Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?

Carcinogenesis

Volumn 17, Issue 3, 1996, Pages 515-523

  Bingham, S A ^a   Pignatelli, B ^b   Pollock, J R A ^c   Ellul, A ^b   Malaveille, C ^b   Gross, G ^d   Runswick, S ^a   Cummings, J H ^a   O'Neill, I K ^a,b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c Pollock and Pool Ltd   (United Kingdom)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; CIGARETTE SMOKE; IRON; NITRATE; NITRITE; NITROSO DERIVATIVE; POLYSACCHARIDE; STARCH;

ADULT; ARTICLE; COLON; COLORECTAL CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS LINKING; DIETARY INTAKE; FECES; FECES LEVEL; FISH; GENE MUTATION; HUMAN; HUMAN EXPERIMENT; MALE; MEAT; NORMAL HUMAN; ONCOGENE K RAS; PH; PRIORITY JOURNAL; WHEAT BRAN;

ADULT; AMINES; ANALYSIS OF VARIANCE; CREATININE; DIETARY FIBER; FECES; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; MALE; MEAT; MUTAGENS; NITRATES; NITRITES; NITROSATION; NITROSO COMPOUNDS; UREA;

EID: 0029959961     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.3.515     Document Type: Article

References (63)

1. Armstrong.B. and Doll.R. (1975) Environmental factors and cancer incidence in different countries. Int. J. Cancer. 15, 617-631.
2. Grovannucci,E., Rimm,E.. Stampfer,M.J., Colditz,G.A. Ascherio,A. and Willett.W.C. (1994) Intake of fat, meat, and fibre in relation to risk of colon cancer in men. Cancer Res.. 54, 2390-2397.
3. Goldbohm.R.A. van den Brandt,P., van't Veer,P.. Brants,H.A.M., Dorant.,E., Sturmans,F. and Hermus,R.J.J. (1994) A prospective study on the relation between meat consumption and the risk of colon cancer. Cancer Res., 54, 718-723.
4. Thorogood,M., Mann,J., Appley,P. and McPherson,K. (1994) Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters. Br. Med. J., 308, 1667-1670.
5. Frentzel Beyme,R. and Chang-Claude,J. (1994) Vegetarian diets and colon cancer: the German experience. Am. J. Clin. Nutr., 59, 1143S-U52S.
6. Potter.J.D,. Slattery.M.L.. Bostick.R.M. and Gapstur.S.M. (1994) Colon cancer, a review of the epidemiology. Epidemiol. Rev. 15, 489-545.
7. Cassidy,A, Bingham,S and Cummings,J.H. (1994) Starch intake and colorectal cancer risk: an international comparison. Br. J. Cancer. 69, 937-942.
8. Bruce.W.R. (1987) Recent hypotheses for the origin of colon cancer. Cancer Res., 47, 4237-4242.
9. Cummings,J.H., Bingham,S., Heaton.K.W. and Eastwood,M.A. (1992) Fecal weight, colon cancer risk and dietary intake of NSP. Gastroenterology. 103, 1783-1789.
10. Bos,J.L. (1989) ras oncogenes in human cancer: a review. Cancer Res , 49, 4682-4689.
11. Rowland.I.R., Granli.T.. Bockman,O.C., Key,P.E. and Massey,R.C (1991) Endogenous N-nitrosation in man assessed by measurement of apparent total N-nitroso compounds in faeces. Carcinogenesis, 12, 1359-1401.
12. Hall,C.N, Badawi,A.E, O'Connor.P.L. and Saffhil,R. (1991) The detection of DNA damage in the DNA of human GI tissue. Br. J. Cancer, 64, 59-63.
13. Jacoby,R.F., Alexander,R.J, Raicht,R.F. and Brasitus,T.A. (1992) K-ras oncogene mutations in rat colon tumours induced by MNU. Carcinogenesis, 13, 45-49.
14. Hoktein,M., Sidransky.D., Vogelstein,B. and Harris.C.C. (1991) p53 mutations in human cancer. Science, 253, 49-53
15. Harris.C.C. (1993) p53 at the cross roads of molecular carcinogenesis and risk assessment. Science, 262, 1980-1981.
16. Angaard,E. (1994) Nitric oxide: mediator, murderer and medicine. Lancer, 343. 1199-1206.
17. Mallett,A.K., Walters,D.G. and Rowland.I.R. (1988) Protein related differences in the excretion of nitrosoproline and nitrate by the rat. Fd Chem. Toxicol. 26, 831-835.
18. Ward.F.W. Coates.M.E. and Walker.R. (1989) Influence of dietary protein and gut microflora on endogenesis synthesis of nitrate and N-nitrosamines in the rat. Fd Chem. Toxicol., 27, 445-449
