메뉴 건너뛰기




Volumn 2, Issue 3-4, 2000, Pages 231-259

Amyloid-β and treatment opportunities for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

4' IODOESORUBICIN; ALPHA SECRETASE INHIBITOR; AMMONIUM CHLORIDE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BAFILOMYCIN A1; BREFELDIN A; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALPASTATIN; CALRETININ; CARBAMAZEPINE; COLCHICINE; CYTOCHALASIN D; DIZOCILPINE; ENZYME INHIBITOR; ESTRADIOL; FREE RADICAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; MEPACRINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NIFEDIPINE; NIMODIPINE; OMEGA CONOTOXIN; RIFAMPICIN; TACRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER;

EID: 0034489963     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2000-23-405     Document Type: Article
Times cited : (9)

References (273)
  • 3
    • 0029115555 scopus 로고
    • The structure of the presenilin 1 (S182) gene identification of six novel mutations in early onset AD families
    • (1995) Nat Genet , vol.11 , pp. 219-222
  • 4
    • 0033616590 scopus 로고    scopus 로고
    • Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715→Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4119-4124
    • Ancolio, K.1    Dumanchin, C.2    Barelli, H.3
  • 5
  • 8
    • 0027085867 scopus 로고
    • Mechanisms of excitotoxicity in neurologic diseases
    • (1992) FASEB J , vol.6 , pp. 3338-3344
    • Beal, M.F.1
  • 14
    • 0024574009 scopus 로고
    • A role for apolipoprotein E, apolipoprotein A-1, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve
    • (1989) J Clin Invest , vol.83 , pp. 1015-1031
    • Boyle, J.K.1    Zoellner, C.D.2    Anderson, L.J.3
  • 15
    • 0001815909 scopus 로고
    • Pathology of Alzheimer's disease
    • Neurodegenerative Diseases Calne DB (ed) (Saunders, Philadelphia)
    • (1994) , pp. 585-613
    • Braak, H.1    Braak, E.2
  • 17
    • 0029549097 scopus 로고
    • Strategies for neuroprotection with glutamate antagonists. Extrapolating from evidence taken from the first stroke and head injury studies
    • (1995) Ann NY Acad Sci , vol.765 , pp. 272-278
    • Bullock, R.1
  • 27
  • 29
    • 0026659777 scopus 로고
    • Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF
    • (1992) Exp Neurol , vol.117 , pp. 114-123
    • Cheng, B.1    Mattson, M.P.2
  • 40
    • 0028972701 scopus 로고
    • Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity
    • (1995) Lancet , vol.346 , pp. 1524-1528
    • Cummings, B.J.1    Cotman, C.W.2
  • 47
    • 0029085982 scopus 로고
    • Excitatory amino acid receptors and neurodegeneration
    • (1995) Therapie , vol.50 , pp. 319-337
    • Doble, A.1
  • 49
    • 0023778493 scopus 로고
    • Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease
    • (1988) Neurosci Lett , vol.91 , pp. 354-359
    • Duyckaerts, C.1    Deaere, P.2    Pouain, V.3
  • 56
    • 0028971529 scopus 로고
    • Candidate gamma-secretases in the generation of the carboxyl terminus of Alzheimer's disease beta A4 amyloid: Possible involvement of cathepsin D
    • (1995) Biochemistry , vol.34 , pp. 14185-14192
    • Evin, G.1    Cappai, R.2    Li, Q.X.3
  • 62
    • 0026780737 scopus 로고
    • Increased expression of beta amyloid precursor protein and microtubule associated protein tau during the differentiation of murine embryonal carcinoma cells
    • (1992) J Neurochem , vol.58 , pp. 1863-1873
    • Fukuchi, K.1    Deeb, S.S.2    Kamino, K.3
  • 66
    • 0028030517 scopus 로고
    • Regulated cleavage of the Alzheimer amyloid precursor protein: Molecular and cellular basis
    • (1994) Biochimie , vol.76 , pp. 300-303
    • Gandy, S.1    Greengard, P.2
  • 70
    • 0000134682 scopus 로고    scopus 로고
    • Cholinesterase inhibitors do more than inhibit cholinesterase
    • Alzheimer's Disease: From Molecular Biology to Therapy Becker R, Giacobini E, (eds) (Birkhauser, Boston, 1997)
    • Giacobini, E.1
  • 71
    • 0033965730 scopus 로고    scopus 로고
    • Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation
    • (2000) Nat Med , vol.6 , pp. 133-134
    • Glabe, C.1
  • 72
    • 0025373986 scopus 로고
    • Expression of beta amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in Alzheimer disease during PCR
    • (1990) Neuron , vol.4 , pp. 253-267
    • Golde, T.E.1    Estus, S.2    Usiak, M.3
  • 75
    • 2542509819 scopus 로고    scopus 로고
    • The impact of different presenilin 1 and presenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's brain: Evidence for other phenotype modifying factors
    • (1999) Brain , vol.122 , pp. 1709-1719
    • Gomez-Isla, T.1    Growdon, W.B.2    McNamara, M.J.3
  • 76
    • 0028915895 scopus 로고
    • Amyloid β protein (Aβ) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42(43)
    • (1995) J Biol Chem , vol.270 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3
  • 83
    • 0026735070 scopus 로고
    • Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3
  • 101
    • 0029347120 scopus 로고
    • The role of β-amyloid in the development of Alzheimer's disease
    • (1995) Drugs Aging , vol.7 , pp. 97-109
    • Li, K.1
  • 102
    • 0006258580 scopus 로고    scopus 로고
