The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study

Journal of Physiology

Volumn 496, Issue 1, 1996, Pages 49-57

  Fray, A E ^a   Forsyth, R J ^b   Boutelle, M G ^c   Fillenz, M ^d  

^a NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d Molecular Sensors Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; CYCLIC AMP; GLUCOSE; GLUTAMIC ACID; GLYCOGEN; ISOPRENALINE; LACTIC ACID; NEUROTRANSMITTER UPTAKE INHIBITOR; PROPRANOLOL;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN LEVEL; BRAIN METABOLISM; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; GLYCOGENOLYSIS; HYDROGEN CLEARANCE; MALE; MICRODIALYSIS; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029857160     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021664     Document Type: Article

References (37)

1. BELL, J. E., HUME, R., BUSUTILL, A. & BURCHELL, A. (1993). Immunocytochemical detection of the microsomal glucose-6-phosphatase in human astrocytes. Neuropathology and Applied Neurobiology 19, 429-435.
2. BERNERS, M. O. M., BOUTELLE, M. G. & FILLENZ, M. (1994). On-line measurement of brain glutamate with an enzyme/polymer-coated tubular electrode. Analytical Chemistry 66, 2017-2021.
3. BITTAR, P., CARNAY, Y., KIRALY, M., PELLERIN, L., BOURAS, C. & MAGISTRETTI, P. J. (1995). Selective distribution of lactate dehydrogenase in neurons and astrocytes: evidence for activity-dependent metabolic trafficking. Neuroscience Abstracts 21, 656.1.
4. BOUTELLE, M. G., FELLOWS, L. K. & COOK, C. (1992). Enzyme packed bed system for the on-line measurement of glucose, glutamate and lactate in brain microdialysate. Analytical Chemistry 64, 1790-1794.
5. BOUTELLE, M. G. & FILLENZ, M. (1996a). Clinical microdialysis: The role of on-line measurement and quantitative microdialysis. Acta Neurochirurgien (in the Press).
6. BOUTELLE, M. G. & FILLENZ, M. (1996b). A combined probe to study the pharmacology of physiologically stimulated retinal blood flow in the rat brain. Journal of Physiology 491.P, 29P.
7. BUNGAY, P. M., MORRISON, P. F. & DEDRICK, L. D. (1990). Steadystate theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sciences 46, 105-119.
8. CATALDO, A. M. & BROADWELL, R, D. (1986). Cytochemieal identification of cerebral glycogen and glucose-6-phosphate activity under normal and experimental conditions. Journal of Electron Microscopy Technique 3, 413-437.
9. 2+ concentration in brain microdialysis. Naunyn-Schmiedeberg's Archives of Pharmacology 342, 528-534.
10. DEROUICHE, A. & FROTSCHER, M. (1991). Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: evidence for transmitter degradation. Brain Research 552, 346-350.
11. DRINGEN, R., GEBHARDT, R. & HAMPRECHT, B. (1993). Glycogen in astrocytes: possible function as lactate supply for neighboring cells. Brain Research 623, 208-214.
12. FELLOWS, L. K. & BOUTELLE, M. G. (1993). Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat. Brain Research 604, 225-231.
13. FELLOWS, L. K., BOUTELLE, M. G. & FILLENZ, M. (1993). Physiological stimulation increases non-oxidative glucose metabolism in the brain of the freely moving rat. Journal of Neurochemistry 60, 1258-1263.
14. FORSYTH, R. J. (1996). Astrocytes and the delivery of glucose from plasma to neurons. Neurochemistry International 28, 231-241.
15. FORSYTH, R. J., BARTLETT, K., BURCHELL, A., SCOTT, H. M. & EYRE, J. A. (1993). Astrocytic glucose-6-phosphatase and the permeability of brain microsomes to glueose-6-phosphate. Biochemical Journal 294, 145-151.
16. FORSYTH, R. J., BARTLETT, K. & EYRE, J. (1996a). Dephosphorylation of 2-deoxyglucose B-phosphate and 2-deoxy glucose export by cultured astrocytes. Neurochemistry International 28, 243-250.
