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Volumn 21, Issue 6, 2000, Pages 1167-1173

Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: Relation to β-catenin and PKC isozymes

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASEIN; FRUCTAN; INULIN; ISOENZYME; PROTEIN KINASE C;

EID: 0034094189     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.6.1167     Document Type: Article
Times cited : (103)

References (56)
  • 3
    • 0031417428 scopus 로고    scopus 로고
    • Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis
    • Chang, W.-C.L., Chapkin, R.S. and Lupton, J.R. (1997) Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis, 18, 721-730.
    • (1997) Carcinogenesis , vol.18 , pp. 721-730
    • Chang, W.-C.L.1    Chapkin, R.S.2    Lupton, J.R.3
  • 4
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He, T.-C., Chan, T.A., Vogelstein, B. and Kinzler, K.W. (1999) PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99, 335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.-C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 6
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K.W. and Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 7
    • 0030818746 scopus 로고    scopus 로고
    • The interactions of APC, E-cadherin and β-catenin in tumour development and progression
    • Ilyas, M. and Tomlinson, I.P.M.L. (1997) The interactions of APC, E-cadherin and β-catenin in tumour development and progression. J. Pathol., 182, 128-137.
    • (1997) J. Pathol. , vol.182 , pp. 128-137
    • Ilyas, M.1    Tomlinson, I.P.M.L.2
  • 9
    • 0026808555 scopus 로고
    • Differential regulation of glycogen synthase kinase-3β by protein kinase C isotypes
    • Goode, N., Hughes, K., Woodgett, J.R. and Parker, P.J. (1992) Differential regulation of glycogen synthase kinase-3β by protein kinase C isotypes. J. Biol. Chem., 267, 16878-16882.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16878-16882
    • Goode, N.1    Hughes, K.2    Woodgett, J.R.3    Parker, P.J.4
  • 10
    • 0028670129 scopus 로고
    • Regulation of protein kinase C and role in cancer biology
    • Blobe, G.C., Obeid, L.M. and Hannun, Y. (1994) Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev., 13, 411-431.
    • (1994) Cancer Metastasis Rev. , vol.13 , pp. 411-431
    • Blobe, G.C.1    Obeid, L.M.2    Hannun, Y.3
  • 11
    • 0028902762 scopus 로고
    • Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids
    • Pongracz, J., Clark, P., Neoptolemos, J.P. and Lord, J.M. (1995) Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. Int. J. Cancer, 61, 35-39.
    • (1995) Int. J. Cancer , vol.61 , pp. 35-39
    • Pongracz, J.1    Clark, P.2    Neoptolemos, J.P.3    Lord, J.M.4
  • 12
    • 0028868935 scopus 로고
    • Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: Potential roles of protein kinase C-α, -βII and -ζ
    • Wali, R.K., Frawley, B.P.J., Hartmann, S., Roy, H.K., Khare, S., Scaglione-Sewell, B.A., Earnest, D.L., Sitrin, M.D., Brasitus, T.A. and Bissonnette, M. (1995) Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-α, -βII and -ζ. Cancer Res., 55, 5257-5264.
    • (1995) Cancer Res. , vol.55 , pp. 5257-5264
    • Wali, R.K.1    Frawley, B.P.J.2    Hartmann, S.3    Roy, H.K.4    Khare, S.5    Scaglione-Sewell, B.A.6    Earnest, D.L.7    Sitrin, M.D.8    Brasitus, T.A.9    Bissonnette, M.10
  • 13
    • 0031926179 scopus 로고    scopus 로고
    • Non-invasive detection of fecal protein kinase C βII and ζ messenger RNA: Putative biomarkers for colon cancer
    • Davidson, L.A., Aymond, C.M., Jiang, Y.-H., Turner, N.D., Lupton, J.R. and Chapkin, R.S. (1998) Non-invasive detection of fecal protein kinase C βII and ζ messenger RNA: putative biomarkers for colon cancer. Carcinogenesis, 19, 253-257.
