Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation

Neurochemistry International

Volumn 37, Issue 2-3, 2000, Pages 83-102

  Hertz, Leif ^a   Yu, Albert C H ^b   Kala, Geeta ^c   Schousboe, Arne ^d  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Ammonia toxicity; Astrocytes; Cerebral ischemia; Glucose metabolism; Glutamate metabolism; Glutamate glutamine cycle; Neurons; Pyruvate carboxylation

Indexed keywords

AMMONIA; GLUTAMIC ACID;

AMINO ACID METABOLISM; ANIMAL TISSUE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL COMPARTMENTALIZATION; CITRIC ACID CYCLE; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HYPERAMMONEMIA; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALIA;

EID: 0034257070     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(00)00012-7     Document Type: Article

References (185)

1. Aas J.E., Berg-Johnsen J., Hegstad E., Laake J.H., Langmoen I.A., Ottersen O.P. Redistribution of glutamate and glutamine in slices of human neocortex exposed to combined hypoxia and glucose deprivation in vitro. Journal of Cerebral Blood Flow and Metabolism. 13:1993;503-515.
2. Albrecht J. Roles of neuroactive amino acids in ammonia neurotoxicity. Journal of Neuroscience Research. 51:1998;133-138.
3. Auer R.N., Siesjo B.K. Hypoglycemia: brain neurochemistry and neuropathology. Baillieres Clinicals Endocrinol. Metab. 7:1993;611-625.
4. 13C-NMR spectroscopy. Brain Research. 765:1997;218-227.
5. 13C-magnetic resonance spectroscopy to studies of neuronal/glial relationships. Developmental Neuroscience. 20:1998;277-288.
6. Back T. Pathophysiology of the ischemic penumbra-revision of a concept. Cellular and Molecular Neurobiology. 18:1998;621-638.
7. 13C]glutamate metabolism in astrocytes during hypoglycemia and hypoxia. Journal of Neuroscience Research. 51:1998;636-645.
8. Barinaga M. What makes brain neurones run? Science. 276:1997;196-198.
9. Barnett N.L., Pow D.V., Plenderleith M.B., Robinson S.R. Inhibition of glutamine synthetase suppresses the electroretinogram B-wave in the rat. Abstracts, Society for Neuroscience. 22:1996;121.
10. Beckstrom H., Julsrud L., Haugeto O., Dewar D., Graham D.I., Lehre K.P., Storm-Mathisen J., Ottersem O.P. Interindividual differences in the levels of the glutamate transporters GLAS and GLT, but no clear correlation with Alzheimer's disease. Journal of Neuroscience Research. 55:1999;218-229.
11. Belayev L., Zhao W., Busto R., Ginsberg M. Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation. Journal of Cerebral Blood Flow and Metabolism. 17:1997;1266-1280.
12. Benjamin A.M., Quastel J.H. Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: A possible role of ammonia in brain function. Journal of Neurochemistry. 25:1975;197-206.
13. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. Journal of Neurochemistry. 43:1984;1369-1374.
14. Bergles D.E., Jahr C.E. Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus. Journal of Neuroscience. 18:1998;7709-7716.
15. Bittar P.G., Charnay Y., Pellerin L., Bouras C., Magistretti P.J. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. Journal of Cerebral Blood Flow and Metabolism. 16:1996;1079-1089.
16. Bolwig T., Quistorff B. In vivo concentration of lactate in the brain of conscious rats before and during seizures: a new ultrarapid technique for the freeze-sampling of brain tissue. Journal of Neurochemistry. 21:1973;1345-1348.
17. Broer S., Rahmanm B., Pellegri G., Pellerin L., Martin J.L., Verleysdonk S., Hamprecht B., Magistretti P.J. Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 expressing xenopus laevis oocytes. Journal of Biological Chemistry. 272:1997;30096-30102.
18. Broer S., Broer A., Schneider H.P., Stegen C., Halestrap A.P., Deitmer J.W. Characterization of the high-affinity monocarboxylate transporter MCT2 in xenopus laevis oocytes. Biochemical Journal. 341:1999;529-535.
