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Volumn 57, Issue 4, 1999, Pages 417-428

Astrocytes: Glutamate producers for neurons

Author keywords

Astrocytes; Brain; Glucose metabolism; Glutamate oxidation; Glutamate production; Neuronal astrocytic interactions

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; MALATE DEHYDROGENASE (DECARBOXYLATING); PYRUVATE CARBOXYLASE;

EID: 0033566731     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990815)57:4<417::AID-JNR1>3.0.CO;2-N     Document Type: Review
Times cited : (397)

References (124)
  • 1
    • 0030886112 scopus 로고    scopus 로고
    • Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats
    • Alexander GM, Grothuse JR, Gordon SW, Schwartzman RJ. 1997. Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats. Brain Res 766:1-10.
    • (1997) Brain Res , vol.766 , pp. 1-10
    • Alexander, G.M.1    Grothuse, J.R.2    Gordon, S.W.3    Schwartzman, R.J.4
  • 2
    • 0025732188 scopus 로고
    • Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry
    • Aoki C, Kaneko T, Starr A, Pickel VM. 1991. Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry. J Neurosci Res 28:531-548.
    • (1991) J Neurosci Res , vol.28 , pp. 531-548
    • Aoki, C.1    Kaneko, T.2    Starr, A.3    Pickel, V.M.4
  • 4
    • 0031595307 scopus 로고    scopus 로고
    • 13C-magnetic resonance spectroscopy to studies of neuronal/glial relationships
    • 13C-magnetic resonance spectroscopy to studies of neuronal/glial relationships. Dev Neurosci 20:277-288.
    • (1998) Dev Neurosci , vol.20 , pp. 277-288
    • Bachelard, H.1
  • 6
    • 0027522345 scopus 로고
    • Evidence using in vivo microdialysis that aminotransferase activities are important in the regulation of the pools of transmitter amino acids
    • Bakkelund AH, Fonnum F, Paulsen RE. 1993. Evidence using in vivo microdialysis that aminotransferase activities are important in the regulation of the pools of transmitter amino acids. Neurochem Res 18:411-415.
    • (1993) Neurochem Res , vol.18 , pp. 411-415
    • Bakkelund, A.H.1    Fonnum, F.2    Paulsen, R.E.3
  • 8
    • 0342315983 scopus 로고    scopus 로고
    • Inhibition of glutamine synthetase suppresses the electroretinogram B-wavein the rat
    • Barnett NL, Pow DV, Plenderleith MB, Robinson SR. 1996. Inhibition of glutamine synthetase suppresses the electroretinogram B-wavein the rat. Soc Neurosci Abstr 22:121.
    • (1996) Soc Neurosci Abstr , vol.22 , pp. 121
    • Barnett, N.L.1    Pow, D.V.2    Plenderleith, M.B.3    Robinson, S.R.4
  • 9
    • 0029887177 scopus 로고    scopus 로고
    • Glutamine stimulates gamma-aminobutyric acid synthesis in synaptosomes but other putative astrocyte-to-neuron shuttle substrates do not
    • Battaglioli G, Martin DL. 1996. Glutamine stimulates gamma-aminobutyric acid synthesis in synaptosomes but other putative astrocyte-to-neuron shuttle substrates do not. Neurosci Lett 209:129-133.
    • (1996) Neurosci Lett , vol.209 , pp. 129-133
    • Battaglioli, G.1    Martin, D.L.2
  • 10
    • 0016746875 scopus 로고
    • Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: A possible role of ammonia in brain function
    • Benjamin AM, Quastel JH. 1975. Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: A possible role of ammonia in brain function. J Neurochem 25:197-206.
    • (1975) J Neurochem , vol.25 , pp. 197-206
    • Benjamin, A.M.1    Quastel, J.H.2
  • 11
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste H, Drejer J, Schousboe A, Diemer NH. 1984. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369-1374.
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 12
    • 0029990892 scopus 로고    scopus 로고
    • Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
    • Bittar PG, Charnay Y, Pellerin L, Bouras C, Magistretti PJ. 1996. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16:1079-1089.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1079-1089
    • Bittar, P.G.1    Charnay, Y.2    Pellerin, L.3    Bouras, C.4    Magistretti, P.J.5
  • 13
    • 0028892038 scopus 로고
    • Generation of ketone bodies from leucine by cultured astroglial cells
    • Bixel MG, Hamprecht B. 1995. Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem 65:2450-2461.
    • (1995) J Neurochem , vol.65 , pp. 2450-2461
    • Bixel, M.G.1    Hamprecht, B.2
  • 14
    • 0031007633 scopus 로고    scopus 로고
    • Cellular distribution of branched-chain aminoacid aminotransferase isoenzymes among rat brain glial cells in culture
    • Bixel MG, Hutson SM, Hamprecht B. 1997. Cellular distribution of branched-chain aminoacid aminotransferase isoenzymes among rat brain glial cells in culture. J Histochem Cytochem 45:685-694.
    • (1997) J Histochem Cytochem , vol.45 , pp. 685-694
    • Bixel, M.G.1    Hutson, S.M.2    Hamprecht, B.3
  • 16
    • 0343775246 scopus 로고    scopus 로고
    • Physiological effects of the specific inhibition of retinal muller cells
    • Bull ND, Barnett NL. 1999. Physiological effects of the specific inhibition of retinal Muller cells. Proc Austr Neurosci Soc 10:190.
