Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 5 39-5, 1999, Pages

  Muoio, Deborah M ^a   Dohm, G Lynis ^b   Tapscott, Edward B ^b   Coleman, Rosalind A ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c IL   (United States)

Author keywords

Fatty acid oxidation; Obesity; Triacylglycerol

Indexed keywords

DIACYLGLYCEROL; GLUCOSE; INSULIN; LEPTIN; OLEIC ACID; TRIACYLGLYCEROL; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; EXTENSOR DIGITORUM LONGUS MUSCLE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; INSULIN RESISTANCE; LIPOGENESIS; MOUSE; NONHUMAN; OBESITY; PARTITION COEFFICIENT; PRIORITY JOURNAL; SOLEUS MUSCLE;

EID: 0033005654     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.5.e913     Document Type: Article

References (50)

1. Auwerx, J., and B. Staels. Leptin. Lancet 351: 737-742, 1998.
2. Berti, L., M. Kellerer, E. Capp, and H. U. Haring. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a PI3-kinase mediated effect. Diabetologia 40: 606-609, 1997.
3. Bessesen, D. H., C. L. Rupp, and R. H. Eckel. Dietary fat is shunted away from oxidation, towards storage in obese Zucker rats. Obes. Res. 3: 179-189, 1995.
4. Chen, H., O. Charlat, L. A. Tartaglia, E. A. Woolf, X. Weng, S. J. Ellis, N. D. Lakey, J. Culpepper, K. J. Moore, R. E. Breitbart, G. M. Duyk, R. I. Tepper, and J. P. Morgenstern. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db / db mice. Cell 84: 491-495, 1996.
5. Cioffi, J. A., A. W. Shafer, T. J. Zupancic, J. Smith-Gbur, A. Mikhail, D. Platika, and H. R. Snodgrass. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2: 585-589, 1996.
6. Cohen, B., D. Novick, and M. Rubinstein. Modulation of insulin activities by leptin. Science 274: 1185-1188, 1996.
7. Colberg, S. R., J. A. Simoneau, F. L. Thaete, and D. E. Kelley. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J. Clin. Invest. 95: 1846-1853, 1995.
8. Dohm, G. L., E. B. Tapscott, W. J. Pories, D. J. Dabbs, E. G. Flickinger, D. Meelheim, T. Fushiki, S. Atkinson, C. W. Elton, and J. F. Caro. An in vitro human skeletal muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82: 486-494, 1988.
9. Drewes, P. A. Clinical Chemistry, Principles and Technics, edited by R. J. Henry, D. C. Cannon, and J. W. Winkelman. Hagerstown, MD: Harper and Row, 1974.
10. Emilsson, V., Y. Liu, M. A. Cawthorne, N. M. Morton, and M. Davenport. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46: 313-316, 1997.
11. Entenman, C. General procedures for separating lipid components of tissue. Methods Enzymol. 3: 301-302, 1957.
12. Espinal, J., G. L. Dohm, and E. A. Newsholme. Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle strips from sedentary, exercised and exercise-trained rats. Biochem. J. 212: 453-458, 1983.
13. Ghilardi, N., S. Ziegler, A. Wiestner, R. Stoffel, M. Heim, and S. C. Radek. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 93: 6231-6235, 1996.
14. Glatz, J. F., and J. H. Veerkamp. Palmitate oxidation by intact preparations of skeletal muscle. Biochim. Biophys. Acta 713: 230-239, 1982.
15. Goodpaster, B. H., and D. E. Kelley. Role of muscle in triglyceride metabolism. Curr. Opin. Lipidol. 9: 231-236, 1998.
16. Harris, R. B. S. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem. Biophys. Res. Commun. 245: 502-509, 1998.
17. Kellerer, M., M. Koch, E. Metzinger, J. Mushack, E. Capp, and U. Haring. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40: 1358-1362, 1997.
18. Kern, M., E. B. Tapscott, R. D. Snider, and G. L. Dohm. Differences in glucose transport rates between perfused and in vitro incubated muscles. Horm. Metab. Res. 22: 366-368, 1990.
19. Kroder, G., M. Kellerer, and H. U. Haring. Effect of leptin on insulin signaling in rat 1 fibroblasts overexpressing HIR (Abstract). Exp. Clin. Endocrinol. Diabetes 104: 66, 1996.
20. Kulkarni, R. N., Z. Wang, R. Wang, J. Hurley, D. M. Smith, M. A. Ghatei, D. J. Withers, J. V. Gardiner, C. J. Bailey, and S. R. Bloom. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J. Clin. Invest. 100: 2729-2736, 1997.
21. Lee, A. D., P. A. Hansen, and J. O. Holloszy. Wortmannin inhibits insulin-stimulated but not contraction stimulated glucose transport activity in skeletal muscle. FEBS Lett. 361: 51-54, 1995.
22. Levin, N., C. Nelson, A. Gurney, R. Vandlen, and F. Sauvage. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. USA 93: 1726-1730, 1996.
23. Liu, Y., V. Emilsson, and M. A. Cawthorne. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob / ob) mice. FEBS Lett. 411: 351-355, 1997.