    • (1998) Carcinogenesis , vol.19 , pp. 253-257
    • Davidson, L.A.1    Aymond, C.M.2    Jiang, Y.-H.3    Turner, N.D.4    Lupton, J.R.5    Chapkin, R.S.6
  • 14
    • 0031426678 scopus 로고    scopus 로고
    • Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes
    • Jiang, Y.-H., Lupton, J.R. and Chapkin, R.S. (1997) Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes. Carcinogenesis, 18, 351-357.
    • (1997) Carcinogenesis , vol.18 , pp. 351-357
    • Jiang, Y.-H.1    Lupton, J.R.2    Chapkin, R.S.3
  • 15
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser, A.R., Pitot, H.C. and Dove, W.F. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-324.
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 17
    • 0031417628 scopus 로고    scopus 로고
    • A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse
    • Paulsen, J.E., Elvsaas, I.-K.Q., Steffensen, I.-L. and Alexander, J. (1997) A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. Carcinogenesis, 18, 1905-1910.
    • (1997) Carcinogenesis , vol.18 , pp. 1905-1910
    • Paulsen, J.E.1    Elvsaas, I.-K.Q.2    Steffensen, I.-L.3    Alexander, J.4
  • 18
    • 0030903037 scopus 로고    scopus 로고
    • Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice
    • Wasan, H.S., Novelli, M., Bee, J. and Bodmer, W.F. (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc. Natl Acad. Sci. USA, 94, 3308-3313.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3308-3313
    • Wasan, H.S.1    Novelli, M.2    Bee, J.3    Bodmer, W.F.4
  • 19
    • 0031417627 scopus 로고    scopus 로고
    • 2-Amino-i-methyl-6-phenylimidazo (4,5-b) pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice
    • Steffensen, I.-L., Paulsen, J.E., Eide, T.J. and Alexander J. (1997) 2-Amino-I-methyl-6-phenylimidazo (4,5-b) pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice. Carcinogenesis, 18, 1049-1054.
    • (1997) Carcinogenesis , vol.18 , pp. 1049-1054
    • Steffensen, I.-L.1    Paulsen, J.E.2    Eide, T.J.3    Alexander, J.4
  • 21
    • 0032416737 scopus 로고    scopus 로고
    • Role of red meat and arachidonic acid in protein kinase C activation in rat colonic mucosa
    • Pajari, A.-M., Häkkänen, P., Duan, R.-D. and Mutanen, M. (1998) Role of red meat and arachidonic acid in protein kinase C activation in rat colonic mucosa. Nutr. Cancer, 32, 86-94.
    • (1998) Nutr. Cancer , vol.32 , pp. 86-94
    • Pajari, A.-M.1    Häkkänen, P.2    Duan, R.-D.3    Mutanen, M.4
  • 22
    • 0016683880 scopus 로고
    • Environmental factors and cancer incidence in different countries
    • Armstrong, B. and Doll, R. (1975) Environmental factors and cancer incidence in different countries. Int. J. Cancer, 15, 617-631.
    • (1975) Int. J. Cancer , vol.15 , pp. 617-631
    • Armstrong, B.1    Doll, R.2
  • 24
    • 0030059268 scopus 로고    scopus 로고
    • Nutrition and colorectal cancer
    • Potter, J.D. (1996) Nutrition and colorectal cancer. Cancer Causes Control, 7, 127-146.
    • (1996) Cancer Causes Control , vol.7 , pp. 127-146
    • Potter, J.D.1
  • 25
    • 0031705635 scopus 로고    scopus 로고
    • Effects of dietary fat and a vegetable-fruit mixture on the development of intestinal neoplasia in the Apc min mouse
    • van Kranen, H.J., van Lersel, P.W.C., Rijnkels, J.M., Beems, D.B., Alink, G.M. and Kreijl, C.F. (1998) Effects of dietary fat and a vegetable-fruit mixture on the development of intestinal neoplasia in the Apc Min mouse. Carcinogenesis, 19, 1597-1601.