    • (1999) Proc Austr Neurosci Soc , vol.10 , pp. 190
    • Bull, N.D.1    Barnett, N.L.2
  • 17
    • 0028966538 scopus 로고
    • Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
    • Cesar M, Hamprecht B. 1995. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase. J Neurochem 64:2312-2318.
    • (1995) J Neurochem , vol.64 , pp. 2312-2318
    • Cesar, M.1    Hamprecht, B.2
  • 18
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DD. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.D.1
  • 21
    • 0017339314 scopus 로고
    • The influence of portocaval anastomosis on the metabolism of labelled octanoate, butyrate and leucine in rat brain
    • Cremer JE. 1977. The influence of portocaval anastomosis on the metabolism of labelled octanoate, butyrate and leucine in rat brain. J Neurochem 28:215-222.
    • (1977) J Neurochem , vol.28 , pp. 215-222
    • Cremer, J.E.1
  • 22
    • 0016278794 scopus 로고
    • Regional changes in amino acid content in developing rat brain
    • Cutler RWP, Dudzinski DS. 1974. Regional changes in amino acid content in developing rat brain. J Neurochem 23:1005-1009.
    • (1974) J Neurochem , vol.23 , pp. 1005-1009
    • Cutler, R.W.P.1    Dudzinski, D.S.2
  • 23
    • 0025041953 scopus 로고
    • Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system
    • D'Amelio F, Eng LA, Gibbs MA. 1990. Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system. Glia 3:335-341.
    • (1990) Glia , vol.3 , pp. 335-341
    • D'Amelio, F.1    Eng, L.A.2    Gibbs, M.A.3
  • 24
    • 0026539793 scopus 로고
    • +] coupled L-glutamate transporter purified from rat brain is located in glial cell processes
    • +] coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience 51:295-310.
    • (1992) Neuroscience , vol.51 , pp. 295-310
    • Danbolt, N.C.1    Storm-Mathisen, J.2    Kanner, B.I.3
  • 25
    • 0342470037 scopus 로고    scopus 로고
    • 14C]glucose into tricarboxylic acid cycle-derived metabolic pools in neurons and glia during and after sensory stimulation
    • 14C]glucose into tricarboxylic acid cycle-derived metabolic pools in neurons and glia during and after sensory stimulation. J Neurochem 69 (Suppl.):S274B.
    • (1997) J Neurochem , vol.69 , Issue.SUPPL.
    • Dienel, G.A.1    Wang, R.Y.2    Cruz, N.F.3
  • 26
    • 0343261205 scopus 로고    scopus 로고
    • Photic stimulation increases glial oxidative metabolism in superior colliculus
    • Dienel GA, Liu K, Chowdhury P, Cruz NF. 1998. Photic stimulation increases glial oxidative metabolism in superior colliculus. Abstracts, Soc Neurosci 24:1166.
    • (1998) Abstracts, Soc Neurosci , vol.24 , pp. 1166
    • Dienel, G.A.1    Liu, K.2    Chowdhury, P.3    Cruz, N.F.4
  • 27
    • 0029836312 scopus 로고    scopus 로고
    • Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures
    • Dringen R, Hamprecht B. 1996. Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures. J Neurochem 67:1375-1382.
    • (1996) J Neurochem , vol.67 , pp. 1375-1382
    • Dringen, R.1    Hamprecht, B.2
  • 28
    • 0031788839 scopus 로고    scopus 로고
    • Glutathione restoration as indicator for cellular metabolism of astroglial cells
    • Dringen R, Hamprecht B. 1998. Glutathione restoration as indicator for cellular metabolism of astroglial cells. Dev Neurosci 20:401-407.
    • (1998) Dev Neurosci , vol.20 , pp. 401-407
    • Dringen, R.1    Hamprecht, B.2
  • 29
  • 30
    • 0027604406 scopus 로고
    • 14C lactate into the glycogen of cultured mouse astroglial cells: Evidence for gluconeogenesis in brain cells
    • 14C lactate into the glycogen of cultured mouse astroglial cells: Evidence for gluconeogenesis in brain cells. Biol Chem Hoppe-Seyler 374:343-347.
    • (1993) Biol Chem Hoppe-Seyler , vol.374 , pp. 343-347
    • Dringen, R.1    Schmoll, D.2    Cesar, M.3    Hamprecht, B.4
  • 31
    • 0028343853 scopus 로고
    • Cerebral alanine transport and alanine aminotransferase reaction: Alanine as a source of neuronal glutamate
    • Erecinska M, Nelson D, Nissim I, Daikhin Y, Yudkoff M. 1994. Cerebral alanine transport and alanine aminotransferase reaction: Alanine as a source of neuronal glutamate. J Neurochem 62:1953-1964.
    • (1994) J Neurochem , vol.62 , pp. 1953-1964
    • Erecinska, M.1    Nelson, D.2    Nissim, I.3    Daikhin, Y.4    Yudkoff, M.5
  • 32
    • 0029382123 scopus 로고
    • Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat
    • Eriksson G, Peterson A, Iverfeldt K, Walum E. 1995. Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. Glia 15:152-156.
