Leptin inhibits insulin secretion by activation of phosphodiesterase 3B

Journal of Clinical Investigation

Volumn 102, Issue 5, 1998, Pages 869-873

  Zhao, Allan Z ^a   Bornfeldt, Karin E ^b   Beavo, Joseph A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

cAMP; Diabetes; Glucagon like peptide 1; Phosphoinositide 3 kinase; cell

Indexed keywords

INSULIN; LEPTIN; PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HORMONAL REGULATION; HORMONE ACTION; INSULIN RELEASE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032169556     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3920     Document Type: Article

References (28)

1. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
2. Campfield, L.A., F.J. Smith, Y. Guisez, R. Devos, and P. Burn. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
3. Muller, G., J. Ertl, M. Gerl, and G. Preibisch. 1997. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J. Biol. Chem. 272:10585-10593.
4. Rossetti, L., D. Massillon, N. Barzilai, P. Vuguin, W. Chen, M. Hawkins, J. Wu, and J. Wang. 1997. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. biol. Chem. 272:27758-27763.
5. Montague, C.T., I.S. Farooqi, J.P. Whitehead, M.A. Soos, H. Rau, N.J. Wareham, C.P. Sewter, J.E. Digby, S.N. Mohammed, J.A. Hurst, et al. 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:903-908.
6. Vaisse, C., J.L. Halaas, C.M. Horvath, J.E.J. Darnell, M. Stoffel, and J.M. Friedman. 1996. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14:95-97.
7. Bjorbaek, C., S. Uotani, S.B. da, and J.S. Flier. 1997. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. biol. Chem. 272:32686-32695.
8. Cohen, B., D. Novick, and M. Rubinstein. 1996. Modulation of insulin activities by leptin. Science. 274:1185-1188.
9. Holz, G.G., and J.F. Habener. 1992. Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem. Sci. 17:388-393.
10. Bentley, J.K., and J.A. Beavo. 1992. Regulation and function of cyclic nucleotides. Curr. Opin. Cell. Biol. 4:233-240.
11. Beavo, J.A. 1995. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75:725-748.
12. Soderling, S.H., S.J. Bayuga, and J.A. Beavo. 1998. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273:15553-15558.
13. Degerman, E., P. Beifrage, and V.C. Manganiello. 1997. Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J Biol. Chem. 272:6823-6826.
14. Zhao, A.Z., H. Zhao, J. Teague, W. Fujimoto, and J.A. Beavo. 1997. Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc. Natl. Acad. Sci. USA. 94: 3223-3228.
15. Yan, C., A.Z. Zhao, J.K. Bentley, K. Loughney, K. Ferguson, and J.A. Beavo. 1995. Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA. 92:9677-9681.
16. Tanizawa, Y., S. Okuya, H. Ishihara, T. Asano, T. Yada, and Y. Oka. 1997. Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells. Endocrinology. 138:4513-4516.
17. Orskov, C., and J.J. Hoist. 1987. Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). Scand. J. Clin. Lab. Invest. 47:165-174.
18. Kreymann, B., G. Williams, M.A. Ghatei, and S.R. Bloom. 1987. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 2:1300-1304.
19. Ahren, B., S. Mansson, R.L. Gingerich, and P.J. Havel. 1997. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am. J. Physiol. Regul. Int. Comp. Physiol. 42:R113-R120.
20. VanHeek, M., D.S. Compton, C.F. France, R.P. Tedesco, A.B. Fawzi, M.P. Graziano, E.J. Sybertz, C.D. Strader, and H.R. Davis. 1997. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J. Clin. Invest. 99:385-390.
21. Considine, R.V., and J.F. Caro. 1996. Serum leptin in normal-weight and obese humans (reply). N. Engl. J. Med. 334:1544.
22. + channels in pancreatic beta-cells. Diabetes. 46:1087-1093.
23. Shafiee, N.R., N.J. Pyne, and B.L. Furman. 1995. Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity. Br. J. Pharmacol. 115:1486-1492.
24. Lester, L.B., L.K. Langeberg, and J.D. Scott. 1997. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc. Natl. Acad. Sci. USA. 94:14942-14947.
25. Brunn, G.J., J. Williams, C. Sabers, G. Wiederrecht, J.C. Lawrence, and R.T. Abraham. 1996. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO (Eur. Mol. Biol. Organ.) J. 15:5256-5267.
26. Beebe, S.J., L.A. Beasley, and J.D. Corbin. 1988. cAMP analogs used to study low-Km, hormone-sensitive phosphodiesterase. Methods Enzymol. 159: 531-540.
27. Akabayashi, A., C.T. Zaia, S.M. Gabriel, I. Silva, W.K. Cheung, and S.F. Leibowitz. 1994. Intracerebroventricular injection of dibutyryl cyclic adenosine 3′,5′-monophosphate increases hypothalamic levels of neuropeptide Y. Brain Res. 660:323-328.
28. Gillard, E.R., A.M. Khan, U.H. Ahsan, R.S. Grewal, B. Mouradi, and B.G. Stanley. 1997. Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus. Am. J. Physiol. 273:R107-R112.