17. FORSYTH, R. J., FRAY, A., BOUTELLE, M. G., FILLENZ, M., MIDDLEDITCH, O. & BURCHELL, A. (1996b). A role for astrocytes in glucose delivery to neurons? Developmental Neuroscience suppl. 67, 13-20.
18. Fox, P. T., RAICHLE, M. E., MINTUN, M. A. & DENCE, C. (1988). Non-oxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464.
19. HORINAKA, N., ARTZ, N., JEHLE, J., KENNEDY, C. & SOKOLOFF, L. (1995). Effect of continuous epinephrine infusion on cerebral blood flow. Neuroscience Abstracts 21, 68.2.
20. JENKINS, W. T. (1961). Glutamic-aspartic transaminase VI. The reaction with certain beta-substituted aspartic acid analogues. Journal of Biological Chemistry 236, 1121-1125.
21. KUHR, W. G., VAN DEN BERG, C. J. & KORF, J. (1988). In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conseious, freely moving rats. Journal of Cerebral Blood Flow and Metabolism 8, 848-856.
22. LEAR, J. L. & KASLIWAL, R. (1991). Autoradiographic measurement of cerebral lactate transport rate constants in normal and activated conditions. Journal of Cerebral Blood Flow and Metabolism 11, 576-580.
23. MAGISTRETTI, P. J., SORG, O. & MARTIN, J.-L. (1993). Regulation of glycogen metabolism in astrocytes: physiological, pharmacological, and pathological aspects. In Astrocytes, ed. MURPHY, S., pp. 243-265. Academic Press, San Diego, CA, USA.
24. MORTON, D. B. & GRIFFITHS, P. H. M. (1985). Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. The Veterinary Record 116, 431-436.
25. OGAWA, S., TANK, D. W., MENON, R., ELLERMAN, J. M., KIM, S.-G., MERKLE, H. & UGURBIL, K. (1992). Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proceedings of the National Academy of Sciences of the USA 89, 5951-5955.
26. PAXINOS, G. & WATSON, C. (1986). The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney, Australia.
27. PEI, Q., ZETTERSTRÖM, T. & FILLENZ, M. (1990). Tail pinch-induced changes in the turnover and release of dopamine and 5-hydroxytryptamine in different brain regions of the rat. Neuroscience 35, 133-138.
28. PELLERIN, L. & MAGISTRETTI, P. J. (1994). Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilisation. Proceedings of the National Academy of Sciences of the USA 91, 10625-10629.
29. 13C magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism 12, 1022-1029.
30. POITRY-YAMATE, C. L., POITRY, S. & TSACOPOULOS, M. (1995). Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina. Journal of Neuroscience 15, 5179-5191.
31. PRICHARD, J., ROTHMAN, D., NOVOTNY, E., PETROFF, O., KUWARABA, T., AVISON, M., HOWSEMAN, A., HANSTOCK, C. & SULMAN, R. (1991). Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings of the National Academy of Sciences of the USA 88, 5829-5831.
32. SELAK, I., SKAPER, S. & VARON, S. (1985). Pyruvate participation in the low molecular weight trophic activity for CNS neurons in gliaconditioned medium. Journal of Neuroscience 5, 23-28.
33. TSACOPOULOS, M. & MAGISTRETTI, P. (1996). Metabolic coupling between glia and neurons. Journal of Neuroscience 16, 877-885.
34. WHEELER, D., BOUTELLE, M. G. & FILLENZ, M. (1995). The role of N-methyl-D-aspartate receptors in the regulation of physiologically released dopamine. Neuroscience 65, 767-774.
35. WOLFENSOHN, S. & LLOYD, M. (1994). Handbook of Laboratory Animal Management and Welfare. Oxford University Press, Oxford.
36. WOLFF, J. R. (1970). The astrocyte as link between capillary and nerve cell. Triangle 9, 153-164.
37. YOUNG, W. (1980). Hydrogen clearance measurement of blood flow: a review of techniques and polarographic principles. Stroke 11, 552-564.