    • (1995) Glia , vol.15 , pp. 152-156
    • Eriksson, G.1    Peterson, A.2    Iverfeldt, K.3    Walum, E.4
  • 33
    • 0021330769 scopus 로고
    • Glutamate: A neurotransmitter in mammalian brain
    • Fonnum F. 1984. Glutamate: A neurotransmitter in mammalian brain. J Neurochem 42:1-11.
    • (1984) J Neurochem , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 34
    • 0031239164 scopus 로고    scopus 로고
    • Use of fluorocitrate and fluoroacetate in the study of brain metabolism
    • Fonnum F, Johnsen A, Hassel B. 1997. Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia 21:106-113.
    • (1997) Glia , vol.21 , pp. 106-113
    • Fonnum, F.1    Johnsen, A.2    Hassel, B.3
  • 35
    • 0030071024 scopus 로고    scopus 로고
    • Astrocytes and the delivery of glucose from plasma to neurons
    • Forsyth RJ. 1996. Astrocytes and the delivery of glucose from plasma to neurons. Neurochem Internat 28:231-241.
    • (1996) Neurochem Internat , vol.28 , pp. 231-241
    • Forsyth, R.J.1
  • 36
    • 0029857160 scopus 로고    scopus 로고
    • The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study
    • Fray AE, Forsyth RJ, Boutelle MG, Fillenz M. 1996. The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study. J Physiol 496:49-57.
    • (1996) J Physiol , vol.496 , pp. 49-57
    • Fray, A.E.1    Forsyth, R.J.2    Boutelle, M.G.3    Fillenz, M.4
  • 37
    • 0342315982 scopus 로고    scopus 로고
    • Changes with age in the utilisation of glucose carbon in liver and brain
    • Gaitonde ME, Richter D. 1996. Changes with age in the utilisation of glucose carbon in liver and brain. J Neurochem 13:309-1318.
    • (1996) J Neurochem , vol.13 , pp. 309-1318
    • Gaitonde, M.E.1    Richter, D.2
  • 38
    • 0032006244 scopus 로고    scopus 로고
    • Cellular distribution and kinetic properties of high-affinity glutamate transporters
    • Gegelashvili G, Schousboe A. 1998. Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res Bull 45:233-238.
    • (1998) Brain Res Bull , vol.45 , pp. 233-238
    • Gegelashvili, G.1    Schousboe, A.2
  • 41
    • 0031595305 scopus 로고    scopus 로고
    • 13C-NMR of glutamate metabolism in the human brain: Initial results at 4 tesla
    • 13C-NMR of glutamate metabolism in the human brain: Initial results at 4 tesla. Dev Neurosci 20:380-388.
    • (1998) Dev Neurosci , vol.20 , pp. 380-388
    • Gruetter, R.1    Seaquist, E.R.2    Kim, S.3    Ugurbil, K.4
  • 42
    • 0032529722 scopus 로고    scopus 로고
    • Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus
    • Gundersen V, Chaudhry FA, Bjaalie JG, Fonnum F, Ottersen OP, Storm-Mathisen J. 1998. Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus. J Neurosci 18:6059-6070.
    • (1998) J Neurosci , vol.18 , pp. 6059-6070
    • Gundersen, V.1    Chaudhry, F.A.2    Bjaalie, J.G.3    Fonnum, F.4    Ottersen, O.P.5    Storm-Mathisen, J.6
  • 45
    • 0024498337 scopus 로고
    • Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures
    • Hansson E, Ronnback L. 1988. Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures. Life Sci 44:27-34.
    • (1988) Life Sci , vol.44 , pp. 27-34
    • Hansson, E.1    Ronnback, L.2
  • 46
    • 0026603607 scopus 로고
    • Selective inhibition of glial cell metabolism in vivo by fluoroacetate
    • Hassel B, Paulsen RE, Johnsen A, Fonnum F. 1992. Selective inhibition of glial cell metabolism in vivo by fluoroacetate. Brain Res 576:120-124.
    • (1992) Brain Res , vol.576 , pp. 120-124
    • Hassel, B.1    Paulsen, R.E.2    Johnsen, A.3    Fonnum, F.4
  • 47
    • 0028340576 scopus 로고
    • NMR spectroscopy of cultured astrocytes: Effects of glutamine and the gliotoxin fluorocitrate
    • Hassel B, Sonnewald U, Unsgard G, Fonnum F. 1994. NMR spectroscopy of cultured astrocytes: Effects of glutamine and the gliotoxin fluorocitrate. J Neurochem 62:2187-2194.
    • (1994) J Neurochem , vol.62 , pp. 2187-2194
    • Hassel, B.1    Sonnewald, U.2    Unsgard, G.3    Fonnum, F.4
  • 49
    • 0030612955 scopus 로고    scopus 로고
    • Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate
    • Hassel B, Bachelard H, Jones P, Fonnum F, Sonnewald U. 1997. Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J Cerebral Blood Flow Metab 17:1230-1238.