19. Bull N.D., Barnett N.L. Physiological effects of the specific inhibition of retinal Muller cells. Proceedings of the Australian Neuroscience Society. 10:1999;190.
20. Butterworth R.F. Effects of hyperammonemia on brain function. 1998. Journal of Inherited and Metabolic Disease 21. Supplementum. 1:1998;6-20.
21. Caragine L.P., Park H.K., Diaz F.G., Phillis J.W. Real-time measurement of ischemia-evoked glutamate release in the cerebral cortex of four and 11 vessel rat occlusion models. Brain Research. 793:1998;255-264.
22. 13C NMR. Journal of Biological Chemistry. 265:1990;12916-12926.
23. Choi D.D. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
24. Chaudry F.A., Lehre K.P., van Lookeren Campagne M., Ottersen O.P., Danbolt N.C., Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron. 15:1995;711-720.
25. Christensen T., Bruhn T., Diemer N.H., Schousboe A. Effect of phenylsuccinate on potassium- and ischemia-induced release of glutamate in rat hippocampus monitored by microdialysis. Neuroscience Letters. 134:1991;71-74.
26. +-induced spreading cortical depression. Journal of Cerebral Blood Flow and Metabolism. 19:1999;380-392.
27. Cutler R.W.P., Dudzinski D.S. Regional changes in amino acid content in developing rat brain. Journal of Neurochemistry. 23:1974;1005-1009.
28. D'Amelio F., Eng L.A., Gibbs M.A. Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system. GLIA. 3:1990;335-341.
29. +]coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience. 51:1992;295-310.
30. de Knegt R.J., Schalm S.W., van der Rijt C.C., Fekkes D., Dalm E., Hekking-Weyma I. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. Journal of Hepatology. 20:1994;19-26.
31. Demestre M., Boutelle M., Fillenz M. Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate. Journal of Physiology. 499:1997;825-832.
32. Derouiche A., Frotcher M. Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: evidence for transmitter degradation. Brain Research. 552:1991;346-350.
33. 14C]glucose into tricarboxylic acid cycle-derived metabolic pools in neurons and glia during and after sensory stimulation. Journal of Neurochemistry. 69:(Supplementum):1997;S274B.
34. Di Monte D.A., Tokar I., Langston J.W. Impaired glutamate clearance as a consequence of energy failure caused by MPP(+) in astrocytic cultures. Toxicology and Applied Pharmacology. 158:1999;296-302.
35. Drejer J., Larsson O.M., Schousboe A. Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Experimental Brain Research. 47:1982;259-269.
36. Dringen R., Wiesinger H., Hamprecht B. Uptake of L-lactate in cultured brain neurons. Neuroscience Letters. 163:1993;5-7.
37. 14C]lactate into the glycogen of cultured mouse astroglial clls. Evidence for gluconeogenesis in brain cells. Biological Chemistry Hoppe Seyler. 374:1993;343-347.
38. Fillenz M., Lowry J.P. Studies of the source of glucose in the extracellular compartment of the rat brain. Developmental Neuroscience. 20:1999;365-368.
39. Fitzpatrick S.M., Cooper A.J.L., Hertz L. Effects of ammonia and β-methylene-D-L-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary cultures. Journal of Neurochemistry. 51:1988;1197-1203.
40. Fonnum F. The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guineapig brain. Biochemical Journal. 106:1968;401-412.
41. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. Journal of Neurochemistry. 42:1984;1-11.
42. Fonnum F., Myhrer T., Paulsen R.E., Wangen K., Oksengard A.R. Role of glutamate and glutamate receptors in memory function and Alzheimer's disease. Annals of the New York Academy of Sciences, 757:1995;475-486.
43. Fonnum F., Johnsen A., Hassel B. Use of fluorocitrate and fluoroacetate in the study of brain metabolism. GLIA. 21:1997;106-113.
44. Fonnum F., Fykse E.M., Roseth S. Uptake of glutamate into synaptic vesicles. Progress in Brain Research. 116:1998;87-101.
