Degradation of amyloid β-protein by a serine protease-α2-macroglobulin complex

Journal of Biological Chemistry

Volumn 271, Issue 14, 1996, Pages 8443-8451

  Qiu, Wei Qiao ^a   Borth, Wolfgang ^b   Ye, Zhen ^a   Haass, Christian ^a   Teplow, David B ^a   Selkoe, Dennis J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID BETA PROTEIN; SERINE PROTEINASE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENILE PLAQUE;

ALPHA-MACROGLOBULINS; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHO CELLS; CRICETINAE; CULTURE MEDIA; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MULTIENZYME COMPLEXES; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES;

ANIMALIA; BOVINAE;

EID: 0013642132     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.14.8443     Document Type: Article

References (35)

1. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10, 373-403
2. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
3. Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., and Muller-Hill, B. (1987) Nature 325, 733-736
4. Mullan, M., and Crawford, F. (1993) Trends Neurosci. 16, 398-403
5. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
6. Cai, X.-D., Golde, T. E., and Younkin, G. S. (1993) Science 259, 514-516
7. Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264, 1336-1340
8. Haass, C., Hung, A. Y., Selkoe, D. J., and Teplow, D. B. (1994) J. Biol. Chem. 269, 17741-17748
9. Mann, D. M. A. (1989) Neurobiol. Aging 10, 397-399
10. Giaccone, G., Tagliavini, F., Linoli, G., Bouras, C., Frigerior, L., Frangione, B., and Bugiani, O. (1989) Neurosci. Lett. 97, 232-238
11. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B., and Zhao, J. (1995) Nature 373, 523-527
12. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M. G., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D. J., Lieberburg, I., and Schenk, D. (1992) Nature 359, 325-327
13. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe. D. J. (1992) Nature 359, 322-325
14. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1992) Science 258, 126-129
15. Resnick, N. M., Maloy, W. L., Guy, H. R., and Zasloff, M. (1991) Cell 66, 541-554
16. Sweeney, P. J., Darker, J. G., Neville, W. A., Humphries, J., and Camilleri, P. (1993) Anal. Biochem. 212, 179-184
17. Beynon, R. J., and Salvesen, R. (1993) in Proteolytic Enzymes: A Practical Approach (Beynon, R. J., and Bond, J. S., eds) pp. 241-249, IRL Press, Oxford
18. Borth, W. (1992) FASEB J. 6, 3345-3353
19. Sottrup-Jensen, L., Stepanik, T. M., Kristensen, T., Wierzbicki, D., Jones, C. M., Lonbland, P. B., Magnusson, S., and Petersen, T. E. (1984) J. Biol. Chem. 259, 8318
20. Uchino, T., Sakurai, Y., Nishigai, M., Takahashi, T., Arakawa, H., Ikai, A., and Takahashi, K. (1993) J. Biol. Chem. 268, 527-533
21. Van Leuven, F., Marynen, P., Cassiman, J., and Van Den Berghe, H. (1988) J. Biol. Chem. 263, 468-471
22. Lorenzo, A., Razzaboni, B., Weir, G. C., and Yankner, B. A. (1994) Nature 368, 756-760
23. Barrow, C. J., Yasuda, A., Kenny, P. T. M., and Zagorski, M. G. (1992) Mol. Biol. 225, 1075-1093
24. Naidu, A., Quon, D., and Cordell, B. (1995) J. Biol. Chem. 270, 1369-1374
25. Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., and Berger, M. (1991) FEBS Lett. 285, 111-114
26. Gool, D. V., de Strooper, B., Leuven, F. V., Triau, E., and Dom, R. (1993) Neurobiol. Aging 14, 233-237
27. Rebeck, G. W., Reiter, J. S., Strickland, D. K., and Hyman, B. T. (1993) Neuron 11, 575-580
28. Rebeck, G. W., Harr, S. D., Strickland, D. K., and Hyman, B. T. (1995) Ann. Neurol. 37, 211-217
29. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
30. Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9649-9653
31. Hyman, B. T., West, H. L., Rebeck, G. W., Lai, F., and Mann, D. M. A. (1995) Arch. Neurol. 52, 373-378
32. McConnell, D. J. (1972) J. Clin. Invest. 51, 1611-1623
33. Vogt, V., and Dugal, B. (1976) Naunyn-Schmiedebergs Arch. Pharmacol. 294, 75-84
34. Tsuji, A., and Karachi, K. (1989) J. Biol. Chem. 264, 16093-16099
35. Tsuji, A., Arai, T., Furcinitti, P. S., Langmore, J. P., and Kurachi, K. (1991) Biochim. Biophys. Acta 1078, 85-93