    • (1997) J Cerebral Blood Flow Metab , vol.17 , pp. 1230-1238
    • Hassel, B.1    Bachelard, H.2    Jones, P.3    Fonnum, F.4    Sonnewald, U.5
  • 50
    • 0029059287 scopus 로고
    • Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate
    • Hawkins RA, DeJoseph MR, Hawkins PA. 1995. Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate. Cell Tissue Res 281:207-214.
    • (1995) Cell Tissue Res , vol.281 , pp. 207-214
    • Hawkins, R.A.1    DeJoseph, M.R.2    Hawkins, P.A.3
  • 51
    • 0027049539 scopus 로고
    • Effects of monoamine transmitters on neurons and astrocytes: Correlation between energy metabolism and intracellular messengers
    • Hertz L, Peng L. 1992. Effects of monoamine transmitters on neurons and astrocytes: Correlation between energy metabolism and intracellular messengers. Progr Brain Res 94:283-301.
    • (1992) Progr Brain Res , vol.94 , pp. 283-301
    • Hertz, L.1    Peng, L.2
  • 52
    • 0033007130 scopus 로고    scopus 로고
    • Does "the mystery of the extra glucose" during CNS activation reflect glutamate synthesis?
    • Hertz L, Fillenz M. 1999. Does "the mystery of the extra glucose" during CNS activation reflect glutamate synthesis? Neurochem Internat 34:71-75.
    • (1999) Neurochem Internat , vol.34 , pp. 71-75
    • Hertz, L.1    Fillenz, M.2
  • 54
    • 0031763269 scopus 로고    scopus 로고
    • Can experimental conditions explain the discrepancy whether or not glutamate stimulates aerobic glycolysis?
    • Hertz L, Swanson RA, Newman GC, Mariff H, Juurlink BHJ, Peng L. 1998. Can experimental conditions explain the discrepancy whether or not glutamate stimulates aerobic glycolysis? Dev Neurosci 20:339-347.
    • (1998) Dev Neurosci , vol.20 , pp. 339-347
    • Hertz, L.1    Swanson, R.A.2    Newman, G.C.3    Mariff, H.4    Juurlink, B.H.J.5    Peng, L.6
  • 55
    • 0023907144 scopus 로고
    • Glutaminase in neurons and astrocytes cultured from mouse brain: Kinetic properties and effects of phosphate, glutamate and ammonia
    • Hogstad S, Svenneby G, Torgner IAa, Kvamme E, Hertz L, Schousboe A. 1988. Glutaminase in neurons and astrocytes cultured from mouse brain: Kinetic properties and effects of phosphate, glutamate and ammonia. Neurochem Res 13:383-388.
    • (1988) Neurochem Res , vol.13 , pp. 383-388
    • Hogstad, S.1    Svenneby, G.2    Torgner, I.Aa.3    Kvamme, E.4    Hertz, L.5    Schousboe, A.6
  • 56
    • 0029130807 scopus 로고
    • Noradrenaline induced stimulation of glutamine metabolism in primary cultures of astrocytes
    • Huang R, Hertz L. 1995. Noradrenaline induced stimulation of glutamine metabolism in primary cultures of astrocytes. J Neurosci Res 41:677-683.
    • (1995) J Neurosci Res , vol.41 , pp. 677-683
    • Huang, R.1    Hertz, L.2
  • 57
    • 0028631489 scopus 로고
    • Signalling effect of monoamines and of elevated potassium concentrations on brain energy metabolism at the cellular level
    • Huang R, Peng L, Chen Y, Hajek I, Zhao Z, Hertz L. 1994. Signalling effect of monoamines and of elevated potassium concentrations on brain energy metabolism at the cellular level. Dev Neurosci 16:337-351.
    • (1994) Dev Neurosci , vol.16 , pp. 337-351
    • Huang, R.1    Peng, L.2    Chen, Y.3    Hajek, I.4    Zhao, Z.5    Hertz, L.6
  • 58
    • 0028406889 scopus 로고
    • Synaptic transmission in the hippocampus: Critical role for glial cells
    • Keyser DO, Pelmar TC. 1994. Synaptic transmission in the hippocampus: Critical role for glial cells. Glia 10:237-243.
    • (1994) Glia , vol.10 , pp. 237-243
    • Keyser, D.O.1    Pelmar, T.C.2
  • 61
    • 0027465673 scopus 로고
    • Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glia of neural primary cultures
    • Kurz GM, Wiesinger H, Hamprecht B. 1993. Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glia of neural primary cultures. J Neurochem 60:1467-1474.
    • (1993) J Neurochem , vol.60 , pp. 1467-1474
    • Kurz, G.M.1    Wiesinger, H.2    Hamprecht, B.3
  • 62
    • 0019944222 scopus 로고
    • Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain
    • Kvamme E, Svenneby G, Hertz L, Schousboe A. 1982. Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain. Neurochem Res 7:761-770.
    • (1982) Neurochem Res , vol.7 , pp. 761-770
    • Kvamme, E.1    Svenneby, G.2    Hertz, L.3    Schousboe, A.4
  • 63
    • 0029091514 scopus 로고
    • Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: Immunogold evidence from hippocampal slice cultures
    • Laake JH, Slyngstad TA, Haug F-MS, Ottersen OP. 1995. Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: Immunogold evidence from hippocampal slice cultures. J Neurochem 65:871-881.