    • (1998) Carcinogenesis , vol.19 , pp. 1597-1601
    • Van Kranen, H.J.1    Van Lersel, P.W.C.2    Rijnkels, J.M.3    Beems, D.B.4    Alink, G.M.5    Kreijl, C.F.6
  • 26
    • 0030612022 scopus 로고    scopus 로고
    • The relationship between dietary fat intake and risk of colorectal cancer: Evidence from the combined analysis of 13 case-control studies
    • Howe, G.R., Aronson, K.J., Benito, E. et al. (1997) The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies. Cancer Causes Control, 8, 215-228.
    • (1997) Cancer Causes Control , vol.8 , pp. 215-228
    • Howe, G.R.1    Aronson, K.J.2    Benito, E.3
  • 27
    • 0017132957 scopus 로고
    • Effect of a diet with high levels of protein and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine
    • Reddy, B.S., Narisawa, T. and Weisburger, J.H. (1976) Effect of a diet with high levels of protein and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine. J. Natl Cancer Inst., 57, 567-569.
    • (1976) J. Natl Cancer Inst. , vol.57 , pp. 567-569
    • Reddy, B.S.1    Narisawa, T.2    Weisburger, J.H.3
  • 28
    • 0021029725 scopus 로고
    • BALB/C mice fed milk or beef protein: Differences in response to 1,2-dimethylhydrazine carcinogenesis
    • Nutter, R.L., Gridley, D.S., Kettering, J.D., Gordon Goude, A. and Slater, J.M. (1983) BALB/C mice fed milk or beef protein: differences in response to 1,2-dimethylhydrazine carcinogenesis. J. Natl Cancer Inst., 71, 867-874.
    • (1983) J. Natl Cancer Inst. , vol.71 , pp. 867-874
    • Nutter, R.L.1    Gridley, D.S.2    Kettering, J.D.3    Gordon Goude, A.4    Slater, J.M.5
  • 29
  • 30
    • 0032464611 scopus 로고    scopus 로고
    • Effect of meat (beef, chicken and bacon) on rat colon carcinogenesis
    • Parnaud, G., Peiffer, G., Tache, S. and Corpet, D.E. (1998) Effect of meat (beef, chicken and bacon) on rat colon carcinogenesis. Nutr. Cancer, 32, 165-173.
    • (1998) Nutr. Cancer , vol.32 , pp. 165-173
    • Parnaud, G.1    Peiffer, G.2    Tache, S.3    Corpet, D.E.4
  • 31
    • 0031811041 scopus 로고    scopus 로고
    • Feeding of a well-cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in 1,2-dimethyldrazine-treated rats
    • Pence, B.C., Landers, M., Dunn, D.M., Shen, C.-L. and Miller, M.F. (1998) Feeding of a well-cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in 1,2-dimethyldrazine-treated rats. Nutr. Cancer, 30, 220-226.
    • (1998) Nutr. Cancer , vol.30 , pp. 220-226
    • Pence, B.C.1    Landers, M.2    Dunn, D.M.3    Shen, C.-L.4    Miller, M.F.5
  • 33
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J.L. (1989) Ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 36
    • 0027463032 scopus 로고
    • Butyrate production from dietary fibre and protection against large bowel cancer in a rat model
    • McIntry, A., Gibson, P.R. and Young, G.P. (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut. 34, 386-391.
    • (1993) Gut. , vol.34 , pp. 386-391
    • McIntry, A.1    Gibson, P.R.2    Young, G.P.3
  • 37
    • 0030810221 scopus 로고    scopus 로고
    • Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations
    • Zoran, D.L., Turner, N.D., Taddeo, S.S., Chapkin, R.S. and Lupton, J.R. (1997) Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations. J. Nutr., 127, 2217-2225.