45. Forsyth R.J. Astrocytes and the delivery of glucose from plasma to neurons. Neurochemistry International. 28:1996;231-324.
46. Fox P.T., Raichle M.E. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Science U.S.A. 83:1986;1140-1144.
47. Fray A.E., Forsyth R.J., Boutelle M.G., Fillenz M. The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study. Journal of Physiology. 496:1996;49-57.
48. Gaitonde M.E., Richter D. Changes with age in the utilisation of glucose carbon in liver and brain. Journal of Neurochemistry. 13:1966;309-1318.
49. Gajkowska B., Gadamski R., Mossakowski M. Immuno-electron microscopic demonstration of GABA and glutamate synapses in Mongolian gerbils hippocampus after ischemia. Folia Neuropathologica. 33:1995;5-19.
50. Gerhart D.Z., Enerson B.E., Zhdankina O.Y., Leino R.L., Drewes L.R. Expression of the monocarboxylate transporter MCT2 by rat brain glia. GLIA. 22:1998;272-281.
51. Gerhart D.Z., Leino R.L., Drewes L.R. Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina. Neuroscience. 92:1999;367-375.
52. Gibbs M.E., O'Dowd B.S., Hertz L., Robinson S.R., Sedman G.R., Ng K.T. Inhibition of glutamine synthetase activity prevents memory consolidation. Cognitive Brain Research. 4:1996;57-64.
53. Ginsberg M.D., Belayev L., Zhao W., Back T., Dalton Dietrich W., Busto R. The pathophysiological significanse of metabolism/blood flow uncoupling in acute ischemic and traumatic brain injury. Kriglstein J. Pharmacology of Cerebral Ischemia. 1996;245-258 Wissenschaftliche Verlagsgesellschaft, Stuttgart.
54. Goldberg M.P., Monyer H., Choi D.W. Hypoxic neuronal injury in vitro depends on extracellular glutamine. Neuroscience Letters. 94:1988;52-57.
55. 13C]glucose. Journal of Neurochemistry. 63:1994;1377-1385.
56. 13C-NMR of glutamate metabolism in the human brain: initial results at 4 Tesla. Developmental Neuroscience. 20:1998;380-388.
57. Gundersen V., Ottersen O.P., Storm-Mathisen J. Selective excitatory amino acid uptake in glutamatergic nerve terminals and in glia in the rat striatum: quantitative electron microscopic immunocytochemistry of exogenous (D)-aspartate and endogenous glutamate and GABA. European Journal of Neuroscience. 8:1996;758-765.
58. Gundersen V., Chaudhry F.A., Bjaalie J.G., Fonnum F., Ottersen O.P., Storm-Mathisen J. Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. Journal of Neuroscience. 18:1998;6059-6070.
59. 13C-NMR spectroscopy studies of pyruvate recycling in brain. Developmental Neuroscience. 20:1998;389-398.
60. 13C nuclear magnetic resonance spectroscopy: a novel approach to the study of middle artery occlusion in the rat. Journal of Cerebral Blood Flow and Metabolism. 18:1998;1223-1232.
61. Hawkins R.A., DeJoseph M.R., Hawkins P.A. Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate. Cell and Tissue Research. 281:1995;207-214.
62. Hertz L., Fillenz M. Does "the mystery of the extra glucose" during CNS activation reflect glutamate synthesis? Neurochemistry International. 34:1999;71-75.
63. Hertz L., Bock E., Schousboe A. GFA content, glutamate uptake and activity of glutamate metabolizing enzymes in differentiating mouse astrocytes in primary cultures. Developmental Neuroscience. 1:1978;226-238.
64. Hertz L., Gibbs M.E., O'Dowd B.S., Sedman G.L., Robinson S.R., Peng L., Huang R., Hertz E., Hajek I., Sykova E., Ng K.T. Astrocyte-neuron interaction during one-trial aversive learning in the neonate chick. Neuroscience and Biobehavioral Reviews. 20:1996;537-551.