    • (1995) J Neurochem , vol.65 , pp. 871-881
    • Laake, J.H.1    Slyngstad, T.A.2    Haug, F.-M.S.3    Ottersen, O.P.4
  • 65
    • 0031018960 scopus 로고    scopus 로고
    • 15N coupling patterns and isotopic shifts
    • 15N coupling patterns and isotopic shifts. Eur J Biochem 243:597-604.
    • (1997) Eur J Biochem , vol.243 , pp. 597-604
    • Lapidot, A.1    Gopher, A.2
  • 66
    • 0031038060 scopus 로고    scopus 로고
    • Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices
    • Largo C, Tombaugh GC, Aitken PG, Herreras O, Somjen GG. 1997. Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. J Neurophysiol 77:9-16.
    • (1997) J Neurophysiol , vol.77 , pp. 9-16
    • Largo, C.1    Tombaugh, G.C.2    Aitken, P.G.3    Herreras, O.4    Somjen, G.G.5
  • 67
    • 0027749708 scopus 로고
    • Kinetics of 2-oxoglutarate uptake by synaptosomes from bovine and rat retina and cerebral cortex and regulation by glutamate and glutamine
    • Lehmann JC, Kapkov D, Shank RP. 1993. Kinetics of 2-oxoglutarate uptake by synaptosomes from bovine and rat retina and cerebral cortex and regulation by glutamate and glutamine. Dev Neurosci 15:330-335.
    • (1993) Dev Neurosci , vol.15 , pp. 330-335
    • Lehmann, J.C.1    Kapkov, D.2    Shank, R.P.3
  • 68
    • 0032194950 scopus 로고    scopus 로고
    • The number of glutamate transporter subtype molecules at glutamatergic synapses: Chemical and stereological quantification in young adult brain
    • Lehre KP, Danbolt NC. 1998. The number of glutamate transporter subtype molecules at glutamatergic synapses: Chemical and stereological quantification in young adult brain. J Neurosci 18:8751-8757.
    • (1998) J Neurosci , vol.18 , pp. 8751-8757
    • Lehre, K.P.1    Danbolt, N.C.2
  • 69
    • 0031015380 scopus 로고    scopus 로고
    • Evidence for the uncoupling of oxygen and glucose utilisation during neuronal activation in rat striatum
    • Lowry JP, Fillenz M. 1997. Evidence for the uncoupling of oxygen and glucose utilisation during neuronal activation in rat striatum. J Physiol 498:497-501.
    • (1997) J Physiol , vol.498 , pp. 497-501
    • Lowry, J.P.1    Fillenz, M.2
  • 71
    • 0028798036 scopus 로고
    • Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange and glutamine synthesis in human brain by NMR
    • Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. 1995. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 15:12-25.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 12-25
    • Mason, G.F.1    Gruetter, R.2    Rothman, D.L.3    Behar, K.L.4    Shulman, R.G.5    Novotny, E.J.6
  • 72
    • 0018552548 scopus 로고
    • Monosodium glutamate neurotoxicity, hyperosmolarity, and blood-brain barrier dysfunction
    • McCall A, Glaeser BS, Millington W, Wurtman RJ. 1979. Monosodium glutamate neurotoxicity, hyperosmolarity, and blood-brain barrier dysfunction. Neurobeh Toxicol 1:279-283.
    • (1979) Neurobeh Toxicol , vol.1 , pp. 279-283
    • McCall, A.1    Glaeser, B.S.2    Millington, W.3    Wurtman, R.J.4
  • 74
    • 0030061356 scopus 로고    scopus 로고
    • Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
    • McKenna MC, Sonnewald U, Huang X, Stevenson JH, Zielke HR. 1996. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem 66:386-393.
    • (1996) J Neurochem , vol.66 , pp. 386-393
    • McKenna, M.C.1    Sonnewald, U.2    Huang, X.3    Stevenson, J.H.4    Zielke, H.R.5
  • 75
    • 0031788835 scopus 로고    scopus 로고
    • Lactate transport by cortical synaptosomes from adult rat brain: Characterization of kinetics and inhibitor specificity
    • McKenna MC, Tildon JT, Stevenson JH, Hopkins IB, Huang X, Couto R. 1998. Lactate transport by cortical synaptosomes from adult rat brain: Characterization of kinetics and inhibitor specificity. Dev Neurosci 20:300-309.
    • (1998) Dev Neurosci , vol.20 , pp. 300-309
    • McKenna, M.C.1    Tildon, J.T.2    Stevenson, J.H.3    Hopkins, I.B.4    Huang, X.5    Couto, R.6
  • 76
    • 0023408979 scopus 로고
    • Acute effects of ammonia on branched chain amino acid oxidation and incorporation into proteins in astrocytes and in neurons in primary cultures
    • Murthy ChRK, Hertz L. 1987. Acute effects of ammonia on branched chain amino acid oxidation and incorporation into proteins in astrocytes and in neurons in primary cultures. J Neurochem 49:735-741.
    • (1987) J Neurochem , vol.49 , pp. 735-741
    • Murthy, Ch.R.K.1    Hertz, L.2
  • 78
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • Norenberg MD, Martinez-Hernandez A. 1979. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161:303-310.
