Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 2, 1999, Pages 674-679

  Seufert, Jochen ^a,b   Kieffer, Timothy J ^a,c   Habener, Joel F ^a,d  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEEDING BEHAVIOR; HORMONAL REGULATION; HYPERINSULINEMIA; INSULIN RELEASE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA; RODENTIA;

EID: 0033582239     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.2.674     Document Type: Article

References (36)

1. Consensus Development Conference on Insulin Resistance (1998) Diabetes Care 21, 310-314.
2. Ferranini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N. & Mingrone, G. (1997) J. Clin. Invest. 100, 1166-1173.
3. Sigal, R. J., El-Hashimy, M., Martin, B. C., Soeldner, J. S., Krolewski, A. S. & Warram, J. H. (1997) Diabetes 46, 1025-1029.
4. Flier, J. S. (1998) J. Clin. Endocrinol. Metab. 83, 1407-1413.
5. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J. & Bauer, T. L. (1996) N. Engl. J. Med.
6. Spiegelman, B. M. & Flier, J. S. (1996) Cell 87, 377-389.
7. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T. & Deeds, J. (1995) Cell 83, 1263-1271.
8. Rosenblum, C. I., Tota, M., Cully, D., Smith, T., Collum, R., Qureshi, S., Hess, J. F., Phillips, M. S., Hey, P. J. & Vongs, A. (1996) Endocrinology 137, 5178-5181.
9. Leibel, R. L. (1997) J. Nutr. 127, 1908S.
10. Emilsson, V., Liu, Y. L., Cawthorne, M. A., Morton, N. M. & Davenport, M. (1997) Diabetes 46, 313-316.
11. Kieffer, T. J., Heller, R. S. & Habener, J. F. (1996) Biochem. Biophys. Res. Commun. 224, 522-527.
12. Harvey, J., McKenna, F., Herson, P. S., Spanswick, D. & Ashford, M. L. (1997) J. Physiol (London) 504, 527-535.
13. Kieffer, T. J., Heller, R. S., Leech, C. A., Holz, G. G. & Habener, J. F. (1997) Diabetes 46, 1087-1093.
14. Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D. & Ashford, M. L. (1997) Nature (London) 390, 521-525.
15. Chen, N. G., Swick, A. G. & Romsos, D. R. (1997) J. Clin. Invest. 100, 1174-1179.
16. Fehmann, H. C., Bode, H. P., Ebert, T., Karl, A. & Gàke, B. (1997) Horm. Metab. Res. 29, 572-576.
17. Fehmann, H. C., Berghofer, P., Brandhorst, D., Brandhorst, H., Hering, B., Bretzel, R. G. & Göke, B. (1997) Acta. Diabetol. 34, 249-252.
18. Fehmann, H. C., Peiser, C., Bode, H. P., Stamm, M., Staats, P., Hedetoft, C., Lang, R. E. & Göke, B. (1997) Peptides (Tarrytown, NY) 18, 1267-1273.
19. Ishida, K., Murakami, T., Mizuno, A., Iida, M., Kuwajima, M. & Shima, K. (1997) Regul. Pept. 70, 179-182.
20. Koyama, K., Chen, G., Wang, M. T., Lee, Y., Shimabukuro, M., Newgard, C. B. & Unger, R. H. (1997) Diabetes 46, 1276-1280.
21. Kulkarni, R. N., Wang, Z. L., Wang, R. M., Hurley, J. D., Smith, D. M., Ghatei, M. A., Withers, D. J., Gardiner, J. V., Bailey, C. J. & Bloom, S. R. (1997) J. Clin. Invest. 100, 2729-2763.
22. Ookuma, M., Ookuma, K. & York, D. A. (1998) Diabetes 47, 219-223.
23. Pallet, A. L., Morton, N. M., Cawthorne, M. A. & Emilsson, V. (1997) Biochem. Biophys. Res. Commun. 238, 267-270.
24. Poitout, V., Rouault, C., Guerre-Millo, M., Briaud, I. & Reach, G. (1997) Endocrinology 139, 822-826.
25. Roduit, R. & Thorens, B. (1997) FEBS Lett. 415, 179-182.
26. Zhao, A. Z., Bornfeldt, K. E. & Beavo, J. A. (1998) J. Clin. Invest. 102, 869-873.
27. Seufert, J., Weir, G. C. & Habener, J. F. (1998) J. Clin. Invest. 101, 2528-2539.
28. Lu, M., Seufert, J. & Habener, J. F. (1997) J. Biol. Chem. 272, 28349-28359.
29. Brasier, A. R., Tate, J. E. & Habener, J. F. (1989) BioTechniques 7, 1116-1122.
30. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A. & Wollheim, C. B. (1992) Endocrinology 130, 167-178.
31. Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L. & Habener, J. F. (1987) Proc. Natl. Acad. Sci. USA 84, 3434-3438.
32. German, M. S., Moss, L. G. & Rutter, W. J. (1990) J. Biol. Chem. 265, 22063-22066.
33. Docherty, K., Clark, A. R., Scott, V. & Knight, S. W. (1991) Proc. Nutr. Soc. 50, 553-558.
34. Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, P., Nielsen, J. H. & Billestrup, N. (1996) Mol. Endocrinol. 10, 652-660.
35. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995) Science 269, 540-543.
36. Habener, J. F. (1993) Endocrinol. Metab. Clin. North Am. 22, 775-794.