24. Martin, W. H. Effects of acute and chronic exercise on fat metabolism. Exerc. Sport Sci. Rev. 24: 203-231, 1996.
25. Muller, G., J. Ertl, M. Gerl, and G. Preibisch. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J. Biol. Chem. 272: 10585-10593, 1997.
26. Muoio, D. M., G. L. Dohm, F. T. Fiedorek, E. B. Tapscott, and R. A. Coleman. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363, 1997.
27. Murakami, T., T. Yamashita, M. Iida, M. Kuwajima, and K. Shima. A short form of the leptin receptor performs signal transduction. Biochem. Biophys. Res. Commun. 231: 26-29, 1997.
28. Oakes, N. D., K. S. Bell, S. M. Furler, S. Cammilleri, A. K. Saha, N. B. Ruderman, D. J. Chrisholm, and E. W. Kraegen. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise. Diabetes 46: 2022-2028, 1997.
29. Pearce, F. J., and R. J. Connett. Effect of lactate and palmitate on substrate utilization of isolated rat soleus. Am. J. Physiol. 238 (Cell Physiol. 7): C149-C159, 1980.
30. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob / ob mice. Science 269: 540-543, 1995.
31. Phillips, D. I. W., S. Caddy, V. Iiic, B. A. Fielding, K. N. Frayn, A. C. Borthwick, and R. Taylor. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950, 1996.
32. Prentki, M., and B. E. Corkey. Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45: 273-283, 1996.
33. Remesar, X., I. Rafecas, J. A. Fernadez-Lopez, and M. Alemany. Is leptin an insulin counter-regulatory hormone? FEBS Lett. 402: 9-11, 1997.
34. Rossetti, L., D. Massillon, N. Barzilai, P. Vuguin, W. Chen, M. Hawkins, and J. W. J. Wu. Short-term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 272: 27758-27763, 1997.
35. Russell, J. C., G. Shillabeer, J. Bartana, D. C. W. Lau, M. Richardson, L. M. Wenzel, S. E. Graham, and P. J. Dolphin. Development of insulin resistance in the JCR-LA-rat - role of triacylglycerols and effects of MEDICA 16. Diabetes 47: 770-778, 1998.
36. Saha, A. K., T. G. Kurowski, and N. B. Ruderman. A malonyl-CoA fuel sensing mechanism in muscle: effects of insulin, glucose and denervation. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E283-E289, 1995.
37. Saha, A. K., D. Vavvas, T. G. Kurowski, A. Apazidis, L. A. Witters, E. Shafrir, and N. B. Ruderman. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E641-E648, 1997.
38. Samec, S., J. Seydoux, and G. Dulloo. Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J. 12: 715-724, 1998.
39. Schwartz, M. W., D. G. Baskin, T. R. Bukowski, J. L. Kuijper, D. Foster, G. Lasser, D. E. Prunkard, D. Porte, S. C. Woods, R. J. Seeley, and D. S. Weigle. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob / ob mice. Diabetes 45: 531-535, 1996.
40. Shimabukuro, M., K. Koyama, G. Chen, M. Wang, F. Trieu, Y. Lee, C. B. Newgard, and R. H. Unger. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA 94: 4637-4641, 1997.
41. Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
42. Storlien, L. H., A. B. Jenkins, D. J. Chrisholm, W. S. Pascoe, S. Khouri, and E. W. Kraegen. Influence of dietary fat composition on development of insulin resistance in rats. Diabetes 40: 280-289, 1991.
43. Strohfeldt, P., C. Heugel, and H. J. Hellreigel. Effect of palmitate on lipolysis in isotopically prelabeled rat skeletal muscle. Horm. Metab. Res. 19: 506-507, 1987.
44. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K. J. Moore, J. S. Smutko, G. G. Mays, E. A. Woolf, C. A. Monroe, and R. I. Tepper. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
45. Weigle, D. S., L. E. Selfridge, M. W. Schwartz, R. J. Seeley, D. E. Cummings, P. J. Havel, J. L. Kuijper, and H. BeltrandelRio. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes 47: 298-302, 1998.
46. Yeh, J. I., E. A. Gulve, L. Rameh, and M. J. Birnbaum. The effects of wortmannin on rat skeletal muscle: dissociation of signaling pathways for insulin and contraction-activated hexose transport. J. Biol. Chem. 270: 2107-2111, 1995.
47. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Science 372: 425-432, 1994.
48. Zhao, A. Z., K. E. Bornfeldt, and J. A. Beavo. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J. Clin. Invest. 102: 869-873, 1998.
49. Zhou, Y., M. Shimabukuro, K. Koyama, Y. Lee, M. Wang, F. Trieu, C. B. Newgard, and R. H. Unger. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc. Natl. Acad. Sci. USA 94: 6386-6390, 1998.
50. Zierath, J. R., E. U. Frevert, J. W. Ryder, P. O. Berggren, and B. B. Kahn. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes 47: 1-4, 1998.