    • (1979) Brain Res , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 79
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection
    • Oldendorf WH. 1971. Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection. Am J Physiol 221:1629-1635.
    • (1971) Am J Physiol , vol.221 , pp. 1629-1635
    • Oldendorf, W.H.1
  • 80
    • 0014984942 scopus 로고
    • Glutamate-induced neuronal necrosis in the infant mouse hypothalamus. An electron microscopic study
    • Olney JW. 1971. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus. An electron microscopic study. J Neuropathol Exp Neurol 30:75-90.
    • (1971) J Neuropathol Exp Neurol , vol.30 , pp. 75-90
    • Olney, J.W.1
  • 81
    • 0027376339 scopus 로고
    • The chemical nature of the main central excitatory transmitter: A critical appraisal based upon release studies and synaptic vesicle localization
    • Orrego F, Villaneuva S. 1993. The chemical nature of the main central excitatory transmitter: A critical appraisal based upon release studies and synaptic vesicle localization. Neuroscience 56:539-555.
    • (1993) Neuroscience , vol.56 , pp. 539-555
    • Orrego, F.1    Villaneuva, S.2
  • 82
    • 0031960218 scopus 로고    scopus 로고
    • Glutamate, glutamine and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats
    • Pascual JM, Carceller F, Roda JM, Cerdan S. 1998. Glutamate, glutamine and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. Stroke 29:1048-1057.
    • (1998) Stroke , vol.29 , pp. 1048-1057
    • Pascual, J.M.1    Carceller, F.2    Roda, J.M.3    Cerdan, S.4
  • 83
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin L, Magistretti PJ. 1994. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625-10629.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 84
    • 0026086524 scopus 로고
    • Differences in transmitter release, morphology and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration
    • Peng L, Juurlink BHJ, Hertz L. 1991a. Differences in transmitter release, morphology and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration. Dev Brain Res 63:1-12.
    • (1991) Dev Brain Res , vol.63 , pp. 1-12
    • Peng, L.1    Juurlink, B.H.J.2    Hertz, L.3
  • 85
    • 0025777874 scopus 로고
    • Utilization of α-ketoglutarate as a precursor for transmitter glutamate in cultured cerebellar granule cells
    • Peng L, Schousboe A, Hertz L. 1991b. Utilization of α-ketoglutarate as a precursor for transmitter glutamate in cultured cerebellar granule cells. Neurochem Res 16:29-34.
    • (1991) Neurochem Res , vol.16 , pp. 29-34
    • Peng, L.1    Schousboe, A.2    Hertz, L.3
  • 87
    • 0028046768 scopus 로고
    • High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes, but have no stimulatory effect in a GABAergic neuronal culture
    • Peng L, Zhang X, Hertz L. 1994a. High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes, but have no stimulatory effect in a GABAergic neuronal culture. Brain Res 663:168-172.
    • (1994) Brain Res , vol.663 , pp. 168-172
    • Peng, L.1    Zhang, X.2    Hertz, L.3
  • 88
    • 0028356044 scopus 로고
    • Alteration in oxidative metabolism of alanine in cerebellar granule cell cultures as a consequence of the development of the ability to utilize alanine as an amino group donor for synthesis of transmitter glutamate
    • Peng L, Zhang X, Hertz L. 1994b. Alteration in oxidative metabolism of alanine in cerebellar granule cell cultures as a consequence of the development of the ability to utilize alanine as an amino group donor for synthesis of transmitter glutamate. Dev Brain Res 79:128-131.
    • (1994) Dev Brain Res , vol.79 , pp. 128-131
    • Peng, L.1    Zhang, X.2    Hertz, L.3
  • 90
    • 0028360382 scopus 로고
    • Glutamate in some retinal neurons is derived solely from glia
    • Pow DV, Robinson SR. 1994. Glutamate in some retinal neurons is derived solely from glia. Neuroscience 60:355-366.
    • (1994) Neuroscience , vol.60 , pp. 355-366
    • Pow, D.V.1    Robinson, S.R.2
  • 91
    • 0002760576 scopus 로고
    • The involvement of Muller cells in the outer retina
    • Djamgoz MBA, Archer SN, Vallerga S, editors. London. Chapman and Hall
    • Reichenbach A, Robinson SR. 1995. The involvement of Muller cells in the outer retina. In: Djamgoz MBA, Archer SN, Vallerga S, editors. Neurobiology and clinical aspects of the outer retina. London. Chapman and Hall. p 395-416.
    • (1995) Neurobiology and Clinical Aspects of the Outer Retina , pp. 395-416
    • Reichenbach, A.1    Robinson, S.R.2
  • 92
    • 0342563517 scopus 로고
    • Selective blockade of muller cell glutamine in cat retina causes ocular dominance shifts in visual cortex
    • Robinson SR, Lee KM, Rosa MGP, Schmid LM, Vaney DI. 1994. Selective blockade of Muller cell glutamine in cat retina causes ocular dominance shifts in visual cortex. Abstracts, Soc Neurosci 20:1575.