    • (1997) J. Nutr. , vol.127 , pp. 2217-2225
    • Zoran, D.L.1    Turner, N.D.2    Taddeo, S.S.3    Chapkin, R.S.4    Lupton, J.R.5
  • 38
    • 0033033115 scopus 로고    scopus 로고
    • Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats
    • Davies, M.J., Bowey, E.A., Adlercretrtz, H., Rowland, I.R. and Rumsby, P.C. (1999) Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats. Carcinogenesis, 20, 927-931.
    • (1999) Carcinogenesis , vol.20 , pp. 927-931
    • Davies, M.J.1    Bowey, E.A.2    Adlercretrtz, H.3    Rowland, I.R.4    Rumsby, P.C.5
  • 39
    • 0030045969 scopus 로고    scopus 로고
    • Comparison of resistant starch with cellulose diet on 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats
    • Sakamoto, J., Shigeyuki, N., Sugawara, K., Iwane, S. and Munakata, A. (1996) Comparison of resistant starch with cellulose diet on 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats. Gastroenterology, 110, 116-120.
    • (1996) Gastroenterology , vol.110 , pp. 116-120
    • Sakamoto, J.1    Shigeyuki, N.2    Sugawara, K.3    Iwane, S.4    Munakata, A.5
  • 40
    • 0030056943 scopus 로고    scopus 로고
    • Wheat bran suppresses potato-starch potentiated colorectal tumorigenesis at the abbarant crypt stage in a rat model
    • Young, G.P., McIntyre, A., Albert, V., Folino, M., Muir, J.G. and Gibson, P.R. (1996) Wheat bran suppresses potato-starch potentiated colorectal tumorigenesis at the abbarant crypt stage in a rat model. Gastroenterology, 110, 508-514.
    • (1996) Gastroenterology , vol.110 , pp. 508-514
    • Young, G.P.1    McIntyre, A.2    Albert, V.3    Folino, M.4    Muir, J.G.5    Gibson, P.R.6
  • 42
    • 0020457082 scopus 로고
    • Effect of a lignan on RNA synthesis in the rat
    • Waters, A.P. and Knowler, J.T. (1982) Effect of a lignan on RNA synthesis in the rat. J. Reprod. Fert., 66, 379-381.
    • (1982) J. Reprod. Fert. , vol.66 , pp. 379-381
    • Waters, A.P.1    Knowler, J.T.2
  • 43
    • 0029951809 scopus 로고    scopus 로고
    • The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity
    • Jenab, M. and Thompson, L.U. (1996) The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity. Carcinogenesis, 17, 1343-1348.
    • (1996) Carcinogenesis , vol.17 , pp. 1343-1348
    • Jenab, M.1    Thompson, L.U.2
  • 45
    • 0028933106 scopus 로고
    • Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin
    • Gibson, G.R., Beatty, E.R., Wang, X. and Cummings, J.H. (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology, 108, 975-982.
    • (1995) Gastroenterology , vol.108 , pp. 975-982
    • Gibson, G.R.1    Beatty, E.R.2    Wang, X.3    Cummings, J.H.4
  • 46
    • 0029817024 scopus 로고    scopus 로고
    • Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans
    • Bouhnik, Y., Flourié, B., Riottot, M., Bisetti, N., Gailing, M., Guibert, A., Bornet, F.R. and Rambaud, J. (1996) Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Nutr. Cancer, 26, 21-29.
    • (1996) Nutr. Cancer , vol.26 , pp. 21-29
    • Bouhnik, Y.1    Flourié, B.2    Riottot, M.3    Bisetti, N.4    Gailing, M.5    Guibert, A.6    Bornet, F.R.7    Rambaud, J.8
  • 47
    • 0031014140 scopus 로고    scopus 로고
    • Short-chain fructo-oligosaccharides reduce the occurence of colon tumours and develop gut-associated lymphoid tissue in Min mice
    • Pierre, F., Perrin, P., Champ, M., Bornet, F., Meflah, K. and Menanteau, J. (1997) Short-chain fructo-oligosaccharides reduce the occurence of colon tumours and develop gut-associated lymphoid tissue in Min mice. Cancer Res., 57, 225-228.