65. Hertz L., Swanson R.A., Newman G.C., Mariff H., Juurlink B.H.J., Peng L. Can experimental conditions explain the discrepancy whether or not glutamate stimulates aerobic glycolysis? Developmental Neuroscience. 20:1998;339-347.
66. Hertz L., Dringen R., Schousboe A., Robinson S.R. Astrocytes: Glutamate producers for neurons. Journal of Neuroscience Research. 57:1999;417-428.
67. Hossmann K.A. Viability thresholds and the penumbra of focal iscemia. Annals of Neurology. 36:1994;557-565.
68. Huang R., Hertz L. Effect on anoxia on glutamate formation from glutamine in cultured neurons: dependence on neuronal subtype. Brain Research. 660:1994;129-137.
69. + of anoxic release of newly synthesized neuronal glutamate. NeuroReport. 6:1995;2404-2408.
70. Huang R., Hertz L. Neuroprotective effect of phenylsuccinate, an inhibitor of cytosolic glutamate formation from glutamine, under anoxic conditions but not during exposure to exogenous glutamate. Neuroscience Letters. 183:1995;22-26.
71. Huang R., Shuaib A., Hertz L. Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions. Brain Research. 618:1993;346-351.
72. Huang R., Kala G., Murthy Ch.R.K., Hertz L. Effects of chronic exposure to ammonia on glutamate and glutamine interconversion and compartmentation in homogenous primary cultures of mouse astrocytes. Neurochemical Research. 19:1994;257-265.
73. + in neuronal cell death durimg and after anoxia/ischemia. Neuroscience and Biobehavioral Reviews. 21:1997;129-134.
74. Izquierdo I., Medina J.H. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiology of Learning and Memory. 68:1997;285-316.
75. Jelinski S.E., Yager J.Y., Juurlink B.H. Preferential injury of oligodendroblasts by a short hypoxic-isdchemic insult. Brain Research. 815:1999;150-153.
76. Jorgensen S.O., Brooksbank B.W., Balazs R. Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer diease. Journal of Neurological Science. 98:1990;63-79.
77. Juurlink B.H.J., Schultke E., Hertz L. Glutathione release and catabolism during energy substrate restriction in astrocytes. Brain Research. 710:1996;229-233.
78. Kaczmarek L. Glutamate receptor-driven gene expression in learning. Acta Neurobiologica Experimentales. 53:1993;187-196.
79. Kala, G., 1991. Cerebrotoxic effects of ammonia at the cellular level. Ph.D. thesis, University of Saskatchewan, Saskatchewan, Canada.
80. + uptake, and enhanced production of ouabain-like compounds in ammonia-treated mouse astrocytes. Neurochemistry International 36, 203-211.
81. Kato H., Kogure K. Biochemical and molecular characteristics of the brain with developing cerebral infarction. Cellular and Molecular Neurobiology. 19:1999;93-108.
82. Kaufman E., Driscoll B.F. Carbon dioxide fixation in neuronal and astroglial cells in culture. Journal of Neurochemistry. 58:1992;258-262.
83. Keyser D.O., Pelmar T.C. Synaptic transmission in the hippocampus: critical role for glial cells. GLIA. 10:1994;237-243.
84. Kojima S., Nakamura T., Nidaira T., Nakamura K., Ooashi N., Ito E., Watase K., Tanaka K., Wada K., Kudo Y., Miyakawa H. Optical detection of synaptically induced glutamate transport in hippocampal slices. Journal of Neuroscience. 19:1999;2580-2588.
85. 13C NMR spectroscopy. NMR Biomedicine. 6:1993;264-277.
86. Kurz G.M., Wiesinger H., Hamprecht B. Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glia of neural primary cultures. Journal of Neurochemistry. 60:1993;1467-1474.
87. Laake J.H., Slyngstad T.A., Haug F.-M.S., Ottersen O.P. Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures. Journal of Neurochemistry. 65:1995;871-881.
88. Laake J.H., Takumi Y., Eidet J., Torgner I.A., Roberg B., Kvamme E., Ottersen O.P. Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum. Neuroscience. 88:1999;1137-1151.
89. 13C] glucose metabolites. Journal of Biological Chemistry. 269:1994;27198-27208.