19. Alison,C. and MacFarlane,G. (1988) Effect of nitrate on methane production and fermentation by slurries of human faecal bacteria. J. Gen. Microbiol., 134, 1397-1405.
20. Macfarlane,G. And Cummings,J.H. (1991) The colonie flora, fermentation, and large bowel digestive function In Philhps.S., Pemberton,J.H. and Shorter,R.G (eds), The Large Intestine. Physiology, Pathophysiology and Disease Raven Press, New York, NY, pp 51-92
21. Layton,DW. Bogen,K.T, Knize,M.G., Hatch,F.T. Johnson,V.M. and Felton.J.S (1995) Cancer risk of heterocyclic amines in cooked foods. Carcinogenesis, 16, 39-52.
22. Kadlubar,FF., Butler.M.A.. Kaderlik,K.R., Chou,H C. and Lang.N.P. (1992) Polymorphisms for aromatic amine metabolism in humans. Environ Hlth Perspect.. 98. 69-74.
23. Knight,T.M., Forman,D., Al Dabbagh,S.A. and Doll.R. (1987) Estimation of dietary intake of nitrate and nitrite in Great Britain. Fd Chem. Toxicol., 25, 277-285.
24. Florin.T., Neale.G. and Cummings,J.H. (1990) The effect of dietary nitrate on nitrate and nitrite excretion in man. Br. J. Nutr., 64, 387-397.
25. Barrington,P.J. Baker.R.S.U. Truswell,A.S., Bonin,A.M., Ryan.A J and Paulin.A.P. (1990) Mutagenicity of basic fractions derived from lamb and beef cooked by common household methods. Fd Chem. Toxicol., 28. 141-146.
26. Holland,B., Welch,A.A., Unwin,I.D., Buss,D.H. Paul,A.A. and Southgate,D A.T. (1991) McCance and Widdowson's The Composition of Foods Royal Society of Chemistry, Letchworth, UK.
27. Department of Health (1991) Dietary reference values for food energy and nutrients for the UK. In Reports on Health and Social Subjects, Vol. 41. HMSO, London, UK.
28. Kalow,W. and Tang,B.K. (1991) Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidate activities. Clin. Pharmacol. Ther., 50. 508-519.
29. Gross,G.A. and Gruter.A. (1992) Quantification of mutagenic HAA in food products. J. Chromatogr., 592. 271-278.
30. Pignatelli,B., Richard.I., Bourhade,M. and Bartch,H. (1987) Improved group determination of total NOC in human gastric juice by chemical denitrosation and thermal energy analysis. Analyst, 112, 945-949
31. Pignatelli,B., Chen,C.S., Thuillier,P. and Bartsch.H. (1990) An improved method for the analysis of total NOC in biological matrices including human gastric juice In Eisenbrand,G., Bozler.G and Nicolai,H (eds), The Significance of N-Nitrosation of Drugs. Gustav Fisher Verlag. Stuttgart, Germany, pp. 124-140.
32. Solorzano,L. (1969) Determination of ammonia in natural water by phenol hypochlorite method. Limnol. Oceanogr., 14, 799-801.
33. Evans,D F, Pye,G . Bramley.R., Clark,A.G., Dyson,T.J. and Hardcastle,J.D. (1988) Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut. 29. 1035-1041
34. Povev,A.C. Bartsch.H and O'Neill,I.K. (1987) Magnetic PEI microcapsules as retrievable traps for carcinogen electrophiles formed in the gastrointestinal tract. Cancer Lett., 26, 45-53.
35. Bingham,S., Ellul,A., Cummings,J.H. and O'Neill.l (1992) Novel detection by magnetic microcapsules in the human GI tract of cross-linking agents. Carcinogenesis, 13, 683-690.
36. Povey,A. and O'Neill,I. (1990) CPTS labelled magnetic microcapsules. Carcinogenesis. 11. 1989-1993.
37. Ellul,A., Povey,A. and O'Neill,I.K. (1990) Presence of endogenous crosslinking agents in GI cavity as detected by transit of magnetic PEI microcapsules. Carcinogenesis, 11, 1577-1582.
38. Bingham,S., Williams,R., Cole,T.J , Price,C and Cummings,J.H. (1988) Reference values for analytes of 24 h urine collections known to be complete. Annls Clin. Biochem., 25, 610-619.
39. Cummings,J.H. Jenkins D.J.A. and Wiggins,H.S. (1976) Measurement of the mean transit time of dietary residue through the human gut. Gut. 17, 210-218.
40. Neuragh,G., Duner,B. and Paine,F. (1976) Environmental NOC Analysis and Formation. IARC Scientific Report no 14. IARC, Lyon, France, pp. 227-236.
