., Sette A., Brenner M., Porcelli S., Bloom B., Modlin R. Differential effects of cytolytic T cell subsets on intracellular infection. Science. 276:1997;1684-1687.
9. Flynn J.L., Goldstein M.M., Triebold K.J., Koller B., Bloom B.R. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA. 89:1992;12013-12017.
10. Van Kaer L., Ashton-Rickardt P.G., Ploegh H.L., Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface Class I molecules, and CD4-8+ T cells. Cell. 71:1992;1205-1214.
11. Spada F.M., Koezuka Y., Porcelli S.A. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J Exp Med. 188:1998;1529-1534.
12. + T cells in control of M. tuberculosis in mice. Unlike CD1, MHC class I presentation of peptides requires TAP molecules to transport peptide. Mice deficient in CD1d were used to demonstrate that CD1d-restricted T cells were not essential for control of this infection.
13. Dascher C.C., Hiromatsu K., Naylor J.W., Brauer P.P., Brown K.A., Storey J.R., Behar S.M., Kawasaki E.S., Porcelli S.A., Brenner M.B., LeClair K.P. Conservation of a CD1 multigene family in the guinea pig. J Immunol. 163:1999;5478-5488. Guinea pigs contain Group 1 CD1 molecules. This discovery suggests that this animal model will be useful to study the importance of CD1-restricted T cells in control of tuberculosis.
14. Mohagheghpour N., Gammon D., Kawamura L.M., van Vollenhoven A., Benike C.J., Engleman E.G. CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19kDa lipoprotein. J Immunol. 161:1998;2400-2406.
15. Zhu X., Stauss H.J., Ivanyi J., Vordermeier H.M. Specificity of CD8+ T cells from subunit vaccinated or infected H-2b mice recognizing the 38 kDa antigen of Mycobacterium tuberculosis. Int Immunol. 9:1997;1669-1676.
16. Lalvani A., Brookes R., Wilkinson R., Malin A., Pathan A., Andersen P., Dockrell H., Pasvol G., Hill A. Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci USA. 95:1998;270-275.
17. •].
18. + T cells present in the lungs of mice infected with M. tuberculosis are activated and produce IFN-γ and TNF-α.
19. Serbina N.V., Liu C.C., Scanga C.A., Flynn J.L. CD8+ cytotoxic T lymphocytes from lungs of M. tuberculosis infected mice express perforin in vivo and lyse infected macrophages. J Immunol. 2000;. in press.
20. Smith S.M., Malin A.S., Lukey P.T., Atkinson S.E., Content J., Huygen K., Dockrell H.M. Characterization of human Mycobacterium bovis bacille Calmette-Guerin-reactive CD8+ T cells. Infect Immun. 67:1999;5223-5230.
21. Canaday D.H., Ziebol C., Noss E.H., Chervenak K.A., Harding C.V., Boom W.H. Activation of human CD8+ αβ TCR+ cells by Mycobacterium tuberculosis via an alternate Class I MHC antigen processing pathway. J Immunol. 162:1999;372-379.
22. Lewinsohn D., Alderson M., Briden A., Riddell S., Reed S., Grabstein K. Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen presenting cells. J Exp Med. 187:1998;1633-1640.
23. Lindahl K.F., Byers D.E., Dabhi V.M., Hovik R., Jones E.P., Smith G.P., Wang C-R., Xiao H., Yoshino M. H2-M3, a full service Class IB histocompatibilitiy antigen. Annu Rev Immunol. 15:1997;851-879.
24. Pamer E.G., Wang C.R., Flaherty L., Lindahl K.F., Bevan M.J. H2-M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes. Cell. 70:1992;215-223.
25. Princiotta M.F., Lenz L.L., Bevan M.J., Staerz U.D. H2-M3 restricted presentation of a Listeria-derived leader peptide. J Exp Med. 187:1998;1711-1719.
26. + T cell response during primary and secondary Listeria monocytogenes infection. The H2-M3-restricted cells did not show enhanced expansion upon rechallenge with the pathogen, indicating diminished memory responses.
27. + T cells provide wild-type levels of IFN-γ in the lungs.
28. Tascon R.E., Stavropoulos E., Lukacs K.V., Colston M.J. Protection against Mycobacterium tuberculosis infection by CD8 T cells requires production of gamma interferon. Infect Immun. 66:1998;830-834.
29. Ting L.M., Kim A.C., Cattamanchi A., Ernst J.D. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol. 163:1999;3898-3906. Indicates, for the first time, that M. tuberculosis may survive despite an apparently effective cellular immune response by blocking the effects of IFN-γ.
30. Yoneda T., Ellner J.J. CD4(+) T cell and natural killer cell-dependent killing of Mycobacterium tuberculosis by human monocytes. Am J Respir Crit Care Med. 158:1998;395-403.
31. Silver R.F., Li Q., Boom W.H., Ellner J.J. Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: requirement for CD4+ T cells in purified protein derivative-positive, but not in purified protein derivative-negative subjects. J Immunol. 160:1998;2408-2417.
32. Stenger S., Hanson D.A., Teitelbaum R., Dewan P., Niazi K.R., Froelich C.S., Ganz T., Thomauszynski S., Melian A., Bogdan C.et al. An antimicrobial activity of cytotoxic T cells mediated by granulysin. Science. 282:1998;121-125.
33. Teitelbaum R., Cammer M., Maitland M.L., Freitag N.E., Condeelis J., Bloom B.R. Mycobacterial infection of macrophages results in membrane-permeable phagosomes. Proc Natl Acad Sci USA. 96:1999;15190-15195.
34. Cooper A.M., D'Souza C., Frank A.A., Orme I.M. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms. Infect Immun. 65:1997;1317-1320.
35. Laochumroonvorapong P., Wang J., Liu C.C., Ye W., Moreira A.L., Elkon K.B., Freedman V.H., Kaplan G. Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect Immun. 65:1997;127-132.
36. -/- and wild-type mice.
37. -/- mice have compensatory immune mechanisms that may confound simple interpretation of data obtained from infection in this model.