90. 15N coupling patterns and isotopic shifts. European Journal of Biochemistry. 243:1997;597-604.
91. Lehre P., Danbolt N.C. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult brain. Journal of Neuroscience. 18:1998;8751-8757.
92. Le Prince G., Delaere P., Fages C., Lefrancois T., Touret M., Salanon M., Tardy M. Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type. Neurochemical Research. 29:1995;859-862.
93. Li S., Mallory M., Alford M., Tanaka S., Masliah E. Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. Journal of Neuropathology and Experimental Neurology. 56:1997;901-911.
94. Lowe S.L., Bowen D.M., Francis P.T., Neary D. Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience. 38:1990;571-577.
95. Lowry J.P., Fillenz M. Evidence for the uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum. Journal of Physiology. 498:1997;497-501.
96. Madsen P.L., Cruz N.F., Dienel G.A. Metabolite flux to and from brain and levels of metabolites in brain of rats during rest, sensory stimulation, and recovery. Journal of Cerebral Blood Flow and Metabolism. 15:1995;S77.
97. Madsen P.L., Hasselbalch S.G., Hagemann L.P., Olsen K., Bulow J., Holm S., Wildschiodtz G., Paulson O.B., Lassen N.A. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. Journal of Cerebral Blood Flow and Metabolism. 15:1995;485-491.
98. Madsen P.J., Linde R., Hasselbach S.G., Paulson O., Lassen N.A. Activation-induced resetting of cerebral oxygen and glucose uptake in the rat. Journal of Cerebral Blood Flow and Metabolism. 18:1998;742-748.
99. Madsen P.L., Cruz N.F., Sokoloff L., Dienel G.A. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. Journal of Cerebral Blood Flow and Metabolism. 19:1999;393-400.
100. Magistretti P.J., Pellerin L., Rothman D.L., Shulman R.G. Energy on demand. Science. 283:1999;496-497.
101. Marcaida G., Felipo V., Hermengildo C., Minana M.D., Grisolia S. Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors. FEBS Letters. 296:1992;67-68.
102. Marcaida G., Minana M.D., Burgal M., Grisolia S., Felipo V. Ammonia prevents activation of NMDA receptors by glutamate in rat cerebellar neuronal cultures. European Journal of Neuroscience. 7:1995;2389-2396.
103. Mason G.F., Gruetter R., Rothman D.L., Behar K.L., Shulman R.G., Novotny E.J. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange and glutamine synthesis in human brain by NMR. Journal of Cerebral Blood Flow and Metabolism. 15:1995;12-25.
104. McKenna M.C., Tildon J.T., Stevenson J.H., Kingwell K. Regulation of astrocyte malic enzyme by metabolities. Transactions of the American Society for Neurochemistry. 24:1993;A54.
105. McKenna M.C., Tildon J.T., Stevenson J.H., Hopkins I.B., Huang X., Couto R. Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificity. Developmental Neuroscience. 20:1998;300-309.
106. 3H]glutamate in rat brin tissue. Brain Research. 115:1976;139-140.
107. Mena X.X., Cotman C.W. Pathologic concentrations of ammonium ions block L-glutamate uptake. Experimental Neurology. 89:1985;259-263.
108. Mitani A., Andou Y., Matsuda S., Arai T., Sakanaka M., Kataoka K. Origin of ischemia-induced glutamate efflux in the CA1 field of the gerbil hippocampus: an in vivo brain microdialysis study. Journal of Neurochemistry. 63:1994;2152-2164.
109. Myhrer T. Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease. Neuroscience and Biobehavioral Reviews. 23:1998;131-139.
110. Newcomb R., Sun X., Taylor L., Curthoys N., Giffard R.G. Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death. Journal of Biological Chemistry. 272:1997;11276-11282.
111. Newcomb R., Pierce A.R., Kano T., Meng W., Bosque-Hamilton P., Taylor L., Curthoys N., Lo E.H. Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Research. 813:1998;103-111.