41. Hecht,S.S. and Hoffmann.D. (1991) N-Nitroso compounds and tobacco induced cancers in man. In O'Neill.I.K., Chen,J. and Bartsch,H. (eds), Relevance to Human Cancer of NOC. IARC, Lyon, France, pp. 54-61.
42. Silvester,K., Bingham,S., Loktionov,A., Cummings,J. and O'Neill,I. (1996) Effect of dietary meat on endogenous NOC formation and frequency of K-rac mutants in faecal isolated colonie cells (abstract). In Proceedings of the Meeting on Molecular Aspects of Carcinogenesis, York, UK
43. Pence,B.P, Butler,M.J., Dunn,D.M , Miller,M.F., Zhao,C. and Landers,M. (1995) Non-promoting effects of lean beef in the rat colon carcinogenesis model. Carcinogenesis, 16, 1157-1160.
44. Reddy,B.S, Narasawa,T. and Weisburger,J. (1976) Effect of a diet with high levels of protein and fat on colon carcinogenesis in rats treated with DMH. J. Nail Cancer Inst.. 57, 567-569.
45. Calmels,S., Ohshima,H., Vincent,P., Gounot,A and Bartsch,H. (1985) Screening of micro-organisms for nitrosation catalysis at pH 7. Carcinogenesis, 6, 911-915.
46. Stouthammer,A H. (1976) Biochemistry and genetics of nitrate reductase in bacteria. Adv. Microbiol. Physiol , 14, 315-375.
47. Rumney,C.J. Rowland,I.R. Coutts,T.M., Randerath,K., Reddy,R., Shah,A B., Ellul,A. and O'Neill,I.K. (1993) Effects of risk associated human dietary macrocomponents on processes related to Carcinogenesis in human flora associated rats. Carcinogenesis. 14, 79-84.
48. Castillo,L. Sanchez,M., Vogt,T., Chapman,T.E., Walker,TC., Tannenbaum,S.R, Ajami.A.M. and Young.V.R. (1995) Plasma arginine. citrulline and ornithine kinetics in adults. Am. J. Physiol., 268. E360-E367.
49. Mallett,A.R., Rowland,I.R. and Brearne,C.A. (1986) Influence of wheat bran on some reductive and hydrolytic activities of the rat cecal flora. Nutr. Cancer, 8. 125-131.
50. Graf,E. and Eaton,J W. (1993) Suppression of colonie cancer by dietary phytic acid. Nutr. Cancer, 19, 11-19.
51. Ullah.A. and Shamsuddin,A.M. (1990) Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis, 11, 2219-2222.
52. Kuratko.C. and Pence,B C. (1995) Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity. Cancer Lett., 95, 181-187.
53. Cummings,J.H . Hill,M.J, Bone,E S., Branch,W.J. and Jenkms.D.J.A. (1979) The effect of meat protein and dietary fibre on colonic function and metabolism. II. Bacterial metabolism in faeces. Am. J Clini Nutr. 32, 2094-2101.
54. Tsujii,M., Kawano.S., Tsuji,S., Nagano,K., Ito,T., Hayashi,N., Fusamoto,H., Kamada,T. and Tamura,K. (1992) Ammonia - a possible promoter in Helicobacter pylori-related gastric carcinogenesis. Cancer Lett., 65. 15-18.
55. Tsujii,M., Kawano,S., Tsuji,S., Ito.T, Nagano,K., Sasaki,Y., Hayashi,N., Fusamoto,H. and Kamada.T (1993) Cell kinetics of mucosal atrophy in rat stomach induced by long term administration of ammonia. Gastroenterotogy, 104, 796-801.
56. Visek,W.J. (1978) Diet and cell growth modulation by ammonia. Am. J. Clin. Nutr., 31, S216-S220.
57. Cummings J.H., Beatty,E.R., Kingman,S.E. Bingham,S. and Englyst,E.R. (1996) Digestion and physiological properties of resistant starch in the human large bowel. Br. J. Nutr., in press.
58. Gross.G.A. (1990) Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products. Carcinogenesis, 11, 1597-1603.
59. Weisburger,J.H. (1993) Heterocyclic amines in foods. Cancer Res., 53, 2422-2424.
60. Yang,C.S. and Yoo,J.-S.H. (1991) Nutrition and hepatic drug metabolism. In Rowland,I.R. (ed.), Nutrition, Toxicity and Cancer. CRC Press, Boca Raton, FL.
61. Anderson,K.E., Conney,A.H. and Kappas,A. (1982) Nutritional influences on chemical biotransformations in humans. Nutr. Rev., 40, 161-171.
62. Haye,J.R., Mgbodile,M.U.K., Merrill,A.H., Nerurkar,L.S. and Campbell,T.C. (1978) The effect of dietary protein depletion and repletion on rat hepatic MFO activities. J. Nutr., 108, 1788-1797.
63. Bingham,S. (1988) Meat, starch and NSP and large bowel cancer. Am. J. Clin. Nutr., 48, 762-767.