    • (1997) Cancer Res. , vol.57 , pp. 225-228
    • Pierre, F.1    Perrin, P.2    Champ, M.3    Bornet, F.4    Meflah, K.5    Menanteau, J.6
  • 48
    • 0028576837 scopus 로고
    • Chemoprevention of colon cancer by dietary fatty acids
    • Reddy, B.S. (1994) Chemoprevention of colon cancer by dietary fatty acids. Cancer Metas. Rev., 13, 285-302.
    • (1994) Cancer Metas. Rev. , vol.13 , pp. 285-302
    • Reddy, B.S.1
  • 49
    • 0022607849 scopus 로고
    • Relationship between colonic luminal pH, proliferation and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets
    • Jacobs, L.R. and Lupton, J.R. (1986) Relationship between colonic luminal pH, proliferation and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets. Cancer Res., 46, 1727-1734.
    • (1986) Cancer Res. , vol.46 , pp. 1727-1734
    • Jacobs, L.R.1    Lupton, J.R.2
  • 50
    • 0030703623 scopus 로고    scopus 로고
    • Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration
    • Mahmoud, N.N., Boolbol, S.K., Bilinski, R.T., Martucci, C., Chadburn, A. and Bertagnolli, M. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res., 57, 5045-5050.
    • (1997) Cancer Res. , vol.57 , pp. 5045-5050
    • Mahmoud, N.N.1    Boolbol, S.K.2    Bilinski, R.T.3    Martucci, C.4    Chadburn, A.5    Bertagnolli, M.6
  • 52
    • 0028299887 scopus 로고
    • Loss of protein kinase C δ isoenzyme immunoreactivity in human adenocarcinomas
    • Craven, P.A. and DeRubertis, F.R. (1994) Loss of protein kinase C δ isoenzyme immunoreactivity in human adenocarcinomas. Digest. Dis. Sci., 39, 481-489.
    • (1994) Digest. Dis. Sci. , vol.39 , pp. 481-489
    • Craven, P.A.1    DeRubertis, F.R.2
  • 53
    • 0028218804 scopus 로고
    • Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon
    • Kahl-Rainer, P., Karner-Hanusch, J., Weiss, W. and Marian, B. (1994) Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon. Carcinogenesis, 15, 779-782.
    • (1994) Carcinogenesis , vol.15 , pp. 779-782
    • Kahl-Rainer, P.1    Karner-Hanusch, J.2    Weiss, W.3    Marian, B.4
  • 54
    • 0031748904 scopus 로고    scopus 로고
    • PKC isoforms: Villains in colon cancer
    • Brasitus, T.A. and Bissonette, M. (1998) PKC isoforms: villains in colon cancer. Gastroenterology, 115, 225-227.
    • (1998) Gastroenterology , vol.115 , pp. 225-227
    • Brasitus, T.A.1    Bissonette, M.2
  • 55
    • 0033577858 scopus 로고    scopus 로고
    • Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
    • Murray, N.R., Davidson, L.A., Chapkin, R.S., Gustafson, W.C., Schattenberg, D.G. and Fields, A.P. (1999) Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J. Cell. Biol., 145, 699-711.
    • (1999) J. Cell. Biol. , vol.145 , pp. 699-711
    • Murray, N.R.1    Davidson, L.A.2    Chapkin, R.S.3    Gustafson, W.C.4    Schattenberg, D.G.5    Fields, A.P.6
  • 56
    • 0030758925 scopus 로고    scopus 로고
    • Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis
    • Chiu, C.-H., McEntee, M.F. and Whelan, J. (1997) Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis. Cancer Res., 57, 4267-4273.
    • (1997) Cancer Res. , vol.57 , pp. 4267-4273
    • Chiu, C.-H.1    McEntee, M.F.2    Whelan, J.3


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