112. Ng K.T., Rickard N.S., O'Dowd B.S., Zhao W.G., Gibbs M.E., Sedman G.M., Robinson S.R., Hertz L. Complex roles of glutamate in the Gibbs-Ng model of one-trial aversive learning in the new-born chick. Neuroscience and Biobehavioral Reviews. 21:1997;45-54.
113. Norenberg M.D. Astroglial dysfunction in hepatic encephalopathy. Metabolic Brain Disease. 13:1998;319-335.
114. Norenberg M.D., Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Research. 161:1979;303-310.
115. Norenberg M.D., Huo Z., Neary J.T., Roig-Cantesano A. The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission. GLIA. 21:1997;124-133.
116. O'Dowd, B.S., 1995. Metabolic activity in astrocytes is essential for the consolidation of one-trial passive avoidance memory in day-old chick. Ph.D. thesis, La Trobe University, Bundoora, Victoria, Australia.
117. Oldendorf W.H. Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection. American Journal of Physiology. 221:1971;1629-1635.
118. Olney J.W. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: an electron microscopic study. Journal of Neuropathology and Experimental Neurology. 30:1971;75-90.
119. Oppong K.N., Bartlett K., Record C.O., al Mardini H. Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat. Hepatology. 22:1995;553-558.
120. Orrego F., Villanueva S. The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization. Neuroscience. 56:1993;539-555.
121. Ottersen O.P. Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses. Journal of Chemical Neuroanatomy. 12:1996;1-14.
122. Ozkan E.D., Ueda T. Glutamate transport and storage in synaptic vesicles. Japanese Journal of Pharmacology. 77:1998;1-10.
123. Palaiologos G., Hertz L., Schousboe A. Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate. Journal of Neurochemistry. 51:1988;317-320.
124. Palaiologos G., Hertz L., Schousboe A. Role of aspartate amino-transferase and mitochondrial dicarboxylate transport for release of endogeneously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochemical Research. 14:1989;359-366.
125. Pascual J.M., Carceller F., Roda J.M., Cerdan S. Glutamate, glutamine and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. Stroke. 29:1998;1048-1057.
126. Peng L., Hertz L., Huang R., Sonnewald U., Petersen S.B., Westergaard N., Larsson O., Schousboe A. Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA. Developmental Neuroscience. 15:1993;367-377.
127. Peng L., Zhang X., Hertz L. High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes, but have no stimulatory effect in a GABAergic neuronal culture. Brain Research. 663:1994;168-172.
128. Peng L., Zhang X., Hertz L. Alteration in oxidative metabolism of alanine in cerebellar granule cell cultures as a consequence of the development of the ability to utilize alanine as an amino group donor for synthesis of transmitter glutamate. Developmental Brain Research. 79:1994;128-131.
129. Pfefferbaum A., Adalsteinsson E., Spielman D., Sullivan E.V., Lim K.O. In vivo brain concentrations of N-acetyl compounds, creatine and choline in Alzheimer disease. Archives of General Psychiatry. 56:1999;185-192.
130. Phillis J.W., O'Regan M.H. Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Research. 730:1996;150-164.
131. Phillis J.W., Song D., O'Regan M.H. Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cortex. Brain Research. 758:1997;9-16.
132. Poitry, S., Poitry-Yamate, C., Ueberfeld, J., MacLeish, P.R., Tsacopoulos, M., 2000. Mechanisms of glutamate metabolic signaling in retinal glia (Muller) cells. Journal of Neuroscience 20, 1809-1821.
133. Pow D.V., Robinson S.R. Glutamate in some retinal neurons is derived solely from glia. Neuroscience. 60:1994;355-366.
134. Procter A.W., Palmer A.M., Francis P.T., Lowe S.L., Neary D., Murphy E., Doshi R., Bowen D.M. Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease. Journal of Neurochemistry. 50:1988;790-802.
135. Raabe W. Synaptic transmission in ammonia intoxication. Neurochemical Pathology. 6:1987;145-166.
136. Raffin C.N., Rosenthal M., Busto R., Sick T.J. Glycolysis, oxidative metabolism, and brain potassium ion clearance. Journal of Cerebral Blood Flow and Metabolism. 12:1992;34-42.
