Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys obesus

International Journal of Obesity

Volumn 23, Issue 1, 1999, Pages 83-89

  Walder, K ^a   Lewandowski, P ^a   Morton, G ^a   Sanigorski, A ^a   De Silva, A ^a   Zimmet, P ^b   Collier, Greg R ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Leptin resistance; Obesity treatment; Psammomys obesus

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HORMONE RESISTANCE; INSULIN BLOOD LEVEL; METABOLIC DISORDER; MULTIFACTORIAL INHERITANCE; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; PSAMMOMYS OBESUS; RODENTIA;

EID: 0032960151     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800763     Document Type: Article

References (20)

1. 1 Zhang YR, Proenca M, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
2. 2 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-549.
3. 3 Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
4. 4 Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
5. 5 Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
6. 6 Cusin I, Rohner-Jeanrenaud F, Stricker-Krongard A, Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Diabetes 1996; 45: 1446-1450.
7. 7 Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1995; 94: 8878-8883.
8. 8 Barnett M, Collier GR, Collier FM, Zimmet P, O'Dea K. A cross-sectional and short-term longitudinal characterisation of NIDDM in Psammomys obesus. Diabetologia 1994; 37: 671-676.
9. 9 Barnett M, Collier GR, Zimmet P, O'Dea K. The effect of restricting energy intake on diabetes in Psammomys obesus. Int J Obes 1994; 18: 789-794.
10. 10 Shafrir E, Gutman A. Psammomys obesus of the Jerusalem colony: A model for nutritionally induced, non-insulin-dependent diabetes. J Basic Clin Physiol Pharm 1993; 4: 83-99.
11. 11 Collier GR, de Silva A, Sanigorski AJ, Walder K, Yamamoto A, Zimmet P. Development of obesity and insulin resistance in the Israeli Sand Rat (Psammomys obesus): Does leptin play a role? Ann N Y Acad Sci 1997; 827: 50-63.
12. 12 Walder K, Willet M, Zimmet P, Collier GR. Ob (obese) gene expression and leptin levels in Psammomys obesus. Biochim Biophys Acta 1997; 1354: 272-278.
13. 13 Walder K, Lee S, Zimmet PZ, Collier GR. Dysregulation of leptin in response to fasting in insulin resistant Israeli sand rats. Metabolism 1997; 47: 125-128.
14. 14 Walder K, Dascaliuc CR, Lewandowski PA, Sanigorski AJ, Zimmet P, Collier GR. The effect of dietary energy restriction on the development of obesity and non-insulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus. Obes Res 1997; 5: 193-200.
15. 15 de Courten M, Zimmet P, Hodge A, Collins V, Nicolson M, Staten M, Dowse G, Alberti KGMM. Hyperleptinaemia: The missing link in the Metabolic Syndrome. Diabetic Med 1997; 14: 200-208.
16. 16 Zimmet P, Hodge A, Nicolson M, Staten M, de Courten M, Moore J, Morawiecki A, Lubina J, Collier G, Alberti G, Dowse G. Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional studies. BMJ 1996; 313: 965-969.
17. 17 Van Heck M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Syvertz EJ, Strader CD, Davis HR Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 1997; 99: 385-390.
18. 18 Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997; 46: 313-316.
19. 19 Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
20. 20 Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Med Sci 1997; 94: 4637-4641.