Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum

Journal of Physiology

Volumn 498, Issue 2, 1997, Pages 497-501

  Lowry, John P ^a   Fillenz, Marianne ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OXYGEN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; CORPUS STRIATUM; ELECTRODE; GLUCOSE UTILIZATION; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME;

EID: 0031015380     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1997.sp021875     Document Type: Article

References (20)

1. BARON, J. C., LEBRUN-GRANDIE, P., COLLARD, P., CROUZEL, C., MESTELAN, G. & BOUSSER, M. G. (1982). Noninvasive measurement of blood flow, oxygen consumption, and glucose utilization in the same brain regions in man by positron emission tomography: Concise communication. Journal of Nuclear Medicine 23, 391-399.
2. BOUTELLE, M. G., ZETTERSTROM, T., PEI, Q., SVENSSON, L. & FILLENZ, M. (1990). In vivo neurochemical effects of tail pinch. Journal of Neuroscience Methods 34, 151-157.
3. FELLOWS, L. K. & BOUTELLE, M. G. (1993). Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat. Brain Research 604, 225-231.
4. FELLOWS, L. K., BOUTELLE, M. G. & FILLENZ, M. (1993). Physiological stimulation increases non-oxidative glucose metabolism in the brain of the freely moving rat. Journal of Neurochemistry 60, 1258-1263.
5. FORSYTH, R. J., FRAY, A., BOUTELLE, M. G., FILLENZ, M., MIDDLEDITCH, C. & BURCHELL, A. (1996). A role for astrocytes in glucose delivery to neurons? Developmental Neuroscience 18, 360-370.
6. FOX, P. T. & RAICHLE, M. E. (1986). Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Sciences of the USA 83, 1140-1144.
7. FOX, P. T., RAICHLE, M. E., MINTUN, M. A. & DENCE, C. (1988). Non-oxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464.
8. FRAY, A. E., FORSYTH, R. J., BOUTELLE, M. G. & FILLENZ, M. (1996). The mechanisms controlling physiologically stimulated changes in rat brain glucose and laetate: a microdialysis study. Journal of Physiology 496, 49-57.
9. JUEPTNER, M. & WEILLER, C. (1995). Does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI. NeuroImage 2, 148-156.
10. LOWRY, J. P., BOUTELLE, M. G. & FILLENZ, M. (1996a). Measurement of brain tissue oxygen at a carbon paste electrode can serve as an index of increases in regional cerebral blood flow. Journal of Neuroscience Methods (in the Press).
11. LOWRY, J. P., BOUTELLE, M. G., O'NEILL, R. D., & FILLENZ, M. (1996b). Characterisation of carbon paste electrodes in vitro for simultaneous amperometric measurement of changes in oxygen and ascorbic acid concentrations in vivo. Analyst 121, 761-766.
12. LOWRY, J. P., MCATEER, K., EL ATRASH, S. S., DUFF, A. & O'NEILL, R. D. (1994). Characterization of glucose oxidase-modified poly(phenylenediamine)-coated electrodes in vitro and in vivo: Homogeneous interference by ascorbic acid in hydrogen peroxide detection. Analytical Chemistry 66, 1754-1761.
13. LOWRY, J. P. & O'NEILL, R. D. (1994). Partial characterization in vitro of glucose oxidase-modified poly(phenylenediamine)-coated electrodes for neurochemical analysis in vivo. Electroanalysis 6, 369-379.
14. MARRETT, S., FUJITA, H., RIBEIRO, L., KUWABARA, H., MEYER, E., EVANS, A. C. & GJEDDE, A. (1993). Evidence for stimulus-specific changes in oxidative metabolism. Annals of Nuclear Medicine 7, S120-121.
15. MORRISON, P. F., BUNGAY, P. M., HSIAO, J. K., BALL, B. A., MEFFORD, I. N. & DEDRICK, R. L. (1991). Quantitative microdyalisis: analysis of transients and application to pharmacokinetics in brain. Journal of Neurochemistry 57, 103-119.
16. MORTON, D. B. & GRIFFITHS, P. H. M. (1985). Guidelines on the recognition of pain, distress and discomfort in experimental animals and a hypothesis for assessment. Veterinary Record 116, 431-436.
17. SOKOLOFF, L. (1992). The brain as a chemical machine. Progress in Brain Research 94, 19-33.
18. TSACOPOULOS, M. & MAGISTRETTI, P. (1996). Metabolic coupling between glia and neurons. Journal of Neuroscience 16, 877-885.
19. WOLFENSOHN, S. & LLOYD, M. (1994). Handbook of Laboratory Animal Management and Welfare. Oxford University Press, Oxford, UK.
20. ZIMMERMAN, J. B. & WIGHTMAN, R. M. (1991). Simultaneous electrochemical measurement of oxygen and dopamine in vivo. Analytical Chemistry 63, 24-28.