137. Raichle M.E. Behind the scenes of functional brain imaging: a historical and physiological perspective. Proceedings of the National Academy of Sciences. U.S.A. 95:1998;765-772.
138. Ratnakumari L., Murthy C.R. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Neuroscience Letters. 161:1993;37-40.
139. Robinson S.R., Lee K.M., Rosa M.G.P., Schmid L.M., Vaney D.I. Selective blockade of Muller cell glutamine in cat retina causes ocular dominance shifts in visual cortex. Abstracts, Society for Neuroscience. 20:1994;1575.
140. 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magnetic Resonance Imaging. 17:1999;291-299.
141. Rothstein J.D., Tabakoff B. Alteration of striatal glutamate release after glutamine synthetase inhibition. Journal of Neurochemistry. 43:1984;1438-1446.
142. Rothstein J.D., Dykes-Holmberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M., Wang Y., Schielke J.P., Welty D.F. Knock-out of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
143. Schousboe A., Westergaard N. Transport of neuroactive amino acids in astrocytes. Ransom B.R., Kettenmann H. Neuroglia. 1995;246-258 Oxford University Press, New York.
144. Schousboe A., Westergaard N., Sonnewald U., Petersen S., Huang R., Peng L., Hertz L. Glutamate and glutamine metabolism and compartmentation in astrocytes. Developmental Neuroscience. 15:1993;359-366.
145. Shank R.P., Bennett G.S., Freytag S.O., Campbell G.L. Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Research. 329:1985;64-367.
146. 13C NMR. Proceedings of the National Academy of Sciences, U.S.A. 96:1999;8235-8240.
147. 13C-NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proceedings of the National Academy of Science, U.S.A. 94:1997;2699-2704.
148. Sibson N.R., Dhankhar A., Mason G.F., Rothman D.L., Behar K.L., Shulman R.G. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings of the National Academy of Science, U.S.A. 95:1998;316-321.
149. Smith C.D., Carney J.M., Starke-Reed P.E., Oliver C.N., Stadtman E.R., Floyd R.A., Markesbery W.R. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proceedings of the National Academy of Science U.S.A. 88:1991;10540-10543.
150. Sochocka E., Juurlink B.H.J., Code W.E., Hertz V., Peng L., Hertz L. Cell death in primary cultures of mouse neurons and astrocytes during exposure to and "recovery" from hypoxia, substrate deprivation and simulated ischemia. Brain Research. 638:1994;21-28.
151. 13C NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the TCA cycle. Journal of Neurochemistry. 61:1993;1179-1182.
152. 13C glucose metabolism in neocortical astrocytes: evidence for mitochondrial heterogeneity. Developmental Neuroscience. 15:1993;351-358.
153. 13C5]glutamine in cultured astrocytes studies by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. Journal of Neurochemistry. 67:1996;2566-2572.
154. Sonnewald U., Westergaard N., Schousboe A. Glutamate transport and metabolism in astrocytes. GLIA. 21:1997;56-63.
155. Storm-Mathisen J., Danbolt N.C., Rothe F., Torp R., Zhang N., Aas J.E., Kanner B.I., Langmoen I., Ottersen O.P. Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue. Progress in Brain Research. 94:1992;225-241.
156. Stryer F. Biochemistry. 4th ed :1995;W.H. Freeman and Co, New York.
157. Sugimoto H., Koehler R.C., Wilson D.A., Sugimoto H., Brusilow S.W., Traystman R.J. Methionine sulfoximine: a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia. Journal of Cerebral Blood Flow and Metabolism. 17:1997;44-49.
158. 3H]aspartate release from rat cerebellum. Neurochemical Research. 21:1996;603-608.
159. Swanson R.A., Graham S.H. Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro. Brain Research. 664:1994;94-100.
160. Swanson R.A., Chen J., Graham S.H. Glucose can fuel glutamate uptake in
161. 2+-dependent release of aspartate and glutamate from hippocampal slices with changing glucose concentrations. Synapse. 1:1987;265-272.
