Activation-induced resetting of cerebral oxygen and glucose uptake in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 7, 1998, Pages 742-748

  Madsen, Peter L ^a   Linde, Rasmus ^a   Hasselbalch, Steen G ^a   Paulson, Olaf B ^a   Lassen, Niels A ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Activation; Cerebral glucose metabolism; Cerebral oxygen metabolism; Lactate; Rat; Uncoupling

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; BRAIN VEIN; CONTROLLED STUDY; GLUCOSE TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031747113     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199807000-00005     Document Type: Article

References (30)

1. +-induced stimulation of glucose utilisation in rat brain. J Cereb Blood Flow Metab 15:97-110
2. Carlsson C, Hägerdal M, Kaasik AE, Siesjö BK (1977) A catecholamine-mediated increase in cerebral oxygen uptake during immobilisation stress in rats Brain Res 119:223-231
3. Cohen PJ, Wollman H, Alexander SC, Chase PE, Behar MG (1964) Cerebral carbohydrate metabolism in man during halothane anaesthesia. Anesthesiology 25:185-91
4. Dienel GA, Cruz NF, Mori K, Sokoloff L (1990) Acid lability of metabolites of 2-deoxyglucose in rat brain: implications for estimates of kinetic parameters of deoxyglucose phosphorylation and transport between and blood and brain. J Neurochem 54:1440-1448
5. Fellows LK, Boutelle MG, Fillenz M (1993) Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat. J Neurochem 60:1258-1263
6. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activation. Science 241:462-464
7. Frahm J, Krüger G, Merboldt K-D, Kleinschmidt A (1996) Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man Mag Reson Med 35:143-148
8. Ghajar JBG, Plum F, Duffy TE (1982) Cerebral oxidative metabolism and blood flow during acute hypoglycemia and recovery in unanesthetized rats. J Neurochem 38:397-409
9. Gjedde A, Crone C (1975) Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol 229:1165-1169
10. Gjedde A, Caronna JJ, Hindfelt B, Plum F (1975) Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anaesthesia. Am J Physiol 229:113-118
11. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen K, Holm S, Paulson OB (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 270:E746-E751
12. Hawkins RA, Williamson DH, Krebs HA (1971) Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 122:13-18
13. Hawkins RA, Miller AL, Nielsen RC, Veech RL (1973) The acute action of ammonia on rat brain metabolism in vivo. Biochem J 134:1001-1008
14. Hawkins RA, Mans AM, Davis DW (1986) Regional ketone body utilisation by rat brain in starvation and diabetes. Am J Physiol 250:E169-E178
15. Horinaka N, Artz N, Jehle J, Takahashi S, Kennedy C, Sokoloff L (1997) Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycaemia and pharmacological doses of deoxyglucose. J Cereb Blood Flow Metab 17:54-63
16. Kante A, Malki MC, Coquard C, Latruffe N (1990) Metabolic control of the expression of mitochondrial D-β-hydroxybutyrate dehydrogenase, a ketone body converting enzyme. Biochim Biophys Acta 1033:291-297
17. Kety SS (1957) The general metabolism of the brain in vivo. In: Metabolism of the Nervous System. London, Persimmon Press, pp 221-237
18. Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27:476-483
19. Keykhah M, Smith DS, Carlsson C, Safo Y, Englebach I, Harp JR (1985) Influence of sufentanil on cerebral metabolism and circulation in the rat. Anesthesiology 63:274-277
20. Madsen PL, Hasselbalch SG, Hageman LP, Olsen KS, Bülow J, Holm S, Wildscøidtz G, Paulson OB, Lassen NA (1995a) Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained by the Kety-Schmidt technique. J Cereb Blood Flow Metab 15:485-491
21. Madsen PL, Cruz NF, Dienel GA (1995b) Metabolite flux to and from brain and levels of metabolites in brain of rats during rest, sensory stimulation, and recovery. J Cereb Blood Flow Metab 15(Suppl 1):S77
22. 1H NMR in human visual cortex during physiologic stimulation. Proc Natl Acad Sci USA 88:5829-5831
23. Pollay M, Stevens FA (1980) Starvation-induced changes in transport of ketone bodies across the blood-brain-barrier. J Neurosci Res 5:163-172
24. Ribeiro L, Kuwabara H, Meyer E, Fujita H, Marrett S, Evans A, Gjedde A (1993) Cerebral blood flow and metabolism during non-specific bilateral visual stimulation in normal subjects. Ann Nucl Med 7(Suppl 1):S122-S123
25. Ruderman NB, Ross PS, Berger M, Goodman MN (1974) Regulation of glucose and ketone-body metabolism in brain of anaesthetised rats. Biochem J 138:1-10
26. 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 12:584-592
27. Siesjö BK (1978) Brain Energy Metabolism. New York, Wiley
28. 14C]deoxyglucose method for the measurement of local cerebral glucose utilisation: theory, procedure, and normal values in the conscious and anaesthetised albino rat. J Neurochem 28:897-916
29. Villringer A, Dirnagl U (1995) Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging. Cerebrovasc Brain Metab Rev 7:240-276
30. Williamson DH, Mellanby J, Krebs HA (1962) Enzymatic determination of D-(-)-beta-hydroxybutyrate and acetoacetate in blood. Biochem J 82:90-96