    • (1994) Abstracts, Soc Neurosci , vol.20 , pp. 1575
    • Robinson, S.R.1    Lee, K.M.2    Rosa, M.G.P.3    Schmid, L.M.4    Vaney, D.I.5
  • 94
    • 0028819598 scopus 로고
    • Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme
    • Schmoll D, Fuhrmann E, Gebhardt R, Hamprecht B. 1995. Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme. Eur J Biochem 227:308-315.
    • (1995) Eur J Biochem , vol.227 , pp. 308-315
    • Schmoll, D.1    Fuhrmann, E.2    Gebhardt, R.3    Hamprecht, B.4
  • 95
    • 0018386655 scopus 로고
    • Phosphate activated glutaminase activity and glutamine uptake in astrocytes in primary cultures
    • Schousboe A, Hertz L, Svenneby G, Kvamme E. 1979. Phosphate activated glutaminase activity and glutamine uptake in astrocytes in primary cultures. J Neurochem 32:943-950.
    • (1979) J Neurochem , vol.32 , pp. 943-950
    • Schousboe, A.1    Hertz, L.2    Svenneby, G.3    Kvamme, E.4
  • 97
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • Shank RP, Bennett GS, Freytag SO, Campbell GL. 1985. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res 329:364-367.
    • (1985) Brain Res , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Freytag, S.O.3    Campbell, G.L.4
  • 100
    • 0023634699 scopus 로고
    • Kinetics of neutral amino acid transport across the blood-brain-barrier
    • Smith QR, Momma S, Aoyagi M, Rapoport SL. 1987. Kinetics of neutral amino acid transport across the blood-brain-barrier. J Neurochem 49:1651-1658.
    • (1987) J Neurochem , vol.49 , pp. 1651-1658
    • Smith, Q.R.1    Momma, S.2    Aoyagi, M.3    Rapoport, S.L.4
  • 101
    • 0028123528 scopus 로고
    • Cell death in primary cultures of mouse neurons and astrocytes during exposure to and "recovery" from hypoxia, substrate deprivation and simulated ischemia
    • Sochocka E, Juurlink BHJ, Code WE, Hertz V, Peng L, Hertz L. 1994. Cell death in primary cultures of mouse neurons and astrocytes during exposure to and "recovery" from hypoxia, substrate deprivation and simulated ischemia. Brain Res 638:21-28.
    • (1994) Brain Res , vol.638 , pp. 21-28
    • Sochocka, E.1    Juurlink, B.H.J.2    Code, W.E.3    Hertz, V.4    Peng, L.5    Hertz, L.6
  • 102
    • 0027104242 scopus 로고
    • The brain as a chemical machine
    • Sokoloff L. 1992. The brain as a chemical machine. Prog Brain Res94:19-33.
    • (1992) Prog Brain Res , vol.94 , pp. 19-33
    • Sokoloff, L.1
  • 103
    • 0027338137 scopus 로고
    • 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the TCA cycle
    • 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the TCA cycle. J Neurochem 61:1179-1182.
    • (1993) J Neurochem , vol.61 , pp. 1179-1182
    • Sonnewald, U.1    Westergaard, N.2    Petersen, S.B.3    Unsgård, G.4    Schousboe, A.5
  • 104
    • 0031239422 scopus 로고    scopus 로고
    • Glutamate transport and metabolism in astrocytes
    • Sonnewald U, Westergaard N, Schousboe A. 1997. Glutamate transport and metabolism in astrocytes. Glia 21:56-63.
    • (1997) Glia , vol.21 , pp. 56-63
    • Sonnewald, U.1    Westergaard, N.2    Schousboe, A.3
  • 105
    • 0025950483 scopus 로고
    • Characterisation of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in cultures of mouse cerebral cortex astrocytes
    • Sorg O, Magistretti PJ. 1991. Characterisation of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in cultures of mouse cerebral cortex astrocytes. Brain Res 563:227-233.
    • (1991) Brain Res , vol.563 , pp. 227-233
    • Sorg, O.1    Magistretti, P.J.2
  • 106
    • 0025127805 scopus 로고
    • Effects of adrenergic agonists on glycogenolysis in primary cultures of astrocytes
    • Subbarao KV, Hertz L. 1990. Effects of adrenergic agonists on glycogenolysis in primary cultures of astrocytes. Brain Res 527:346-349.
    • (1990) Brain Res , vol.527 , pp. 346-349
    • Subbarao, K.V.1    Hertz, L.2
  • 107
    • 0028116520 scopus 로고
    • Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro
    • Swanson RA, Graham SH. 1994. Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro. Brain Res 664:94-100.
    • (1994) Brain Res , vol.664 , pp. 94-100
    • Swanson, R.A.1    Graham, S.H.2
  • 108
    • 0026541812 scopus 로고
    • Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography
    • Swanson RA, Morton MT, Sagar SM, Sharp FR. 1992. Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography. Neuroscience 51:451-461.
