The apolipoprotein E allele ε4 does not correlate with the number of senile plaques or neurofibrillary tangles in patients with Alzheimer's disease

Journal of Neurology Neurosurgery and Psychiatry

Volumn 61, Issue 4, 1996, Pages 352-356

  Landén, Mikael ^a   Thorsell, Annika ^a   Wallin, Anders ^a   Blennow, Kaj ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Alzheimer's disease; Apolipoprotein E; Neurofibrillary tangles; Senile plaques; Vascular dementia

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; TAU PROTEIN;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRONTAL CORTEX; GENE FREQUENCY; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIINFARCT DEMENTIA; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; ONSET AGE; PRIORITY JOURNAL; SENILE PLAQUE;

EID: 0029857204     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.61.4.352     Document Type: Article

References (55)

1. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240:622-30.
2. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985; 76:1501-13.
3. Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH. Lipoproteins and their receptors in the central nervous system. J Biol Chem 1987;262:14352-60.
4. Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lioproteins. Biochem Biophys Acta 1987;917:148-61.
5. Poirier J, Hess M, May PC, Finch CE. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol Brain Res 1991;11:97-106.
6. Stoll G, Mueller HW, Trapp BD, Griffin JW. Oligodendrocytes but not astrocytes express apolipoprotein E after injury of rat optic nerve. Glia 1989;2:170-6.
7. Poirier J, Hess M, May PC, Finch CE. Cloning of hippocampal poly(A) RNA sequences that increase after entorhinal cortex lesion in adult rat. Mol Brain Res 1991; 9:191-5.
8. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 1991;541:163-6.
9. Pericak-Vance MA, Bebout JL, Gaskell PC, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034-50.
10. Wisniewski T, Frangione B. Apolipoprotein E. A pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992;135:235-8.
11. Strittmatter WJ, Weisgraber KH, Huang DY, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:8098-102.
12. Zannis VI, Breslow JL, Uttermann G, et al. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res 1982;23:911-4.
13. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:1977-81.
14. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurol 1993;43:1467-72.
15. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261:921-3.
16. Noguchi S, Murakami K, Yamada N. Apolipoprotein E genotype and Alzheimer's disease: letter. Lancet 1993; 342:737.
17. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-9.
18. Saunders AM, Schmader K, Breitner JC, et al. Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 1993;342:710-1.
19. Lehtimäki T, Pirttilä T, Mehta PD, Wisniewski HM, Frey H, Nikkari T. Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease. Hum Genet 1995;95:39-42.
20. Hardy J, Crook R, Prihar G, Roberts G, Raghavan R, Perry R. Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease. Neurosci Lett 1994;182:1-2.
21. Lippa CF, Smith TW, Saunders AM, et al. Apolipoprotein E genotype and Lewy body disease. Neurol 1995;45: 97-103.
22. Bëtard C, Robitaille Y, Gee M, et al. Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. Neuroreport 1994;5:1893-6.
23. Pickering-Brown SM, Mann DMA, Bourke JP, et al. Apolipoprotein E4 and Alzheimer's disease pathology in Lewy body disease and in other beta-amyloid-forming diseases [letter]. Lancet 1994;343:1155.
24. Frisoni GB, Calabresi L, Geroldi C, et al. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia. Dementia 1994;5:240-2.
25. Frisoni GB, Geroldi C, Bianchetti A, et al. Apolipoprotein E epsilon 4 allele frequency in vascular dementia and Alzheimer's disease [letter]. Stroke 1994;25:1703-4.
26. Shimano H, Ishibashi S, Murase T, et al. Plasma apolipoproteins in patients with multi-infarct dementia. Atherosclerosis 1989;79:257-60.
27. Harrington CR, Louwagie J, Rossau R, et al. Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease. Am J Pathol 1994;145: 1472-84.
28. Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994;309:636-8.
29. Stengård JH, Pekkanen J, Sulkava R, Ehnholm C, Erkinjuntti T. Apolipoprotein E polymorphism, Alzheimers disease and vascular dementia among elderly Finnish men. Acta Neur Scand 1995;92:297-8.
30. Ma J, Yee A, Brewer HB, Jr., Das S, Potter H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments: see comments. Nature 1994;372:92-4.
31. Strittmatter WJ, Weisgraber KH, Goedert M, et al. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 1994;125: 163-74.
32. Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994;17: 525-30.
33. Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 1994;264: 850-2.
34. Sanan DA, Weisgraber KH, Russell SJ, et al. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J Clin Invest 1994;94:860-9.
35. LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, Frail DE. Isoform-specific binding of apolipoprotein E to β-amyloid. J Biol Chem 1994;269:23403-6.
36. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993;11: 575-80.
37. Schmechel DE, Saunders AM, Strittrnatter WJ, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:9649-53.
38. Hyman BT, West HL, Rebeck GW, et al. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc Natl Acad Sci USA 1995;92:3586-90.
39. Soininen H, Kosunen O, Helisalmi S, et al. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele. Neurosci Lett 1995 Mar 3 1995;187:79-82.
40. Morris CM, Benjamin R, Leake A, et al. Effect of apolipoprotein E genotype on Alzheimers disease neuropathology in a cohort of elderly Norwegians. Neurosci Lett 1995;201:45-8.
41. Strittmatter WJ, Saunders AM, Goedert M, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci USA 1994;91:11183-6.
42. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimers disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimers Disease. Neurology 1984;34: 939-44.
43. Alafuzoff I, Iqbal K, Fridén H, Adolfsson R, Winblad B. Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol 1987;74: 209-25.
44. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985;42:1097-105.
45. Adolfsson R, Gottfries CG, Nyström L, Winblad B. Prevalence of dementia disorders in institutionalized Swedish old people. The work load imposed by caring for these patients. Acta Psychiatr Scand 1981;63:225-44.
46. Worm-Petersen J, Pakkenberg H. Atherosclerosis of cerebral arteries, pathological and clinical correlations. Gerontology 1980;221:237-47.
47. Alafuzoff I, Adolfsson R, Grundke-Iqbal I, Winblad B. Perivascular deposits of serum proteins in cerebral cortex in vascular dementia. Acta Neuropathol (Berl) 1985;66: 292-8.
48. Richey PL, Siedlak SL, Smith MA, Perry G. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis. Biochem Biophys Res Commun 1995;208: 657-63.
49. Gearing M, Schneider JA, Robbins RS, et al. Regional variation in the distribution of apolipoprotein E and A in Alzheimers disease. J Neuropathol Exp Neurol 1995;54: 833-41.
50. Kida E, Golabek AA, Wisniewski T, Wisniewski KE. Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain. Neurosci Lett 1994;167:73-6.
51. Hansen LA, Galasko D, Samuel W, Xia Y, Chen X, Saitoh T. Apolipoprotein-E epsilon-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease. Neurosci Lett 1994;182:63-5.
52. Oyama F, Shimada H, Oyama R, Ihara Y. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population. Brain Res Mol Brain Res 1995;29:92-8.
53. Han SH, Hulette C, Saunders AM, et al. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp Neurol 1994;128:13-26.
54. Benzing WC, Mufson EJ. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to Tau and PHF in Alzheimer's disease. Exp Neurol 1995;132: 162-71.
55. Holtzman DM, Pitas RE, Kilbridge J, et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 1995;92:9480-4.