162. Tabernero A., Vicario C., Medina J.M. Lactate spares glucose as a metabolic fuel in neurons and astrocytes from primary cultures. Neuroscience Research. 26:1996;369-376.
163. Tansey F.A., Farooq M., Cammer W. Glutamine synthetase in oligodendrocytes and astrocytes: new biochemical and immunocytochemical evidence. Journal of Neurochemistry. 56:1991;266-272.
164. Tildon J.T., Roeder L.M. Glutamine oxidation by dissociated cells and homogenates of rat brain: kinetics and inhibitor studies. Journal of Neurochemistry. 42:1984;1069-1076.
165. Torp R., Andine P., Hagberg H., Karagulle T., Blackstad T.W., Ottersen O.P. Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: a semiquantitative electron microscopic study in rat hippocampus. Neuroscience. 41:1991;433-447.
166. Torp R., Arvin B., Le Peillet E., Chapman A.G., Ottersen O.P., Meldrum B.S. Effect of ischaemia and re-perfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW 1003C87. Experimental Brain Research. 96:1993;365-376.
167. Ungerer A., Mathis C., Melan C. Are glutamate receptors specifically implicated in some forms of memory processes? Experimental Brain Research. 123:1998;45-51.
168. Vannucci S.J., Maher F., Sibson I.A. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. GLIA. 21:1997;2-21.
169. Vanzetta I., Grinvald A. Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science. 286:1999;1555-1558.
170. Ventura R., Harris K.M. Three-dimensional relationships between hippocampal synapses and astrocytes. Journal of Neuroscience. 19:1999;6897-6990.
171. Vogel R., Hamprecht B., Wiesinger H. Malic enzyme isoforms in astrocytes: comparative study on activities in rat brain tissue and in astroglia-rich primary cultures. Neuroscience Letters. 247:1998;123-126.
172. Wallace J.C., Jitrapakdee S., Chapman-Smith A. Pyruvate carboxylase. International Journal of Biochemistry and Cell Biology. 30:1998;1-5.
173. Waniewski R.A., Martin D.L. Preferential utilization of acetate by astrocytes is attributable to transport. Journal of Neuroscience. 18:1998;5225-5233.
174. Westergaard N., Varming T., Peng L., Sonnewald U., Hertz L., Schousboe A. Uptake, release and metabolism of alanine in neurons and astrocytes in primary cultures. Journal of Neuroscience Research. 35:1993;540-545.
175. Westergaard N., Sonnewald U., Schousboe A. Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited. Developmental Neuroscience. 17:1995;203-211.
176. 13C]glutamate. GLIA. 17:1996;160-168.
177. Wiesinger H., Hamprecht B., Dringen R. Metabolic pathways for glucose in astrocytes. GLIA. 21:1997;22-34.
178. Yu A.C.H., Hertz L. Uptake of glutamate, GABA and glutamine in a predominantly GABAergic and a predominantly glutamatergic nerve cell population in culture. Journal of Neuroscience Research. 7:1982;23-35.
179. Yu A.C.H., Hertz L. Metabolic sources of energy in astrocytes. Hertz L., Kvamme E., McGeer E.G., Schousboe A. Glutamine, Glutamate and GABA in the Central Nervous System. 1983;431-439 Alan R. Liss, New York.
180. 14C-labelled glutamate in astrocytes. Journal of Neurochemistry. 39:1982;954-966.
181. Yu A.C.H., Drejer J., Hertz L., Schousboe A. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. Journal of Neurochemistry. 41:1983;1484-1487.
182. 14C-labelled glutamate in astrocytes in primary cultures. Journal of Neurochemistry. 42:1984;594-597.
183. Yu A.C., Gregory G.A., Chan P.H. Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures. Journal of Cerebral Blood Flow and Metabolism. 9:1989;20-28.
184. Yudkoff M. Brain metabolism of branched-chain amino acids GLIA. 21:1997;92-98.
185. 14C]glutamine oxidative metabolism in the rat hippocampus as determined by microdialysis. Journal of Neurochemistry. 71:1998;1315-1320.