    • Identification of the major Ab1-42 degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
    • (2000) Nat Med , pp. 6143-6150
    • Iwata, N.1    Tsubuki, S.2    Takai, Y.3
  • 103
    • 0028169925 scopus 로고
    • Visualization of Aβ42(43) and Aβ40 is senile plaques with end-specific Aβ monoclonal: Evidence that an initially deposited species is Aβ42(43)
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3
  • 104
    • 0026040620 scopus 로고
    • Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis
    • (1991) Neurobiol Aging , vol.12 , pp. 585-592
    • Jacobsen, J.S.1    Blume, A.J.2    Vitek, M.P.3
  • 107
    • 0027195933 scopus 로고
    • Seeding one-dimensional crystallization of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie
    • (1993) Cell , vol.173 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury, P.T.2
  • 111
    • 0027130674 scopus 로고
    • Cerebral microvasculature and immunological factors in Alzheimer's disease
    • (1993) Clin Neurosci , vol.1 , pp. 204-211
    • Kalaria, R.N.1
  • 116
    • 0028817351 scopus 로고
    • Cell-type and amyloid precursor protein-type specific inhibition of Aβ releaseby Bafilomycin A1 a selective inhibitor of vacuolar ATPases
    • (1995) J Biol Chem , vol.270 , pp. 2419-2422
    • Knops, J.1    Suomensaari, S.2    Lee, M.3
  • 118
    • 13344282063 scopus 로고    scopus 로고
    • Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
    • (1996) Nat Med , vol.2 , pp. 224-229
    • Kovacs, D.M.1    Fausett, H.J.2    Page, K.J.3
  • 132
    • 0025861679 scopus 로고
    • Is the pattern of nerve cell loss in aging and Alzheimer's disease a real, or only an apparent selectivity
    • (1991) Neurobiol Aging , vol.12 , pp. 340-343
    • Mann, D.M.1
  • 135
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
    • (1993) Neuron , vol.10 , pp. 243-254
    • Mattson, M.1    Cheng, B.2    Culwell, A.3
  • 136
    • 0028916920 scopus 로고
    • Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
    • (1995) Brain Res , vol.676 , pp. 219-224
    • Mattson, M.P.1    Goodman, Y.2
  • 147
    • 0034610792 scopus 로고    scopus 로고
    • Caspases find a new place to hide
    • (2000) Nature , vol.403 , pp. 29-30
    • Mehmet, H.1
  • 162
  • 163
    • 18844472315 scopus 로고
    • Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: Inverse correlation with severity of dementia and effect of apolipoprotein E genotype
    • (1995) Ann Neurol , vol.37 , pp. 512-518
    • Nitsch, R.M.1    Rebeck, G.W.2    Deng, M.3
  • 167
    • 0027745626 scopus 로고
    • NGF and the treatment of Alzheimer's disease
    • (1993) Exp Neurol , vol.124 , pp. 5-15
    • Olson, L.1
  • 195
    • 0027761330 scopus 로고
    • Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrage with amyloidosis-Dutch type and Alzheimer's disease
    • (1993) Am J Pathol , vol.142 , pp. 1449-1457
    • Rozemuller, A.J.1    Roos, R.A.2    Bots, G.T.3
  • 203
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 211
    • 0027367764 scopus 로고
    • Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease
    • (1993) Trends Neurosci , vol.16 , pp. 403-409
    • Selkoe, D.J.1
  • 214
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 235
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 237
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.-D.3
  • 238
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1    Town, T.2    Paris, D.3
  • 239
    • 0032507032 scopus 로고    scopus 로고
    • The ApoEepsilon 4 allele and the risk of Alzheimer's disease among African Americans, whites, and hispanics
    • (1998) JAMA , vol.279 , pp. 751-755
    • Tang, M.X.1    Stern, Y.2    Marder, K.3
  • 240
    • 0024370110 scopus 로고
    • Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene
    • (1989) Ann Med , vol.21 , pp. 91-94
    • Tanzi, R.E.1
  • 241
    • 0029041760 scopus 로고
    • Clinical implications for basic research: A promising animal model for Alzheimer's disease
    • (1995) New Eng J Med , vol.332 , pp. 1512-1513
    • Tanzi, R.E.1
  • 248
    • 0028177379 scopus 로고
    • Concentrations of alpha-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia
    • (1994) Neurosci Lett , vol.174 , pp. 73-76
    • Tohgi, H.1    Abe, T.2    Nakanishi, M.3
  • 250
    • 0029863551 scopus 로고    scopus 로고
    • Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger
    • (1996) J Biol Chem , vol.271 , pp. 6839-6844
    • Tomiyama, T.1    Shoji, A.2    Kataoka, K.3
  • 255
  • 259
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the 9M-Best study (Benefit and efficacy in severely demented patients during treatment with memantine
    • (1999) Int J Geriat Psychiatry , vol.14 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 261
    • 0031037424 scopus 로고    scopus 로고
    • Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
    • (1997) Ann Neurol , vol.41 , pp. 82-93
    • Winkler, J.1    Ramirez, G.A.2    Kuhn, H.G.3
  • 272
    • 0028945660 scopus 로고
    • Evidence that Aβ42 is the real culprit in Alzheimer's disease
    • (1995) Ann Neurol , vol.37 , pp. 287-288
    • Younkin, S.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.