    • (1992) Neuroscience , vol.51 , pp. 451-461
    • Swanson, R.A.1    Morton, M.T.2    Sagar, S.M.3    Sharp, F.R.4
  • 109
    • 0029073149 scopus 로고
    • Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia
    • Takahashi S, Driscoll BF, Law MJ, Sokoloff L. 1995. Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia. Proc Natl Acad Sci USA 92:4616-4620.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4616-4620
    • Takahashi, S.1    Driscoll, B.F.2    Law, M.J.3    Sokoloff, L.4
  • 110
    • 0025958468 scopus 로고
    • Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence
    • Tansey FA, Farooq M, Cammer W. 1991. Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence. J Neurochem 56:266-272.
    • (1991) J Neurochem , vol.56 , pp. 266-272
    • Tansey, F.A.1    Farooq, M.2    Cammer, W.3
  • 111
    • 0028210971 scopus 로고
    • Glial cells transform glucose to alanine which fuels the neurons in the honey-bee retina
    • Tsacopoulos M, Veuthey AL, Saravelos SG, Perrottet P, Tsoupras G. 1994. Glial cells transform glucose to alanine which fuels the neurons in the honey-bee retina. J Neurosci 14:1939-1946.
    • (1994) J Neurosci , vol.14 , pp. 1939-1946
    • Tsacopoulos, M.1    Veuthey, A.L.2    Saravelos, S.G.3    Perrottet, P.4    Tsoupras, G.5
  • 112
    • 0031238676 scopus 로고    scopus 로고
    • Glucose transporter proteins in brain: Delivery of glucose to neurons and glia
    • Vannucci SJ, Maher F, Sibson IA. 1997. Glucose transporter proteins in brain: Delivery of glucose to neurons and glia. Glia 21:2-21.
    • (1997) Glia , vol.21 , pp. 2-21
    • Vannucci, S.J.1    Maher, F.2    Sibson, I.A.3
  • 113
    • 0032524879 scopus 로고    scopus 로고
    • Malic enzyme isoforms in astrocytes: Comparative study on activities in rat brain tissue and in astroglia-rich primary cultures
    • Vogel R, Hamprecht B, Wiesinger H. 1998. Malic enzyme isoforms in astrocytes: Comparative study on activities in rat brain tissue and in astroglia-rich primary cultures. Neurosci Lett 247:123-126.
    • (1998) Neurosci Lett , vol.247 , pp. 123-126
    • Vogel, R.1    Hamprecht, B.2    Wiesinger, H.3
  • 115
    • 0028167909 scopus 로고
    • Release of α-ketoglutarate, malate and succinate from cultured astrocytes: Possible role in amino acid transmitter homeostasis
    • Westergaard N, Sonnewald U, Schousboe A. 1994. Release of α-ketoglutarate, malate and succinate from cultured astrocytes: Possible role in amino acid transmitter homeostasis. Neurosci Lett 176:105-109.
    • (1994) Neurosci Lett , vol.176 , pp. 105-109
    • Westergaard, N.1    Sonnewald, U.2    Schousboe, A.3
  • 116
    • 0028879327 scopus 로고
    • Metabolic trafficking between neurons and astrocytes: The glutamate/glutamine cycle revisited
    • Westergaard N, Sonnewald U, Schousboe A. 1995. Metabolic trafficking between neurons and astrocytes: The glutamate/glutamine cycle revisited. Dev Neurosci 17:203-211.
    • (1995) Dev Neurosci , vol.17 , pp. 203-211
    • Westergaard, N.1    Sonnewald, U.2    Schousboe, A.3
  • 118
    • 0031238567 scopus 로고    scopus 로고
    • Metabolic pathways for glucose in astrocytes
    • Wiesinger H, Hamprecht B, Dringen R. 1997. Metabolic pathways for glucose in astrocytes. Glia 21:22-34.
    • (1997) Glia , vol.21 , pp. 22-34
    • Wiesinger, H.1    Hamprecht, B.2    Dringen, R.3
  • 119
    • 0025744947 scopus 로고
    • Histochemistry of glutamate metabolising enzymes in the rat cerebellar cortex
    • Würdig S, Kugler P. 1991. Histochemistry of glutamate metabolising enzymes in the rat cerebellar cortex. Neurosci Lett 130:165-168.
    • (1991) Neurosci Lett , vol.130 , pp. 165-168
    • Würdig, S.1    Kugler, P.2
  • 121
    • 0021037707 scopus 로고
    • Pyruvate carboxylase activity in primary cultures of astrocytes and neurons
    • Yu ACH, Drejer J, Hertz L, Schousboe A. 1983. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J Neurochem 41:1484-1487.
    • (1983) J Neurochem , vol.41 , pp. 1484-1487
    • Yu, A.C.H.1    Drejer, J.2    Hertz, L.3    Schousboe, A.4
  • 122
    • 0024595699 scopus 로고
    • Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures
    • Yu AC, Gregory GA, Chan PH. 1989. Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures. J Cereb Blood Flow Metab 9:20-28.
    • (1989) J Cereb Blood Flow Metab , vol.9 , pp. 20-28
    • Yu, A.C.1    Gregory, G.A.2    Chan, P.H.3
  • 123
    • 0031239010 scopus 로고    scopus 로고
    • Brain metabolism of branched-chain amino acids (1997)
    • Yudkoff M. 1997. Brain metabolism of branched-chain amino acids (1997). Glia 21:92-98.
    • (1997) Glia , vol.21 , pp. 92-98
    • Yudkoff, M.1


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